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},
"code": "E54",
"name": "Недостаточность аскорбиновой кислоты",
"icd_name": "Недостаточность аскорбиновой кислоты",
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0
],
"periodicity": 4,
"slug": "e54_nedostatochnost_askorbinovoy_kisloty",
"lead": "Гиповитаминоз С",
"description": "Недостаточность аскорбиновой кислоты (гиповитаминоз С) обусловлена дефицитом ее в организме. Тяжелый дефицит ее приводит к развитию цинги.",
"etiology": "<p>Гиповитаминоз С может развиваться при приеме ацетилсалициловой кислоты, эстрогенов, пероральных контрацептивов, а также при алкоголизме, гипертиреозе, проведении гемодиализа.</p>",
"pathogenesis": "<p>Аскорбиновая кислота играет важную роль в окислительно-восстановительных процессах, углеводном обмене, оказывает универсальное влияние на проницаемость сосудистой стенки, развитие и функцию костной, хрящевой ткани, кожи, надпочечников и других органов. Недостаток аскорбиновой кислоты со временем приводит к угнетению Т-системы иммунитета, что способствует развитию инфекционных осложнений.</p>",
"diagnostics": "<p>Важное значение особенно в I стадии заболевания имеет определение экскреции аскорбиновой кислоты с мочой.</p>\r\n<p>Во II и III стадиях цинги клиническая симптоматика (гингивит, стоматит, выпадение зубов, распространенные петехиальные сыпи и кровоизлияния под кожу в мышцы, суставы, остеопороз и др.) в сочетании с анамнестическими данными о неполноценном питании дает возможность установить правильный диагноз.</p>",
"treatment": "<p>Лечение больных цингой в I стадии можно проводить амбулаторно. Назначают аскорбиновую кислоту по 0,1 г 3—5 раз в сутки. При ухудшенном всасывании витамина С его вводят внутримышечно по 1—2 мл 5% раствора. Одновременно назначают витамин Р (рутин, кверцетин и др.) 100—150 мг/сут. <br />Больные с II и III стадиями цинги должны лечиться в стационаре. Им показана диета, богатая белками (до 120—150 г/сут). При цинге II стадии суточная доза аскорбиновой кислоты должна быть не менее 500 мг, при III стадии — 1000 мг, при этом не менее 1/3 дозы следует вводить парентерально.</p>\r\n<p>Эффективно введение в вену 1—2 мл 5% раствора аскорбината натрия вместе с глюкозой. Назначают также витамины Р (150—300 мг), B1 (20 мг), рибофлавин (10 мг). Активную витаминотерапию проводят не менее месяца, затем дозы постепенно снижают.</p>",
"prevention": "",
"clinical_picture": "<p>К I стадии цинги относят случаи, характеризующиеся умеренной слабостью, болью в ногах, повышенной кровоточивостью, цинготной пурпурой, нерезким гингивитом; трудоспособность снижена умеренно.</p>\r\n<p>Во II стадии геморрагии приобретают распространенный характер. Отмечается геморрагический <a href=\"/symptom/vypot/\" title=\"Перейти на страницу симптома Выпот\">выпот</a> в суставы, плевру. Гингивит и стоматит резко выражены; у больных повышается температура. Они нуждаются в стационарном лечении.</p>\r\n<p>Стадия III характеризуется тяжелым общим состоянием больных, резким исхуданием, дальнейшим нарастанием кровоточивости, анемизации, возникновением долго незаживающих язв конечностей, развитием инфекционных осложнений (пневмонии, туберкулез, дизентерия, <a href=\"/symptom/sistemnoe_vospalenie/\" title=\"Перейти на страницу симптома Системное воспаление\">сепсис</a> одонтогенный и др.).</p>",
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},
"code": "E50",
"name": "Недостаточность витамина A",
"icd_name": "Недостаточность витамина A",
"gender": 0,
"age_min": 0,
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"cause": [
0
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"slug": "e50_nedostatochnost_vitamina_a",
"lead": "Это патологическое состояние, возникающее вследствие дефицита в организме этого витамина и проявляющееся ухудшением зрения - в первую очередь гемералопией («куриная» слепота), конъюнктивитом, ксерофтальмией, гиперкератозом кожи. ",
"description": "",
"etiology": "<p>Недостаточность витамина А может быть обусловлена нарушением абсорбции витамина в кишечнике при его хронических заболеваниях, целиакии, болезнях печени и поджелудочной железы, железодефицитной анемии, длительном употреблении минерального масла. При потреблении с пищей небольших количеств жира также снижается абсорбция витамина А.</p>\r\n<p>Причиной недостаточности витамина могут быть и чрезмерные потери его организмом. Так, экскреция витамина А увеличивается при раке, болезнях мочевыводящих путей и хронических инфекционных заболеваниях. Низкое потребление белка приводит к недостаточности белка-переносчика и способствует снижению уровня витамина в плазме.</p>",
"pathogenesis": "",
"diagnostics": "<p>При гиповитаминозе А понижено содержание в крови ретинола или каротина (ниже 200 мкг/л), нарушена темновая адаптация, развивается гемералопия. При биомикроскопии глаза на слизистой конъюнктивы могут выявляться белесые и желтоватые мелкие бляшки.</p>",
"treatment": "<p>азначают диету, богатую витамином А и провитаминами, а также препараты ретинола. Растворы ретинола применяют внутрь и в виде внутримышечных инъекций.</p>\r\n<p>Суточная лечебная доза 25 000-100 000 ME ретинола (при приеме внутрь дозу делят на 2-3 приема, больше одной инъекции в сутки обычно не делают), продолжительность курса лечения 2-4 нед. Ретинол содержится в поливитаминных препаратах.</p>",
"prevention": "<p>Профилактика гиповитаминоза А состоит в рациональном питании и назначении внутрь препаратов ретинола (5000-10 000 ME) в течение не менее 2-3 нед. До и после проведенного профилактического курса целесообразно определить содержание в сыворотке крови ретинола или каротина.</p>",
"clinical_picture": "<p>Наблюдаются сухость в полости рта и носа, <a href=\"/symptom/izmeneniya_struktury_kozhi/\" title=\"Перейти на страницу симптома Изменения структуры кожи\">сухость кожи</a>, ее <a href=\"/symptom/shelushenie_kozhi/\" title=\"Перейти на страницу симптома Шелушение кожи\">шелушение</a>, повышенное <a href=\"/symptom/vypadenie_volos/\" title=\"Перейти на страницу симптома Выпадение волос\">выпадение волос</a>. Ухудшается сумеречное зрение («куриная» <a href=\"/symptom/slepota/\" title=\"Перейти на страницу симптома Слепота \">слепота</a>). Одновременно возможны <a href=\"/symptom/svetoboyazn/\" title=\"Перейти на страницу симптома Светобоязнь\">светобоязнь</a> (<a href=\"/symptom/glaznaya_bol/\" title=\"Перейти на страницу симптома Глазная боль\">боль в глазах</a> при ярком освещении) и ксерофтальмия (сухость конъюнктивы с утратой присущего ей блеска, снижение секреции слезных желез, появление бляшек Искерского - Бито, разбросанных по склере). В наиболее тяжелых случаях воспалительные процессы в роговице могут осложняться ее некротическим размягчением (кератомаляция), что обычно заканчивается слепотой.</p>\r\n<p>Сочетание гемералопии с ксерофтальмией позволяет с высокой достоверностью думать о недостаточности витамина А.</p>",
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"etiology": "<p>Люди в возрасте испытывают авитаминоз витамина Д вследствие нарушения работы почек, которые утрачивают способность перерабатывать данный элемент. Существуют также болезни кишечника, которые нарушают всасывание витамина D: Болезнь Крона, муковисцидоз и целиакия. У взрослых людей, страдающих ожирением, также наблюдается нехватка витамина Д.</p>\r\n<p>Нехватка витамина D провоцируются следующими факторами:</p>\r\n<ul>\r\n<li>Пятидесятилетний возраст;</li>\r\n<li>Беременность и период грудного вскармливания;</li>\r\n<li>Смуглая кожа;</li>\r\n<li>Болезни почек и печени;</li>\r\n<li>Применением антацидов;</li>\r\n<li>Веганская и вегетарианская диета.</li>\r\n</ul>",
"pathogenesis": "",
"diagnostics": "<p>Для диагноза у взрослых основное значение имеют данные биохимических лабораторных исследований (снижение содержания неорганического фосфора в крови ниже 30 мг/л; повышение активности щелочной фосфатазы).</p>",
"treatment": "<p>Лечебным препаратом является эргокальциферол, выпускаемый в виде драже по 500 МЕ и масляный раствор по 500 и 1000 МЕ в капсулах (для профилактических целей). С лечебной целью назначают внутрь по 500 - 1000 МЕ в день, курсом, согласно инструкции по лечению рахита. Однако применение витаминов группы D (в силу возможности возникновения токсических гипервитаминозов) требует известной осторожности и должно проводиться под наблюдением врача.</p>",
"prevention": "<p>Если говорить о профилактических мерах характерного недуга, то стоит обязательно отметить, что начинаться они должны с изменения своего привычного рациона. Врач назначает ребенку специальную лечебную диету, которая восполнит нехватку витамина Д. Питаться таким образом необходимо продолжительный период времени, помня о слабых местах организма пациента.Если говорить о лекарственных средствах, способствующих профилактике гиповитаминоза витамина Д, то в данном случае врач назначает поливитаминные комплексы, БАДы и витаминно-минеральные комплексы, также укрепляющие весь организм.</p>\r\n<p> </p>\r\n<p> </p>",
"clinical_picture": "<p>Симптомы у детей – рахит, у взрослых – немотивированная <a title=\"Перейти на страницу симптома Слабость\" href=\"/symptom/slabost/\">слабость</a>, <a title=\"Перейти на страницу симптома Утомляемость\" href=\"/symptom/utomlyaemost/\">утомляемость</a>, деминерализация зубов с быстрым прогрессированием кариеса (особенно у беременных женщин), остеопороз, боль в области костей, в мышцах, парестезии.</p>",
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},
"code": "E55.9",
"name": "Недостаточность витамина D неуточненная",
"icd_name": "Недостаточность витамина D неуточненная",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "e55.9_nedostatochnost_vitamina_d_neutochnennaya",
"lead": "микронутриентная недостаточность, приводящая к нарушению фосфорно-кальциевого обмена, противоинфекционного и противоопухолевого иммунитета, репродуктивных функций",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Жирорастворимый витамин D присутствует в организме в двух основных формах: D2 поступает исключительно с пищей, D3 синтезируется в коже под воздействием УФ-лучей и содержится в пищевых продуктах. Дефицит микронутриента развивается по причине его недостаточного эндогенного синтеза или экзогенного поступления, чему способствуют:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Климатические условия. Географически большая часть территории РФ расположена в северной широте. Ограниченное количество солнечных дней в году и низкие температуры в осенне-зимний период приводят к тому, что с ноября по март эндогенный витамин D в коже практически не вырабатывается. Применение солнцезащитных кремов снижает синтез витамина D более чем на 90%.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Особенности диеты. Риск витаминодефицита повышен у пациентов с лактазной недостаточностью, аллергией на молочный белок. В группе риска – приверженцы вегетарианства, лица с однообразным питанием, в рационе которых отсутствует жирная рыба, молочные продукты, яйца, грибы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нарушение всасывания и метаболизма. Формированию гиповитаминоза D способствует мальабсорбция жиров, наблюдаемая у пациентов с НЯК, болезнью Крона, целиакией, муковисцидозом, лучевым энтероколитом. С аналогичной проблемой сталкиваются лица, перенесшие бариатрическое вмешательство.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повышенный расход микронутриента. Увеличение потери белка, связанного с 25(OH)D, отмечается при нефротическом синдроме. Ускорение катаболизма витамина D вызывает прием антиконвульсантов, ГКС, антиретровирусных препаратов. Усиленное расходование запасов нутриента отмечается при гранулематозном поражении легких (саркоидозе, туберкулезе, бериллиозе), грибковых инфекциях (кокцидиомикозе, гистоплазмозе).</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Дефекты гена рецептора витамина Д. Снижение чувствительности к витамину в ряде случаев может быть вызвано генетическими мутациями гена VDR на хромосоме 12q12-q14. При дефектах VDR нарушается связывание одноименного белка с витамином D, вследствие чего страдает кальциевый обмен. Данное состояние проявляется витамин D-резистентным рахитом, патологическими переломами, первичным гиперпаратиреозом.</span></li>\r\n<li></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Факторы риска</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Определенные состояния и заболевания ассоциированы с более высоким риском дефицита витамина D. К категории лиц, в первую очередь нуждающихся в проведении биохимического скрининга, относятся:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">беременные и кормящие: особенно при наличии гестационного диабета, ожирения, отказе от профилактического приема добавок витамина D;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">пожилые люди: у лиц старше 65 лет отмечается 4-кратное снижение синтеза эндогенного витамина D;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">темнокожие: меланин защищает кожу от солнечной инсоляции и снижает способность к синтезу холекальциферола;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">пациенты с хроническими заболеваниями: ХПН, нарушениями всасывания, ожирением, легочными инфекциями.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основным методом распознавания дефицита витамина D служит определение его сывороточного уровня. Результаты анализа интерпретируются в совокупности с жалобами и объективными данными. Обследование, назначаемое врачом-терапевтом, включает.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исследование уровня витамина D. Скрининговым анализом является определение концентрации 25(OH)D (референсные значения 30-100 нг/мл). Кроме этого, может потребоваться проведение комплексного анализа на витамины D2 и D3, метаболиты витамина.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Другие анализы. Для получения полной картины состояния минерального обмена целесообразно определение сывороточного кальция, фосфора, магния, ПТГ, остазы. Исключить D-резистентный рахит позволяет выявление мутаций гена рецептора витамина D.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исследование костной системы. При скелетных деформациях и переломах показана рентгенография трубчатых костей, костей черепа, таза, позвоночника, грудной клетки. Для исследования минеральной плотности костной ткани выполняется ультразвуковая или рентгеновская остеоденситометрия.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основными направлениями коррекции гиповитаминоза Д являются пересмотр рациона питания и прием витаминных препаратов. С пациентами, имеющими дефицит витамина D, работают нутрициологи, эндокринологи. В рамках консервативной терапии показаны:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диетотерапия. Пищевыми источниками микронутриента служат рыба (лосось, сельдь, тунец, сардина, макрель), молоко, сливочное масло, сметана, яичный желток, грибы, говяжья печень. Однако суточная потребность в витамине, как правило, не покрывается только диетой, особенно при нарушении функции печени, почек, мальабсорбции.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Прием препаратов витамина D. Является обязательным компонентом терапии дефицита витамина D. Применяются препараты в форме холекальциферола (D3) и эргокальциферола (D2). Доза и длительность приема зависит от возраста, выраженности витаминодефицита, сопутствующих состояний, климатических условий. Сначала препараты назначаются в насыщающих дозах, затем – в поддерживающих. При необходимости используются кальцийсодержащие добавки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Физическая реабилитация. При рахите рекомендован массаж с элементами лечебной гимнастики, общее УФО. Полезны морские и хвойные ванны. Методы восстановительного лечения взрослых с последствиями дефицита витамина D включают двигательную реабилитацию: ЛФК, дозированную ходьбу, гидрокинезотерапию. Проводится массаж, озонотерапия, электрофорез, миостимуляция, ультразвуковая терапия.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"prevention": "<p><span id=\"docs-internal-guid-9d6129a0-7fff-2253-1d80-4b58c203e7f9\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">В качестве профилактики гиповитаминоза D рекомендуется пребывание на солнце в теплое время года в течение 5-15 минут дважды в день без использования солнцезащитного крема. Целесообразно ежедневное употребление продуктов, обогащенных витамином D, профилактический прием препаратов микронутриента с октября по март включительно.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пациенты с дефицитом витамина D могут предъявлять различные жалобы, многие из которых являются неспецифическими:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">снижение физической выносливости, общая слабость даже при достаточном объёме сна;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">мышечная слабость, особенно в области шеи, плечевого и тазoвого пояса, бедра, лопаточной области;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">спазмы в мышцах;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">боли в суставах;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">диффузные боли в мышцах;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушение равновесия;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">хроническая боль;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">плохая концентрация внимания;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; 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font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">повышенное артериальное давление;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">набор веса;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сухость кожи;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выпадение волос;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">частые простудные заболевания;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">плохое заживление ран.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Костные проявления дефицита витамина D: недостаток витамина D отрицательно сказывается на обмене кальция и фосфора, поэтому основными проявлениями дефицита витамина D у детей являются рахит. Остеомаляция (размягчение костей) и остеопороз (разряжение костной ткани) чаще проявляются у взрослых.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Рахит (снижение образования костной ткани) — это нарушение минерализации растущей кости из-за несоответствия между потребностями организма ребёнка в фосфоре и кальции и недостаточностью систем их доставки в организм.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Остеомаляция (размягчение кости) — это нарушение минерализации уже созревшей костной ткани после завершения её роста.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Остеопороз (хрупкость, ломкость костей у взрослых) — заболевание, при котором происходит снижение костной массы из-за образования дефектов в органическом каркасе кости, что приводит к повышенной ломкости костей и склонности к переломам.</span></li>\r\n</ul>\r\n<p> </p>",
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},
"code": "E56",
"name": "Недостаточность витаминов",
"icd_name": "Недостаточность других витаминов",
"gender": 0,
"age_min": 0,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "e56_nedostatochnost_vitaminov",
"lead": "группа заболеваний, которые возникают в результате дефицита в организме одного или нескольких витаминов",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Авитаминоз – это дефицит в организме человека одного витамина или группы витаминов.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Основной причиной авитаминозов является несбалансированное питание, вследствие чего человек не получает необходимые витамины. Такая ситуация наблюдается как при добровольном ограничении в пище, например, при строгих диетах с целью похудения, так и при вынужденном — при низком уровне дохода, у людей без постоянного места жительства, страдающих наркоманией. Остальные причины витаминного дефицита объединяются в следующие группы:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственные факторы. В литературе описаны врожденные формы гиповитаминозов, обусловленные генетическим мутациями. Они могут затрагивать обмен любых жирорастворимых витаминных нутриентов, а также фолиевой кислоты, соединений группы В – В1, В2, В6, В12. Признаки состояния манифестируют в детском возрасте, его коррекция затруднена.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нарушения пищеварения. Мальабсорбция витаминов наблюдается при хронических гастроэнтеритах, болезни Крона, целиакии, других заболеваниях. Симптомы проявляются на разных этапах – переваривания, высвобождения нутриентов, всасывания готовых биоактивных форм.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Расстройства доставки витаминов. При дефектах транспортных белков, что чаще всего бывает при поражении печени, витаминные вещества не перемещаются к органам-мишеням, поэтому симптомы витаминодефицита бывают даже при нормальном уровне нутриентов в крови. Реже встречаются расстройства взаимодействия транспортных протеинов с клеточными рецепторами.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нарушения клеточного метаболизма. При отсутствии определенных ферментов изменяется течение внутриклеточных биохимических процессов, что приводит к неспособности соединения превращаться в активную форму, либо «выключает» нутриент из метаболических реакций, провоцируя появление соответствующих признаков.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Антивитамины. Так называются соединения, имеющие структурное сходство с витаминами, но не выполняющие их функции (например, сульфаниламиды, изониазид, метотрексат). К этой группе также принадлежат вещества, способные связывать или разрушать полезные нутриенты — тиаминазы, деактивирующие витамин В1, яичный белок авидин, нарушающий функции биотина.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Все вышеописанные этиологические факторы авитаминозов относятся к патологическим. Однако существуют физиологические причины витаминной недостаточности — несоответствие между поступлением нутриентов в организм и повышенной потребностью в них. Это наблюдается у женщин во время беременности, грудного вскармливания, у детей в периоды «скачков роста», у людей, интенсивно тренирующихся в спортзале или занятых тяжелой физической работой.</span></p>\r\n<p><span><span> </span></span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Отдельно выделяют дисвитаминозы — состояния, при которых гипо- или авитаминоз определенных нутриентов сопровождается симптомами гипервитаминоза другого либо нескольких витаминов. Расстройство возникает вследствие избирательного всасывания нутриентов в кишечнике, при несбалансированной диете с преобладанием одной группы продуктов. Иногда признаки дисвитаминоза развивается у тех, кто самостоятельно бесконтрольно принимает витаминные монопрепараты.</span></p>\r\n<p><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витаминонутриенты подразделяются на 2 группы: жирорастворимые — А (ретинол), D (эрго- и холекальциферол), Е (токоферол), К (менахинон, филлохинон), водорастворимые — С (аскорбиновая кислота), В1 (тиамин), В2 (рибофлавин), В6 (пиридоксин), В9 (фолиевая кислота), В12 (цианокобаламин), РР (ниацин). Также выделяют витаминоподобные соединения, дефицит которых не вызывает ярких клинических симптомов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамины — низкомолекулярные соединения, которые являются кофакторами для более чем 100 ферментов, необходимых для корректного протекания метаболических процессов. Такая функция в большей степени присуща водорастворимым веществам, которые зачастую называются энзимовитаминами. Жирорастворимые нутриенты в основном выполняют сигнальные функции, стимулируют работу эндокринной системы, за что они получили название гормоновитаминов.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отличительная черта всех витаминных соединений — они не могут синтезироваться в достаточном количестве в организме человека (а некоторые вещества вовсе не вырабатываются эндогенно), поэтому для правильного метаболизма необходимо регулярное поступление этих веществ извне. Если ежедневное потребление нутриента не соответствует физиологической норме, нарушаются соответствующие биохимические реакции, появляются клинические признаки расстройства.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптомы авитаминозов, как правило, довольно специфичны, поэтому заподозрить их удается при клиническом осмотре больного у врача общей практики (семейного доктора, терапевта или педиатра). Особое внимание уделяется выяснению характера питания больного, наличия у него признаков хронических заболеваний ЖКТ или других факторов риска. Расширенная диагностика включает следующие методы:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Определение уровня витаминов. Это основной анализ, используемый для подтверждения диагноза. При обнаружении признаков недостатка жирорастворимых форм он дает максимально точные результаты, а вот колебания водорастворимых нутриентов в течение суток могут стать причиной диагностической ошибки, поэтому при сомнительных данных необходимо повторное исследование.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Другие анализы крови. Гемограмма проводится, чтобы оценить количество гемоглобина, число, форму эритроцитов, что необходимо для выявления лабораторных симптомов разных типов анемий. Обязательно выполняется коагулограмма для оценки свертываемости крови. При необходимости назначается биохимическое исследование уровня электролитов, кислотно-основного баланса.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гормональные исследования. При возможных признаках гиповитаминоза D показано определение содержания паратгормона. Симптомы нарушения фертильности при недостатке А и Е — повод к расширенному исследованию на половые гормоны (эстрогены, гестагены, андрогены), гонадотропные гормоны гипофиза.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Инструментальные методы. Для выяснения причины витаминодефицита необходимы исследования ЖКТ: фиброгастродуоденоскопия, рентгенография с пассажем бария по кишечнику, КТ или МРТ органов брюшной полости. При подозрении на витаминодефицит D рекомендована рентгенография костей скелета.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основная цель терапии – поступление в организм пациента недостающих витаминов. Лечение авитаминоза базируется на разработке соответствующей диеты. Вещества, получаемые человеком из пищи, быстро всасываются в кишечнике. Оптимально подобранный рацион включает в себя разные группы питательных элементов, которые участвуют в обменных процессах. Их присутствие в употребляемых блюдах ускоряет выздоровление пациента.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Медикаментозный курс включает пероральный прием поливитаминных препаратов. Гиповитаминозы тяжелой формы лечатся посредством инъекций. Монопрепараты редко используются при лечении витаминной недостаточности. Авитаминозы сопровождаются нарушением баланса нескольких групп витаминов в организме человека. Поливитаминные комплексы способствуют быстрому решению этой проблемы. Отказ от них возможен при индивидуальной непереносимости отдельных компонентов препарата пациентом.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для профилактики авитаминоза пациентам рекомендуется:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">употреблять в пищу продукты, богатые витаминами;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">в осенне-зимний период принимать поливитаминные препараты;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">придерживаться сбалансированного питания;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">следить за правильным приготовлением и хранением пищевых продуктов.</span></p>\r\n</li>\r\n</ul>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптомы витаминной недостаточности зависят от нехватки конкретного вещества.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамин А (ретинол). Авитаминоз проявляется дерматологическими и офтальмологическими нарушениями. Человек утрачивает способность нормально ориентироваться в темноте, испытывает дискомфортные ощущения при ярком свете. Кожа страдает от недостатка влаги, становится чрезмерно сухой.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамин С. Недостаток проявляется хрупкостью сосудов, кровоточивостью десен и развитием цинги.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамины группы В. Авитаминоз сопровождается разными клиническими проявлениями. Нехватка витамина В1 (тиамин) вызывает заболевание бери-бери. Оно проявляется мышечной слабостью, головными болями, повышением артериального давления и тахикардией.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При недостатке витамина В2 (рибофлавин) появляются «заеды» в области уголков губ. Кожа становится чрезмерно сухой. Возможно развитие хронической анемии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нехватка витамина В6 вызывает неврологические нарушения, кожные заболевания. Возможно появление себорейного дерматоза, поражающего волосистую часть головы, развитие анемии. У детей нередко возникают судороги. Недостаток витамина В12 вызывает развитие анемии. Она сопровождается общей слабостью, тахикардией, одышкой, головокружением, потерей сознания.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамин D. Он может синтезироваться в коже при контакте с прямыми солнечными лучами и поступать вместе с пищей, развивается рахит у детей. У взрослых людей, особенно в период климакса, может прогрессировать остеопороз. Витаминная недостаточность делает кости хрупкими, провоцирует появление переломов, физической слабости, проблем со сном.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамин Е. Выполняет роль антиоксиданта. Провоцирует распад эритроцитов, негативно влияет на репродукцию человека, состояние кожи, ногтей и волос.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Витамин К. Его нехватка вызывает нарушения свертываемости крови, провоцирует появление синяков и кровотечений.</span></li>\r\n</ul>\r\n<p> </p>",
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"name": "мышечная боль"
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{
"name": "боль в мышцах"
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{
"name": "мышцы болят"
},
{
"name": "Миалгия"
},
{
"name": "ломота"
},
{
"name": "боль в мышцах рук"
},
{
"name": "боль в мышцах ног"
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{
"name": "боль в мышцах после тренировки"
},
{
"name": "боль в мышцах спины"
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{
"name": "боль икроножная"
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"lead": "Мышечная боль, которая периодически возникает у людей при нагрузке или в покое, называется миалгией. Она может вызываться различными причинами и сопровождаться другими симптомами",
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{
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"name": "Учащенный пульс"
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{
"name": "Сердце колотится"
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],
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},
"code": "E53.9",
"name": "Недостаточность витаминов группы B неуточненная",
"icd_name": "Недостаточность витаминов группы B неуточненная",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "e53.9_nedostatochnost_vitaminov_gruppy_b_neutochnennaya",
"lead": "витамины группы В относятся к водорастворимым, соответственно, не могут накапливаться в тканях, поскольку избыток выводится мочевыделительной системой. Исключение составляет витамин В12. Для нормальной жизнедеятельности организма они должны поступать с пищей ежедневно в необходимых количествах, а недостаток ведет к различным нарушениям.",
"description": "<p><span id=\"docs-internal-guid-02f0785a-7fff-e09c-08a1-d7a7c8c623f6\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Витамины группы В отвечают за нормальное функционирование нервной системы, а значит и за психическое здоровье. Они играют немаловажную роль в процессе метаболизма углеводов, способствуют их превращению в глюкозу, которая необходима для поддержания работы мозга. Это способствует улучшению настроения и умственной деятельности.</span></span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выделяют следующие предпосылки дефицита витаминов группы B:</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Первичные — экзогенные и алиментарные:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">нарушение принципов рационального питания;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">низкое содержание витаминов в пище;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">голодание и применение несбалансированных диет;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">неправильное хранение и приготовление продуктов, ведущее к дефициту витаминов группы B в них;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">особенности национальной, традиционной или религиозной кухни.</span></li>\r\n</ul>\r\n<p><span style=\"background-color: transparent; font-size: 7pt; white-space: pre-wrap;\">Вторичные — эндогенные:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">снижение синтеза витаминов группы B нормальной кишечной микрофлорой из-за заболевания органов ЖКТ, а также дефицит в результате побочного действия лекарственных препаратов, например, из-за приема антибиотиков или химиотерапии;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">снижение всасывания из-за заболеваний ЖКТ — синдром мальабсорбции, болезни печени, генетические поломки;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">наследственные или врожденные дефекты, приводящие к незрелости транспортных форм витаминов группы B;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">наличие внутрикишечных паразитов, которые потребляют поступающие питательные вещества;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">инактивация применяемыми лекарственными препаратами или ксенобиотиками;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">повышенная экскреция из-за заболеваний почек.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Кроме того, отдельной группой стоят причины, при которых возникает повышенная потребность в витаминах:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">период интенсивного роста — детский возраст, беременность;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">интенсивные физические и психические нагрузки;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">длительные стрессовые ситуации;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">неблагоприятные факторы окружающей среды — воздействие радионуклидов, тяжелых металлов, пестицидов и других ксенобиотиков.</span></li>\r\n</ul>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для подтверждения диагноза дефицита витамина В используются следующие процедуры:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клинический опрос. В беседе пациенты предъявляют жалобы, характерные для анемического и неврологического синдрома: слабость, головокружения, одышка в сочетании с ощущением онемения и покалывания в ногах, снижением чувствительности в конечностях. В анамнезе может отмечаться приверженность вегетарианству и строгим диетам, недоедание, хронические заболевания кишечника и синдром мальабсорбции.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Общий анализ крови. В результатах анализа определяется сниженный уровень эритроцитов и гемоглобина, гиперхромия, макроцитоз, пойкилоцитоз, лейкопения, тромбоцитопения, лимфоцитоз, сниженное или нормальное количество ретикулоцитов. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Анализ на витамин B. Исследуется концентрация витамина в сыворотке крови из вены.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выделяют два вида коррекции дефицита витаминов группы B: лечебную и профилактическую.</span></p>\r\n<p> </p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечебная тактика подразумевает применение высоких доз витаминов группы B длительными курсами. Коррекция проводится под строгим контролем врача при наличии клинических и лабораторных данных, подтверждающих витаминный дефицит. В настоящее время первичные алиментарные авитаминозы встречаются редко. В основном данная форма дефицита витаминов группы B развивается на фоне патологии желудочно-кишечного тракта или при наследственных нарушениях витаминного обмена. В этом случае прием пероральных форм препаратов не всегда оказывает ожидаемое лечебное воздействие, поэтому некоторым группам пациентов назначается инъекционное введение витаминных поли- или монопрепаратов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактическая тактика устранения дефицита витаминов группы B подразумевает прием препаратов в дозировке, близкой к суточной потребности. Такая терапия может назначаться и без доказанной витаминной недостаточности.</span></li>\r\n</ul>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Авитаминоз, как многие заболевания и патологические отклонения гораздо проще предупредить, чем впоследствии бороться с их последствиями. Профилактика недостатка витаминов группы В озвучена такими рекомендациями:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первое - это нормализация и сбалансированность рациона питания. Продукты, поступающие на стол человека должны перекрывать суточную норму всего спектра витаминов, необходимых для здоровой работы организма.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ведение здорового образа жизни. Нет курению, алкоголю и наркотикам.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исключить гиподинамию.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При появлении первых признаков авитаминоза, пересмотреть меню, обратиться за консультацией к диетологу или своему лечащему доктору.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Проходить периодические профилактические курсы, пропивая витаминно – минеральные комплексы. Особенно это актуально в весенне - осенний период, во время послеоперационной реабилитации или инфекционного поражения организма.</span></p>\r\n</li>\r\n</ul>",
"clinical_picture": "<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В1-авитаминоз приводит к развитию болезни Бери-бери, для которой характерно поражение сердечно-сосудистой и нервной системы. Больные жалуются на парезы, нарушение кожной чувствительности, слабость, одышку, тахикардию, расстройство зрения и нарушение психики.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Недостаток В2. Развивается дистрофия кожи и слизистых, дерматиты, конъюнктивиты, стоматиты.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Авитаминоз В3. Развивается пеллагра, характеризуется комплексом 3Д: дерматит, диарея, деменция.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Недостаток В5. Выпадение волос или их раннее поседение, боли в мышцах, судороги.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В6. Характерны полиневриты верхних и нижних конечностей, дерматиты, анемии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Авитаминоз В12 характеризуется мегалобластной анемией, полинейропатией.</span></li>\r\n</ul>\r\n<p> </p>",
"image": null,
"image_alt": null,
"standard_type": 0,
"danger": 20,
"published": 1,
"parent": 6255,
"block_rubric": 50,
"standards": []
}
]
}
