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"lead": "расширение участка сосуда с истончением его стенки, от чего возникает риск ее разрыва",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основной причиной развития аневризмы бывает врождённая слабость соединительной ткани, заболевания соединительной ткани. Иногда аневризма может развиваться на фоне атеросклеротических изменениях в артерии, при высоком артериальном давлении или после травмы шеи.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пусковым моментом для развития расширения сонной артерии может послужить лучевая терапия опухолей шеи. Расширение внутренней сонной артерии иногда наблюдается после стентирования или удаления атеросклеротической бляшки.</span></p>",
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"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностической алгоритм аневризмы сонной артерии включает в себя: </span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">анамнестические данные; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">результаты физического осмотра (пальпируемая мешковидная опухоль в области шеи); УЗИ шеи. Это исследование служит для определения размера и расширения аневризмы; ангиографию – золотой стандарт диагностики аневризмы сонной артерии; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">контрастная КТ – обладает такими преимуществами, как легкая и быстрая применимость; является минимально инвазивным методом, который дает возможность увидеть изменения сосудистой стенки, объемом менее 1 мм; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">магнитно-резонансная ангиография – является неинвазивным методом, который может визуализировать сосудистые структуры без необходимости использования контрастной среды или рентгеновского излучения. МРА может показывать тромбированные части аневризмы и остаточные характеристики потока крови.</span></li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Неврологи назначают пациентам, у которых диагностирована аневризма сонной артерии, препараты, снижающие концентрацию липидов в крови (ловастатин, симвастин, аторвастин), антиагреганты (клопидогрель, дипиридамол). Больных консультирует сосудистый хирург.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Радикальный метод лечения аневризмы сонной артерии – хирургическое вмешательство. Сосудистые хирурги проводят следующие операции:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Эндартерэктомию сонной артерии и ветвей;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Востановление кровеносного сосуда головного мозга с помощью имплантата;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Эндоваскулярное стентирование сонной артерии;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Клипирование аневризмы;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Эмболизацию аневризмы.</span></li>\r\n</ul>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы предотвратить осложнения аневризмы сонной артерии, следует отказаться от курения, злоупотребления спиртных напитков, нормализовать массу тела. Лица старше пятидесяти лет должны ежегодно проходить скрининговые исследования.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аневризма сонной артерии проявляется следующими неврологическими симптомами:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Цефальгией (головной болью);</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Диплопией (двоением в глазах);</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Птозом (опущение века);</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Анизокорией (сужением одного зрачка);</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Снижением реакции зрачка на свет;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Выпадением полей зрения;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Периферическим парезом лицевого нерва (опущением нижнего века, нарушением выработки слезы, асимметрией лица).</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В зависимости от локализации аневризмы сонной артерии неврологи определяют следующие симптомы:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Полный или частичный паралич одной половины тела;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Невозможность выполнить произвольные движения;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Речевые расстройства;</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Эмоциональную лабильность.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Медленно увеличивающаяся аневризма сонной артерии проявляется симптомами сдавления головного мозга. У пациентов развивается сосудисто-мозговая недостаточность.</span></p>",
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vertical-align: baseline; white-space: pre-wrap;\">вторичный синдром — это проявление или осложнение других патологий.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причины синдрома Рейно</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первичный синдром связан с нарушениями в работе автономной нервной системы, но причины этих нарушений до конца не ясны.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возможные причины вторичного синдрома:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">системные заболевания соединительной ткани: системная склеродермия (синдром Рейно присутствует в 95 % случаев этого заболевания), системная красная волчанка, синдром Шёгрена, дерматомиозит, полимиозит и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">васкулиты: гранулематоз с полиангиитом (гранулематоз Вегенера), узелковый полиартериит, синдром Чёрджа — Стросса, гигантоклеточный артериит и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">другие сосудистые заболевания: атеросклероз, артериовенозная фистула, синдром вибрации руки, синдром канала Гийона и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гематологические нарушения: множественная миелома, полицитемия, криоглобулинемия, антифосфолипидный синдром и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">злокачественные опухоли: рак лёгких, кишечника, женских половых органов, предстательной железы и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">болезни нервной системы и нейровегетативные расстройства: идиопатическая периферическая нейропатия, синдром запястного канала, рефлекторная симпатическая дистрофия и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">эндокринные заболевания: гипотиреоз, сахарный диабет, акромегалия, феохромоцитома и др.;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">воздействие лекарственных средств и токсических веществ: химиотерапии, Циклоспорина, симпатомиметиков, наркотиков, никотина, мышьяка, органических растворителей и др.</span></li>\r\n</ul>\r\n<p><span id=\"docs-internal-guid-651b7ff6-7fff-9b60-e056-fd4229301b9a\"> </span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Как правило, диагностика болезни Рейно не представляет для профессионалов особой сложности, но комплексное обследование все равно требуется. После осмотра, холодовых проб и сбора анамнеза пациентам назначают:</span></p>\r\n<p> </p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">биохимию крови; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гемограмму; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">коагулограмму; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">общий анализ мочи; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">иммунограмму; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ – исследование внутренних органов; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">томографию позвоночника; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">допплерографию сосудов, а также некоторые другие исследования.</span></li>\r\n</ul>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первым принципом терапии синдрома Рейно служит исключение провоцирующих моментов – курения, охлаждения, вибрации и других бытовых и производственных факторов. Проводится выявление и лечение первичного заболевания, обусловившего развитие синдрома Рейно. Среди вазодилататоров при синдроме Рейно эффективно назначение антагонистов кальция - нифедипина, алпростадила, селективных блокаторов кальциевых каналов - верапамила, никардипина дилтиазема. При необходимости применяются ингибиторы АПФ (каптоприл), селективные блокаторы HS2-серотониновых рецепторов (кетансерин).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При синдроме Рейно производится назначение антиагрегантных препаратов - дипиридамола, пентоксифиллина, низкомолекулярных декстранов (реополиглюкина). Прогрессирование и резистентность синдрома Рейно к лекарственной терапии служит показанием к проведению хирургической симпатэктомии или ганглиэктомии. При развившемся ишемическом приступе неотложными мерами является согревание конечности в теплой воде, массирование с помощью шерстяной ткани, предложение пациенту горячего питья. При затяжном приступе назначают инъекционные формы спазмолитиков (дротаверина, платифиллина), диазепама, блокады.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При синдроме Рейно используются немедикаментозные методики - психотерапия, рефлексотерапия, физиотерапия, гипербарическая оксигенация. При синдроме Рейно, обусловленном системными коллагенозами, показано проведение сеансов экстракорпоральной гемокоррекции. Новым словом в лечении синдрома Рейно является терапия с использованием стволовых клеток, направленная на нормализацию периферического кровотока. Стволовые клетки способствуют открытию новых коллатералей в сосудистом русле, стимулируют регенерацию поврежденных нервных клеток, что в итоге ведет к прекращению пароксизмов вазоконстрикции.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первичной профилактики, которая позволила бы предотвратить развитие болезни, на сегодняшний день не существует. Однако можно уменьшить количество приступов, для этого нужно избегать факторов риска сосудистого спазма:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отказаться от курения, употребления алкоголя, кофе и кофеинсодержащих напитков;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ограничить время пребывания на холоде, в том числе в холодных и влажных помещениях, по возможности переехать в местность с мягким и тёплым климатом;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">носить рукавицы вместо перчаток, теплосберегающее бельё, тёплые шапки;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отказаться от работы, связанной с локальным или местным переохлаждением, вибрацией или перенапряжением кистей рук;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">не принимать препараты, которые могут вызвать уменьшение просвета сосудов (симпатомиметиков, Клонидина и др.);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">избегать эмоциональных перегрузок, при необходимости принимать седативные средства (Реланиум, Элениум, Сибазон и др.), использовать психотерапию, гипноз, аутотренинг.</span></li>\r\n</ul>\r\n<p> </p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматика синдрома Рейно обусловлена пароксизмальным вазоспазмом и развивающимися вследствие этого повреждениями тканей. В типичных случаях при синдроме Рейно поражаются IV и II пальцы стоп и кистей, иногда – подбородок, уши и нос. Приступы ишемии вначале кратковременны, редки; возникают под воздействием холодовых агентов, вследствие волнения, курения и т. д. Внезапно развивается парестезия, похолодание пальцев, кожа становится алебастро-белого цвета. Онемение сменяется жжением, ломящей болью, чувством распирания. Приступ завершается резкой гиперемией кожи и ощущением жара.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Прогрессирование синдрома Рейно приводит к удлинению времени приступов до одного часа, их учащению, спонтанному возникновению без видимых провокаций. После высоты пароксизма наступает цианотическая фаза, появляется незначительная отечность тканей. В промежутки между приступами стопы и кисти остаются холодными, цианотичными, влажными. Для пароксизмов ишемии при синдроме Рейно характерно симметричное и последовательное развитие проявлений: сначала на пальцах кистей, затем - стоп. Последствиями ишемии тканей в случае длительного и тяжелого течения синдрома Рейно могут стать трофические изменения в виде плохо заживающих трофических язв, участков некрозов, дистрофических поражений ногтевых пластин, остеолиза и деформации фаланг, гангрены.</span></p>",
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