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"code": "P20",
"name": "Внутриутробная гипоксия",
"icd_name": "Внутриутробная гипоксия",
"gender": 0,
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"lead": "внутриутробный синдром, сопровождающийся комплексом изменений со стороны плода, которые обусловлены недостаточным поступлением к его органам и тканям кислорода",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Внутриутробная гипоксия — это патологическое состояние плода, возникающее вследствие нарушения транспортировки кислорода от организма матери к ребенку или же нарушение функции поглощения кислорода тканями плода. </span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вызвать острую гипоксию могут:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">быстрые или длительные роды - длительные роды опасны продолжительным временем сдавливания головки в родовых путях. Быстрые роды представляют опасность тем, что у ребенка не хватает времени для адаптации и правильного разворота в родовых каналах;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">преждевременное излитие вод - продолжительный безводный период может стать причиной гипоксии;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">нарушение кровообращения пуповины - повреждение петель пуповины, образование узлов, крепкое обвитие пуповиной во время родов, отрыв пуповины способствуют возникновению гипоксии;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">слабость родовой деятельности - длительная низкопродуктивная активность матки препятствует продвижению плода по родовым путям, утомляет женский организм и вызывает кислородное голодание плода;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">преждевременная отслойка плаценты - это критическое состояние, которое представляет угрозу матери и ребенку. Часть плаценты отслаивается от матки, разрываются питающие сосуды. Матка не может сокращаться так, как в ней располагается плод. Начинается острая гипоксия у плода и кровотечение у женщины; </span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">разрыв матки - экстренное состояние, которое может повлечь за собой скоропостижную гибель беременной и плода. Причинами разрыва может служить истончение шва на матке.</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">повышенный тонус матки;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">применение наркотических обезболивающих средств при родах;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">гипотония - низкое артериальное давление у матери ухудшает приток крови к плоду и вызывает дефицит кислорода.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хроническая форма</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причинами хронической кислородной недостаточности плода могут быть самые разные заболевания и состояния беременной:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">заболевания дыхательной системы (астма, бронхит, воспаление легких и т. д);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">болезни сердечно-сосудистой системы (анемия, порок сердца, гипер- или гипотония, сердечная недостаточность и т. п);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">сахарный диабет, нарушение работы щитовидной железы, гормональный сбой;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">антифосфолипидный синдром. Патология, при которой велика вероятность наступления бесплодия, осложнения беременности, невынашивания ребенка;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">несовместимость резус-факторов крови матери и плода;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">гестоз (поздний токсикоз беременности);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">нарушение функционирования плаценты, которое характеризуется эндокринной, питательной, транспортной, метаболической дисфункцией плаценты;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">перенашивание беременности;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">многоплодная беременность может быть причиной неравномерного поступления крови к плодам и один из плодов может испытывать нехватку кислорода;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">инфекционные заболевания половой, кишечной, мочевой систем, а также ОРВИ;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">прием алкоголя, курение.</span></li>\r\n</ul>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Подозрение на то, что плод испытывает гипоксию, могут возникнуть при изменении его двигательной активности – беспокойном поведении, усилении и учащении шевелений. Длительная или прогрессирующая гипоксия приводит к ослаблению шевелений плода. Если женщина замечает такие изменения, ей следует немедленно обратиться к гинекологу, осуществляющему ведение беременности. При прослушивании сердцебиения плода акушерским стетоскопом врач оценивает частоту, звучность и ритм сердечных тонов, наличие шумов. Для выявления гипоксии плода современная гинекология использует проведение кардиотокографии, фонокардиографии плода, допплерометрии, УЗИ, амниоскопии и амниоцентеза, лабораторных исследований.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В ходе кардиотокографии удается отследить ЧСС плода и его двигательную активность. По изменению сердцебиения в зависимости от покоя и активности плода судят о его состоянии. Кардиотокография, наряду с фонокардиографией, широко применяется в родах. При допплерографии маточно-плацентарного кровотокаизучается скорость и характер кровотока в сосудах пуповины и плаценты, нарушение которого приводит к гипоксии плода. Кордоцентез под контролем УЗИ проводится для забора пуповинной крови и исследования кислотно-щелочного равновесия. Эхоскопическим признаком гипоксии плода может служить выявляемая задержка его роста. Кроме того, в процессе акушерского УЗИ оценивается состав, объем и цвет околоплодных вод. Выраженное многоводие или маловодие могут сигнализировать о неблагополучии.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Проведение амниоскопии и амниоцентеза через канал шейки матки позволяет визуально оценить прозрачность, цвет, количество околоплодной жидкости, наличие в ней включений (хлопьев, мекония), провести биохимические пробы (измерение рН, исследование содержания гормонов, ферментов, концентрации CO2). Амниоскопия противопоказана при предлежании плаценты, кольпите, цервиците, угрозе прерывания беременности. Непосредственная оценка амниотической жидкости осуществляется после ее излития в I периоде родов. В пользу гипоксии плода свидетельствует примесь в околоплодных водах мекония и их зеленоватый цвет.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В случае выявления гипоксии плода беременная госпитализируется в акушерско-гинекологический стационар. Наличие гипоксии плода требует коррекции имеющейся акушерской и экстрагенитальной патологии матери и нормализации фетоплацентарного кровообращения. Беременной показан строгий покой, оксигенотерапия. Проводится терапия, направленная на снижение тонуса матки (папаверин, дротаверин, эуфиллин, гексопреналин, тербуталин), уменьшение внутрисосудистой свертываемости (дипиридамол, декстран , гемодериват крови телят, пентоксифиллин).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хроническая гипоксия плода требует введения препаратов, улучшающих клеточную проницаемость для кислорода и метаболизм (эссенциальных фосфолипидов, витаминов Е, С, В6, глутаминовой кислоты, глюкозы), антигипоксантов, нейропротекторов. При улучшении состояния беременной и уменьшении явлений гипоксии плода беременной может быть рекомендована дыхательная гимнастика, аквагимнастика, УФО, индуктотермия. При неэффективности комплексных мер и сохранении признаков гипоксии плода на сроке свыше 28 недель показано родоразрешение в экстренном порядке (экстренное кесарево сечение).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Роды при хронической гипоксии плода ведутся с использованием кардиомниторинга, позволяющего своевременно применять дополнительные меры. При острой гипоксии, развившейся в родах, ребенку требуется реанимационная помощь. Своевременная коррекция гипоксии плода, рациональное ведение беременности и родов позволяют избежать развития грубых нарушений у ребенка. В дальнейшем все дети, развивавшиеся в условиях гипоксии, наблюдаются у невролога; нередко им требуется помощь психолога и логопеда.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ответственная подготовка к беременности позволяет предупредить кислородное голодание у будущего ребенка. Она предусматривает:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">лечение экстрагенитальной патологии;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">терапию болезней репродуктивной системы;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">отказ от вредных привычек;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">рациональное питание.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Предупредить проблему позволяет правильный выбор способа родоразрешения, профилактика родовых травм.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выраженность изменений, развивающихся у плода под воздействием гипоксии, определяется интенсивностью и длительностью испытываемой кислородной недостаточности. Начальные проявления гипоксии вызывают у плода учащение сердцебиения, затем - его замедление и приглушенность тонов сердца. В околоплодных водах может появиться меконий. При гипоксии легкой степени увеличивается двигательная активность плода, при тяжелой – движения урежаются и замедляются.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При выраженной гипоксии у плода развиваются нарушения кровообращения: отмечается кратковременный тахикардия и подъем АД, сменяющиеся брадикардией и спадом АД. Реологические нарушения проявляются сгущением крови и выходом плазмы из сосудистого русла, что сопровождается внутриклеточным и тканевым отеком. В результате повышенной ломкости и проницаемости сосудистых стенок возникают кровоизлияния. Снижение тонуса сосудов и замедление кровообращение приводит к ишемизации органов. При гипоксии в организме плода развивается ацидоз, изменяется баланс электролитов, нарушается тканевое дыхание. Изменения в жизненно важных органах плода может вызывать его внутриутробную гибель, асфиксию, внутричерепные родовые травмы.</span></p>",
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"description": " \r\nВрожденная пневмония — это остро протекающее инфекционно-воспалительное заболевание легких, которое проявляется в первые 72 часа жизни. ",
"etiology": "<p>Воспаление легких у новорожденных вызывают различного рода болезнетворные микроорганизмы, грибы, вирусы, простейшие. К ним относятся возбудители: стафилококк, стрептококк, пневмококк, вирус простого герпеса, цитомегаловирус, микоплазмы, хламидии, грибы рода Кандида и множество других. Пути попадания инфекции различны. </p>\r\n<p>Классифицируют бронхогенный (заражение происходит через легкие во время прохождения по родовым путям) и гематогенный (инфицирование ребенка матерью через кровь во время вынашивания плода) способ ее проникновения в детский организм. </p>\r\n<p>К группе риска относятся младенцы, период дородового развития которых происходил с такими осложнениями, как: </p>\r\n<ul>\r\n<li>внутриутробная гипоксия (недостаток получения кислорода плодом); </li>\r\n<li>застойные явления в легких при гипотрофии, то есть недоразвитие дыхательных путей; </li>\r\n<li>пороки сердца, легких; </li>\r\n<li>нарушение иммунитета, передающееся по наследству; </li>\r\n<li>недостаток или избыток витаминов в организме плода; </li>\r\n<li>хронические болезни матери и перенесенные инфекции в период созревания ребенка; </li>\r\n<li>патологические кровотечения во время беременности; </li>\r\n<li>слишком раннее отхождение околоплодных вод; </li>\r\n<li>повреждения головного мозга и верхних дыхательных путей при родах. </li>\r\n</ul>",
"pathogenesis": "<p>Возбудитель, проникнув в легкие через кровь или дыхательные пути, вызывает здесь воспалительный процесс (как правило, двусторонний). Это сопровождается отеком тканей, патологической продукцией секрета, очаговым спаданием альвеол. В результате — легкие не в состоянии качественно исполнять свою функцию, а организм новорожденных страдает от недостаточности кислорода, избытка углекислого газа, нарушения обменных процессов. При отсутствии адекватного лечения возможны опасные последствия: тяжелые дыхательные расстройства, отек легких, нарушение сердечной деятельности, полиорганная недостаточность. </p>",
"diagnostics": "<p>В общем анализе крови выявляют повышение (или снижение) числа лейкоцитов, сдвиг формулы влево, появление незрелых форм. </p>\r\n<p>Исследование мочи поможет определить кетоацидоз, поражение почек. </p>\r\n<p>На рентгенографии грудной клетки выявляют характерные воспалительные инфильтраты, усиление легочного рисунка, расширение прикорневой зоны. </p>\r\n<p>Бактериологические и серологические исследования крови (ликвора) дают возможность определить возбудителя и его чувствительность к лекарственным средствам. </p>",
"treatment": "<p>Уход. Необходимо поддерживать оптимальную температуру окружающей среды, недопустимо переохлаждение и перегревание ребенка. Правильный уход предусматривает свободное пеленание, частые перемены положения ребенка, регулярную обработку кожи и слизистых оболочек. </p>\r\n<p>Оксигенотерапия применяется для борьбы с дыхательной недостаточностью и в зависимости от ее степени тяжести осуществляется путем ингаляций, помещения ребенка в кислородную палатку, </p>\r\n<p>Вскармливание. Способ кормления (грудь, соска, зонд) и количество пищи определяется возрастом ребенка и его состоянием. </p>\r\n<p>В качестве этиотропной (направленной на возбудителя) терапии назначаются антибактериальные препараты с учетом чувствительности к ним возбудителя. </p>\r\n<p>Инфузионная терапия с целью детоксикации. </p>\r\n<p>Кислородотерапия. </p>\r\n<p>Пассивная иммунотерапия. При тяжелом течении пневмонии показаны специфические иммуноглобулины. </p>\r\n<p>Местная терапия: - СВЧ на грудную клетку 5-7 сеансов, далее электрофорез с эуфиллином, новокаином, препаратами кальция 7-10 сеансов; - отвлекающая терапия - горчичное обертывание грудной клетки; - регулярные санации трахеобронхиального дерева или бронхоскопии с промыванием бронхов антисептическими растворами. </p>",
"prevention": "<p>Профилактика врожденной пневмонии заключается в устранении предрасполагающих факторов к развитию пневмонии, соблюдении санэпидрежима в родильном доме, в отделениях больниц для новорожденных. </p>",
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},
"code": "P36",
"name": "Бактериальный сепсис новорожденного",
"icd_name": "Бактериальный сепсис новорожденного",
"gender": 0,
"age_min": 0,
"age_max": 39,
"cause": [
4,
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],
"periodicity": 2,
"slug": "p36_bakterialnyy_sepsis_novorozhdennogo",
"lead": "Нарушение здоровья, относящееся к группе инфекционные болезни, специфичные для перинатального периода",
"description": "Сепсис новорожденных – это тяжелое инфекционное заболевание, возникающее у детей первого месяца жизни. При нем образуются: гнойное воспаление одного или нескольких органов, полиорганная недостаточность (нарушение функций всех органов), циркуляция бактерий в крови (бактериемия). Сепсис — одна из основных причин смерти новорожденных.",
"etiology": "<p>Неонатальный сепсис вызывается условнопатогенной бактериальной микрофлорой. Наиболее частой причиной инфицирования в период внутриутробного развития плода и чаще в интранатальный период является S. Agalacticae — представитель стрептококков группы А. Реже сепсис вызывает E. Coli и другая кишечная грамотрицательная флора. </p>\r\n<p>Большую роль играют острые и хронические инфекционные заболевания у матери, различные акушерские вмешательства, длительный безводный период,эндометрит, наличие других гнойно-воспалительных очагов у матери (гнойный мастит и др. ).</p>\r\n<p>Предрасполагающими факторами являются внутриутробная гипоксия, внутричерепная родовая травма, незрелость новорожденного, повреждение кожи новорожденного во время акушерских операций и такие манипуляции, как интубация, катетеризация подключичных и пупочных вен и др. </p>",
"pathogenesis": "<p>Входными воротами чаще бывают раневая поверхность на коже, слизистых оболочках, пупочная рана и пупочные сосуды, а также неповрежденная кожа и слизистые оболочки верхних дыхательных путей, желудочно-кишечного тракта. При внутриутробном сепсисе очаг инфекции обычно локализуется в плацента или каком-либо органе беременной. Нередко входные ворота и первичный септический очаг определить не удается. </p>\r\n<p>Возбудитель проникает в кровеносную систему, вызывая бактериемию, токсинемию и антигенную стимуляцию продуктами жизнедеятельности и распада. В ответ на инфекцию организм отвечает системной воспалительной реакцией, проявляющейся выбросом провоспалительных цитокинов и активацией нейтрофилов, системы комплемента, свертывания крови и агрегацией тромбоцитов. Чрезмерный системный ответ, наряду с токсическим и антигенным воздействием возбудителя, приводит к повреждающему действию на органы и системы организма. Нарушается микроциркуляция, проницаемость и функции эндотелия капилляров, развивается синдром внутрисосудистого свертывания. В дальнейшем возникает полиорганная недостаточность. </p>",
"diagnostics": "<p>Клинический анализ крови: повышение количества лейкоцитов (клетки крови, отвечающие за иммунитет) либо их резкое снижение. </p>\r\n<p>Повышение уровня С-реактивного белка и прокальцитонина в крови (показатели острого воспалительного процесса в организме). </p>\r\n<p>Посев крови для выделения возбудителя и определения чувствительности к антибиотикам (какие антибиотики действуют на данного возбудителя в данном случае). </p>\r\n<p>Посев спинномозговой жидкости либо мочи, либо гнойного отделяемого с кожи (в зависимости от входных ворот инфекции (например, гноя с пуповинного остатка, если первично возникло его поражение). Взятый материал сеют на питательную среду и через определенное время анализируют, какие возбудители размножились. </p>",
"treatment": "<p>Лечение включает: </p>\r\n<ul>\r\n<li>Нахождение ребенка в кувезе (специальном аппарате для выхаживания новорожденных, в котором поддерживается оптимальная температура и влажность воздуха). </li>\r\n<li>Вскармливание предпочтительно грудное. В тяжелых случаях — парентеральтное (введение питательных растворов внутривенно). </li>\r\n<li>Антибактериальная терапия (действует непосредственно на причину болезни, то есть на бактерии) является кардинальным направлением в лечении сепсиса. Антибиотики сначала назначаются исходя из предположения о наиболее вероятных возбудителях инфекции у данного больного. После получения результатов посева крови с определением чувствительности данных возбудителей к антибиотикам возможна коррекция терапии. </li>\r\n<li>Инфузионная терапия (внутривенное введение растворов). </li>\r\n<li>Иммунокорригирующая терапия — внутривенное введение иммуноглобулинов, интерферонов. </li>\r\n<li>Переливание крови и плазмы крови (проводят для восполнения клеточного состава крови, факторов свертывания крови, плазма – для плазмофереза, то есть очищения жидкого компонента крови). </li>\r\n<li>С целью местного лечения гнойных очагов производится вскрытие фурункулов и абсцессов, перевязки с антибактериальными и ферментными препаратами; назначается УВЧ, СВЧ, электрофорез. </li>\r\n</ul>",
"prevention": "<p>Профилактика сепсиса новорожденных включает выявление и санацию инфекций мочеполовой сферы у беременной, соблюдение противоэпидемических мероприятий медперсоналом родильных домов и отделений новорожденных, тщательный гигиенических уход за новорожденным, естественное вскармливание. Вопрос о сроках вакцинации новорожденных с сепсисом против туберкулеза и против гепатита В , проводимой в первые дни жизни, решается в индивидуальном порядке.</p>",
"clinical_picture": "<p>Предвестниками сепсиса новорожденных могут выступать вялость или беспокойство, снижение аппетита, обильные частые срыгивания, плохая прибавка в весе. </p>\r\n<p>В период разгара развивается температурная реакция (повышение или снижение температуры тела), отечный синдром или обезвоживание, снижение массы тела. Характерным признаком сепсиса новорожденных является грязновато-серый (землистый) оттенок кожных покровов, желтушность, мраморность кожи, сыпь. </p>\r\n<p>Вследствие токсического поражения различных органов возникают увеличение печени и селезенки, поражение легких (учащение дыхания, синюшность, дыхательная недостаточность), поражение сердца (тахикардия или брадикардия, артериальная гипотензия), диспепсия, мочевой синдром (снижение диуреза, острая почечная недостаточность), кровотечения, надпочечниковая недостаточность. Чаще всего септицемия осложняется присоединением пневмонии (воспаления легких), которая выступает как самостоятельное интеркуррентное заболевание. </p>\r\n<p>Септикопиемия или сепсис новорожденных с гнойными очагами характеризуется возникновением на фоне интоксикации вторичных очагов отсева в мозговых оболочках, легких, костях, печени, других органах. Чаще всего септикопиемия протекает с развитием гнойного менингита, абсцедирующей пневмонии, остеомиелита; реже – с формированием абсцесса печени, гнойного артрита, поражения глаз, желудка или кишечника. </p>\r\n<p>В восстановительном периоде происходит опорожнение гнойных очагов, стихание интоксикации, постепенное восстановление нарушенных функций. </p>\r\n<p>Молниеносная форма сепсиса новорожденных протекает с развитием септического шока: стремительным ухудшением состояния ребенка, снижением температуры тела, брадикардией, кровоточивостью, отеком легких, острой почечной недостаточностью. Летальный исход при молниеносном течении сепсиса новорожденных наступает в течение 3-5 суток. </p>",
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{
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