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"code": "C34",
"name": "Рак бронхов и легкого",
"icd_name": "Рак бронхов и легкого",
"gender": 0,
"age_min": 35,
"age_max": 100,
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"periodicity": 4,
"slug": "c34_rak_bronhov_i_legkogo",
"lead": "злокачественное новообразование, развивающееся из покровного эпителия бронхов различного калибра и бронхиальных желез.",
"description": "Рак бронхов и легкого обычно рассматривают вместе, объединяя их названием \"бронхопульмональный рак\". ",
"etiology": "<p>Развитию рака легкого могут предшествовать хронические воспалительные процессы: хроническая пневмония, бронхоэктатическая болезнь, хронический бронхит, рубцы в легком после ранее перенесенного туберкулеза и т. п. Немалую роль играет и курение, так как, согласно большинству статистик, рак легкого у курящих наблюдается значительно чаще, чем у некурящих. Так, при выкуривании двух и больше пачек сигарет в сутки частота рака легкого возрастает в 15- 25 раз. Другие факторы риска - работа на асбестовом производстве, облучение.</p>",
"pathogenesis": "<p>По гистологической структуре раки легкого чаще всего бывают плоскоклеточными, хотя наблюдаются также железистые формы (аденокарциномы), резко анаплазированные - мелкоклеточный рак, овсянноклеточный и некоторые другие варианты.</p>",
"diagnostics": "<p>Когда центральный рак лёгкого находится на ранней стадии, распознать его очень трудно. Осмотр терапевта, рентгенологические исследования — малоэффективны. Если сделать такому человеку бронхоскопию с биопсией, то правильный диагноз может быть поставлен. Иногда распознать болезнь на ранних стадиях помогает компьютерная томография. Если рак периферический, то сделать биопсию невозможно, так как добраться до подозрительного места с помощью бронхоскопии просто не получится. Поэтому проводится трансторакальная игловая биопсия, то есть забор кусочка ткани через прокол в грудной стенке. Если очаги есть в области средостения (части грудной полости, находящейся между грудиной, позвоночником, диафрагмой, плеврой и поверхностями лёгких), проводится медиастиноскопия (осмотр с целью биопсии через разрез на шее). Иногда нельзя обойтись без диагностических торакоскопии и торакотомии (вскрытия грудной полости). Чтобы уточнить, насколько опухоль распространена, применяются самые разные диагностические методы: УЗИ, бронхоскопия, мультиспиральная компьютерная, магнитно-резонансная и позитронно-эмиссионная томография, а также радионуклидные исследования. Без этого невозможно выбрать лучший подход к лечению конкретного пациента.<br /><br /><br /></p>",
"treatment": "<p>Выбор лечения зависит от гистологической формы рака, его распространенности, наличия метастазов. При немелкоклеточном раке лёгкого лечение рака легкого может быть как чисто хирургическим, так и комбинированным. Последний метод дает лучшие отдаленные результаты. При комбинированном лечении его начинают с проведения дистанционной гамма-терапии на зону первичной опухоли и метастазов. После интервала в 2-3 педели предпринимают хирургическое вмешательство: удаление всего легкого - пульмонэктомия - или удаление одной (двух) доли - лобэктомия и билобэктомия. Операции на легком, особенно у ослабленных раковых больных, - крайне ответственное и тяжелое вмешательство, требующее специальной подготовки больного, высокой квалификации хирурга, умелого обезболивания и тщательного послеоперационного ухода.Рецидивы рака легкого возникают после недостаточно радикальных операций, обычно в виде возобновления роста опухоли в оставленной культе бронха в тех случаях, когда имелась значительная инфильтрация его стенки далеко за видимыми пределами опухоли. Лечение рецидивов обычно сугубо паллиативное. При диссеминированной форме заболевания основным методом лечения является химиотерапевтический. В качестве дополнительного метода применяют лучевую терапию. Оперативное вмешательство применяют очень редко. При распространённом раке, наличии отдалённых метастазов, поражении надключичных лимфатических узлов или экссудативном плеврите показана комбинированная химиотерапия. При отсутствии эффекта от химиотерапии или наличии метастазов в головном мозге облучение даёт паллиативный эффект. При очень распространенных, неоперабельных формах рака легкого с паллиативной целью проводят дистанционную гамма-терапию или курсы химиотерапии, иногда комбинируя оба эти метода. Паллиативная лучевая терапия или лечение противоопухолевыми средствами позволяет получить временное улучшение и продлить жизнь больному.</p>",
"prevention": "<p>Лучший способ уменьшить вероятность развития рака лёгкого — это бросить курить и избегать пассивного курения. По имеющимся данным, после 10 лет без курения риски становятся минимальными. Если человек работает на «вредном» производстве, то обязательно нужно защищать дыхательные пути от контакта с асбестовой пылью и тяжёлыми металлами.<br /><br /><br /></p>",
"clinical_picture": "<p>Симптомы бронхопульмонального рака различны в зависимости от того, где возникает первичная опухоль - в бронхе или в ткани легкого. При раке бронха (центральный рак) заболевание обычно начинается с сухого надсадного кашля, а затем появляется <a title=\"Перейти на страницу симптома Влажный кашель\" href=\"../../../symptom/vlazhnyy_kashel/\">мокрота</a>, нередко с примесью крови. Очень характерно для этой формы периодическое беспричинное возникновение воспаления легкого - так называемого пневмонита, сопровождающегося усилением кашля, высокой температурой, общей слабостью, иногда болями в груди.</p>\r\n<full></full>\r\n<p>Причиной развития пневмоиитов служит временная закупорка бронха опухолью вследствие присоединяющегося воспаления. При этом наступает ателектаз (безвоздушность) того или иного сегмента или доли легкого, который неизбежно сопровождается вспышкой инфекции в ателектазировавном участке. При уменьшении воспалительного компонента вокруг опухоли или распаде ее просвет бронха снова частично восстанавливается, ателектаз исчезает, и все явления временно прекращаются с тем, чтобы вспыхнуть вновь через несколько месяцев. Очень часто эти \"волны\" пневмонита принимают за грипп, обострение бронхита и проводят медикаментозное лечение, не обследуя больного рентгенологически. В других случаях проводят просвечивание легких по стихании явлений пневмонита, когда исчезает характерный для рака симптом ателектаза, и болезнь остается нераспознанной. В дальнейшем течение заболевания принимает стойкий характер: упорный <a title=\"Перейти на страницу симптома Кашель\" href=\"../../../symptom/kashel/\">кашель</a>, нарастающая <a title=\"Перейти на страницу симптома Слабость\" href=\"../../../symptom/slabost/\">слабость</a>, <a title=\"Перейти на страницу симптома Высокая температура 38-42° \" href=\"../../../symptom/vysokaya_temperatura_38-42/\">повышение температуры</a> и боли в груди. Нарушения дыхания могут быть значительными при развитии гиповентиляции и ателектаза доли или всего легкого. Для периферического рака легкого, развивающегося в самой легочной ткани, начало болезни почти безсимптомно. В этих стадиях опухоль нередко обнаруживают случайно при профилактическом рентгенологическом обследовании больного. Лишь с увеличением размеров, присоединяющимся воспалением или при прорастании опухолью бронха или плевры возникает яркая симптоматика сильных болей, кашля с повышением температуры. В запущенной стадии вследствие распространения опухоли в полость плевры развивается раковый плеврит с прогрессирующим накоплением кровянистого выпота.</p>",
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},
"code": "C32",
"name": "Рак гортани",
"icd_name": "Рак гортани",
"gender": 0,
"age_min": 40,
"age_max": 65,
"cause": [
3,
0
],
"periodicity": 1,
"slug": "c32_rak_gortani",
"lead": "злокачественное новообразование гортани, происходящее из эпителиальной ткани.",
"description": "Рак гортани – это злокачественные новообразования, которые возникают во всех отделах гортани (вестибулярном, среднем, и подсвязочном) и чаще всего образуются из эпителия.\r\nРак гортани занимает лидирующее место среди опухолей головы и шеи и 8 место во всей структуре онкологических заболеваний. Ежегодно в мире отмечается увеличение на 8-10% числа больных этой формой рака.",
"etiology": "<p>Раку гортани зачастую предшествует хронический многолетний ларингит. Особое значение в возникновении рака гортани относятся предраковые заболевания:</p>\r\n<ul>\r\n<li>длительно существующая папиллома</li>\r\n<li>лейкоплакия слизистой оболочки гортани</li>\r\n<li>дискератозы</li>\r\n<li>пахидермия</li>\r\n<li>фиброма на широком основании</li>\r\n<li>кисты гортанных желудочков</li>\r\n<li>хронические воспалительные процессы</li>\r\n</ul>\r\n<p>Часто наблюдается малигнизация папиллом и лейкоплакии.</p>",
"pathogenesis": "",
"diagnostics": "<p>При диагностике используются следующие процедуры: Непрямая ларингоскопия, внешний осмотр и пальпация. Фиброларингоскопия. Данный метод является одним из основных методов в диагностике рака горла. При проведении этой процедуры есть возможность осмотреть все отделы гортани в большом разрешении и без «слепых зон». Инструмент вводится в гортань легко и безопасно, есть возможность взять биопсию для цитологического исследования. Ко всему прочему, есть возможность визуализации подскладочного отдела и выполнения высококачественной фотосъемки. Морфологическое исследование (гистологическое, цитологическое) материала полученного при биопсии, пункции и соскобах. Компьютерная томография (КТ) гортани. Используется для оценки состояний хрящей гортани, которые нельзя увидеть при ларингоскопии. Также этот метод дает дополнительную информацию о вестибулярном отделе гортани и гортаноглотке. Магнитно-резонансная томография (МРТ). Этот метод позволяет оценить состояние голосовых складок, подскладочного отдела, просвета гортанных желудочков, черпалонадгортанных складок, грушевидных синусов. Рентгенография легких. Используется в случае подозрения на отдаленные метастазы. Ультразвуковое исследование печени и лимфоузлов шеи. Используется в случае подозрения на отдаленные и регионарные метастазы. При наличии увеличенных регионарных лимфоузлов — пункция их для цитологического подтверждения. Все эти методы позволяют однозначно поставить диагноз и назначить подходящее лечение.</p>\r\n<p> </p>",
"treatment": "<p>Существует консервативное и хирургическое лечение рака гортани. В настоящее время достаточно много внимания уделяется качеству жизни пациентов, поэтому при ранних стадиях рака среднего и надскладочного отдела начинают с консервативного лечения – лучевой и химиотерапии. Оно по эффективности одинаково с хирургическим, однако не нарушает функции гортани, и больные могут продолжать трудовую деятельность.</p>\r\n<full></full>\r\n<p class=\"ramka2\">Комбинированное лечение – сочетание хирургии и лучевой терапии. Проводится пациентам с большими опухолями и распространенностью процесса. Предоперационная лучевая терапия способствует уменьшению размеров опухоли и снижает жизнеспособность раковых клеток. Однако после больших доз ЛТ <a href=\"/symptom/yazva_naruzhnaya/\" title=\"Перейти на страницу симптома Язва наружная\">рана</a> может заживать хуже.</p>\r\n<p>Операция</p>\r\n<p>Объемы операций могут различными. Возможно удаление части гортани (резекция), при этом сохраняется дыхательная функция и голос. При больших опухолях гортань удаляется полностью, после таких операций дыхание осуществляется через трахеостому и человек лишается звучного <a href=\"/symptom/sluhovye_gallyucinacii/\" title=\"Перейти на страницу симптома Слуховые галлюцинации\">голоса</a>. Для восстановления речи проводятся занятия с логопедом, пациенты учатся образовывать звук с помощью заглатываемого в желудок воздуха, такая речь позволяет общаться с окружающими людьми и даже вернутся к труду. Кроме того, применяются специальные силиконовые голосовые протезы.</p>\r\n<p> </p>\r\n<p>Лучевая терапия</p>\r\n<p>Лучевая терапия, облучения рака гортани проводится с боковых полей и включает всю гортань и зону регионарного метастазирования. Общие реакции – <a href=\"/symptom/slabost/\" title=\"Перейти на страницу симптома Слабость\">слабость</a>, головные боли, <a href=\"/symptom/toshnota/\" title=\"Перейти на страницу симптома Тошнота\">тошнота</a>. Местные реакции возникают в гортани и на коже шеи. Больные жалуются на боли при глотании, <a href=\"/symptom/otek_tkaney/\" title=\"Перейти на страницу симптома Отек тканей\">отек тканей</a> шеи. Изменения в гортани характеризуются <a href=\"/symptom/vospalenie/\" title=\"Перейти на страницу симптома воспаление\">воспаление</a> и отеком слизистой и голосовых связок. Это может приводить к усилению охриплости и сужению просвета гортани, поэтому при большом размере опухоли пациенту предлагается наложение трахеостомы (ниже расположения опухоли в трахею вводится трубка, через которую пациент дышит, она после лечения удаляется). При лучевой терапии функция звукообразования не страдает и после лечения восстанавливается звучный голос.</p>\r\n<p>Химиотерапия</p>\r\n<p>Химиотерапия при раке гортани применяется только в сочетании с лучевым и хирургическим лечением. Используются в основном препараты платины – цисплатин. Наблюдение осуществляется в первый год каждый месяц, на второй год – раз в 4 месяца, с 3 до 5 лет – раз в полгода, а после пяти раз в год.</p>",
"prevention": "<p>Рак гортани, как и любое заболевание, легче предупредить, чем вылечить. Поэтому: откажитесь от курения и неумеренного употребления алкоголя; соблюдайте правила индивидуальной профилактики при работе с перечисленными ранее химическими веществами; своевременно лечите хронические заболевания гортани, удаляйте доброкачественные новообразования. В заключение отметим, что при появлении длительно не проходящих охриплости и осиплости не следует месяцами заниматься самолечением или ожидать самоизлечения. Необходимо как можно раньше обратиться к врачу и не отказываться от предложенных обследований и лечения.</p>\r\n<p> </p>",
"clinical_picture": "<p>Признаки заболевания весьма разнообразны и зависят от формы и места роста опухоли, степени ее распространения. Начальный период заболевания характеризуется незначительными и часто скрыто протекающими симптомами. Должны насторожить следующие симптомы: <a href=\"/symptom/ohriplost/\" title=\"Перейти на страницу симптома Охриплость\">Охриплость</a> или другие изменения <a href=\"/symptom/sluhovye_gallyucinacii/\" title=\"Перейти на страницу симптома Слуховые галлюцинации\">голоса</a>. <a href=\"/symptom/otek_tkaney/\" title=\"Перейти на страницу симптома Отек тканей\">Припухлость</a> в области шеи. <a href=\"/symptom/bol_v_gorle/\" title=\"Перейти на страницу симптома Боль в горле\">Боль в горле</a> и ощущение дискомфорт при глотании, першение. Ощущение инородного тела в гортани при глотании. Постоянный <a href=\"/symptom/kashel/\" title=\"Перейти на страницу симптома Кашель\">кашель</a>. <a href=\"/symptom/vydeleniya_iz_uha/\" title=\"Перейти на страницу симптома Выделения из уха\">Боль в ухе</a>. <a href=\"/symptom/anormalnaya_poterya_vesa/\" title=\"Перейти на страницу симптома Анормальная потеря веса\">Потеря веса</a>.</p>\r\n<p> </p>",
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}
]
}
