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"code": "B53",
"name": "Другие виды паразитологически подтвержденной малярии",
"icd_name": "Другие виды паразитологически подтвержденной малярии",
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"lead": "Нарушение здоровья, относящееся к группе протозойные болезни",
"description": "Малярия - группа трансмиссивных инфекционных заболеваний, передаваемых человеку при укусах самками комаров рода Anopheles («малярийных комаров») и сопровождающихся лихорадкой, ознобами, спленомегалией (увеличением размеров селезёнки), гепатомегалией (увеличением размеров печени), анемией. Характеризуется хроническим рецидивирующим течением. Вызывается паразитическими протистами рода Plasmodium ",
"etiology": "<p>Возбудители малярии — простейшие рода Plasmodium ovale. </p>\r\n<p>Источником болезни являются люди, в крови которых циркулируют зрелые гаметоциты. При кровососании вместе с кровью в желудок комара проникают гаметоциты, и комар становится резервуаром инфекции. Ведущий механизм заражения человека — трансмиссивный, реализующийся самками комаров рода Anopheles при кровососании. </p>\r\n<p>Возможен парентеральный путь заражения при гемотрансфузиях, использовании плохо обработанного или не подлежащего повторном у использованию инструментария, а также передача плазмодиев от матери к плоду (при тропической малярии) — так называемая шизонтная малярия. </p>",
"pathogenesis": "<p>Человек заражается плазмодиями в момент инокуляции (впрыскивания) самкой малярийного комара одной из стадий жизненного цикла возбудителя (так называемых спорозоитов) в кровь или лимфатическую систему, которое происходит при кровососании. </p>\r\n<p>После кратковременного пребывания в крови спорозоиты малярийного плазмодия проникают в гепатоциты печени, давая тем самым начало доклинической печёночной (экзоэритроцитарной) стадии заболевания. В процессе бесполого размножения, называемого шизогонией, из одного бывшего спорозоита, который в клетке печени превращается в шизонта, в итоге образуется от 2000 до 40 000 печёночных мерозоитов. В большинстве случаев эти дочерние мерозоиты через 1—6 недель снова попадают в кровь. </p>\r\n<p> </p>",
"diagnostics": "<p>Диагноз устанавливается на основе выявления паразитов в мазках крови. Традиционно используют два типа мазков — тонкий и толстый (или так называемую «толстую каплю»). Тонкий мазок позволяет с большей надёжностью определить разновидность малярийного плазмодия, поскольку внешний вид паразита (форма его клеток) при данном типе исследования лучше сохраняется. Толстый мазок позволяет микроскописту просмотреть больший объём крови, поэтому этот метод чувствительнее, но внешний вид плазмодия при этом изменяется, что не позволяет легко различать разновидности плазмодия. Поставить диагноз на основе микроскопического исследования зачастую бывает затруднительно, так как незрелые трофозоиты разных видов малярийного плазмодия плохо различимы, и обычно необходимо несколько плазмодиев, находящихся на разных стадиях созревания, для надёжной дифференциальной диагностики. </p>\r\n<p>В настоящее время используются также быстрые диагностические тесты с использованием иммунохимических наборов и ПЦР диагностика (определения генома паразита в крови). </p>",
"treatment": "<p>Режим: </p>\r\n<ul>\r\n<li>полупостельный (малярия без осложнений);</li>\r\n<li>постельный (при развитии осложнений).</li>\r\n</ul>\r\n<p> Диета (легкоусвояемая); </p>\r\n<ul>\r\n<li>диета №5</li>\r\n<li>диета №7 (при развитии нефротического синдрома).</li>\r\n</ul>\r\n<p> Обильное питье до 2,5-3,0 л жидкости. </p>\r\n<p>Медикаментозное лечение </p>\r\n<p>Лечение проводится препаратом хлорохином. Лечение хлорохином не гарантирует полного, радикального излечения трехдневной малярии, так как гематошизотропные препараты не действуют на гипнозоиты в печени, поэтому курс купирующего лечения должен дополняться назначением радикального лечения гистошизотропным препаратом Примахин. </p>\r\n<p>Лечение неосложненной малярии, устойчивой к хлорохину проводится хинином. При устойчивости к хинину применяют артемизинин (экстракт полыни) и его производные. </p>\r\n<p>Лечение осложненной малярии (церебральная малярия, малярийный алгид) проводят в отделении интенсивной терапии. </p>",
"prevention": "<p>Методы, которые используются для предотвращения распространения болезни или для защиты в областях, эндемичных для малярии, включают профилактические лекарственные средства, уничтожение комаров и средства для предотвращения укусов комаров. </p>\r\n<p>Современные лекарственные средства для профилактики включают мефлохин (Лариам), доксициклин и атовакуон-прогуанил гидрохлорид. </p>",
"clinical_picture": "<p>Инкубационный период, составляет 11-16 дней.</p>\r\n<p>Заболевание характеризуется невысокой паразитемией, рецидивирующим течением, интермиттирующей (чередование периодов нормальной и высокой температуры) лихорадкой с трехдневной или ежедневной периодичностью, вечерним временем наступления пароксизмов, умеренно выраженным увеличением печени и селезенки, анемией, обычно мягким доброкачественным течением с частым спонтанным выздоровлением после небольшого числа приступов.</p>\r\n<p>Клинические проявления заболевания очень сходны с таковыми при трехдневной малярии, но все же имеют свои особенности.</p>\r\n<p>Селезенка, как и печень, увеличивается крайне медленно и может быть доступна пальпации только через несколько недель от момента первичного приступа. Выраженных ознобов, нарушения общего состояния при этой форме малярии практически не наблюдается. Можно также отметить спонтанность прекращения приступов при сохраняющейся на низком уровне паразитемии.</p>\r\n<p>Прогноз при овале-малярии благоприятный, заболевание заканчивается полным выздоровлением.</p>",
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"code": "A98",
"name": "Геморрагическая лихорадка",
"icd_name": "Другие вирусные геморрагические лихорадки, не классифицированные в других рубриках",
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"age_min": 0,
"age_max": 100,
"cause": [
2,
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"slug": "a98_gemorragicheskaya_lihoradka",
"lead": "Термином \"геморрагическая лихорадка\" объединяется группа заболеваний вирусного происхождения со сходными проявлениями, при которых ведущая роль отводится поражению сосудов с развитием тромбозов или кровоточивости",
"description": "",
"etiology": "<p>Геморрагическую лихорадку могут вызывать пять основных видов вируса - тогавирусы, филовирусы, флавивирусы, аренавирусы, буньявирусы.</p>\r\n<p>Это группа инфекций, характеризующихся природной очаговостью, то есть распространением в местностях, где много диких животных, носителей вирусов и переносчиков из разряда клещей или комаров. Основные животные, которые могут быть источниками данных лихорадок это белки, летучие мыши, домашние грызуны и обезьяны.</p>\r\n<p>Для некоторых видов геморрагических лихорадок характерны и другие пути распространения. Выделяют воздушно-пылевой путь, парентеральный (через кровь и другие биологические жидкости), пищевой, водный, через контакты с зараженными животными.</p>\r\n<p>Чаще всего болеют люди, работа которых связана с животными, дикой природой и сельхозугодиями. Городские жители при заболевании в основном имеют контакты с грызунами. </p>\r\n<p> </p>",
"pathogenesis": "<p>В упрощенном виде механизмы повреждения при геморрагических лихорадках можно представить таким образом:</p>\r\n<ul>\r\n<li>повреждение сосудов вирусами или продуктами их метаболизма,</li>\r\n<li>нарушение целостности стенок сосудов, их , выделение в просвет биологически активных веществ,</li>\r\n<li>формирование из-за дефицита кровоточивости и развития так называемого ДВС-синдрома (массивного одновременного свертывания крови в одних сосудах и параллельного кровотечения из-за низкой свертываемости в других).</li>\r\n</ul>\r\n<p>В результате формируется гипоксия тканей (нехватка кислорода) и нарушения в работе сердца, легких, почек и головного мозга, происходит массивная потеря крови. При этом тяжесть болезни будет зависеть от вида лихорадки, степени активности иммунитета и особенностей организма человека. Зачастую геморрагические лихорадки протекают тяжело и заканчиваются высокой летальностью.</p>",
"diagnostics": "<p>Основа диагностики – это клиническая картина с указаниями на пребывание в неблагоприятном районе, укусы насекомых или контакт с животными. Но для подтверждения диагноза необходимо обнаружение вирусов в крови или антител к ним. Проводится:</p>\r\n<ul>\r\n<li>общий анализ крови,</li>\r\n<li>общий анализ мочи (особенно для лихорадок с почечным синдромом),</li>\r\n<li>биохимический анализ крови и мочи,</li>\r\n<li>серологические пробы,</li>\r\n<li>иммунохимические и ПЦР методы выделения вируса или антител к нему,</li>\r\n<li>при необходимости проводят выделение и исследование вирусов.</li>\r\n</ul>\r\n<p>Геморрагические лихорадки стоит различать с тяжелым капилляро-токсическим гриппом, риккетсиозами и менингококковой инфекцией – все они сопровождаются кровоточивостью и похожи по проявлениям. Кроме того, необходимо отличать эти инфекции от болезней крови с кровоточивостью (болезнь Шенляйна-Геноха или Верльгофа).</p>",
"treatment": "<p>Диагностикой и лечением занимаются врачи-инфекционисты, а иногда и реаниматологи.</p>\r\n<p>Все люди с подозрением на геморрагическую лихорадку подлежат госпитализации в боксированное отделение инфекционной больницы.</p>\r\n<p>В период острых проявлений показано парентеральное питание, в период выздоровления – легкая растительно-молочная диета с обогащением витаминами, особенно укрепляющими сосудистые стенки – витаминами РР, С или К.</p>\r\n<p>Кроме того, применяют внутривенные вливания растворов глюкозы, переливания крови, препараты железа, антигистаминные средства. При необходимости вводят тромбоцитарную массу, факторы свертывания.</p>\r\n<p>Постельный режим в изоляторе соблюдается до полного выздоровления. В дальнейшем пациент наблюдается еще достаточно длительно у инфекциониста и терапевта.</p>",
"prevention": "<p>К основным методам борьбы с геморрагическими лихорадками относят:</p>\r\n<ul>\r\n<li>уничтожение грызунов и насекомых-переносчиков,</li>\r\n<li>тщательная очистка участков жилых застроек от травы и кустарников, заболоченных мест,</li>\r\n<li>при работе в полях и лесах необходимо ношение защитной одежды, применение репеллентов,</li>\r\n<li>для профилактики некоторых видов геморрагических лихорадок разработаны вакцины – желтой лихорадки и омской геморрагической лихорадки.</li>\r\n</ul>",
"clinical_picture": "<p>Геморрагическая - это классическая инфекционная болезнь со стадийностью течения. Выделяют следующие стадии:</p>\r\n<ul>\r\n<li>инкубационную – она, в зависимости от вида вируса, может длиться от нескольких суток до трех недель,</li>\r\n<li>начальную стадию или период продрома, длящийся от суток до недели,</li>\r\n<li>период разгара болезни с проявлением всех типичных признаков геморрагической лихорадки и длящийся от одной до двух недель,</li>\r\n<li>период реконвалесценции или выздоровления (или в некоторых случаях - летальный исход).</li>\r\n</ul>\r\n<p>Выздоровление может длиться до нескольких месяцев, особенно в случае тяжелого течения и остаточных явлений.</p>\r\n<p>В начальном периоде симптомы геморрагической лихорадки обычно неспецифические. Обычно проявляются:</p>\r\n<ul>\r\n<li>симптомы общей интоксикации,</li>\r\n<li>высокая температура,</li>\r\n<li>расстройства сознания вплоть до бреда,</li>\r\n<li>точечные кровоизлияния на коже в зоне шеи и лица, склер и в области рта,</li>\r\n<li>нарушения ритма сердца с учащением или замедлением частоты,</li>\r\n<li>снижение давления,</li>\r\n<li>в анализах крови выявляется воспалительная реакция (лейкоцитоз, может быть со сдвигом) с незначительным снижением тромбоцитов.</li>\r\n</ul>\r\n<full></full>\r\n<p>В период разгара может быть:</p>\r\n<ul>\r\n<li>временное снижение температуры,</li>\r\n<li>общее улучшение состояния, после чего вновь наступает ухудшение,</li>\r\n<li>нарастает токсикоз,</li>\r\n<li>прогрессируют нарушения сознания,</li>\r\n<li>развиваются мелкие тромбозы и из мест инъекций, с поверхностей слизистых, пищеварительного и мочеполового тракта,</li>\r\n<li>нарушаются функции легких, почек, сердца.</li>\r\n</ul>\r\n<p>В периоде выздоровления постепенно все симптомы исчезают, работа органов восстанавливается.</p>",
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}
]
}
