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"description": "Микроцефалия – недоразвитие черепа и головного мозга, сопровождающее умственной отсталостью и неврологическими отклонениями. \r\n ",
"etiology": "<p>Первичной считается микроцефалия, развитие которой произошло в результате наследования ребенком дефектных генов от одного или обоих родителей. К хромосомным заболеваниям относятся: </p>\r\n<ul>\r\n<li>Синдром Дауна; </li>\r\n<li>Синдром Эдвардса; </li>\r\n<li>Синдром Патау; </li>\r\n<li>Синдром кошачьего крика и т.д. </li>\r\n</ul>\r\n<p>Вторичная микроцефалия развивается в результате воздействия неблагоприятных факторов в период эмбрионального развития плода, когда происходит закладка и формирование структур головного мозга. Генетический аппарат родителей при этом не нарушен. </p>\r\n<p>Вторичная микроцефалия может быть обусловлена: </p>\r\n<ul>\r\n<li>Вирусными заболеваниями (краснухой, цитомегалией, корью); </li>\r\n<li>Токсоплазмозом; </li>\r\n<li>Злоупотреблением алкоголем; </li>\r\n<li>Злоупотреблением наркотиками; </li>\r\n<li>Приемом некоторых медикаментов; </li>\r\n<li>Голоданием; </li>\r\n<li>Внутриутробной гипоксией плода; </li>\r\n<li>Механическими травмами. </li>\r\n</ul>",
"pathogenesis": "<p>При первичной микроцефалии возникает остановка роста мозга (и вслед за ним черепа) без указаний на дегенеративный процесс или повреждение. Истинная микроцефалия всегда имеет наследственный характер. Она возникает в результате раннего поражения зародышевых клеток и обусловленного этим искаженного развития мозга. При этом отсутствуют признаки перенесенных мозговых заболеваний. </p>\r\n<p>Вторичная (ложная, или церебропатическая) микроцефалия возникает в результате рано перенесенного мозгового заболевания. Чаще оно носит воспалительный или травматический характер. </p>",
"diagnostics": "<p>Диагностика микроцефалии включает: </p>\r\n<p>Жалобы и анамнез: уменьшение размеров головы, задержка в психоречевом развитии, снижение мышления, памяти, внимания, расторможенность, неусидчивость. Перинатальный анамнез отягощен, в анамнезе возможны перенесенные нейроинфекции. Окружность черепа не увеличивается или увеличивается незначительно. <br /> Физикальное обследование: маленькая окружность головы, лоб скошен, затылок уплощен, отмечается выраженная диспропорция между лицевым и мозговым черепом, большие выступающие уши. У 95% больных отмечается неврологическая симптоматика: нарушение мышечного тонуса, спастические парезы, судороги, умственная отсталость, расстройство координации движений, косоглазие. <br /> Инструментальные исследования: на ЭЭГ задержка формирования возрастной корковой ритмики, диффузные изменения электрогенеза головного мозга. </p>",
"treatment": "<p>Современное лечение микроцефалии заключается в основном в симптоматической поддержке больного при помощи медикаментозных препаратов, а также в комплексных реабилитационных мероприятиях, направленных на максимальную адаптацию и социализацию ребенка. В качестве лекарственной терапии для лечения микроцефалии применяются препараты, улучшающие обменные процессы в мозговой ткани, витаминные комплексы и т. д. По показаниям - противосудорожные и седативные препараты. В рамках реабилитационных мероприятий детям с микроцефалией необходимы занятия лечебной физкультурой, массаж, трудотерапия.</p>",
"prevention": "<p>Профилактика микроцефалии у детей предусматривает тщательное планирование беременности, обследование на инфекции (TORCH-комплекс, ПЦР), антенатальную охрану плода. Раннее внутриутробное выявление микроцефалии является основанием для решения вопроса об искусственном прерывании беременности. Медико-генетическое консультирование семей, имеющих детей с микроцефалией, необходимо для оценки потенциального риска при последующих беременностях.</p>",
"clinical_picture": "<p>Объем черепа у ребенка с микроцефалией уменьшен уже при рождении, в дальнейшем его развитие заметно отстает от возрастной нормы. Отмечается преобладание лицевого черепа над мозговым. Типичный внешний вид больного с микроцефалией характеризуется узким и скошенным лбом, выступающими надбровными дугами, большими ушами. Большой родничок и черепные швы закрываются уже в первые месяцы жизни. В дальнейшем больные с микроцефалией обычно отстают в массе и росте (вплоть до карликовости), имеют диспропорциональное телосложение, узкое высокое (готическое) небо, большие редкие зубы. </p>\r\n<p>Неврологические нарушения при микроцефалии могут включать мышечную дистонию, спастические парезы, атаксию, судороги, косоглазие. Часто дети с микроцефалией могут страдать эпилепсией и детским церебральным параличом. Дети с микроцефалией поздно начинают держать головку, сидеть, ползать, ходить. Отмечается грубая задержка речевого развития, нечеткость артикуляции, резкая ограниченность словарного запаса, нарушение понимания обращенной речи. </p>\r\n<p>Степень интеллектуальных нарушений у ребенка с микроцефалией может варьировать от дебильности до идиотии. При нерезко выраженной умственной отсталости больные с микроцефалией могут быть обучаемы, способны к самообслуживанию и выполнению несложных поручений. Однако в большинстве случаев дети с микроцефалией требуют ухода, контроля и надзора со стороны взрослых. </p>\r\n<p>По особенностям темперамента дети с микроцефалией могут быть отнесены к торпидной или эретической группе. В первом случае детям свойственна малоподвижность, вялость, безучастность к окружающему, пассивно-подражательная деятельность; во втором случае – гиперактивность, суетливость, подвижность, неустойчивое внимание. Эмоциональная сфера у больных с микроцефалией остается относительно сохранной: дети приветливы, добродушны; реже - эмоционально неустойчивы и склонны к аффективным вспышкам. </p>",
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}
]
}