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},
"code": "N63",
"name": "Образование в молочной железе неуточненное",
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"lead": "заболевание молочной железы, при котором происходит нарушение соотношения эпителиальных и соединительных компонентов ткани, сопровождающееся формированием доброкачественных новообразований",
"description": "<p><span id=\"docs-internal-guid-50ed7b02-7fff-5cee-90fe-19ccf6db51c7\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Мастопатия - это доброкачественное заболевание, характеризующееся дисгормональным патологическим процессом, происходящим в молочной железе.</span></span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Точные причины мастопатии неизвестны, но обнаружено что способствует развитию болезни нарушение гормонального баланса – избыток эстрогена и пролактина, недостаток прогестерона. В результате разрастаются соединительная и жировая ткани груди, замещая железистую, что приводит к образованию уплотнений.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Известно несколько факторов, повышающих риск возникновения фиброзно-кистозных изменений в молочных железах:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственная предрасположенность. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Если у матери или бабушки (по материнской линии) женщины диагностировали доброкачественные или злокачественные образования в молочных железах, то у нее существует высокая вероятность развития мастопатии. Подобная ситуация объясняется передачей мутировавших генов.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Частые стрессы, депрессия, агрессия, хроническое недосыпание. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Подобные состояния затормаживают выработку дофамина, из-за чего усиленно синтезируется пролактин, стимулирующий деление клеток молочной железы. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">К тому же в недостаточном количестве производится прогестерон, что приводит к повышению уровня эстрогенов. В результате увеличивается количество млечных протоков и их длина.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Аборты, выкидыши, отсутствие грудного вскармливания. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">В начале беременности активно синтезируется пролактин – гормон, который подготавливает молочные железы к выработке молока. Но вышеперечисленные факторы резко нарушают процесс, из-за чего железистая ткань восстанавливается неравномерно и появляются уплотнения.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Поздние беременность и роды (после 30 лет). </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">При длительном отсутствии беременности в организме женщины повышается концентрация эстрогенов, из-за чего активно делятся клетки соединительной ткани, что способствует увеличению количества молочных протоков.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Диеты. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Во время диет организм испытывает недостаток веществ, необходимых для выработки гормонов. В результате нарушается метаболизм и происходят гормональные сбои.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Воспаления женских половых желез, операции на яичниках. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Понижается выработка прогестеронов, но эстрогены продолжают синтезироваться в жировой ткани, что приводит к их преобладанию над прогестероном.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Поликистоз. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Несмотря на то, что яичники вырабатывают мало эстрогенов, концентрация этих гормонов повышается. Это связано с тем, что кисты способствуют усиленному синтезу андрогенов, превращающихся в эстрогены под влиянием ароматазы – фермента, вырабатываемого надпочечниками.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Травмирование молочных желез. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Различные травмы (ранения, порезы, удары, ношение жестких бюстгальтеров) провоцируют местное воспаления и способствуют появлению гематом. В результате происходит активное деление клеток, из-за чего в тканях молочной железы могут образовываться уплотнения.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хронические болезни печени. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нарушается синтез белка, связывающего эстроген, из-за чего существенно повышается концентрация гормона.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нарушение функционирования щитовидной железы. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">При гипотиреозе гипофиз стимулирует синтез тиреотропного гормона, чтобы активировать синтез гормонов щитовидной железы. В то же время усиливается и выработка пролактина.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Прием лекарств. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Некоторые медикаменты (Церукал, Эглонил, Резерпин) блокируют дофамин, из-за чего повышается уровень эстрогена.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Опухоли гипоталамо-гипофизарной системы. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Под воздействием новообразований (как злокачественных, так и доброкачественных) гипофиз активно синтезирует гормоны: ЛГ, ФСГ, пролактин. В результате яичники активируют выработку эстрогена и уменьшают синтез прогестерона, что приводит к разрастанию тканей молочной железы.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Лишний вес. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Клетки жировой ткани способны вырабатывать эстроген. Следовательно, увеличение подкожно-жировой клетчатки провоцирует повышение концентрации эстрогенов.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Сексуальная неудовлетворенность. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нарушается кровоток в области малого таза, что приводит к застою крови. В результате происходят сбои в работе яичников при выработке гормонов.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Спровоцировать развитие мастопатии молочных желез также способны ранние менструации, поздний климакс, бесплодие, прохождение заместительной гормональной терапии.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В развитии мастопатии молочной железы важную роль играют дисгормональные расстройства. Особое значение имеют:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">относительная или абсолютная гиперэстрогения (избыток эстрогенов);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">прогестерон-дефицитное состояние (нехватка прогестерона).</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Относительная гиперэстрогения сопровождается изменением уровня эстрогена относительно прогестерона, но, в свою очередь, данные гормоны всё же находятся в пределах нормы. Абсолютная гиперэстрогения характеризуется повышением целевого уровня эстрогенов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Т</span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">аким образом при повышении эстрогена происходит пролиферация — разрастание протокового альвеолярного эпителия, в то время как прогестерон пытается препятствовать этому процессу благодаря своим способностям: он снижает экспрессию рецепторов эстрогенов и уменьшает локальный уровень активных эстрогенов. Эти свойства прогестерона ограничивают стимуляцию разрастания тканей молочной железы.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При гормональном дисбалансе (избытке эстрогенов и дефиците прогестерона) в тканях молочной железы возникает отёк и гипертрофия внутридольковой соединительной ткани, а пролиферация протокового эпителия приводит к образованию кист. При возникающих прогестерон-дефицитных состояниях избыточная концентрация эстрогенов приводит к разрастанию тканей молочной железы и нарушению рецепторного аппарата.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностикой и лечением мастопатии занимаются три специалиста: гинеколог, гинеколог-эндокринолог и маммолог. Для обнаружения диффузных патологических изменений в ткани органа, определения формы, размера, количества образований применяются методы инструментального обследования:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Рентгенологическое исследование молочных желез – маммография. Метод является одним из наиболее информативных и специфичных, предполагает снимок груди в двух проекциях. Выполняется преимущественно в первой фазе менструального цикла.</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">УЗИ. Показано всем женщинам до 40 лет, с 40 лет обязательна маммография, а УЗИ желательно раз в год.</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Дуктография. В молочную железу через сосок вводят контрастное вещество и делают рентгеновские снимки. Так изучается система млечных протоков.</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Цифровой томосинтез. Рекомендован при неоднозначных результатах маммографии. Послойные изображения грудных желез реконструируются компьютерной программой в объемное изображение, что позволяет более детально рассмотреть все структуры органа.</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">МРТ.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При подозрении на онкологическое заболевание врач назначает тонкоигольную аспирационную биопсию молочной железы, цитологическое исследование выделений из соска.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для определения гормонального фона в организме при мастопатии проводят лабораторные анализы половых гормонов и инструментальное обследование органов эндокринной системы:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">анализ крови на пролактин, прогестерон, эстрадиол, гормоны щитовидной железы, фолликулостимулирующий и лютеинизирующий гормоны;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">определение онкомаркеров к молочной железе;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ внутренних органов;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рентгенография турецкого седла;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">КТ гипофиза.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Существует два способа лечения мастопатии. Консервативный включает в себя прием медикаментов и диету, хирургический — удаление новообразований на поздних стадиях.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Медикаментозное лечение</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Медикаментозное лечение мастопатии молочной железы назначают после УЗИ / маммографического обследования. Препараты прописывает врач-эндокринолог. Среди них:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Гестагены. Влияют на диффузные процессы. Снижают плотность железистой и фиброзной ткани.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Антиэстрогены. Снижают количество эстрогена в организме.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Андрогены. Прописывают женщинам старше 45 лет.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Ингибиторы пролактина. Уменьшают боль, сокращают размер узлов в молочной железе.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Оральные контрацептивы. Позволяют блокировать овуляцию. Это стабилизирует гормональный фон и производит обратный рост заболевания.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Негормональные препараты улучшают циркуляцию в тканях, снижают болевые ощущения. Это такие средства, как:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">нейролептики, седативные препараты — снимают нервное напряжение, успокаивают, т.к. стресс — одна из причин развития патологии;</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">йодосодержащие — балансируют половые и тиреоидные гормоны.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хирургия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">К хирургическим методам прибегают при крупных размерах новообразований, которые вызваны мастопатией молочной железы. Разделяют следующие вмешательства, которые проводят под контролем УЗИ:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Малоинвазивные. Специальную иглу вводят в полость кисты и вытягивают жидкость. Для того чтобы новообразование рассосалось, вводят склерозирующие вещества. Операция занимает менее трех часов и проходит под общим наркозом.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вылущивание. Врач делает небольшой надрез в области ареол и через него удаляет капсулу новообразования. Метод эффективен, если у пациентки обнаружено несколько кист.</span></li>\r\n<li><span style=\"font-size: 7pt; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Секторальная резекция. Удаление патологии вместе с частью здоровых тканей. Необходимо на поздних стадиях заболевания и подозрениях на злокачественность.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Диета</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">При мастопатии следует соблюдать диету. 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"prevention": "<p><span id=\"docs-internal-guid-f881134e-7fff-84c8-2f8a-bc6b612fe2d3\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Регулярное обследование молочных желез – единственный правильный способ выявления рака на ранней стадии, когда заболевание эффективно лечится. Регулярное самообследование и ежегодное инструментальное обследование – УЗИ молочных желез до 40 лет, или маммография и УЗИ молочных желез после 40 лет – правильный и необходимый минимум обследования современной женщины.</span></span></p>",
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"code": "F42",
"name": "Обсессивно-компульсивное расстройство",
"icd_name": "Обсессивно-компульсивное расстройство",
"gender": 0,
"age_min": 5,
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3
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"slug": "f42_obsessivno-kompulsivnoe_rasstroystvo",
"lead": "Нарушение здоровья, относящееся к группе невротические, связанные со стрессом и соматоформные расстройства",
"description": " Обсессивно-компульсивное расстройство – это группа психологических заболеваний, характеризующаяся возникновением навязчивых мыслей (обсессий), с которыми человек пытается бороться с помощью таких же навязчивых действий (компульсий). ",
"etiology": "<p>Этиология ОКР не выяснена, на этот счет существует несколько гипотез. Причины могут быть биологическими, психологического или социально-общественного характера. </p>\r\n<p>Биологические причины: </p>\r\n<ul>\r\n<li>родовые травмы; </li>\r\n<li>патологии вегетативной нервной системы; </li>\r\n<li>особенности передачи сигнала в мозг; </li>\r\n<li>нарушение метаболизма с изменением обмена веществ, необходимых для нормальной работы нейронов (снижение уровня серотонина, повышение концентрации дофамина); </li>\r\n<li>черепно-мозговые травмы в анамнезе; </li>\r\n<li>органическое поражение мозга (после менингита); </li>\r\n<li>хронический алкоголизм и наркотическая зависимость; </li>\r\n<li>наследственная предрасположенность; </li>\r\n<li>осложненные инфекционные процессы. </li>\r\n</ul>\r\n<p>Социально-общественные и психологические факторы: </p>\r\n<ul>\r\n<li>детская психологическая травма; </li>\r\n<li>психологическая семейная травма; </li>\r\n<li>строгое религиозное воспитание; </li>\r\n<li>чрезмерная опека родителей; </li>\r\n<li>профессиональная деятельность в условиях стресса; </li>\r\n<li>потрясение, связанное с угрозой для жизни. </li>\r\n</ul>",
"pathogenesis": "<p>На сегодняшний день наиболее распространена и признана нейротрансмиттерная теория. Суть этой теории состоит в том, что имеется связь обсессивно-компульсивного расстройства с нарушениями коммуникации между определенными областями коры головного мозга и базальными ганглиями. </p>\r\n<p>Обозначенные структуры взаимодействуют посредством серотонина. Так, ученые считают, что при ОКР наблюдается недостаточный уровень серотонина ввиду усиленного обратного захвата (нейронами), что препятствует передаче импульса следующему нейрону.[7][8] В целом же необходимо сказать, что патогенез данного расстройства достаточно сложен и до конца не изучен. </p>\r\n<p> </p>",
"diagnostics": "<p>Для точного диагноза, обсессивные симптомы или компульсивные действия, либо и те и другие должны иметь место наибольшее количество дней за период по крайней мере 2 недели подряд и быть источником дистресса и нарушения активности. Обсессивные симптомы должны иметь следующие характеристики: </p>\r\n<ul>\r\n<li>они должны быть расценены как собственные мысли или импульсы больного; </li>\r\n<li>должны быть по крайней мере одна мысль или действие, которым больной безуспешно сопротивляется, даже если наличествуют другие, которым больной более не сопротивляется; </li>\r\n<li>мысль о выполнении действия не должна быть сама по себе приятна (простое уменьшение напряженности или тревоги не считается в этом смысле приятным); </li>\r\n<li>мысли, образы или импульсы должны быть неприятно повторяющимися. </li>\r\n</ul>\r\n<p>Хотя обсессивные мысли и компульсивные действия обычно сосуществуют, целесообразно устанавливать один из этих типов симптоматики в качестве доминирующего у некоторых больных, поскольку они могут реагировать на разные виды терапии. </p>\r\n<p> </p>",
"treatment": "<p>Терапия навязчивых состояний включает медикаментозное лечение и психотерапию в качестве обязательных элементов </p>\r\n<p>Психотерапия </p>\r\n<p>Она предполагает использование таких лечебных методик, как: </p>\r\n<p>Когнитивно-поведенческая коррекция, которую разработал американский психиатр Д. Шварц. Методика дает больному возможность противостоять влиянию расстройства, изменяя порядок ритуальных действия, упрощая их, чтобы постепенно свести к минимуму. В основе метода — осознанное отношение человека к своей психической проблеме и поэтапное сопротивление её признакам. </p>\r\n<p>«4 шага» — другая методика, разработанная тем же специалистом в области психиатрии. Ее действие основано на том, что врач объясняет больному: </p>\r\n<ul>\r\n<li>какие из его опасений оправданы, а какие спровоцированы воздействием ОКР, а потому не имеют смысла; </li>\r\n<li>как, попав в ту или иную ситуацию, действовал бы здоровый человек; </li>\r\n<li>каким образом можно пресекать навязчивые мысли. </li>\r\n</ul>\r\n<p>Экспозиция и предупреждение — одна из самых эффективных форм коррекции поведения у страдающих ОКР. При этом экспозиция заключается в погружение больного в условия, провоцирующие дискомфорт в связи с обсессиями. Врач инструктирует, как оказывать сопротивление позывам выполнить компульсивные действия, формируя предупреждение патологической ответной реакции. По данным статистики подавляющее большинство прошедших такое лечение добиваются стойкого улучшения состояния.Эффект от психотерапии может длиться много месяцев. </p>\r\n<p>В лечении ОКР применяются и другие разновидности психокоррекции: </p>\r\n<ul>\r\n<li>групповая и семейная;</li>\r\n<li>рациональная и аверсивная;</li>\r\n<li>иные виды. </li>\r\n</ul>\r\n<p>Медикаментозная терапия психотропными препаратами </p>\r\n<p>Максимальную эффективность при ОКР показали антидепрессанты. При нарастании тревожности на первых этапах лечения их дополняют транквилизаторами. При хронических случая ОКР, когда антидепрессанты из ряда ингибиторов обратного захвата серотонина оказываются неэффективными, все больше назначают атипичные антипсихотические препараты. </p>\r\n<p> </p>",
"prevention": "<p> Первичная психопрофилактика: </p>\r\n<ul>\r\n<li>Предотвращение психотравмирующих влияний на работе и в быту. </li>\r\n<li>Предотвращение ятрогений и дидактогений (правильное воспитание ребёнка, например, не прививать ему мнения о его неполноценности или превосходстве, не порождать чувство глубокого страха и вины при совершении «грязных» поступков, здоровые отношения между родителями). </li>\r\n<li>Предотвращение семейных конфликтов. </li>\r\n</ul>\r\n<p>Вторичная психопрофилактика (предотвращение рецидивов): </p>\r\n<ul>\r\n<li>Изменение отношения больных к психотравмирующим ситуациям путём бесед (лечение убеждением), самовнушения и внушения; своевременное лечение при их выявлении. Проведение регулярной диспансеризации. </li>\r\n<li>Способствование увеличению яркости в помещении — убрать плотные шторы, использовать яркое освещение, максимально использовать светлое время суток, светолечение. Свет способствует вырабатыванию серотонина. </li>\r\n<li>Общеукрепляющая и витаминотерапия, достаточный сон. </li>\r\n<li>Диетотерапия (полноценное питание, отказ от кофе и алкогольных напитков, включить в меню продукты питания с повышенным содержанием триптофана (аминокислоты, из которой образуется серотонин): финики, бананы, сливы, инжир, томаты, молоко, сою, чёрный шоколад). </li>\r\n<li>Своевременное и адекватное лечение других заболеваний: эндокринных, сердечно-сосудистых, особенно атеросклероза сосудов мозга, злокачественных новообразований, железо- и витамин B12-дефицитной анемии. </li>\r\n<li>Обязательно избегать возникновения пьянства и тем более алкоголизма, наркомании и токсикомании. Употребление алкогольных напитковнерегулярно в малых количествах действует седативно, поэтому не может спровоцировать рецидив. Влияние употребления «лёгких наркотиков» типа марихуаны на рецидив ОКР не исследовалось, поэтому их также лучше избегать. </li>\r\n</ul>\r\n<p>Всё вышесказанное относилось к индивидуальной психопрофилактике. Но необходимо на уровне учреждений и государства в целом проводить социальную психопрофилактику — оздоровление труда и бытовых условий, службы в вооружённых силах. </p>",
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