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},
"code": "D55",
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"gender": 0,
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3,
0
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"slug": "d55_anemiya_vsledstvie_fermentnyh_narusheniy",
"lead": "относится к группе гемолитических анемий, развитие которых связано с дефицитом различных ферментов",
"description": "",
"etiology": "<p>Относительно часто встречается анемия вследствие дефицита пируваткиназы. Заболевание наследственное, передается гомозиготно.</p>\r\n<p>Пируваткиназа (а также другие ферменты гликолизного обмена) принимает участие в синтезе АТФ, дефицит этого фермента ведет к снижению содержания АТФ в эритроцитах, а это, в свою очередь, – к нарушению концентрации ионов натрия и калия в эритроцитах (Na+↑; K+↓). В результате такого сдвига возникает функциональная и морфологическая неполноценность красных кровяных клеток.</p>",
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"treatment": "<p>Проводится заместительная терапия (ферментативная), используются симптоматические средства. Нередко назначение рибофлавина дает стойкий положительный эффект.</p>",
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