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"etiology": "<p>Причиной развития тропической лихорадки является арбовирус рода Flavivirus, который проникает в кровь человека через укус зараженной самки комара. Вирус денге обладает резистентностью к низким температурам и высушиванию. Не выдерживает нагревания до 60°С, воздействия ультрафиолетовых лучей, обработку формалином или эфиром. </p>\r\n<p>Вирус денге имеет четыре серотипа: DEN-I, DEN-II, DEN-III, DEN-IV. Зависимость формы и тяжести протекания болезни от заражения определенным типом вируса не установлены. </p>\r\n<p>Источником инфекции является больной человек, обезьяны и летучие мыши. Передачу инфекции от больного человека осуществляют комары рода Aedes (A. albopictus и A. Aegypti, A. Polinesiensis, A. Cutellaris). Комары становятся заразными на 8-12 день после кровососания и сохраняют пожизненную способность к передаче вируса. В большей степени к лихорадке денге восприимчивы дети до 2-х лет, пожилые и ослабленные люди, а также приезжие лица, в т. ч. туристы. </p>",
"pathogenesis": "<p>После укуса москита в течение 3-5 дней происходит размножение вируса в регионарных лимфоузлах и эндотелии сосудов. По истечении периода первичной репликации вирусные частицы проникают в кровь, обусловливая развитие вирусемии, которая клинически проявляется лихорадочно-интоксикационным синдромом. Вторая волна лихорадки связана с проникновением вирусов в органы и ткани. Купирование клинической симптоматики наступает по мере накопления в крови вируснейтрализующих ант</p>\r\n<p>Инкубационный период составляет в среднем 3—15 дней (чаще 5—7 дней). </p>\r\n<p>Классическая лихорадка денге (заболевает человек при первичном инфицировании): </p>\r\n<p>повышение температуры до 39—40 °С (к концу 3-х суток температура резко снижается, а через 1—3 дня вновь повышается, далее опять снижается через 2—3 дня) </p>\r\n<p>учащение пульса в начале заболевания, а через 2—3 дня он сильно урежается </p>\r\n<p>озноб </p>\r\n<p>боли в костях (чаще в позвоночнике) </p>\r\n<p>боли в суставах (особенно в коленных суставах) </p>\r\n<p>боли в мышцах </p>\r\n<p>анорексия (отказ от еды из-за отсутствия аппетита) </p>\r\n<p>адинамия (резкий упадок сил) </p>\r\n<p>тошнота </p>\r\n<p>головокружение </p>\r\n<p>бессонница </p>\r\n<p>покраснение и отёчность лица </p>\r\n<p>покраснение глаз </p>\r\n<p>покраснение горла </p>\r\n<p>различная зудящая сыпь (сначала сыпь появляется на туловище, затем распространяется на конечности и сохраняется 3—7 дней): </p>\r\n<p>петехиальная — точечные кровоизлияния </p>\r\n<p>скарлатиноподобная — покраснение кожи, на фоне которого определяются пятнышки величиной с просяное зерно. </p>\r\n<p>уртикарная — возвышающиеся над поверхностью кожи отёчные волдыри ярко-розового цвета размером от 0,5 до нескольких сантиметров, сильно зудящие. </p>\r\n<p> </p>\r\n<p>ител. </p>",
"diagnostics": "<p>Критерии, разработанные ВОЗ, позволяют заподозрить лихорадку денге в случае развития: лихорадочного синдрома, сохраняющегося 2-7 дней; тромбогеморрагического синдрома; увеличения печени и шокового синдрома. Также учитывается наличие эпидемиологических предпосылок (посещение эндемичных регионов, укусов москитов, вспышек инфекции) и типичных клинических симптомов (двухволновой лихорадки, артралгии, миалгии, экзантемы). </p>\r\n<p>Лабораторные методы исследования: </p>\r\n<ul>\r\n<li>общий анализ крови - снижение тромбоцитов, увеличение гематокрита. </li>\r\n<li>выявление антител (реакция связывания комплемента, реакция торможения гемагглютинации, реакция нейтрализации) </li>\r\n<li>выявление РНК вируса лихорадки Денге методом ПЦР (позволяет дифференцировать вирус различных типов). </li>\r\n<li> </li>\r\n</ul>",
"treatment": "<p>Больных госпитализируют в стационар. </p>\r\n<p>При классической форме заболевания назначают: </p>\r\n<ul>\r\n<li>болеутоляющие препараты; </li>\r\n<li>витамины; </li>\r\n<li>антигистаминные препараты. </li>\r\n</ul>\r\n<p>Показаны строгий постельный режим и обильное питьё: не менее 200 гр. каждые 2 часа, или более 2 литров в день. ВОЗ рекомендует свежевыжатые соки, молоко. Употребление только воды может привести к сдвигу электролитического баланса. Предпочтительны витамины С, К, B. </p>",
"prevention": "<p> Для предупреждения инфицирования в регионах, эндемичных по развитию лихорадки денге, необходимо использовать репелленты и фумигаторы, отпугивающие комаров, противомоскитные сетки. Особую актуальность имеет уничтожение комаров-переносчиков вируса денге, применение инсектицидов, борьба с заболоченностью и засорением территории, хранение запасов воды в закрытых емкостях.</p>",
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