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"lead": "онкологическое заболевание дыхательных путей, характеризующееся наличием новообразования, которое произрастает из тканей стенки трахеи",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Одна из основных причин возникновения рака трахеи – отягощенная наследственность. Риск развития злокачественного новообразования значительно увеличивается, если подобный диагноз был поставлен близким родственникам.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">К другим причинам относятся:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Активное и пассивное курение.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вирусная инфекция. Главный инфекционный агент – вирус папилломы человека.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Применение лучевой терапии в борьбе с онкологией смежных с трахеей органов.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выделяют 4 стадии первичной онкопатологии трахеи. Учитывается степень распространенности опухолевого процесса, вовлеченность лимфатических узлов, наличие отдаленных от опухоли метастатических очагов.</span></p>",
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"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При обращении в клинику пациент направляется на комплексное обследование, которое включает:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные исследования. Диагностика включает биохимическое и развернутое клиническое исследование крови, определение онкомаркеров РЭА, коагулограмму и общий анализ мочи. При проведении исследования крови могут быть определены характерные специфические изменения.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Физикальное обследование. Врач оценивает функциональный статус для определения сопутствующих патологий и вторичных признаков заболевания, оказывающих влияние на выбор лечебной тактики.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Инструментальные методы. Проводится трахео-бронхоскопию, при которой делают биопсия. Данный метод является наиболее информативным, т. к. позволяет не только визуализировать опухоль, но и определить ее размеры, а также область локализации. Бронхоскопия оценивает угрозу осложнений и позволяет получить материал для проведения морфологического исследования.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Среди дополнительных диагностических мер следует выделить УЗИ шейной и надключичной зоны, рентген грудины, компьютерной томографии органов грудной клетки и ЭКГ.</span></p>",
"treatment": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основным методом лечения рака трахеи является хирургическое удаление опухоли. Хирург удаляет пораженный участок трахеи с захватом небольших участков выше и ниже, затем соединяет оставшиеся концы. Такие операции очень сложны из-за особенностей кровоснабжения трахеи. Если сильно повредить кровеносные сосуды, то заживление будет происходить дольше и хуже.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Некоторым пациентам, которым противопоказано хирургическое лечение, могут быть выполнены эндоскопические вмешательства. Они помогают уменьшить злокачественную опухоль и впоследствии упросить ее удаление:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лазерная хирургия предполагает уничтожение опухолевой ткани с помощью луча лазера высокой интенсивности.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Криохирургия. Во время процедуры на злокачественное новообразование наносят жидкий азот в виде спрея, и низкая температура уничтожает раковые клетки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Брахитерапия является разновидностью лучевой терапии. Источник излучения находится на конце бронхоскопа, его направляют непосредственно на злокачественную опухоль. Раковые клетки получают максимальную дозу облучения, при этом практически не затрагиваются здоровые ткани.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Фотодинамическая терапия. На поверхность опухоли наносят специальное вещество — фотосенсибилизатор, а затем воздействуют на нее светом определенной длины волны. Под действием света фотосенсибилизатор активируется и разрушает опухолевые клетки.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если неоперабельная опухоль блокирует просвет трахеи, можно выполнить паллиативные хирургические вмешательства. Во время стентирования в заблокированный участок устанавливают короткую трубку с сетчатой стенкой из металла — стент. Это эндоскопическая процедура. Также можно выполнить трахеостомию — сформировать отверстие, которое будет сообщать просвет трахеи с передней поверхностью шеи ниже места сужения. Через эту трахеостому пациент сможет дышать.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лучевая терапия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лучевую терапию зачастую назначают после удаления рака трахеи, чтобы уничтожить опухолевые клетки, которые могли остаться в организме пациента. </span></p>",
"prevention": "<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отказ от курения и алкоголя</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Своевременное лечение хронических заболеваний</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Соблюдение правил работы с токсичными веществами</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ежегодное прохождение профилактических осмотров</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптомы рака трахеи возникают, когда опухоль достигает определенных размеров:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">приступообразный кашель (трахеит, бронхит);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выделение небольшого количества густой мокроты;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">наличие кровянистых прожилок в отделяемой слизи;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">одышка, которая возникает сначала после физической нагрузки, а затем и в состоянии покоя;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">изменение голоса (осиплость или полное исчезновение).</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">На присутствие опухоли в области трахеи могут также указывать такие симптомы, как боли в горле, дискомфорт в области грудины, болезненность при глотании, свист при дыхании, снижение аппетита и повышение температуры тела без видимых на то причин. Проявляться онкологический процесс может частыми фарингитами и ангинами, изменениями в анализах крови и увеличением лимфатических узлов в области шеи и под челюстью.</span></p>",
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},
"code": "C32",
"name": "Рак гортани",
"icd_name": "Рак гортани",
"gender": 0,
"age_min": 40,
"age_max": 65,
"cause": [
3,
0
],
"periodicity": 1,
"slug": "c32_rak_gortani",
"lead": "злокачественное новообразование гортани, происходящее из эпителиальной ткани.",
"description": "Рак гортани – это злокачественные новообразования, которые возникают во всех отделах гортани (вестибулярном, среднем, и подсвязочном) и чаще всего образуются из эпителия.\r\nРак гортани занимает лидирующее место среди опухолей головы и шеи и 8 место во всей структуре онкологических заболеваний. Ежегодно в мире отмечается увеличение на 8-10% числа больных этой формой рака.",
"etiology": "<p>Раку гортани зачастую предшествует хронический многолетний ларингит. Особое значение в возникновении рака гортани относятся предраковые заболевания:</p>\r\n<ul>\r\n<li>длительно существующая папиллома</li>\r\n<li>лейкоплакия слизистой оболочки гортани</li>\r\n<li>дискератозы</li>\r\n<li>пахидермия</li>\r\n<li>фиброма на широком основании</li>\r\n<li>кисты гортанных желудочков</li>\r\n<li>хронические воспалительные процессы</li>\r\n</ul>\r\n<p>Часто наблюдается малигнизация папиллом и лейкоплакии.</p>",
"pathogenesis": "",
"diagnostics": "<p>При диагностике используются следующие процедуры: Непрямая ларингоскопия, внешний осмотр и пальпация. Фиброларингоскопия. Данный метод является одним из основных методов в диагностике рака горла. При проведении этой процедуры есть возможность осмотреть все отделы гортани в большом разрешении и без «слепых зон». Инструмент вводится в гортань легко и безопасно, есть возможность взять биопсию для цитологического исследования. Ко всему прочему, есть возможность визуализации подскладочного отдела и выполнения высококачественной фотосъемки. Морфологическое исследование (гистологическое, цитологическое) материала полученного при биопсии, пункции и соскобах. Компьютерная томография (КТ) гортани. Используется для оценки состояний хрящей гортани, которые нельзя увидеть при ларингоскопии. Также этот метод дает дополнительную информацию о вестибулярном отделе гортани и гортаноглотке. Магнитно-резонансная томография (МРТ). Этот метод позволяет оценить состояние голосовых складок, подскладочного отдела, просвета гортанных желудочков, черпалонадгортанных складок, грушевидных синусов. Рентгенография легких. Используется в случае подозрения на отдаленные метастазы. Ультразвуковое исследование печени и лимфоузлов шеи. Используется в случае подозрения на отдаленные и регионарные метастазы. При наличии увеличенных регионарных лимфоузлов — пункция их для цитологического подтверждения. Все эти методы позволяют однозначно поставить диагноз и назначить подходящее лечение.</p>\r\n<p> </p>",
"treatment": "<p>Существует консервативное и хирургическое лечение рака гортани. В настоящее время достаточно много внимания уделяется качеству жизни пациентов, поэтому при ранних стадиях рака среднего и надскладочного отдела начинают с консервативного лечения – лучевой и химиотерапии. Оно по эффективности одинаково с хирургическим, однако не нарушает функции гортани, и больные могут продолжать трудовую деятельность.</p>\r\n<full></full>\r\n<p class=\"ramka2\">Комбинированное лечение – сочетание хирургии и лучевой терапии. Проводится пациентам с большими опухолями и распространенностью процесса. Предоперационная лучевая терапия способствует уменьшению размеров опухоли и снижает жизнеспособность раковых клеток. Однако после больших доз ЛТ <a href=\"/symptom/yazva_naruzhnaya/\" title=\"Перейти на страницу симптома Язва наружная\">рана</a> может заживать хуже.</p>\r\n<p>Операция</p>\r\n<p>Объемы операций могут различными. Возможно удаление части гортани (резекция), при этом сохраняется дыхательная функция и голос. При больших опухолях гортань удаляется полностью, после таких операций дыхание осуществляется через трахеостому и человек лишается звучного <a href=\"/symptom/sluhovye_gallyucinacii/\" title=\"Перейти на страницу симптома Слуховые галлюцинации\">голоса</a>. Для восстановления речи проводятся занятия с логопедом, пациенты учатся образовывать звук с помощью заглатываемого в желудок воздуха, такая речь позволяет общаться с окружающими людьми и даже вернутся к труду. Кроме того, применяются специальные силиконовые голосовые протезы.</p>\r\n<p> </p>\r\n<p>Лучевая терапия</p>\r\n<p>Лучевая терапия, облучения рака гортани проводится с боковых полей и включает всю гортань и зону регионарного метастазирования. Общие реакции – <a href=\"/symptom/slabost/\" title=\"Перейти на страницу симптома Слабость\">слабость</a>, головные боли, <a href=\"/symptom/toshnota/\" title=\"Перейти на страницу симптома Тошнота\">тошнота</a>. Местные реакции возникают в гортани и на коже шеи. Больные жалуются на боли при глотании, <a href=\"/symptom/otek_tkaney/\" title=\"Перейти на страницу симптома Отек тканей\">отек тканей</a> шеи. Изменения в гортани характеризуются <a href=\"/symptom/vospalenie/\" title=\"Перейти на страницу симптома воспаление\">воспаление</a> и отеком слизистой и голосовых связок. Это может приводить к усилению охриплости и сужению просвета гортани, поэтому при большом размере опухоли пациенту предлагается наложение трахеостомы (ниже расположения опухоли в трахею вводится трубка, через которую пациент дышит, она после лечения удаляется). При лучевой терапии функция звукообразования не страдает и после лечения восстанавливается звучный голос.</p>\r\n<p>Химиотерапия</p>\r\n<p>Химиотерапия при раке гортани применяется только в сочетании с лучевым и хирургическим лечением. Используются в основном препараты платины – цисплатин. Наблюдение осуществляется в первый год каждый месяц, на второй год – раз в 4 месяца, с 3 до 5 лет – раз в полгода, а после пяти раз в год.</p>",
"prevention": "<p>Рак гортани, как и любое заболевание, легче предупредить, чем вылечить. Поэтому: откажитесь от курения и неумеренного употребления алкоголя; соблюдайте правила индивидуальной профилактики при работе с перечисленными ранее химическими веществами; своевременно лечите хронические заболевания гортани, удаляйте доброкачественные новообразования. В заключение отметим, что при появлении длительно не проходящих охриплости и осиплости не следует месяцами заниматься самолечением или ожидать самоизлечения. Необходимо как можно раньше обратиться к врачу и не отказываться от предложенных обследований и лечения.</p>\r\n<p> </p>",
"clinical_picture": "<p>Признаки заболевания весьма разнообразны и зависят от формы и места роста опухоли, степени ее распространения. Начальный период заболевания характеризуется незначительными и часто скрыто протекающими симптомами. Должны насторожить следующие симптомы: <a href=\"/symptom/ohriplost/\" title=\"Перейти на страницу симптома Охриплость\">Охриплость</a> или другие изменения <a href=\"/symptom/sluhovye_gallyucinacii/\" title=\"Перейти на страницу симптома Слуховые галлюцинации\">голоса</a>. <a href=\"/symptom/otek_tkaney/\" title=\"Перейти на страницу симптома Отек тканей\">Припухлость</a> в области шеи. <a href=\"/symptom/bol_v_gorle/\" title=\"Перейти на страницу симптома Боль в горле\">Боль в горле</a> и ощущение дискомфорт при глотании, першение. Ощущение инородного тела в гортани при глотании. Постоянный <a href=\"/symptom/kashel/\" title=\"Перейти на страницу симптома Кашель\">кашель</a>. <a href=\"/symptom/vydeleniya_iz_uha/\" title=\"Перейти на страницу симптома Выделения из уха\">Боль в ухе</a>. <a href=\"/symptom/anormalnaya_poterya_vesa/\" title=\"Перейти на страницу симптома Анормальная потеря веса\">Потеря веса</a>.</p>\r\n<p> </p>",
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