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},
"code": "A17+",
"name": "Туберкулез нервной системы",
"icd_name": "Туберкулез нервной системы",
"gender": 0,
"age_min": 0,
"age_max": 100,
"cause": [
2
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"periodicity": 1,
"slug": "a17+_tuberkulez_nervnoy_sistemy",
"lead": "Нарушение здоровья, относящееся к группе туберкулез",
"description": "\r\nТуберкулез нервной системы обычно наблюдается в форме туберкулезного менингита (воспаление мягких мозговых оболочек) и солитарных (одиночных) туберкулем мозга. Туберкулезное воспаление мозговых оболочек является одной из самых тяжелых форм туберкулеза\r\n\r\nВ последние годы туберкулезный менингит встречается в 7—9% случаев. Он может быть единственной локализацией туберкулезного процесса, но чаще (70—80% случаев) развивается при самых различных формах легочного и внелегочного туберкулеза.",
"etiology": "<p>Возбудителями туберкулёза являются микобактерии — кислотоустойчивые бактерии рода Mycobacterium. Всего известно 74 вида микобактерий. Они широко распространены в почве, воде, среди людей и животных. Однако туберкулёз у человека вызывает условно выделенный комплекс, включающий в себя Mycobacterium tuberculosis(человеческий вид), и другими близкородственными видами) или иначе палочками Коха</p>\r\n<p>Микобактерии туберкулеза передаётся воздушно-капельным путём при разговоре, кашле и чихании больного.</p>\r\n<p>Палочкой туберкулезную микобактерию назвали не случайно: она тонкая, 1-10 мкм в длину и 0,2-0,6 мкм в ширину, прямая или слегка искривленная, концы скругленные, поверхность тела может быть слегка зернистой. МБТ уникальна тем, что под воздействием различных факторов среды она может дробиться на мелкие частички, или наоборот, слепляться, а затем снова возвращаться в обычную форму и становится возбудителем заболевания.</p>\r\n<p>Туберкулезные микобактерии могут долго жить во внешней среде. На пыльном тротуаре они остаются жизнеспособными 10 дней, между книжных страниц – 3 месяца, в воде – 5 месяцев. МБТ не любят солнечного света, но выдерживают нагревание до 80 градусов Цельсия пять минут. В засушенном виде бактерии сохраняются в течение 6 мес, а в замороженном – 30 лет.</p>\r\n<p>МБТ не имеют органоидов движения – ни жгутиков, ни ресничек – поэтому остаются там, где их «высадил» носитель. Для роста и размножения им нужна температура от 29 до 42 градусов Цельсия, оптимальные условия – 37-38 градусов, так что организм человека создает для этого просто идеальные условия.</p>",
"pathogenesis": "<p>Туберкулезный менингит развивается у лиц, инфицированных МБТ, больных туберкулезом легких или других органов. У детей он возникает как осложнение первичного туберкулезного комплекса или туберкулеза внутригрудных лимфатических узлов, у взрослых — как осложнение диссеминированного (гематогенного) туберкулеза. Туберкулезный менингит может быть единственным клиническим проявлением активного туберкулезного процесса, когда источник метастазирования МБТ клиническими методами не обнаруживается. Туберкулема мозга является вторичным заболеванием, т. е. возникает при наличии туберкулеза легких, внутригрудных лимфатических узлов или других органов, наиболее часто в фазе диссеминации.</p>\r\n<p>Туберкулез нервной системы и мозговых оболочек возникает гематогенным (через кровь), лимфогенным (по лимфатическим сосудам) или периневральным (по току спиномозговой жидкости) путями при распространении МБТ из очагов в легких, пораженных внутригрудных лимфатических узлов или других внелегочных очагов.</p>\r\n<p>Первый этап развития туберкулезного менингита — гематогенный, который завершается прорывом гематоэнцефалического барьера и инфицированием сосудистых сплетений головного мозга.</p>\r\n<p> Второй этап — ликворогенный. Микобактерии туберкулеза из сосудистых сплетений попадают в спинномозговую жидкость, оседают на основании мозга, что приводит к поражению мягкой мозговой оболочки.</p>",
"diagnostics": "<p>Туберкулез нервной системы диагностируется фтизиатром совместно со специалистами в области неврологии. Проводится пункция спиномозговой жидкости, где оценивается ее цвет, прозрачность, давление, клеточный состав. «Золотым стандартом» диагностики туберкулезного менингита является выделение микобактерий из спиномозговой жидкости методом посева. Вместе с тем бактериологическое подтверждение диагноза регистрируется менее чем в 20% случаев. Более высокая чувствительность достигается при выявлении генетического материала микобактерии методом ПЦР — 26,0%, а определение антигенов микобактерий и противотуберкулезных антител — 36%.</p>\r\n<p>Проводится рентгенография органов грудной клетки для выявления первичного очага туберкулезной инфекции.</p>\r\n<p>Компьютерная/магнитно-резонансная томография головного мозга на ранних этапах не позволяет обнаружить изменения, но позднее появляются признаки увеличения желудочков мозга, а также отек мозга и очаговую ишемию. Также данные методы применяются для дифференциальной диагностики с другими церебральными поражениями.</p>\r\n<p>Рентгенограмма черепа позволяет выявить туберкулему при отложении в нем солей кальция. Основными методами визуализации туберкулемы мозга являются КТ и МРТ.</p>\r\n<p>Офтальмоскопия позволяет выявить застойные диски зрительных нервов.</p>",
"treatment": "<p>Больным показан строгий постельный режим. Вставать можно только после купирования менингеальных симптомов, выходить на улицу — только после нормализации показателей спиномозговой жидкости. Для лечения туберкулеза нервной системы применяются противотуберкулезные препараты, разрушающие или препятствующие размножению микробной клетки.</p>\r\n<p>Ориентиром длительности химиотерапии является санация спиномозговой жидкости, лечение после которой продолжают еще 6 мес. В лечении туберкулезного менингита очень важна дегидратационная терапия. Для этого делают «разгрузочные» спинномозговые пункции, а также применяют диуретические препараты под контролем водно-электролитного баланса.</p>\r\n<p>В целях повышения эффективности этиотропной химиотерапии и профилактики осложнений необходимо в острый период заболевания назначать глюкокортикостероидные гормоны. Длительность лечения гормонами — от 4 нед до 2 мес. Всем больным назначают препараты, влияющие на мозговое кровообращение.</p>\r\n<p>В комплексном лечении менингита большое внимание уделяют витаминотерапии. Во время лечения туберкулезного менингита необходимо систематически проводить спинномозговые пункции для контроля за эффективностью лечения. Лечение туберкулем головного мозга — оперативное удаление, техника которого такая же, как и при удалении опухолей мозга. Туберкулему удаляют полностью, вылущивая ее в пределах здоровой ткани. Операционное поле тщательно изолируют во избежание попадания частиц туберкулемы в окружающее субарахноидальное пространство. Хирургическое лечение туберкулем проводят в сочетании спротивотуберкулезной терапией, дегидратационной терапией, общеукрепляющим и последующим санаторным лечением. Длительность лечения определяется течением послеоперационного периода, характером неврологических расстройств и туберкулезного процесса во внутренних органах.</p>",
"prevention": "<p>Основной профилактикой туберкулёза на сегодняшний день является вакцина БЦЖ (BCG). Она защищает от самой опасной формы туберкулёза — туберкулёзного поражения нервной системы. В соответствии с «Национальным календарём профилактических прививок» прививку делают в роддоме при отсутствии противопоказаний в первые 3—7 дней жизни ребёнка. В 7 при отрицательной реакции Манту и отсутствии противопоказаний проводят ревакцинацию.</p>\r\n<p>С целью выявления туберкулёза на ранних стадиях всем взрослым необходимо проходить флюорографическое обследование в поликлинике не реже 1 раза в год (в зависимости от профессии, состояния здоровья и принадлежности к различным «группам риска»).</p>\r\n<p>Необходимо вести здоровый образ жизни:</p>\r\n<ul>\r\n<li>не курить, не употреблять алкогольные напитки и наркотики, т.к. они значительно снижают защитные силы организма;</li>\r\n<li>заниматься физической культурой, спортом и закаливанием, это значительно повысит устойчивость организма к туберкулезу и другим болезням;</li>\r\n<li>полноценно питаться;</li>\r\n<li>стараться избегать нервных стрессов;</li>\r\n<li>соблюдать правила гигиены дома, на улице, в школе, на работе;</li>\r\n<li>по возможности не находиться вблизи кашляющего человека;</li>\r\n<li>соблюдать правила личной гигиены.</li>\r\n</ul>\r\n<p> </p>\r\n<p>Профилактика заболевания лиц, бывших в контакте с больным:</p>\r\n<ul>\r\n<li>специальное лечение (превентивная терапия и химиопрофилактика) тех людей, у которых имеется высокий риск развития туберкулеза;</li>\r\n<li>людям, недавно бывшим в контакте с больными и инфицированными туберкулезом, необходимо пройти флюорографию и реакцию Манту;</li>\r\n<li>изоляция и лечение заразных больных в противотуберкулезных учреждениях;</li>\r\n<li>дезинфекция;</li>\r\n<li>отстранение больных туберкулезом от определенных видов работ (пищевые производства, животноводческие хозяйства, учреждения коммунального хозяйства, детские учреждения, лечебно-профилактические учреждения, а также профессии, связанные с широким кругом общения);</li>\r\n<li>не допускать больных туберкулезом к прохождению службы в армии и на флоте.</li>\r\n</ul>\r\n<p> </p>",
"clinical_picture": "<p>Туберкулезный менингит обычно развивается постепенно. Больные ощущают недомогание, вялость, раздражительность, светобоязнь, нарушение сна, задержку стула. В этот период может незначительно повышаться температура тела. Затем начинает наростать головная боль, к которой присоединяется рвота, постепенно развиваются менингеальные симптомы, температура тела повышается до 38—39 °С. При отсутствии лечения у больных появляются амышечная слабость, безразличие к окружающему, спутанность сознания, далее развиваются сопорозное состояние, кома, и, как правило к концу третьей недели наступает смерть.</p>\r\n<p>Возможно и «нетипичное» острое начало с высокой лихорадкой и менингеальными симптомами, которое наблюдается в основном у детей младшего возраста. Характерными для туберкулезного менингита являются менингеальный синдром, параличи и парезы черепных нервов и спинномозговых нервных корешков, симптомы поражения вещества мозга. Менингеальный синдром проявляется головной болью, обусловленной воспалением мягкой мозговой оболочки, контрактурами мышц вследствие раздражения нервных корешков. О контрактурах судят по наличию следующих признаков: ригидность затылочных мышц (из-за болезненности невозможно запрокинутую голову нагнуть вперед); симптомы Кернига (невозможно у лежащего на спине больного разогнуть в коленном суставе ногу, согнутую в тазобедренном суставе) и Брудзинского (сгибание головы вызывает сгибание ног); втяжение мышц живота; «поза легавой собаки» - положение больного на боку с запрокинутой головой и подтянутыми к животу ногами.</p>\r\n<p>Характерно поражение черепных нервов с соответствующей неврологической симптоматикой опущение верхнего века, расширение зрачков, нарушение движения глазных яблок, мышц лица, языка, глотательных мышц). При корешковых поражениях у больных обнаруживаются опоясывающие боли вокруг груди, живота, периферические парезы и параличи, нарушения функции тазовых органов (характерны запоры). При появлении очаговых поражений вещества головного мозга появляются гемипарез (ослабление мышц одной стороны тела), гемиплегия (паралич одной стороны тела). Заболевание может сопровождаться вегетососудистыми нарушениями в виде сосудистых реакций, красного стойкого дермографизма, спонтанно возникающих красных пятен на коже, брадикардии (урежение ритма сердца), нарушения сна, аппетита.</p>\r\n<p>Клинические проявления туберкулемы сходны с таковыми при опухолях центральной нервной системы. Иногда течение туберкулем бессимптомное и их обнаруживают лишь на вскрытии (при супратенториальной локализации). Продолжительность заболевания от нескольких месяцев до 2—3 лет.</p>\r\n<p>Встречаются два типа развития болезни. Первый тип — заболевание начинается остро с подъема температуры и напоминает инфекционное заболевание с быстрым развитием симптомов поражения мозга, последующим волнообразным течением и длительно сохраняющейся субфебрильной температурой. При таком течении часто диагностируют менингит и менингоэнцефалит. Второй тип — постепенное начало и медленное развитие болезни с ремиссиями. Течение болезни при этом сходно с таковым при опухолях головного мозга. Для клинической картины туберкулем свойственны мозговые и очаговые симптомы, характер которых зависит от локализации туберкулемы.</p>",
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},
"code": "A17.0+",
"name": "Туберкулезный менингит (G01*)",
"icd_name": "Туберкулезный менингит (G01*)",
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"slug": "a17.0+_tuberkuleznyy_meningit_g01",
"lead": "воспаление мозговых оболочек, вызванное проникшими в них микобактериями туберкулеза",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Туберкулезный менингит развивается при проникновении микобактерий туберкулеза в мозговые оболочки. Источником туберкулезной инфекции может выступать:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">диссеминированный туберкулез легких</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">генитальный туберкулез</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">туберкулез костей</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">туберкулез молочной железы</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">туберкулез почек</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">туберкулез гортани и др.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В редких случаях инфицирование происходит контактным путем: при наличии туберкулеза костей черепа возбудитель попадает в церебральные оболочки, при туберкулезе позвоночника — в оболочки спинного мозга. По некоторым данным примерно в 17% случаев туберкулезный менингит обусловлен лимфогенным инфицированием. Наиболее подвержены менингиту туберкулезной этиологии оказались пациенты со сниженным иммунитетом вследствие ВИЧ, гипотрофии, алкоголизма, наркомании, пожилого возраста.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основной способ инфицирования мозговых оболочек — гематогенный, при котором микобактерии разносятся с током крови. При этом их проникновение в церебральные оболочки связано с повышением проницаемости гематоэнцефалического барьера. Первоначально поражаются сосудистые сплетения мягкой оболочки, затем микобактерии проникают в цереброспинальную жидкость и инициируют воспаление в паутинной и мягкой оболочках — лептоменингит. В большинстве случаев поражаются оболочки основания головного мозга, возникает так называемый базилярный менингит. Специфическое воспаление может распространяться дальше на оболочки полушарий, а с них — на вещество головного мозга с развитием туберкулезного менингоэнцефалита.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Морфологически наблюдается серозно-фибринозное воспаление оболочек с наличием бугорков. Изменения в сосудах оболочек (некроз, тромбоз) могут стать причиной расстройства кровообращения отдельной области мозгового вещества. У пациентов, проходивших лечение, воспаление оболочек носит локальный характер, отмечается формирование сращений и рубцов. У детей часто возникает гидроцефалия.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При проявлении менингеальных признаков диагностированием заболевания занимается фтизиатр при совместной работе с неврологом. После первичного осмотра и сбора анамнеза назначаются инструментальные исследовательские манипуляции:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Люмбальная пункция. Производится забор цереброспинальной субстанции. Уже на стадии забора отмечаются такие аномалии, как повышенный напор течения. Жидкость иногда вытекает струей с повышенным давлением. Цвет субстанции неизменен, прозрачность сохраняется. При лабораторном изучении может наблюдаться повышенное содержание клеточных элементов на фоне снижения содержания сахара и хлоридных соединений. Чем ниже содержание глюкоза в растворе, тем серьезнее диагностический показатель заболевания. Типичным признаком выступает отделение паутинной пленки при отстаивании жидкости в течение 1-2 суток. Анализ также показывает большое количество белка в растворе. Туберкулезная палочка может быть обнаружена в 10 случаях из ста. При спинальной патологии субстанция имеет желтоватый оттенок. Давление при вытекании при этом меняется мало, повышено клеточное содержание, снижение уровня сахаров.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Компьютерное сканирование. Проводится с целью отделения природы болезни от иных форм менингеального синдрома. Томография помогает определить степень поражения мозговых зон, определить химическую составляющую аномального участка. Эксперты способны различить гнойные формы менингита и энцефалита, осложненное течение других инфекций от туберкулезного варианта аномалии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Магнитно-резонансный скрининг (томография) головного мозга. Также проводится с целью дифференциации болезни. На сканах аппарата отчетливо проявляются границы поражения, степень разрушенности нервной ткани, рубцовые образования, уплотнения, участки скопления жидкости.</span></li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Специфическое противотуберкулезное лечение начинают при малейшем подозрении на туберкулезную этиологию менингита, поскольку прогноз напрямую зависит от своевременности терапии. Наиболее оптимальной считается схема лечения, включающая изониазид, рифампицин, пиразинамид и этамбутол. Вначале препараты вводятся парентерально, затем внутрь. При улучшении состояния спустя 2-3 мес. отменяют этамбутол и пиразинамид, снижают дозу изониазида. Прием последнего в сочетании с рифампицином продолжают не менее 9 мес.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Параллельно проводят лечение, назначенное неврологом. Оно состоит из дегидратационной (гидрохлоротиазид, фуросемид, ацетазоламид, маннитол) и дезинтоксикационной (инфузии декстрана, солевых р-ров) терапии, глютаминовой кислоты, витаминов (С, В1 и B6). В тяжелых случаях показана глюкокортикоидная терапия; спинальный туберкулезный менингит является показанием для введения препаратов непосредственно в субарахноидальное пространство. При наличии парезов в схему лечения включают неосмтигмин, АТФ; при развитии атрофии зрительного нерва — никотиновую кислоту, папаверин, гепарин, пирогенал.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В течение 1-2 мес. пациент должен придерживаться постельного режима. Затем постепенно расширяют режим и в конце 3-его месяца пациенту разрешают ходить. Результативность лечения оценивают по изменениям в цереброспинальной жидкости. В день проведения контрольной люмбальной пункции необходим постельный режим. ЛФК и массаж рекомендуют не ранее 4-5 мес. заболевания. В течение 2-3 лет после окончания терапии пациентам, перенесшим туберкулезный менингит, следует 2 раза в год проходить 2-месячные противорецидивные курсы лечения.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В качестве профилактики рекомендуется вовремя проходить вакцинацию против туберкулеза, ежегодно обращаться к рентгенографии органов дыхания, как можно раньше выявлять заболевших лиц и группы, контактировавшие с ними.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматика имеет четко разграниченные стадии протекания:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Начальная форма. Продолжается на протяжении 7-14 дней. Первично манифестируются вечерние головные боли, проявляется слабость, ухудшение общего самочувствия, раздражительность или полное отсутствие интереса к происходящему вокруг. Симптомы нарастают, появляется отвращение к пище, тошнота, заканчивающаяся рвотой. Диагностировать ТМ на данной стадии сложно, так как признаки имеют неспецифический характер.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Этап раздражения. Резко нарастает температура до 39-40 градусов. Болезненность в голове не снижается при приеме обычных анальгетиков, появляется повышенная светочувствительность в глазах, болезненная реакция на громкие звуки и легкие прикосновения. Больной ощущает потребность к постоянному сну, на кожных покровах появляются пятна, которые также внезапно исчезают, что связано с нарушением сосудистой функциональности. Мускулатура затылочной части находится в постоянном напряжении. К концу второго периода человек заторможен, сознание нечеткое, характерна лежачая поза на боку с подтянутыми ногами и откидыванием головы назад.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Паралитический этап. Сознание полностью утрачивается, часто происходят приступы парализации, чувствительность полностью нарушена. Дыхание и ритм сердца сменяется от резкого замедления к учащению, температура или сильно повышена или заметно падает ниже нормы. Если на данной стадии не проводятся медицинские мероприятия, неизбежен летальный исход, так как происходит полное купирование дыхательных и сердечных центров мозговой структуры.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Помимо мозговой патологии имеет место и спинальный туберкулезный менингит. Развивается при попадании патогенов в спинномозговой канал из пораженных костных волокон позвоночного столба. Помимо описанных выше симптомов присоединяются сильные опоясывающие боли в теле, которые не снимаются даже мощными анальгетиками. В конце последнего периода проявляются тазовые расстройства, характеризующиеся недержанием.</span></p>",
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},
"code": "A18",
"name": "Туберкулез других органов",
"icd_name": "Туберкулез других органов",
"gender": 0,
"age_min": 0,
"age_max": 94,
"cause": [
2,
4,
5,
7,
10
],
"periodicity": 4,
"slug": "a18_tuberkulez_drugih_organov",
"lead": "Нарушение здоровья, относящееся к группе туберкулез",
"description": "Внелегочный туберкулез представляет собой заболевание, вызываемое микобактериями туберкулеза, характеризующееся поражением различных органов (кожи, костей, суставов, органов мочеполовой системы, глаз, желудка, кишечника).",
"etiology": "<p>Возбудителями туберкулёза являются микобактерии - кислотоустойчивые бактерии рода Mycobacterium. Всего известно 74 вида таких микобактерий. Они широко распространены в почве, воде, среди людей и животных. Туберкулёз у людей чаще всего возникает при заражении человеческим и бычьим видами возбудителя. Выделение M. Bovis (бычий) отмечается преимущественно у жителей сельской местности, где путь передачи в основном алиментарный (с пищей). Отмечается также птичий туберкулез, который встречается преимущественно у иммунодефицитных носителей. </p>\r\n<p>Впервые эти кислотоустойчивые микроорганизмы выделил Роберт Кох в конце XIX века. Микобактерии очень устойчивы к различным факторам окружающей среды. В воде они способны жить до 5 месяцев, на пыли сохраняются около 10 дней. Данные бактерии чувствительны к прямым солнечным лучам и ультрафиолетовому свету. В сухой мокроте кипящая вода убивает их за 45 минут, в свежей мокроте – за 5 минут. Большинство микобактерий устойчивы ко многим лекарствам, что в значительной степени затрудняет терапию.</p>",
"pathogenesis": "<p>Большое значение имеет первичная локализация инфекционного очага. Различают следующие пути передачи туберкулёза:</p>\r\n<ul>\r\n<li>Воздушно-капельный. Туберкулёзные микобактерии попадают в воздух с капельками при кашле, разговоре и чихании больного активным туберкулёзом. При вдыхании эти капельки с микобактериями попадают в лёгкие здорового человека. Это самый распространённый путь заражения.</li>\r\n<li>Алиментарный. Проникновение происходит через пищеварительный тракт.</li>\r\n<li>Контактный. Описаны случаи заражения через конъюнктивуглаза маленьких детей и взрослых. При этом иногда обнаруживается острый конъюнктивит и воспаление слёзного мешочка. Заражение туберкулёзом через кожу встречается редко.</li>\r\n<li>Внутриутробное заражение туберкулёзом. Заражение происходит или при поражении туберкулёзом плаценты, или при инфицировании повреждённой плаценты во время родов больной туберкулёзом матерью. Такой путь заражения туберкулёзом встречается крайне редко.</li>\r\n</ul>\r\n<p>Микобактерии туберкулеза, попавшие в кровяное русло, вызывают воспаление в стенке кровеносных сосудов и проникают в прилежащие ткани. В поражённых туберкулёзом органах развивается специфическое «холодное» туберкулёзное воспаление, носящее преимущественно гранулематозный характер и приводящее к образованию множественных бугорков со склонностью к распаду.</p>\r\n<p> </p>",
"diagnostics": "<p>Диагностика внелегочного туберкулеза значительно затруднена. Для его своевременного выявления тщательно изучают анамнез, проводят объективное обследование, общеклинические анализы крови, мочи, спиномозговой жидкости, рентгенологическое обследование, в том числе компьютерная томография, магниторезонансная томография, радиоизотопное и ультразвуковое исследование внутренних органов, гистологическое исследование (биопсия), бактериологическая верификация (посев на микобактерии туберкулеза патологического материала), офтальмологическое исследование, провокационные туберкулиновые пробы.</p>",
"treatment": "<p>Лечение больных внелегочным туберкулезом должно быть длительным, непрерывным, включать несколько лекарственных препаратов и обязательно проходить под контролем врача. Первоначально лечение проводят в туберкулезном диспансере до прекращения выделения микроорганизмов. После чего больные выписываются для продолжения амбулаторного лечения. Пациентам, прошедшим курс терапии туберкулеза рекомендовано лечение в специализированных санаториях и профилакториях.</p>\r\n<p>Основой терапии таких больных является современная противотуберкулезная химиотерапия, хирургическое лечение.</p>\r\n<p>Кроме химиотерапии, большое внимание должно уделяться интенсивному, качественному и разнообразному питанию больных туберкулёзом, набору массы тела при пониженной массе, коррекции гиповитаминозов, анемии, лейкопении.</p>",
"prevention": "<p>Существуют специфические и неспецифические меры профилактики внелегочного туберкулеза.</p>\r\n<p>Специфические меры профилактики туберкулеза включают:</p>\r\n<ol>\r\n<li>Проведение вакцинации и ревакцинациипротив туберкулеза. Вакцинация БЦЖ проводится всем новорожденным детям на 3 – 5 день жизни, а ревакцинация – не инфицированным туберкулезом клинически здоровым детям и подросткам в возрасте 7 лет с отрицательным результатом пробы Манту.</li>\r\n<li>Флюорографического обследования 1 раз в год,начиная с 15 лет;</li>\r\n<li>Проведение химиопрофилактики(употребление специфических противотуберкулезных препаратов); химиопрофилактика назначается здоровым людям, подвергающимся высокому риску заболеть туберкулезом (вступавших в контакт с больными с открытой формой туберкулеза).</li>\r\n</ol>\r\n<p>К неспецифическим мерам относятся:</p>\r\n<ul>\r\n<li>Мероприятия, повышающие защитные силы организма(ведение здорового образа жизни, рациональный режим труда и отдыха, правильное полноценное питание, отказ от курения и употребления алкоголя, закаливание, занятие физкультурой и др.);</li>\r\n<li>Мероприятия, оздоравливающие жилищную и производственную среду(снижение скученности и запыленности помещений, улучшение вентиляции).</li>\r\n</ul>",
"clinical_picture": "<p>Туберкулез мозговых оболочек и головного мозга развивается постепенно на протяжении 1-2 недель, чаще всего у детей и лиц с иммунодефицитом, у больных сахарным диабетом. Продромальный (предшествующий появлению явных признаков заболевания) период длится от 1 до 4 недель. При этом появляются расстройства сна, общая слабость, апатия, сонливость, потеря аппетита. Затем присоединяется рвота, головная боль становится интенсивной и упорной, усиливается при шуме, ярком свете, сопровождается рвотой, заторможенностью, ригидностью затылочных мышц (запрокидывание головы). Выявляются поражения черепных нервов: птоз (опущение верхнего века), расширение зрачка, косоглазие, ассиметричность лица, нарушение речи, параличи, ухудшение зрения.</p>\r\n<p>Туберкулез органов пищеварительного тракта характеризуется сочетанием общей интоксикации (слабости, утомляемости, потливости, повышения температуры тела) с болью в животе, нарушением стула (запоры, чередующиеся с поносами), симптоматикой диспепсии, , иногда кровянистыми примесями в кале. Осложнениями могут быть кишечные свищи, кишечная непроходимость, острый перитонит, кишечное кровотечение.</p>\r\n<p>Туберкулез костей, суставов - чаще всего поражается позвоночник, тазобедренный и коленный суставы. При поражении костей отмечается их болезненность, склонность к переломам. При распространении туберкулеза на сустав и окружающие его ткани возникают постоянные боли в суставе, ограничение его подвижности. При повреждении позвонков может возникнуть деформация позвоночника с образованием горба.</p>\r\n<p>Туберкулез органов мочеполовой системы – одна из наиболее частых локализаций внелегочного туберкулеза. При локализации очага инфекции в почках больные отмечают появление боли в спине, возможно крови в моче. Реже развивается туберкулез мочевыводящих путей, в этом случае проявлениями будет дизурия (нарушение процесса мочеиспускания), болезненность при мочеиспускании. Туберкулез половых органов (генитальный туберкулез) может быть причиной бесплодия.</p>\r\n<p>Туберкулез кожи характеризуется появлением плотных узелков под кожей, при прогрессировании увеличивающихся и вскрывающихся на кожу с выделением белых творожистых масс. При этом чаще поражается кожа лица, груди, бедер, голени.</p>\r\n<p>Туберкулез периферических лимфатических узлов – чаще выявляется у детей и подростков. В 80% случаев поражаются шейные лимфатические узлы, реже подмышечные (15-20%) и паховые (до 5%). Начало заболевания постепенное. Наблюдается повышение температуры до 37,5оС, умеренные или незначительные проявления интоксикации (слабость, потливость, утомляемость). Увеличиваются лимфатические узлы одной или нескольких групп, в начале болезни до 0,5 мм. Они неплотные, подвижные, безболезненные, не спаянные между собой и с окружающими тканями. При прогрессировании процесса лимфоузлы увеличиваются в размерах, появляется болезненность.</p>\r\n<p>Туберкулез глаз - одна из тяжелых форм внелегочного туберкулеза. Различают туберкулезное аллергическое поражение глаз (развиваются неспецифическая воспалительная реакция в глазу больного с резкими признаками туберкулезной интоксикации организма вследствие активации внеглазного очага поражения) и метастатический туберкулез глаз (в результате развития специфического очага воспаления непосредственно в глазу путем заноса микобактерий туберкулеза с током крови из других очагов). Наиболее часто процесс локализуется в сосудистом тракте глаза. Осложнениями могут быть вторичная глаукома, катаракта. При развитии осложнений больные надолго теряют трудоспособность, а некоторые из них становятся инвалидами.</p>\r\n<p> </p>\r\n<p> </p>",
"image": null,
"image_alt": null,
"standard_type": 3,
"danger": 101,
"published": 2,
"parent": null,
"block_rubric": 2,
"standards": [
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},
{
"id": 8123,
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{
"id": 3008,
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"name": "Суставы болят"
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{
"name": "Ломит"
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{
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{
"name": "Боль в локтевом суставе"
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{
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{
"name": "Боль в суставах ног"
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{
"name": "Боль в суставах у ребенка"
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{
"name": "Боль в суставах у детей"
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{
"name": "Боль в суставах при беременности"
},
{
"name": "Боль в суставах рук"
}
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},
"code": "A18.0+",
"name": "Туберкулез костей и суставов",
"icd_name": "Туберкулез костей и суставов",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "a18.0+_tuberkulez_kostey_i_sustavov",
"lead": "заболевание опорно-двигательного аппарата, которое характеризуется прогрессирующим разрушением костей и приводит к анатомическим и функциональным нарушениям пораженных частей скелета",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Туберкулез костей – это инфекционное заболевание, возбудителем которого является туберкулезная палочка Коха. Заражение может произойти воздушно-капельным путем, с пищей, через грязные руки. Инфекция разносится по кровеносным сосудам и лимфатическим путям по всему организму, попадая во все ткани и органы, включая костную ткань. В некоторых случаях возможно вторичное инфицирование, когда патогенные микроорганизмы попадают в кости и суставы из уже пораженных легких.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Однако попадание в организм инфекции не всегда приводит к развитию заболевания. При сильном иммунитете зародившийся патологический процесс купируется и самоликвидируется. Развитие туберкулеза может начаться на фоне ослабления иммунной системы в совокупности с влиянием других негативных факторов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Конкретными причинами этого могут стать:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чрезмерная нагрузка на опорно-двигательный аппарат;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Переохлаждение;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Недостаточное и несбалансированное питание;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Травмы опорно-двигательного аппарата;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Рецидивы других инфекционных заболеваний;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Неблагоприятные бытовые условия;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Длительный контакт с больными туберкулезом;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Тяжелые условия труда.</span></li>\r\n</ul>\r\n<p> </p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первичный очаг возникает в легких, затем микобактерии распространяются по лимфатическим и кровеносным сосудам и попадают в кость. Наибольшему риску подвергаются участки кости с хорошим кровоснабжением (позвонки, эпифизарные отделы бедренных костей, костей голени, плечевых костей и костей предплечья). В результате размножения палочек Коха в кости появляются небольшие бугорки-гранулемы. При увеличении гранулем костное вещество разрушается, формируются абсцессы, которые в последующем могут вскрываться наружу, образуя свищи.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В большинстве случаев микобактерии «оседают» в непосредственной близости от сустава, поэтому при распространении инфекции в процесс вовлекаются внутрисуставные структуры. Выделяют три фазы развития туберкулеза костей. Первая – первичный остит (образование очага в кости), вторая – вторичный артрит (переход инфекции на сустав), третья – постартритическая (остаточные явления, рецидивы и т. д.). Выраженность остаточных явлений зависит от времени начала лечения, адекватности терапии и состояния организма больного.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Туберкулез костей и суставов довольно сложно диагностировать, особенно на ранних этапах заболевания.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При подозрении на инфицирование микобактерией больному назначают комплексное обследование:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">анализ крови, мочи, мокроты;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рентгенография, рентгеноскопия;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">обзорная томография;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">биохимические и цитологические анализы;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">артрография;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">проба Манту;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">подробный сбор анамнеза.</span></li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Туберкулёз костей и уставов – местное проявление туберкулёзной инфекции. Неспецифическая терапия включает рациональное питание, лечебную физкультуру, санаторно-курортное лечение. Специфическое лечение проводится препаратами направленного действия (тубазидом, ортивазидом, рифампицином и пр.).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В начальных стадиях заболевания применяются следующие методы местного воздействия:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Иммобилизация поражённой конечности гипсовыми повязками;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постоянное вытяжение;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Обеспечение покоя для позвоночника ношением корсета или пребыванием в гипсовой кровати.</span></li>\r\n</ul>\r\n<p><strong id=\"docs-internal-guid-e7316054-7fff-3f5a-8c1c-aaa4f22ea49e\" style=\"font-weight: normal;\"> </strong></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хирургическое лечение</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При неэффективности местной терапии прибегают к радикальным оперативным вмешательствам:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Некрэктомии;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Резекции суставов;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Радикальному удалению туберкулёзного очага.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В артритическую стадию хирурги выполняют внутрисуставную некрэктомию, синовэктомию, экономую резекцию сустава. В постартритической стадии применяют остеотомию, артропластику, имплантацию искусственных суставов, различные методы фиксации позвоночника.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактика заболевания заключается в минимизации контактов с больными активным туберкулезом, предупреждении интоксикаций, травм и переохлаждений. Существенную роль играет улучшение общего уровня жизни и обеспечение социального благополучия. Родителям рекомендуют не отказываться от проведения плановых туберкулиновых проб детям. Следует серьезно относиться к неспецифическим симптомам (слабости, разбитости, незначительному повышению температуры), если они сохраняются в течение нескольких недель. Нужно обращаться к врачу при появлении постоянных болей в костях и мышцах, даже если эти боли слабо выражены.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В первой фазе заболевания симптомы очень размыты и слабо выражены. Многие не обращают внимания на ощущение тяжести в позвоночнике, незначительные боли в спине или суставах, которые прекращаются во время отдыха. У детей наблюдаются повышенная раздражительность, вялость, быстрая утомляемость, плохой аппетит, нарушения сна, небольшое повышение температуры, вегетативные расстройства. Эта фаза может продолжаться от нескольких недель до нескольких месяцев.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Во второй фазе появляются сильные боли в позвоночнике и суставах, похожие на болевой синдром при межреберной невралгии или радикулите. Мышцы спины теряют эластичность, становятся жесткими. Ограниченная подвижность суставов приводит к скованности движений.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возможны признаки интоксикации, степень выраженности которой определяется активностью и распространенностью туберкулезного процесса. Обычно интоксикация более выражена у детей и нередко отсутствует у взрослых.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Внешние проявления заболевания заключаются в изменении походки, хромоте, поднятых плечах, косолапости. В области пораженного сустава или позвонка наблюдаются припухлость, мышечные спазмы, атрофия мягких тканей. Повышается местная температура, параллельно с атрофией мышц отмечается утолщение кожной складки над зоной поражения.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При развитии абсцесса кожа воспаляется, затем образуется свищ, через который выделяется жидкий серый гной с вкраплениями в виде крошек. На этой стадии очень велика вероятность присоединения вторичной инфекции.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В фазе затухания воспалительный процесс постепенно угасает, общее состояние больного улучшается. Наблюдаются остаточные деформации. При своевременной диагностике и лечении возможно восстановление нормального функционирования пораженных туберкулезом костных отделов.</span></p>",
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