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},
"code": "K66.1",
"name": "Гемоперитонеум",
"icd_name": "Гемоперитонеум",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "k66.1_gemoperitoneum",
"lead": "внутрибрюшное кровотечение, приводящее к излитию свободной крови в брюшную полость",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гемоперитонеум может осложнять широкий круг состояний: закрытые повреждения живота, торакоабдоминальные травмы, патологические процессы в брюшной полости и забрюшинном пространстве, оперативные вмешательства, гинекологические заболевания и т. д. Гемоперитонеум развивается вследствие нарушения целостности сосудов брюшной полости и может иметь травматическое и нетравматическое происхождение.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Травматический гемоперитонеум возникает при тупых тупых травмах живота (ударах, падениях, ДТП, сдавлении), проникающих (огнестрельных, ножевых) ранениях живота, интраоперационной травме. При этом чаще всего повреждаются паренхиматозные органы – печень, селезенка, поджелудочная железа, а также сосуды, проходящие в связках, складках брюшины, брыжейках кишок, сальнике. Повреждение внутренних органов костными отломками может наблюдаться при переломе нижних ребер.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нетравматический гемоперитонеум встречается при внематочной беременности, апоплексии яичника, разрыве аневризмы аорты, гемангиоме печени, заболеваниях, приводящих к снижению свертываемости крови (механической желтухе, малярии, болезнях крови, геморрагических диатезах), длительной терапии фибринолитиками и антикоагулянтами.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В хирургической практике патология может развиваться в результате повреждения органов при проведении инвазивной диагностики (ангиографии, пункционной биопсии), прорезывания или соскальзывания операционных лигатур после операций резекции желудка, аппендэктомии, грыжесечения, гемиколэктомии, холецистэктомии, надвлагалищной ампутации матки, нефрэктомии, спленэктомии, резекции печени и др.</span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выявить отклонение можно при первичном осмотре с помощью пальпации. При глубоком виде вмешательства человек ощущает резкие боли в месте изъяна. Наблюдается также перкуссия живота и его аускультация. Возможны также и пальцевое ректальное и гинекологическое исследования, пункция заднего свода влагалища (кульдоцентеза).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Необходимы лабораторные анализы, а именно анализы крови на степень гематокрита и на содержание эритроцитов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Применяются также УЗИ-диагностика малого таза, брюшины и ретроперитонеального пространства, обзорный рентген.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В лабораторных исследованиях при данном недуге выявляются признаки кровоизлияния – снижение уровня гематокрита, нарастающее уменьшение числа эритроцитов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">С помощью УЗИ диагностируется наличие анэхогенной жидкости или организованных гематом. Рентген также позволяет выявить присутствие имеющейся жидкости, провести дифференциальную диагностику с гематомой передней стенки, забрюшинной и перфоративной язвой.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Окончательный диагноз ставится на основе пункции и введения “шарящего” катетера или лапароскопии.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При подозрении на данную патологию показана экстренная госпитализация пациента в отделение абдоминальной хирургии. На этапе доврачебной помощи категорически запрещается введение обезболивающих, в т. ч. наркотических, препаратов. При массивном кровотечении для борьбы с гиповолемическим шоком осуществляется интенсивная терапия, включающая введение аналептиков, переливание растворов и кровезаменителей, проведение реанимационных мероприятий. При недавнем внутрибрюшном кровотечении может быть произведена реинфузия крови, излившейся в брюшную полость крови.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В условиях хирургического стационара пациентам с гемоперитонеумом показано проведение лапаротомии для выявления источника кровотечения и его остановки. При травматических повреждения внутренних органов может производиться резекция печени, спленэктомия, лигирование сосудов и др. вмешательства. При внематочной беременности или апоплексии яичника выполняется тубэктомия, удаление придатков. В постоперационном периоде проводится гемостатическая, антибактериальная терапия; осуществляется мониторинг показателей крови, АД, пульса; выполняется динамическое УЗИ, КТ органов брюшной полости и забрюшинного пространства.</span></p>",
"prevention": "<p><span id=\"docs-internal-guid-b902e5f1-7fff-a332-299d-0d309330d12e\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Профилактика включает предупреждение травматизма, соблюдение техники проведения операций и манипуляций, своевременное выявление и лечение заболеваний, которые могут стать причиной гемоперитонеума.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клинические проявления определяются характером повреждения, интенсивностью внутрибрюшного кровотечения и величиной кровопотери. Внезапно возникающий гемоперитонеум сопровождается признаками геморрагического шока и локальными симптомами. Острая кровопотеря проявляется головокружением, потемнением в глазах, бледностью кожных покровов и видимых слизистых, холодным потом, жаждой, адинамией, обморочным состоянием, иногда – двигательным возбуждением. Объективно определяется тахикардия (120-140 уд. в мин.) с пульсом слабого наполнения, артериальная гипотония.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Острая резкая боль в брюшной полости может носить локальный или диффузный, разлитой характер; при раздражении кровью диафрагмальной брюшины иррадиирует в надплечье и лопатку. Нарастающий или массивный гемоперитонеум может сопровождаться увеличением объема живота; иногда (обычно у детей) – синюшностью пупка, сквозь который просвечивает кровь.</span></p>",
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{
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{
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{
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{
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{
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{
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font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нетравматический гемоперикард – возникает вследствие других, непрямых причин.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Травмогемоперикард может возникать:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после сильных травма грудной клетки, ранений груди или сердца;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после любых внутрисердечных манипуляций (пункционная биопсия, инъекции, введение катетера);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после операций на сердце (установка КС, катетерная абляция, медиастинотомия, некачественно проложенные швы и пр.);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после проведения стернальной пункции.</span></p>\r\n</li>\r\n</ul>\r\n<p><strong style=\"font-weight: normal;\"> </strong></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нетравматическая разновидность гемоперикарда возникает:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после левожелудочкового повреждения вследствие острого инфаркта миокарда;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при прорыве околосердечных и коронарных сосудистых стенок;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при разрыве аневризмы сердца или аорты;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">в результате разрыва сердечных тканей на фоне абсцесса, миокардического эхинококкоза, гуммозного воспаления миокарда;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при опухолях сердца;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при повышенной кровоточивости вследствие геморрагического диатеза или гемофилии;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после туберкулезного, гнойного или идиопатического воспаления перикарда;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при проведении гемодиализа на фоне недостаточной функции почек;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при аутоиммунных заболеваниях с поражением соединительной ткани.</span></p>\r\n</li>\r\n</ul>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Скопление небольшого количества крови в полости перикарда протекает практически бессимптомно и не отражается на функции сердца. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Скопление крови в пределах 200 мл сопровождается появлением начальной симптоматики; более 200 мл - опасное для жизни состояние. Кровотечение приводит к сдавлению сердца, снижению сократительной способности миокарда. Наполнение левого желудочка и ударный объем стремительно падает, появляется глубокая системная гипотония. За счет компрессии коронарных артерий усугубляется ишемия миокарда.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При 400-500 мл скопившейся крови, как правило, наступает остановка сердечной деятельности.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Во время первой консультации врач сначала изучает симптомы, которые беспокоят пациента, и историю его болезни. После этого он проводит осмотр, обращает внимание на наличие или отсутствие отеков и бледности кожи, характерных для заболеваний сердце. Также специалист прослушивает сердце с помощью стетоскопа (для гидроперикарда и перикардита характерны специфические шумы) и проводит простукивание пальцами по грудной клетке, позволяющее определить границы сердца. По результатам осмотра врач может предположить диагноз и направить пациента на инструментальные исследования для его подтверждения.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для диагностики гидроперикарда и причин его развитию могут назначить:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">электрокардиограмму (ЭКГ) – показывает электрическую проводимость сердца, сердечный ритм, изменения которого свидетельствуют о заболеваниях;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">эхокардиографию – УЗИ сердца, которое позволяет оценить структурное состояние сердца, определить расстояние между перикардиальными листками, характерное для гидроперикарда;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">пункцию перикарда – инвазивная процедура, которая позволяет извлечь жидкость из перикарда, после чего ее отдают на анализ (это единственный способ точно определить характер скопившейся жидкости);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рентген, КТ грудной клетки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">лабораторные анализы.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ сердца является основным методом диагностики гидроперикарда. Исследование позволяет измерить расстояние между листками перикарда, увеличение которого происходит только при скоплении жидкости в сердечной сумке. Другие обследования проводят, чтобы уточнить диагноз, оценить общее состояние пациента и определить причину развития гидроперикарда.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия проходит стационарно в кардиохирургическом отделении. При небольших размерах, не приводящих к нарушению деятельности, осуществляют консервативную терапию: пациенту показан покой, холод на район груди, назначение гемостатиков, обезболивающих препаратов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При ранении сердца и сосудов показано неотложное оперативное вмешательство с целью устранения условия кровотечения в перикардиальную щель. При нарастании дефекта и явных проявлений развития тампонады осуществляется хирургическое дренирование полости перикарда или перикардиоцентез с аспирацией скопившейся крови. Данную процедуру при гемоперикарде выполняют под обязательным контролем ЭКГ, ЭхоКГ и мониторингом показателей гемодинамики.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Одновременно проводятся реанимационные мероприятия по полному возмещению кровопотери и восстановлению гомеостаза. В зависимости от этиологии гемоперикарда в дальнейшем проводится лечение основного заболевания.</span></p>",
"prevention": "<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #2e2d31; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Предотвращение травм грудной клетки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #2e2d31; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">соблюдение режима и рекомендаций после перенесенных операций на органах груди;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #2e2d31; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">своевременная диагностика и лечение заболеваний сосудов и системы крови.</span></p>\r\n</li>\r\n</ul>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выраженность симптомов напрямую зависит от количества крови, излившейся в перикардиальную полость и от степени сдавливания сердца.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Значительные нарушения в работе сердца и его сдавливание наблюдаются при попадании в околосердечную сумку 150-200 мл крови.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Именно этого объёма крови достаточно для повышения внутриперикардиального давления, изменения тока крови в правом предсердии, уменьшения объёма левого предсердия, уменьшения сердечного выброса.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нарушения в кровообращении отражаются на питании всех органов и тканей, в первую очередь реагирует головной мозг. При сдавливании сердца пережимаются коронарные артерии, что ведёт к кислородному голоданию с последующим формированием ишемии.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При гемоперикарде наблюдается следующая симптоматика:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ощущение тяжести за грудиной;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выраженная слабость, апатия;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выраженная одышка;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">потливость;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">боли в области сердца жгучего, тупого или давящего характера;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушения акта глотания;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">обморочные состояния;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">набухание вен на лице, шее, верхних конечностях;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">страх смерти и нарастание беспокойства;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">цианоз кожных покровов и слизистых оболочек;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">внезапное побледнение кожи.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При прощупывании пульса отмечается его слабое наполнение и некоторое учащение. Из-за сердечной недостаточности снижается кровяное давление. При аускультации выявляется глухость сердечных тонов. В определённых случаях тоны не прослушиваются, и не определяется сердечный толчок. При перкуссии выявляется расширение границ сердца.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При увеличении объёма крови в перикардиальной сумке, состояние пациента резко ухудшается, что связано с усилением тампонады. Скопление 400-500 мл крови считается крайне опасным для жизни.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Указанный объём крови способен вызвать остановку сердечной деятельности.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При незначительном скоплении жидкости в полости перикарда работа сердца не нарушается, а состояние больного остаётся удовлетворительным. Хроническое течение гемоперикарда может проявляться следующей симптоматикой:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ухудшение аппетита;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">асцит;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">набухание вен на шее;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">плохая переносимость физических нагрузок;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">увеличение размеров печени;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre; margin-left: 36pt;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">затруднение дыхания при горизонтальном положении тела.</span></p>\r\n</li>\r\n</ul>",
"image": null,
"image_alt": null,
"standard_type": 0,
"danger": 50,
"published": 1,
"parent": 6527,
"block_rubric": 95,
"standards": []
},
{
"id": 11013,
"symptoms": [],
"alternative_names": [],
"complications": [],
"medicine_branches": [],
"who": [
{
"id": 14056,
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"diseased": 31844,
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"diseased_70_74": 5686,
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"disease": 6520
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У детей частыми причинами гемолитико-уремического синдрома являются острая кишечная инфекция (90%) и инфекции верхних дыхательных путей (10 %).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Заражение энтерогеморрагической Е. coli может произойти при контакте с животными (кошками, крупным рогатым скотом) или инфицированным человеком; употреблении недостаточно термически обработанных мясных изделий, непастеризованных молочных продуктов, фруктовых соков, загрязненной воды. Для гемолитико-уремического синдрома характерна сезонность: на фоне ОКИ - преимущественно теплое время года (июнь-сентябрь), на фоне вирусных инфекций - зимне-весенний период.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Установлена связь между развитием гемолитико-уремического синдрома у взрослых и употреблением некоторых медикаментов (циклоспорина А, митомицина С, эстроген - содержащих контрацептивов, противоопухолевых препаратов), трансплантацией костного мозга, злокачественными новообразованиями, системной красной волчанкой и антифосфолипидным синдромом, беременностью. Выявлены семейные случаи гемолитико-уремического синдрома с аутосомным типом наследования обусловленные дефектом системы комплемента, нарушением обмена простациклина, недостаточностью антитромботических факторов и др.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В основе гемолитико-уремического синдрома может лежать активация тромбоцитов иммунными комплексами (например, комплексом антиген – антитело после прививок живыми вакцинами против полиомиелита, против ветряной оспы, против кори, АКДС).</span></p>",
"pathogenesis": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">После употребления зараженной E. coli пищи или воды возбудитель связывается со специфическими рецепторами толстой кишки, размножается и вызывает гибель клеток, что обычно сопровождается диареей, а в случае инфицирования штаммами, продуцирующими веротоксин возникает повреждение сосудов слизистой оболочки кишки с развитием геморрагического колита. Высвобождающийся в кишечнике веротоксин поступает в печень, где подвергается метаболизму. Проникновение его в системный кровоток возможно по порто-кавальным анастомозам, через которые в норме сбрасывается до 6% оттекающей от кишечника крови. Поступление веротоксина в системную циркуляцию приводит к микроциркуляторным нарушениям в органах-мишенях, формируя клиническую картину гемолитико-уремического синдрома или, реже, тромботической тромбоцитопенической пурпуры (ТТП). Первым органом-мишенью на пути проникшего в кровоток веротоксина являются легкие, в которых возникают зоны лейкоцитарной инфильтрации и дозозависимой секвестрации активированных гранулоцитов в сосудах микроциркуляторного русла. С увеличением степени эндотоксемии распространение повреждающего действия гранулоцитов на легкие приводит к формированию респираторного дистресс-синдрома. Повреждению других органов, в частности, почек, также предшествует секвестрация активированных гранулоцитов в микроциркуляторной системе и интерстиции органа. Предполагается, что вовлечение различных органов в патологический процесс при гемолитико-уремическом синдроме может отображать различное, возможно, зависящее от возраста, распределение рецепторов к веротоксину у детей и взрослых.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагноз гемолитико-уремического синдрома основан на выявлении характерных клинических признаков, осложняющих течение ОКИ или ОРВИ: гемолитической анемии, тромбоцитопении, ДВС-синдрома, азотемии.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При гемолитико-уремическом синдроме в крови обнаруживаются анемия, анизоцитоз и полихроматофилия эритроцитов (наличие фрагментированных форм), присутствие свободного гемоглобина, снижение количества тромбоцитов, лейкоцитоз, умеренная непрямая гипербилирубинемия, возрастание уровня мочевины и креатинина, гипонатриемия, гиперкалиемия, ацидоз (в олигоанурической стадии ОПН), гипоальбуминемия.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Моча приобретает коричневато-ржавый цвет, в ней могут появиться фибриновые комки, отмечается гематурия, протеинурия, гемоглобинурия. У детей с ОКИ выполняют бактериологическое исследование кала на выявление штаммов энтеропатогенной Е. coli. При тяжелых неврологических нарушениях возможно проведение КТ головного мозга и люмбальной пункции для исключения кровотечения и менингита.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение гемолитико-уремического синдрома определяется периодом развития заболевания и тяжестью поражения почечной ткани. Чем раньше ребенок с гемолитико-уремическим синдромом поступает в стационар, тем выше вероятность его успешного и полного излечения. Патогенетическая терапия включает нормализацию агрегатного состояния крови с использованием антиагрегантов, гепаринотерапии; улучшение микроциркуляции (трентал, эуфиллин); коррекцию антиоксидантного статуса (витамины А и Е).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При бактериальной этиологии гемолитико-уремического синдрома назначаются антибиотики широкого спектра действия; при инфекции, вызванной энтеропатогенной Е. coli, прием антибиотиков и препаратов, замедляющих моторику кишечника, не рекомендуется. При олигоанурии показана коррекция водно-электролитных расстройств, подавление реакций метаболического распада и инфекционного процесса. Для коррекции тяжелой анемии используется инфузия эритроцитарной массы.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В половине случаев типичного гемолитико-уремического синдрома необходимо раннее проведение заместительной терапии: обменного плазмафереза, перитонеального диализа или гемодиализа. Гемодиализ проводится ежедневно в течение всего олигоуремического периода. В случае развития терминальной стадии ХПН показана трансплантация почки.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лучшими способами профилактики гемолитико-уремического синдрома являются качественная кулинарная обработка пищевых продуктов, особенно мясных, личные меры гигиены (мытье рук, исключение купания в грязных водоемах), уменьшение фекального загрязнения мяса во время или после убоя животных.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В клинической картине гемолитико-уремического синдрома различают продромальный период, разгар заболевания и восстановительный период. Продолжительность продромального периода составляет от 2 до 7 суток. Для него характерно появление признаков поражения ЖКТ или дыхательных путей.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гемолитико-уремический синдром на фоне ОКИ, вызванной энтеропатогенной Е. coli, имеет ярко выраженную симптоматику. Развиваются симптомы гастроэнтерита или колита (часто кровавая диарея), тошнота, рвота, абдоминальные боли, лихорадка. Постепенно общее состояния ребенка ухудшается, повышенная возбудимость сменяется вялостью.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В период разгара гемолитико-уремического синдрома превалируют проявления гемолитической анемии, тромбоцитопении и ОПН: бледность и иктеричность кожного покрова, склер и слизистых оболочек; пастозность век, голеней; кожный геморрагический синдром в виде петехий или экхимозов, иногда - носовые кровотечения, в тяжелых случаях - снижение диуреза (олигурия или анурия). Тяжесть и продолжительность дизурии зависит от степени и глубины повреждения почек.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гемолитико-уремический синдром может проявляться полиорганной патологией: поражением ЦНС, печени, поджелудочной железы, сердца, артериальной гипертензией. В 50% случаев гемолитико-уремического синдрома наблюдаются неврологические нарушения: подергивания мышц, гиперрефлексия, децеребрационная ригидность, гемипарезы, судороги, ступор, кома (особенно выраженные у детей первых лет жизни). Выявляются гепатоспленомегалия, кардиомиопатия, тахикардия, аритмия.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В самых тяжелых случаях возможно легочное кровотечение, развитие отека легких, синдрома «ригидного легкого», сердечно-легочной недостаточности, отека головного мозга. Поражение ЖКТ может проявляться эзофагитом, энтероколитом, гепатитом, панкреатитом, а также некрозом, перфорацией, инвагинацией кишечника.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Продолжительность гемолитико-уремического синдрома обычно составляет 1-2 недели, затем наступает стабилизация и в 70% случаев - постепенное восстановление нарушенных функций: улучшение выделения мочи, повышение уровня тромбоцитов, нормализация уровня гемоглобина. При тяжелом течении наступает либо летальный исход вследствие экстраренальных поражений, либо формирование ХПН.</span></p>",
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},
"code": "R82.3",
"name": "Гемоглобинурия",
"icd_name": "Гемоглобинурия",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "r82.3_gemoglobinuriya",
"lead": "ряд синдромов, в основе которых лежит внутрисосудистое повреждение эритроцитов с выходом гемоглобина за пределы сосудистого русла и в мочу",
"description": "<p><span id=\"docs-internal-guid-a140c118-7fff-38a8-0b40-af4bfe621c6e\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Гемоглобинурия – это одна из форм гемолитической анемии (гемоглобинемии), точнее симптом патологического внутрисосудистого повреждения красных кровяных телец (эритроцитов), когда гемоглобин массово выходит в околососудистую среду и мочу. Присутствие гемоглобина в моче – это прямое свидетельство интенсивного распада эритроцитов, причиной которого может стать как внутреннее заболевание (грипп, пневмония, острая инфекция), так и внешний фактор – переохлаждение, чрезмерная физическая нагрузка, травмы, интоксикация.</span></span></p>",
"etiology": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гемоглобинурия наблюдается при некоторых заболеваниях крови, переливании иногруппной крови, отравлениях некоторыми красителями (анилин) и ядами (карболовая кислота, бертолетова соль), обширных ожогах, когда большая часть гемоглобина находится в связанном состоянии, а его небольшая свободная фракция образуется за счёт разрушения стенки эритроцитов. Истинная гемоглобинурия не существует без гемоглобинемии и связанной с ней желтухи. Гемоглобинурия также наблюдается при длительной физической нагрузке, беге, ходьбе и др.</span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основным макроскопическим признаком гемоглобинурии служит изменение цвета и структуры собранной мочи. Цвет мочи может быть темно-красным, коричневым или почти черным. При отстаивании моча отчетливо разделяется на 2 слоя: верхний – прозрачный и нижний – содержащий примесь в виде детрита. Лабораторными тестами, подтверждающими гемоглобинурию, служат проба с сульфатом аммония, обнаружение гемосидерина в осадке, исследование мочи методом электрофореза или иммуноэлектрофореза.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для уточнения общей картины крови исследуется гемограмма. С целью выявления компонентов комплемента или антител, фиксированных на поверхности эритроцитов, проводится проба Кумбса. Показано исследование коагулограммы, биохимических показателей крови (билирубина, мочевины, щелочной фосфатазы и др.). Для оценки состояния кроветворения, особенно в случае панцитопении при пароксизмальной ночной гемоглобинурии, требуется проведение пункции костного мозга и исследование миелограммы.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечебная тактика при различных формах гемоглобинурии определяется гематологом. Маршевая и пароксизмальная холодовая гемоглобинурия обычно разрешаются без специального вмешательства. В случае развития хронической аутоиммунной холодовой гемоглобинурии назначаются глюкокортикоиды и иммунодепрессанты (циклофосфамид, азатиоприн).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия пароксизмальной ночной гемоглобинурии в основном симптоматическая: трансфузии эритроцитов, введение непрямых антикоагулянтов, прием препаратов железа. При гипоплазии красного костного мозга назначаются глюкокортикостероиды (преднизолон), анаболические препараты (метандиенон) или андрогены, антитимоцитарный иммуноглобулин. При выраженном гиперспленизме может быть оправдана спленэктомия. При отсутствии эффекта от других методов лечения пароксизмальной ночной гемоглобинурии решается вопрос о пересадке костного мозга, от совместимого по HLA-системе донора.</span></p>\r\n<p><span id=\"docs-internal-guid-b751125d-7fff-92c6-882d-c8fa6478e08c\"> </span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">С целью предотвращения развития гемоглобинурии рекомендуется избегать провоцирующих факторов: отравлений, интоксикаций, инфекционной заболеваемости, чрезмерных физических нагрузок, травм и пр.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмальная ночная гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отличительной особенностью пароксизмальной ночной гемоглобинурии (болезни Маркиафавы-Микели) служат приступы внутрисосудистого гемолиза (гемолитические кризы), развивающиеся преимущественно в ночное время. Гемолитические кризы могут провоцироваться переохлаждением, инфекцией, вакцинацией, гемотрансфузиями, физическими нагрузками, хирургическими вмешательствами.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмы гемолиза эритроцитов сопровождаются лихорадочным состоянием, артралгиями, сонливостью, болями за грудиной, в животе и пояснице. Признаком нарастающей железодефицитной анемии служат общая слабость, желтушность кожных покровов и слизистых оболочек. Характерно увеличение печени и селезенки. Выделение мочи темного цвета отмечается только у четверти пациентов с пароксизмальной ночной гемоглобинурией.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наиболее опасными проявлениями пароксизмальной ночной гемоглобинурии служат тромбозы брыжеечных сосудов, сосудов почек, периферических сосудов. Тромбоз печеночных вен сопровождается резким увеличением размеров печени, прогрессирующим асцитом, варикозным расширением вен пищевода. Постоянная гемосидеринурия часто приводит к возникновению канальцевого нефрита; на высоте гемолитического криза может развиться острая почечная недостаточность.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Маршевая гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматика маршевой гемоглобинурии обычно более стертая и развивается постепенно. Озноб и повышение температуры нехарактерны. Отмечается слабость, которая также может быть следствием общего физического утомления от марш-броска. Вместе с тем, патогномоничным признаком данной формы гемоглобинурии является темная окраска мочи. После прекращения маршевой нагрузки самочувствие нормализуется, моча светлеет. Практически у всех лиц, столкнувшихся с маршевой гемоглобинурией, имеется выраженный поясничный лордоз.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Холодовая пароксизмальная гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Редкая форма гемолитической анемии - пароксизмальная холодовая гемоглобинурия протекает приступообразно. Пароксизмы холодовой гемоглобинурии обычно провоцируются переохлаждением и сопровождаются гипертермией (иногда до 40°С), потрясающими ознобами, тошнотой и рвотой, абдоминальными болями. Выявляется гепато- и спленомегалия, желтоватый цвет кожи и склер, характерная окраска мочи.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмальная холодовая гемоглобинурия, вызванная острыми вирусными инфекциями, обычно разрешается вместе с основным заболеванием. При сифилисе и малярии заболевание может длиться годами.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
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"description": "Гемиплегия – неврологический синдром, проявляющийся полным отсутствием произвольных движений в верхней и нижней конечности на одной стороне. ",
"etiology": "<p>К органическим причинам гемиплегии относятся: </p>\r\n<ul>\r\n<li>Нарушение кровообращения головного мозга (кровоизлияние в мозг, спазм сосудов мозга, тромбоз мозговых сосудов);</li>\r\n<li>Воспалительные заболевания головного мозга (абсцесс мозга, арахноидит);</li>\r\n<li>Опухоли головного мозга; </li>\r\n<li>Нарушение обусловлено повреждением двигательной пирамидной системы мозга. </li>\r\n</ul>\r\n<p>Функциональная гемиплегия вызвана истерией и является симптомом диссоциативного расстройства. </p>\r\n<p>К факторам риска гемиплегии относятся: </p>\r\n<ul>\r\n<li>Заболевания сердца и сосудов в пожилом возрасте;</li>\r\n<li>Травмы мозга в анамнезе;</li>\r\n<li>Роды с осложнениями (риск для детей);</li>\r\n<li>Заболевания крови;</li>\r\n<li>Переедание;</li>\r\n<li>Алкогольная и наркотическая зависимость, курение.</li>\r\n</ul>",
"pathogenesis": "<p>Анатомический субстрат развития гемиплегии – поражение на различных уровнях пирамидного пути, по которому передача нервного импульса осуществляется в верхне-нижнем направлении: от клеток коры головного мозга через его структуры к мотонейронам (двигательным нервным клеткам), располагающимся в передних рогах спинного мозга. </p>\r\n<p>В нижнем отделе (хвостовом, или каудальном) продолговатого мозга волокна пирамидного тракта совершают частичный перекрест, поэтому, как правило, поражение левой половины тела говорит о повреждении структур правого полушария (и наоборот, если повреждение располагается ниже перекреста – гемиплегия определяется на стороне повреждения). </p>",
"diagnostics": "<p>Поскольку патология обладает специфической симптоматикой, с установлением правильного диагноза зачастую не возникает проблем. Однако для дифференциации различных форм необходим комплексный подход. </p>\r\n<p>В первую очередь необходимо: </p>\r\n<ul>\r\n<li>ознакомиться с историей болезни – для установления основного патологического этиологического фактора; </li>\r\n<li>собрать и проанализировать жизненный анамнез – для выявления возможных причин формирования врожденной разновидности болезни; </li>\r\n<li>провести тщательный физикальный осмотр; </li>\r\n<li>осуществить комплекс неврологических тестов – таким образом специалистом осуществляется определение состояния рефлексов и мышц больной руки и ноги; </li>\r\n</ul>\r\n<p>Лабораторные исследования в данном случае включают в себя: </p>\r\n<ul>\r\n<li>общий и биохимический анализ крови; </li>\r\n<li>микроскопическое изучение спинномозговой жидкости; </li>\r\n<li>общеклинический анализ мочи. </li>\r\n</ul>\r\n<p>Инструментальных методы включают проведение: </p>\r\n<ul>\r\n<li>электромиографии; </li>\r\n<li>КТ и МРТ головного мозга – помогает отличить между собой центральную форму с альтернирующей разновидностью; </li>\r\n<li>доплерографии сосудов головного мозга; </li>\r\n<li>электроэнцефалографии; </li>\r\n<li>люмбальной пункции – для получения ликвора. </li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p>При комплексной терапии гемиплегии применяются: </p>\r\n<ul>\r\n<li>Препараты, улучшающие обменные и трофические процессы в нервной ткани; </li>\r\n<li>Нейропротекторы - это средства, которые предупреждают повреждение нейронов мозга, обусловленное действием патогенного фактора; </li>\r\n<li>Миорелаксанты - препараты, расслабляющие мускулатуру; </li>\r\n<li>Антиоксиданты - препараты, нейтрализующие окислительное действие свободных радикалов; </li>\r\n<li>ингибиторы холинэстеразы, витамигы группы В - препараты, способствующие передаче нервного импульса; </li>\r\n<li>физиотерапевтическое воздействие (массаж, электрофорез, кинезотерапия, ЛФК). </li>\r\n</ul>",
"prevention": "<p> К общим профилактическим рекомендациям относятся: </p>\r\n<ul>\r\n<li>контроль над адекватным протеканием беременности; </li>\r\n<li>полный отказ от вредных привычек; </li>\r\n<li>правильное и сбалансированное питание; </li>\r\n<li>умеренная физическая активность (ЛФК); </li>\r\n<li>избегание травм головы и спинного мозга; </li>\r\n<li>своевременное обнаружение и лечение патологических этиологических факторов (в частности, наиболее частой причины – ишемического инсульта), которые могут привести к развитию такой проблемы; </li>\r\n<li>регулярное прохождение полноценного профилактического осмотра в медицинском учреждении с посещением всех клиницистов. </li>\r\n</ul>",
"clinical_picture": "<p>Симптомы центральной гемиплегии: </p>\r\n<ul>\r\n<li>полное отсутствие активных движений в пораженных конечностях, мимических мышцах на стороне, противоположной поражению; </li>\r\n<li>спастический гипертонус мышц; </li>\r\n<li>симптом складного ножа (мышечное сопротивление при попытке пассивно согнуть конечность пациента в коленном или локтевом суставах, после преодоления начального сопротивления сгибание происходит без затруднений); </li>\r\n<li>повышение сухожильных и надкостничных рефлексов в парализованных конечностях;</li>\r\n<li>снижение брюшных рефлексов на стороне гемиплегии; </li>\r\n<li>снижение глубокой и поверхностной чувствительности (тактильной, температурной, болевой, давления); </li>\r\n<li>снижение суставных рефлексов (Лери, Майера); </li>\r\n<li>патологические рефлексы конечностей (Бабинского, Гордона, Оппенгейма, Шеффера, разгибательные Редлиха и Россолимо, Бехтерева – Менделя, Жуковского и др.); </li>\r\n<li>выявление рефлексов спинального автоматизма; </li>\r\n<li>содружественные синкинезии (непроизвольные мышечные сокращения и движения, сопутствующие активному двигательному акту). </li>\r\n</ul>\r\n<p>При периферической гемиплегии мышечный тонус понижен (возможно сочетание спастических изменений мышечного тонуса с гипотонией), рефлексы также снижены на стороне поражения. Мимические мышцы в данном случае в патологический процесс не вовлекаются. </p>",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причины гематосальпинкса следующие: </span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Прерывание беременности по фаллопиевым трубам. В случае самопроизвольного аборта просвет канальцев закрывается сгустками крови, образующими гематосальпинкс. Кровотечение обычно не прекращается или длится некоторое время. Поэтому стенки мышц постепенно растягиваются, что может привести к разрыву трубки. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Врожденные дефекты. Это отсутствие естественных каналов (атрезия) на конце матки, влагалища или девственной плевы. С началом менструации кровь постепенно накапливается во внутренних половых органах и заполняет влагалище, матку, а затем начинает заполнять и растягивать маточные трубы. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Кручение придатков. Чаще всего возникает при патологии воспалительной трубки, но может протекать и в здоровом состоянии. В основном скручивание придатков происходит у молодых женщин при резких движениях тела, упражнениях, вызывающих повышение внутрибрюшного давления. Пережимаются трубы, травмируются сосуды перепонок, полость начинает наполняться кровью. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Эндометриоз. Поражение маточных труб при эндометриозе встречается менее чем в 10% случаев и обычно связано с эндометриозом тела матки. Очаги эндометриоидной ткани прикрепляются к стенке маточных труб и растут в ней, производя геморрагическое содержимое и образуя гематосальпинкс.</span></li>\r\n</ul>\r\n<p> </p>",
"pathogenesis": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гематосальпинкс основан на скоплении геморрагического содержимого (крови) в маточной трубе. Процесс может быть однонаправленным или двунаправленным. Кровь поступает из матки или из патологически измененных сосудов слизистой оболочки. Ворсинки, расположенные на брюшном конце трубки, пропитываются кровью и затем склеиваются фибриновыми нитями. Закрытая трубка - это закрытая полость, в которой собирается кровь. Постепенно жидкость превращается в сгустки, а затем в комковатую опухоль крови.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При подозрении на гематосальпинкс пациентку осматривает акушер-гинеколог, хирург. В больнице проводится лабораторное, физикальное и инструментальное обследование: </span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные тесты. Анализы крови (общий анализ, биохимия, коагулограмма) обращают внимание на признаки кровопотери и скорость свертывания. При подозрении на беременность проводится тест на бета-ХГЧ. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гинекологический осмотр. Осмотр на стуле нужно проводить очень осторожно, чтобы не разорвать маточную трубу избытком крови.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Комбинированное УЗИ матки и насадок. Во время УЗИ визуализируются расширенные маточные трубы, заполненные неоднородным содержимым (кровь, гной), множественные спайки и перегородки, может возникать грязевое явление - конгломераты, вытесненные датчиком, состоящие из формованных элементов. В ректально-маточной полости часто определяется жидкость. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностическая лапароскопия. Лапароскопия - золотой стандарт диагностики гематосальпинкса. При наличии острых абдоминальных симптомов точный дифференциальный диагноз можно поставить только во время операции.</span></li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гематосальпинкс чаще всего проявляется как неотложное хирургическое состояние, поэтому лечение начинается с удаления поражённой маточной трубы (сальпингэктомии) или тубоовариального образования при невозможности выделить яичник, санации брюшной полости при разрыве образования. Предпочтительный доступ — лапароскопический.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Трубная пункция с удалением содержимого не рекомендуется. Во-первых, кровяная опухоль не всегда состоит из жидкого содержимого. Во-вторых, тубарные стенки истончаются, атрофируются, при эвакуации крови может произойти разрыв. При атрезии нижних отделов полового тракта после удаления трубы производится осторожная аспирация содержимого из влагалища с последующей реканализацией.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы не допустить развития гематосальпинкса, необходимо тщательно лечить воспалительные заболевания органов малого таза; соблюдать личную и интимную гигиену; проходить регулярные профилактические осмотры. Не позднее 3 лет девочка должна быть обследована детским гинекологом на предмет выявления пороков развития.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиническая картина складывается из симптомов кровотечения и клиники «острого живота». Когда ворсины хориона при трубной беременности прорастают в стенку, она разрывается, и на первый план выходят признаки острой хирургической патологии: резкая боль внизу живота (острая или приступообразная), рефлекторная рвота, нарушение функции кишечника и мочевого пузыря. Пациентки принимают вынужденное сидячее положение, выражение лица страдальческое, с заострёнными чертами. Такая же клиника характерна для перекрута придатков.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В дальнейшем присоединяются симптомы нарастающего внутрибрюшного кровотечения: бледность кожных покровов, тахикардия, холодный пот. Зрачки больной расширены от испуга, дыхание поверхностное и прерывистое. Появляется боль в плече и лопатке со стороны поражения, обусловленная раздражением кровью грудобрюшного нерва.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Температура тела остаётся нормальной или даже пониженной. Через несколько часов может появиться лихорадка, обусловленная всасыванием продуктов разрушения эритроцитов в брюшной полости. Из половых путей наблюдаются скудные тёмные или шоколадные кровянистые выделения.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиника гематосальпинкса вследствие пороков развития отличается. Проявления нарастают постепенно, процесс затягивается на годы. Жалобы впервые возникают с началом менструаций, когда кровь, не имея выхода наружу, начинает скапливаться внутри полового тракта.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чем ниже уровень атрезии, тем дольше происходит накопление крови. В результате может образоваться кровяная опухоль огромного размера. Интенсивность болевых ощущений увеличивается с каждыми последующими месячными, не купируется обезболивающими. В дальнейшем боли сохраняются и в межменструальном периоде.</span></p>",
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},
"code": "N85.7",
"name": "Гематометра",
"icd_name": "Гематометра",
"gender": 0,
"age_min": 15,
"age_max": 60,
"cause": [
"0"
],
"periodicity": 1,
"slug": "n85.7_gematometra",
"lead": "патологическое скопление крови в полости матки вследствие нарушения ее оттока во время менструации или других состояний, сопровождаемых маточным кровотечением.",
"description": "<p><span id=\"docs-internal-guid-454eb5c0-7fff-2915-ba51-c03d0267f34a\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Гематометра — патологическое состояние женской репродуктивной системы, проявляющееся накоплением крови внутри матки.</span></span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гематометру могут вызывать как приобретенные причины, так и врожденные. Среди наследственных аномалий репродуктивных органов, приводящих к накоплению крови во внутриматочном пространстве, присутствуют атрезия влагалища, внутриматочная перегородка и другие заболевания. Когда наследственные аномалии не удается обнаружить и скорректировать в подростковом возрасте, при начале месячных может возникнуть гематометра.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основные приобретенные первопричины гематометры включают разнообразные патологические образования в шеечном канале и матке, они приводят к созданию физической преграды для отхождения внутриматочного содержимого. К ним относятся раковые опухоли, узлы миомы, полипы шеечного канала, сгустки крови, частицы абортированного зародыша, куски плаценты и т. д. Препятствием к выходу крови может быть стойкое сужение маточной шейки, обусловленное противораковой терапией, оперативным вмешательством и другими травмирующими факторами.</span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностировать гематометру позволяет совокупность анамнестических, клинических и инструментальных данных. На консультации гинеколога выясняется характер менструальной функции, недавно перенесенные внутриматочные вмешательства, акушерский анамнез. При влагалищном исследовании определяется увеличенная матка мягковатой консистенции, болезненная при пальпации. Перед продолжением диагностического поиска необходимо исключить маточную беременность, поэтому пациентке назначаются соответствующие тесты, проводится УЗИ органов малого таза.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Подтвердить диагноз гематометры позволяет зондирование полости матки: при введении зонда через цервикальный канал в полость матки удается получить кровь. При интравагинальном ультразвуковом сканировании в полости матки визуализируется жидкостное содержимое, кровяные сгустки, а также патологические образования (полип, миома матки и др.). С помощью лабораторных исследований (мазка на флору, бакпосева) можно получить данные за инфекционный процесс. В сложных для диагностики случаях выполняется гистероскопия; она дает возможность не только установить причину гематометры, но и провести лечебные мероприятия.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия гематометры направлена на ликвидацию ее первопричины — закупорки пути, по которому содержимое матки выходит во влагалище. Для ликвидации этой патологии и профилактики рецидивов применяются следующие терапевтические меры:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вакуум-аспирация или выскабливание нацелены на очищение маточных структур в случае их закупорки фрагментами плаценты, плода.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нормальный выход содержимого матки может быть обеспечен при помощи обычного зондирования полости этого органа. В таком случае вакуумная аспирация может не потребоваться.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">После очистки маточной полости от патологических скоплений, производится ее антибактериальная обработка. Пациентке показана противовоспалительная терапия, основанная на приеме антибиотиков и применении нестероидных противовоспалительных средств.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В случае маточной атонии (снижения сократительной способности матки) используется медикаментозная терапия для увеличения способности этого органа к сокращению.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для ликвидации спазма шейки матки применяются спазмолитики.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В случае анатомических препятствий для выхода маточных выделений требуется их хирургическое устранение. Для этого используют гистерорезектоскопию или выскабливание. При наиболее сложном течении заболевания может быть применена гистерэктомия.</span></li>\r\n</ul>\r\n<p> </p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для исключения аномалий женских половых органов детский гинеколог должен осмотреть девочку еще до наступления пубертата, а отсутствие менструаций к 16-летнему возрасту является серьезным поводом для углубленного гинекологического обследования.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Важную профилактическую роль играет планирование беременности, исключение абортов, своевременное лечение хирургической патологии органов малого таза, контроль за выполнением внутриматочных манипуляций, адекватное ведение родов и послеродового периода. Предупредить послеродовую гематометру помогает грудное вскармливание, частое мочеиспускание, прикладывание к животу пузыря со льдом – эти мероприятия улучшаются сокращение миометрия и сосудов матки.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Интенсивность симптомов гематометры определяется природой этого заболевания, этапностью, объемом кровяных выделений, накопившихся внутри матки. Порой болевая симптоматика слабо выражена.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Стандартные проявления следующие:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">схваткообразные болевые ощущения внизу живота, распространяющиеся в смежные области, усиливающиеся в случае физического напряжения;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">внезапная остановка кровотечения в 1-е сутки после родов или прерывания беременности;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отсутствие месячных у подростков, вызванное наследственными патологиями в строении репродуктивных органов;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">чувство тяжести в области над лобком;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">тахикардия;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">общее ухудшение самочувствия, недомогание;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">увеличение температуры, лихорадочные состояния;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">головокружение;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гипотония;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">потеря сознания (редко).</span></li>\r\n</ul>\r\n<p> </p>",
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