Disease List – Django REST framework

ВОзвращает список болезней. Можно фильтр/искать

search, age, gender, parent, symptoms, sort_name, sort_by, rand, branches

GET /disease/?format=api&ordering=description&page=222

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept

{
    "count": 11794,
    "next": "http://api.symptomd.ru/disease/?format=api&ordering=description&page=223",
    "previous": "http://api.symptomd.ru/disease/?format=api&ordering=description&page=221",
    "results": [
        {
            "id": 10924,
            "symptoms": [],
            "alternative_names": [],
            "complications": [],
            "medicine_branches": [],
            "who": [
                {
                    "id": 13958,
                    "gender": 1,
                    "diseased": 1425412,
                    "deaths": 0,
                    "danger": 0.0,
                    "mortality": 0.0,
                    "outpatient_days": 9,
                    "hospital_days": 115,
                    "diseased_1": 42361,
                    "diseased_1_4": 159225,
                    "diseased_5_9": 90482,
                    "diseased_10_14": 44776,
                    "diseased_15_19": 33629,
                    "diseased_20_24": 30656,
                    "diseased_25_29": 33815,
                    "diseased_30_34": 50350,
                    "diseased_35_39": 62984,
                    "diseased_40_44": 66143,
                    "diseased_45_49": 83793,
                    "diseased_50_54": 126340,
                    "diseased_55_59": 201215,
                    "diseased_60_64": 153837,
                    "diseased_65_69": 110547,
                    "diseased_70_74": 67815,
                    "diseased_75_79": 42918,
                    "diseased_80_84": 18579,
                    "diseased_85_89": 4645,
                    "diseased_90_94": 1115,
                    "diseased_95": 0,
                    "disease": 6498
                },
                {
                    "id": 13959,
                    "gender": 2,
                    "diseased": 1345610,
                    "deaths": 0,
                    "danger": 0.0,
                    "mortality": 0.0,
                    "outpatient_days": 9,
                    "hospital_days": 117,
                    "diseased_1": 29229,
                    "diseased_1_4": 107057,
                    "diseased_5_9": 67087,
                    "diseased_10_14": 37153,
                    "diseased_15_19": 32399,
                    "diseased_20_24": 26236,
                    "diseased_25_29": 33455,
                    "diseased_30_34": 35216,
                    "diseased_35_39": 50535,
                    "diseased_40_44": 61804,
                    "diseased_45_49": 83286,
                    "diseased_50_54": 131532,
                    "diseased_55_59": 155832,
                    "diseased_60_64": 167101,
                    "diseased_65_69": 123433,
                    "diseased_70_74": 95788,
                    "diseased_75_79": 66735,
                    "diseased_80_84": 31695,
                    "diseased_85_89": 8100,
                    "diseased_90_94": 1585,
                    "diseased_95": 176,
                    "disease": 6498
                }
            ],
            "thumbnail_100x100": null,
            "thumbnail_300x300": null,
            "thumbnail_600x600": null,
            "symptom_count": 0,
            "symptom_matched": 0,
            "relevance": 7.605727612527755,
            "who_popularity": 2771022.0,
            "group_population": 364333584,
            "who_danger": 0.0,
            "svg": {
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            },
            "code": "H90.1",
            "name": "Кондуктивная потеря слуха односторонняя с нормальным слухом на противоположном ухе",
            "icd_name": "Кондуктивная потеря слуха односторонняя с нормальным слухом на противоположном ухе",
            "gender": 0,
            "age_min": 1,
            "age_max": 100,
            "cause": [],
            "periodicity": 1,
            "slug": "h90.1_konduktivnaya_poterya_sluha_odnostoronnyaya_s_normalnym_sluhom_na_protivopolozhnom_uhe",
            "lead": "",
            "description": "",
            "etiology": "",
            "pathogenesis": "",
            "diagnostics": "",
            "treatment": "",
            "prevention": "",
            "clinical_picture": "",
            "image": null,
            "image_alt": null,
            "standard_type": 3,
            "danger": 1,
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            "parent": 6498,
            "block_rubric": 89,
            "standards": []
        },
        {
            "id": 10925,
            "symptoms": [
                {
                    "id": 2816,
                    "synonyms": [
                        {
                            "name": "боль в ухе"
                        },
                        {
                            "name": "выделение из уха"
                        },
                        {
                            "name": "ухо течет"
                        }
                    ],
                    "body_points": [
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                    ],
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                {
                    "id": 3003,
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                        {
                            "name": "Температура 37-38°"
                        },
                        {
                            "name": "Субфебрильная температура"
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                    ],
                    "body_points": [
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                    "age_max": 100,
                    "slug": "povyshennaya_temperatura_37-38",
                    "lead": "Температура 37-38 °, при продолжительном повышении температуры следует обратиться к врачу",
                    "image": null,
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                },
                {
                    "id": 77,
                    "synonyms": [
                        {
                            "name": "ухо плохо слышит"
                        }
                    ],
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            "name": "Кондуктивная потеря слуха неуточненная",
            "icd_name": "Кондуктивная потеря слуха неуточненная",
            "gender": 0,
            "age_min": 1,
            "age_max": 100,
            "cause": [
                "0"
            ],
            "periodicity": 1,
            "slug": "h90.2_konduktivnaya_poterya_sluha_neutochnennaya",
            "lead": "нарушение слуха, которое характеризуется затрудненным проведением звуковых волн к звуковоспринимающему аппарату",
            "description": "",
            "etiology": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сбой в системе звукопроведения может случиться как на этапе прохождения звуковой волны через наружное ухо, так и на этапе прохождения через среднее. Наружное ухо состоит из ушной раковины и наружного слухового прохода. Среднее ухо имеет ещё более сложное строение. Оно включает барабанную перепонку, слуховую (евстахиеву) трубу, слуховые косточки (стремечко, молоточек, наковальня). Всё вместе &ndash; это очень слаженная система. Даже незначительный сбой в работе одной из выше названных структур приводит к ухудшению слуха. Причинами нарушений в наружном ухе, приводящим к кондуктивной тугоухости, являются следующие заболевания и состояния: </span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">серные пробки; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">посторонний предмет, застрявший в слуховом проходе; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">наружный отит (или как его ещё называют &laquo;ухо пловца&raquo;); </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">экзостозы (образования новой костной ткани на поверхности кости доброкачественного характера); </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">остеомы слухового прохода (доброкачественная костная опухоль); </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">травмы наружного уха;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">атрезия слухового прохода (состояние, при котором полностью или частично отсутствует слуховой проход).</span></li>\r\n</ul>\r\n<p><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">При всех этих состояниях звуковая волна задерживается в наружном ухе и не может пройти дальше в среднее ухо. Бывают случаи, когда звуковая волна успешно проходит через наружное ухо, но встречает препятствие на уровне среднего уха. Причины кондуктивной тугоухости, вызванные нарушениями в работе среднего уха: </span></p>\r\n<ul>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">повреждения барабанной перепонки (разрыв барабанной перепонки может случиться из-за травмы уха, включая ковыряние в ухе острым предметом; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">акустической травмы, резких перепадов атмосферного давления, а также вследствие тимпаносклероза); </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">воспалительные заболевания среднего уха (различные виды среднего отита); </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">воспаление слуховой трубы (евстахиит, тубоотит); </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">отосклероз (патологическое разрастание костной ткани в ухе); </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">холестеатома (доброкачественное образование в среднем ухе);</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">блокировка просвета слуховой трубы разросшимися аденоидами; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">травмы уха с повреждением слуховых косточек.&nbsp;</span></li>\r\n</ul>",
            "pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В основе патогенеза кондуктивной тугоухости лежит дисфункция звукопроводящей системы &ndash; внешнего слухового прохода, барабанной перепонки, полости среднего уха и слуховых косточек, эндолимфы или мембран улитки. В норме все эти структуры отвечают за усиление и передачу звука к структурам системы звуковосприятия. Нарушение хотя бы одного из звеньев этой цепочки приводит к искажению колебаний и общему ухудшению слуха. Функция кортиевого органа, слухового нерва и задних отделов верхней височной извилины, отвечающих за восприятие и обработку услышанного, не нарушается. За счет этого у больных сохраняется нормальная костная проводимость звуков. В тяжелых случаях ее чувствительность превышает воздушную, из-за чего человек полноценно воспринимает только собственную речь.</span></p>\r\n<p><span id=\"docs-internal-guid-119b9fb3-7fff-7e9f-3603-a50b81959b20\">&nbsp;</span></p>",
            "diagnostics": "<p><span id=\"docs-internal-guid-819cf277-7fff-9b74-5732-1217120d8351\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Пациенту с подозрением на кондуктивную тугоухость проводят следующие мероприятия: </span></span></p>\r\n<ul>\r\n<li><span id=\"docs-internal-guid-819cf277-7fff-9b74-5732-1217120d8351\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">сбор анамнеза &ndash; доктор расспрашивает пациента о жалобах, о перенесённых заболеваниях, травмах, повреждениях уха;</span></span></li>\r\n<li><span id=\"docs-internal-guid-819cf277-7fff-9b74-5732-1217120d8351\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">отоскопия &ndash; осмотр ушной раковины, слухового прохода, целостности барабанной перепонки. </span></span><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">На этом этапе выявляют воспалительные процессы в наружном ухе, серные пробки, инородные предметы в слуховом проходе; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">исследование слуха при помощи камертонов, шёпотной речи; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">аудиометрическое исследование, позволяющее определить остроту слуха; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">тимпанометрическое исследование, помогающее изучить состояние среднего уха, степень подвижности слуховых косточек, состояние барабанной перепонки; </span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">при подозрении на наличие образований в ухе и изменения его структур проводятся рентгенологическое исследование, компьютерная томография, магнитно-резонансная томография.</span></li>\r\n</ul>",
            "treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечебные мероприятия при этом заболевании направлены на устранение ведущего этиологического фактора, нарушающего звукопроведение. Таким образом, лечебная тактика сводится к применению фармакологических средств или проведению хирургического вмешательства. Основные методы лечения:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Фармакотерапия. Интенсивная антибиотикотерапия показана на ранних стадиях ухудшения слуха, возникшего в результате воспалительных заболеваний &ndash; внешнего или среднего отита, евстахиита. Как правило, используются антибиотики широкого спектра действия. При поражении слухового прохода показано промывание уха растворами антисептиков, назначение НПВС или глюкокортикоидов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Оперативное лечение. Хирургическая тактика может подразумевать извлечение инородного тела из уха, восстановление функций барабанной перепонки (мирингопластика, тимпанопластика), дренирование барабанной полости, протезирование слуховых косточек (оссикулопластика), удаление гнойных масс из сосцевидного отростка (мастоидотомия) и т. п.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Слухопротезирование. Применение слуховых аппаратов показано при развитии изменений во внешнем или среднем ухе, не поддающихся лечению. Искусственное усиление воспринимающих звуков компенсирует функцию звукопроводящей системы, за счет чего к человеку возвращается способность слышать.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>",
            "prevention": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы снизить риск развития тугоухости, важно вовремя пролечивать воспалительные процессы в ушах и носоглотке. Соблюдайте правильную гигиену ушей. Не ковыряйте в ухе посторонними предметами. Избегайте травм головы. И посещайте лор-врача в профилактических целях, чтобы диагностировать снижение слуха на ранней стадии.</span></p>",
            "clinical_picture": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Самый главный признак кондуктивной тугоухости &ndash; резкое или постепенное снижение слуха. Пациент начинает хуже слышать шёпот и разговорную речь. Если вокруг шумно, становится трудно различить слова собеседника. Звуки воспринимаются нечётко, приглушённо. Отмечается заложенность ушей. Себя начинаешь слышать громче, чем всё, происходящее вокруг. В зависимости от причины, вызвавшей тугоухость, могут наблюдаться и другие признаки: </span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ухудшение слуха может быть односторонним или двусторонним; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">появление боли в ушах; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">повышение температуры тела; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выделения из слухового прохода. </span></li>\r\n</ul>\r\n<p><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Последние симптомы развиваются обычно на фоне воспалительных процессов в ушах.</span></p>",
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            "etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пресбиакузис &ndash; это проявление возрастных изменений, формирующихся в результате естественных процессов старения и длительного воздействия различных патологических факторов. Вторая группа причин ускоряет природные дегенеративные явления и обуславливает развитие тугоухости в более раннем возрасте. В этот список входит:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Работа в условиях сильного шума или вибрации. Острые и хронические акустические травмы, вибрационная болезнь сопровождаются повреждением структуры звуковоспринимающего аппарата, что ускоряет возрастные дегенеративные изменения.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Использование ототоксических препаратов. Ятрогенная ототоксичность, обусловленная длительным приемом аминогликозидных антибиотиков, петлевых диуретиков, НПВС и химиотерапевтических препаратов, напрямую способствует раннему развитию пресбиакузиса.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Дисметаболические патологии. При сахарном диабете высокий уровень глюкозы в крови способствует нарушению кровоснабжения внутреннего уха и более быстрому формированию возрастных дегенеративных изменений. Подагра, ревматизм и тиреотоксикоз вызывают изменение состава и реологических свойств эндолимфы и перилимфы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сердечно-сосудистые патологии. Стабильно высокое артериальное давление и атеросклеротическое поражение артерий &ndash; причины ишемии слуховых центров головного мозга и недостаточности притока артериальной крови к рецепторному аппарату. Аналогичные проявления вызывает остеохондроз шейного отдела позвоночника.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Воспалительные или механические повреждения уха. Хронические и ранее перенесенные осложненные острые средние отиты, лабиринтит, черепно-мозговые травмы делают рецепторные структуры более восприимчивыми к другим патологическим факторам и ускоряют местные процессы старения.</span></li>\r\n</ul>\r\n<p>&nbsp;</p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">&nbsp;</span></p>",
            "pathogenesis": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пресбиакузис &ndash; это результат возрастных изменений звуковоспринимающего аппарата. Ведущую роль в данном процессе играет атрофия артериальных сосудов, которые участвуют в кровоснабжении улитки, в частности &ndash; деваскуляризация спиральной связки и сосудистой полости. В результате развиваются дегенеративные изменения волосковых клеток и нервных окончаний кортиевого органа, отвечающих за образование и передачу нервного импульса. Сопутствующий атеросклероз является не только причиной поражения кровеносных сосудов, но и отложения атероматозных патологических масс на анатомических структурах барабанной полости. Согласно некоторым теориям, пресбиакузис вызывает скопление большого количества нейтрального жира на основной мембране лабиринта с дегенераций сенсорного эпителия.</span></p>",
            "diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постановка диагноза пресбиакузиса помимо исследования функции слуха требует определения способствующих его развитию заболеваний и тщательной дифференциальной диагностики. Важнейшее значение имеют правильно собранные отоларингологом жалобы и данные анамнеза, их сопоставление с возрастом пациента. Это позволяет предварительно установить все предрасполагающие факторы, проследить динамику развития симптомов. К другим используемым методикам относятся:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Тональная пороговая аудиометрия. У большинства пациентов пресбиакузис характеризуется выраженным ухудшением функции звуковоспринимающей системы, что отображается одновременным снижением как воздушной, так и костной проводимости. Характер кривых на аудиограмме зависит от формы заболевания, может быть восходящим, нисходящим или равномерным по всему диапазону звуковых частот.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пробы с камертонами. При выполнении пробы Ринне звук вибрирующих бранш камертона слабо слышен во всех положениях, но напротив слухового прохода звук несколько громче. Во время теста Вебера звучащий камертон плохо выслушивается с обеих сторон или не воспринимается вовсе.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Компьютерная стабилолитрия. Методика информативна при сопутствующей вертебробазилярной недостаточности и наличии вестибулярных симптомов. Применяется для дифференцировки аналогичных проявлений отогенного и вертеброгенного происхождения.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сканирование. КТ височных костей с контрастным усилением позволяет выявить нарушение кровоснабжения и сформировавшиеся участки ишемии структур внутреннего уха, исключить наличие опухолевых образований этой области. Несколько реже с целью визуализации корковых центров слуха используется МРТ головного мозга.</span></li>\r\n</ul>\r\n<p>&nbsp;</p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">&nbsp;</span></p>",
            "treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Эффективность проводимой терапии зависит от морфологической и функциональной сохранности воспринимающих структур, обратимости присутствующих изменений. Основной метод лечения на ранних этапах развития пресбиакузиса &ndash; консервативный. В терапевтическую программу входит:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Медикаментозная терапия. Основная цель фармакотерапии &ndash; улучшение микроциркуляции и метаболизма в рецепторных структурах, нормализация синаптической передачи нервного импульса. Применяются витамины группы В, А и Е, аскорбиновая и глютаминовая кислоты, биогенные стимуляторы, ноотропы, АТФ. При необходимости проводится дезинтоксикационная, десенсибилизирующая, дегидратационная терапия. В качестве симптоматического лечения используется меатотимпанальная блокада.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Слухопротезирование. Производится при длительном существовании слуховых нарушений или отсутствии положительной динамики на фоне фармакотерапии. Приборами выбора являются внешние слуховые аппараты, которые подбираются для каждого пациента в индивидуальном порядке. При тугоухости тяжелой степени тяжести показана кохлеарная имплантация.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Физиотерапия. Положительным эффектом обладает электрофорез с никотиновой кислотой, акупунктура, пневмомассаж барабанных перепонок и продувание слуховых труб.</span></li>\r\n</ul>\r\n<p>&nbsp;</p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">&nbsp;</span></p>",
            "prevention": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактика пресбиакузиса заключается в полноценном лечении сердечно-сосудистых патологий, метаболических нарушений, заболеваний среднего и внутреннего уха, соблюдении техники безопасности на производстве, ограничении использования ототоксических медикаментов.</span></p>",
            "clinical_picture": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиническая картина определяется формой патологии. У большинства больных первичным признаком пресбиакузиса становится ухудшение восприятия разговорной речи. Изначально этот симптом проявляется невозможностью разобрать слова собеседника в условиях наличия внешних шумов: работы двигателя автомобиля, разговоров других людей, шума улицы и так далее. Затем восприятие ухудшается даже без внешних раздражителей. Одновременно незаметно для человека происходит симметричное снижение остроты слуха. Далее возникает прогрессирующий двухсторонний шум в ушах, который может напоминать свист, звон или гул. У больных с сопутствующей вертебробазилярной недостаточностью часто развиваются вестибулярные нарушения, которые усиливаются при наклонах головы. К ним относится приступообразное позиционное головокружение, шаткость ходьбы, ощущение падения, слабовыраженная тошнота, спонтанный нистагм.</span></p>",
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            "etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В большинстве случаев речь идет о естественном выделении ушной серы, которая покидает ушной канал. Обильные выделения серы могут быть вызваны разными причинами &ndash; например, повышенной влажностью, из-за которой в ухе образуется достаточно много пота, который покидает ушной канал, вымывая оттуда серу.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Есть несколько основных причин выделений из уха:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ушная инфекция &ndash; это одна из самых распространенных причин отореи. Ушная инфекция развивается, когда бактерии или вирусы проникают в среднее ухо, минуя защитный слой ушной серы. Некоторые вирусные инфекции сопровождаются повышенной выработкой секрета, который начинает вытекать из уха</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">травма ушного канала может стать причиной появления гнойных или кровянистых выделений из уха. Неаккуратное использование ватных палочек, резкий перепад давления в самолете, слишком громкая музыка &ndash; все это может стать причиной разрыва барабанной перепонки, который сопровождается выделением секрета</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">внешний отит или ухо пловца возникает, когда бактерии или грибок поражают ткани ушного канала. Как правило, это случается после длительного пребывания в воде, из-за чего болезнь принято называть &laquo;ухом пловца&raquo;. Инфекция, закрепившаяся в ушном канале, провоцирует выделение жидкого секрета и гноя</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">перелом костей черепа &ndash; чрезвычайно редкая причина выделений из уха. Однако если у пациента, пережившего травму головы, появились необычные выделения из уха, ему следует немедленно обратиться за медицинской помощью.</span></li>\r\n</ul>\r\n<p>&nbsp;</p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">&nbsp;</span></p>",
            "pathogenesis": "",
            "diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Осмотр и сбор анамнеза</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сначала врач расспрашивает пациента с выделениями из уха о его симптомах, возможных занятиях/действиях, которые могли повлиять на ушной канал или барабанную перепонку (например, плавание; введение в ухо инородных тел, в том числе ватных тампонов, а также использование ушных капель), о хронических инфекциях уха и сопутствующих заболеваниях.&nbsp;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Затем врач проводит осмотр уха и окружающих тканей.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Данные, полученные при сборе анамнеза и осмотре, часто указывают на причину выделений из уха и на обследование, которое может потребоваться.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Обследование</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отоскопия</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Риноскопия</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исследование функции черепно-мозговых нервов</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если при обследовании не удается сразу установить чем вызваны те или иные симптомы, необходимо провести дополнительные исследования: \u2028</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аудиограмма</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">КТ височных костей или МРТ с контрастом</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Биопсия (при наличии грануляционной ткани в слуховом проходе)</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>",
            "treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При выявлении серной пробки врач удаляет ее, предварительно размягчив специальными препаратами. Удаляют пробки с помощью промывания или аспирации и кюретажа.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ирригация возможна только при отсутствии противопоказаний, о которых врач обязательно сообщит (перфорация барабанной перепонки, наружный отит).</span></p>\r\n<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение при отите может включать обезболивание, физиотерапию и этиотропную терапию в зависимости от возбудителя заболевания. Аллергическая природа выделений из уха требует использования антигистаминных препаратов. Холестеатома лечится только хирургическим путем.</span></p>",
            "prevention": "<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы снизить риск ушных выделений, рекомендуется защищать уши от воды и переохлаждений, вовремя лечить ЛОР-болезни и регулярно наблюдаться у отоларинголога.&nbsp;</span></p>",
            "clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Количество, цвет, прозрачность, запах, консистенция выделений из уха, а также сопутствующие симптомы, &ndash; широко варьируют. Так,</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">истечение гноя присуще, в основном, инфекционно-воспалительным процессам бактериальной или грибковой этиологии;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">примесь крови в той или иной концентрации характерна для отореи при травмах или онкопатологии;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">прозрачные текучие выделения типичны для аллергических наружных отитов, экссудативных средних отитов, травматической ликвореи (см. выше).</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В большинстве случаев оторея сопровождается следующими симптомами (единичными или в различных сочетаниях):</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">снижение остроты слуха, чувство заложенности или инородного тела, восприятие внешнего звука словно сквозь вату или из-под воды;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">оталгия (болевой синдром с локализацией во внешних или внутренних структурах уха);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">головная боль;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">вестибулярные нарушения (головокружение, дискоординация, утрата равновесия и пр.);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">разного рода шумы в ухе;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ринит (насморк), нередко с симптомами синусита (воспаления придаточных пазух носа);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">субфебрилитет, реже высокая температура тела.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p>&nbsp;</p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\">&nbsp;</p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">&nbsp;</span></p>",
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