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"7"
],
"periodicity": 1,
"slug": "a21_tulyaremiya",
"lead": "Туляремия — острая зоонозная бактериальная природно-очаговая инфекционная болезнь с разнообразными",
"description": "<p>Характеризуется лихорадкой, интоксикацией, воспалительными изменениями в области входных ворот инфекции, регионарным лимфаденитом.</p>",
"etiology": "<p>Возбудитель —грамотрицательная полиморфная (преимущественно кокковидная) неподвижная палочка, не образующая спор и капсул.</p>\r\n<p>Туляремия — классическая природно-очаговая болезнь, облигатный зооноз. Источником возбудителя инфекции служат около 150 видов животных, включая 105 видов млекопитающих, 25 видов птиц, несколько видов рыб, лягушек, других гидробионтов. На территории России основной резервуар и источник инфекции — грызуны (мышевидные, кролики, зайцы, водяные крысы, ондатры, хомяки и др.). Выделения и трупы павших животных содержат большое количество возбудителей, которые обсеменяют объекты окружающей среды, в том числе и водные, и длительно в них сохраняются. Между грызунами передача инфекции осуществляется алиментарным путём. Среди домашних животных резервуаром инфекции могут быть овцы, свиньи, крупный рогатый скот, лошади, но заражение людей чаще всего происходит в природных очагах при прямом и косвенном контакте с грызунами. Больной человек не может быть источником инфекции для окружающих.</p>\r\n<p>Переносчики инфекции, поддерживающие существование возбудителя в природных очагах, — кровососущие насекомые (иксодовые и гамазовые клещи, комары, слепни).</p>\r\n<p>В организм человека возбудитель может проникать через микротравмы кожного покрова и неповреждённую слизистую оболочку миндалин, ротоглотки, желудочно-кишечный тракт, дыхательных путей, глаз.</p>",
"pathogenesis": "<p>F. tularensis проникает в организм человека через кожу (даже внешне не повреждённую) и слизистые оболочки глаз, дыхательных путей, миндалин и ЖКТ. При инфицировании через кожу или аэрогенным путём для развития болезни достаточно пятидесяти жизнеспособных микроорганизмов, а при алиментарном заражении — более 108 микробных клеток.</p>\r\n<p>В месте входных ворот инфекции происходит размножение возбудителя с развитием некротически-воспалительной реакции и первичного аффекта (кожная язва, проходящая стадии <a title=\"Перейти на страницу симптома Папулы\" href=\"/symptom/papuly/\">папулы</a>, везикулы и <a title=\"Перейти на страницу симптома Пустулы\" href=\"/symptom/pustuly/\">пустулы</a>; на миндалинах — некротическая ангина, в лёгких — очаговая некротическая пневмония, на конъюнктиве — конъюнктивит). Затем возбудитель проникает в регионарные лимфатические узлы, вызывая развитие специфического лимфаденита — первичного бубона. Здесь происходит частичная гибель бактерий, сопровождаемая выделением эндотоксина (ЛПС-комплекс), усиливающего местный воспалительный процесс и вызывающего развитие интоксикации при поступлении в кровь.</p>",
"diagnostics": "<p>Диагностика туляремии основана на клинических, эпидемиологических и лабораторных данных.</p>\r\n<p>В общем анализе крови в начальном периоде обнаруживают нормоцитоз или небольшой лейкоцитоз, увеличение СОЭ. Периоду разгара болезни свойственна лейкопения с лимфо- или моноцитозом. Нейтрофильный лейкоцитоз отмечают только при нагноении бубонов.</p>\r\n<p>Для специфической диагностики туляремии применяют серологические и аллергические тесты, бактериологическое исследование и биологическую пробу.</p>",
"treatment": "<p>Больных с подозрением на туляремию госпитализируют по клиническим показаниям. Окна в палатах должны быть закрыты сеткой, чтобы не допустить трансмиссивного пути распространения инфекции.</p>\r\n<p>В остром периоде больным необходимы постельный режим и полноценное питание, обогащённое витаминами. Большое значение имеет уход.</p>\r\n<p>Основные этиотропные препараты — аминогликозиды и тетрациклины (стандарт лечения).</p>\r\n<p>Патогенетическую терапию, включающую дезинтоксикацию, антигистаминные и противовоспалительные препараты (салицилаты), витамины и сердечно-сосудистые средства, проводят по показаниям.</p>",
"prevention": "<p>Основа специфической профилактики — вакцинация лиц старше семи лет, пребывающих или работающих на территории, эндемичной по туляремии. Применяют живую сухую туляремийную вакцину.</p>\r\n<p>Неспецифическая профилактика предусматривает контроль за природными очагами туляремии, своевременное выявление эпизоотий среди диких животных, проведение дератизационных и дезинсекционных мероприятий.</p>\r\n<p>При водной вспышке запрещают употреблять некипячёную воду и купаться, а при заражении колодезной воды принимают меры к очистке колодца от трупов грызунов и проводят дезинфекцию воды.</p>\r\n<p>При угрозе трансмиссивного заражения рекомендуется применять репелленты, защитную одежду, ограничивается въезд непривитого населения на неблагополучные территории.</p>\r\n<p>Для профилактики промысловых заражений целесообразно использовать перчатки при снятии шкурок с убитых грызунов и дезинфицировать руки. Проводят мероприятия по дезинсекции и дезинфекции на складах хранения шкурок. Необходима тщательная термическая обработка мяса (например, заячьего) перед употреблением в пищу.</p>\r\n<p>При скирдовании сена и обмолоте хлеба употребляют очки-консервы и защитные маски.</p>\r\n<p>Среди населения районов, неблагополучных по туляремии, необходимо проводить систематическую разъяснительную и санитарно-просветительную работу.</p>\r\n<p>Лиц, контактировавших с больным, не изолируют, так как заболевшие не заразны. В жилье больного осуществляют дезинфекцию.</p>",
"clinical_picture": "<p>Инкубационный период составляет от нескольких часов до 3 нед (в среднем 3–7 дней).</p>\r\n<p>По тяжести инфекционного процесса различают лёгкие, средней тяжести и тяжёлые формы туляремии.</p>\r\n<p>По длительности течения выделяют острую (до 3 мес), затяжную (до 6 мес), рецидивирующую формы туляремии и, кроме того, инаппарантную (бессимптомную, латентную) туляремию, которую обнаруживают преимущественно во время эпидемических вспышек при лабораторном исследовании.</p>\r\n<p>Туляремия протекает циклически. Выделяют следующие периоды заболевания: инкубационный, начальный, период разгара и выздоровления.</p>\r\n<p>Симптомы начального периода одинаковы при всех клинических формах. Типично острое начало: с озноба, лихорадки и симптомов интоксикации. Температура в течение нескольких часов поднимается до 38–40 °С и выше. Одновременно возникают <a title=\"Перейти на страницу симптома Головная боль\" href=\"/symptom/golovnaya_bol/\">головная боль</a>, <a title=\"Перейти на страницу симптома Головокружение\" href=\"/symptom/golovokruzhenie/\">головокружение</a>, <a title=\"Перейти на страницу симптома Слабость\" href=\"/symptom/slabost/\">слабость</a>, разбитость, мышечные боли (особенно в поясничной области и икроножных мышцах), ухудшение аппетита, нарушения сна, повышенная <a title=\"Перейти на страницу симптома потливость\" href=\"/symptom/potlivost/\">потливость</a>. Возможны <a title=\"Перейти на страницу симптома Брадикардия\" href=\"/symptom/bradikardiya/\">брадикардия</a>, <a title=\"Перейти на страницу симптома Низкое давление\" href=\"/symptom/nizkoe_davlenie/\">гипотония</a>, гепатоспленомегалия.</p>\r\n<p>Продолжительность начального периода 2–3 дня. Позже возникают признаки, характерные для той или иной клинической формы, но общие симптомы для всех форм — <a title=\"Перейти на страницу симптома Высокая температура 38-42° \" href=\"/symptom/vysokaya_temperatura_38-42/\">лихорадка</a>, характерный внешний вид больного и интоксикация.</p>\r\n<p>Продолжительность лихорадочного периода 2–3 нед (от 5–7 до 30 дней), но иногда, при рецидивирующем течении или присоединении осложнений, он может удлиняться до нескольких месяцев. </p>\r\n<p>Характерен внешний облик больных: лицо одутловато и гиперемировано, в тяжёлых случаях — синюшно-багрового цвета (особенно вокруг глаз, губ, мочек ушей). Нередко вокруг подбородка отмечают бледный треугольник, обнаруживают признаки конъюнктивита, инъекцию сосудов склер, точечные кровоизлияния на слизистой оболочке полости рта. Возможны носовые кровотечения. Больные эйфоричны.</p>\r\n<p>На кожных покровах с третьего дня болезни может возникать <a title=\"Перейти на страницу симптома Сыпь\" href=\"/symptom/syp/\">сыпь</a> эритематозного, папулёзного или петехиального характера, которая разрешается пластинчатым и(или) отрубевидным шелушением, пигментацией. У лиц пожилого возраста бывают узловатые эритемы.</p>\r\n<p>Осложнения чаще отмечаются при генерализованной форме туляремии. Возможно развитие инфекционно-токсического шока, менингита, менингоэнцефалита, перикардита, миокардиодистрофии, полиартрита, вегетативных неврозов, перитонита (вследствие нагноения и самопроизвольного вскрытия мезентериальных лимфатических узлов при абдоминальной форме), перфорации роговицы, бронхоэктазий, абсцесса и гангрены лёгких (при пневмонической форме). Течение любой формы может осложниться туляремийной пневмонией.</p>",
"image": "http://api.symptomd.ru/storage/9e223c0e79de04277c0c1cfde8cde3ea_BG8Txmh.png",
"image_alt": "Туляремия",
"standard_type": 1,
"danger": 26,
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"parent": null,
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"standards": []
},
{
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{
"id": 2866,
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{
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{
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{
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"lead": "Повышение температуры тела человека более 38° С может быть опасно для здоровья и требует медицинской помощи",
"image": null,
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{
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{
"name": "Болит голова"
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{
"name": "Боль в висках"
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{
"name": "Голова болит"
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{
"name": "Мигрень "
},
{
"name": "Боль в голове при наклоне"
},
{
"name": "Боль головная у детей"
},
{
"name": "Боль при повороте головы"
},
{
"name": "Височная боль"
},
{
"name": "Колющая боль в голове"
},
{
"name": "Покалывание в голове"
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{
"name": "Жжение в голове "
},
{
"name": "Боль в лобной части головы "
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{
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