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"etiology": "<p>Возбудитель относится к семейству пикорнавирусов, к группе энтеровирусов (кишечным вирусам), куда входят также Коксаки- и ЕСНО-вирусы и существует в виде 3 независимых типов (I, II и III). Наиболее часто встречается 1 тип. </p>\r\n<p>Вирус устойчив во внешней среде (в воде сохраняется до 100 суток, в испражнениях — до 6 мес), хорошо переносит замораживание. Не разрушается пищеварительными соками. Разрушается при нагревании до 50 градусов Цельсия в течение 30 минут. Быстро погибает при кипячении, под действием ультрафиолетового облучения и при высушивании. Даже незначительные концентрации хлора инактивируют вирус. Источник инфекции — человек (больной или переносящий заражение бессимптомно); возбудитель выделяется через рот (несколько суток), а затем с испражнениями (несколько недель, а иногда и месяцев). Заражение может произойти воздушно-капельным путём, но чаще — при попадании в рот активного вируса (через загрязнённые руки, пищу). Механическим переносчиком вируса могут быть мухи. </p>\r\n<p>Заболеваемость полиомиелитом преобладает в летне-осенние месяцы. Чаще болеют дети от 6 месяцев до 5 лет. Большинство заболеваний связано с вирусом типа I. </p>",
"pathogenesis": "<p>Кишечная фаза </p>\r\n<p>Входными воротами для инфекции является слизистая оболочка носоглотки и тонкой кишки, в эпителии и лимфатических образованиях которых происходит первичная репродукция вируса. Затем вирус проникает в ток крови и обусловливает вирусемию. </p>\r\n<p>Фаза вирусемии </p>\r\n<p>Эта фаза характеризуется проникновением вируса во многие органы и ткани, такие как лимфатические узлы, селезенка, печень, легкие, сердечная мышца, жировая ткань, особенно бурый жир. </p>\r\n<p>Невральная фаза </p>\r\n<p>Следующим этапом развития патогенеза полиомиелита является проникновение вируса в различные органы, в частности в ЦНС. В ЦНС в патологический процесс чаще всего вовлекаются мотонейроны передних рогов спинного мозга, двигательные клетки черепных нервов. В тяжелых случаях могут поражаться нейроны задних рогов, клетки спинальных ганглиев и даже проксимальные отделы периферических нервов. В головном мозге повреждаются ретикулярная формация, вестибулярные ядра, глубинные структуры. </p>\r\n<p>Вирус действует на эндотелий сосудов, повышая их проницаемость. В результате чего происходит сдавление, отек здоровых участков нервной ткани, возникает клеточная инфильтрация, тигролиз - все это является морфологическим субстратом полиомиелита. Распространение вируса в организме человека может закончиться на любом этапе, что и определяет развитие той или иной формы полиомиелита. </p>",
"diagnostics": "<p>Лабораторные исследования: пробы крови для серологических исследований, общий анализ крови и мочи. </p>\r\n<p>Инструментальные исследования: </p>\r\n<ul>\r\n<li>Электромиография. При помощи ЭМГ регистрируются биоэлектрические потенциалы, возникающие на нервно-мышечной периферии. Поражение двигательных клеток в передних рогах спинного мозга выражается, прежде всего, четкими изменениями ритма. Это обусловлено тем, что пораженные мотонейроны возбуждаются одновременно (синхронно), что приводит с урежению колебаний потенциалов. Существует отчетливая связь между тяжестью поражения мышц и изменениями электромиограммы. ЭМГ тяжело пораженных мышц характеризуется «биоэлектрическим молчанием». </li>\r\n<li>Рентгенография конечностей для исключения вывихов, подвывихов, остеопороза.. </li>\r\n<li>Магниторезонансная томография спинного мозга - признаки атрофического процесса в передних рогах спинного мозга. </li>\r\n</ul>",
"treatment": "<p>Немедикаментозное лечение </p>\r\n<ol>\r\n<li>Лечебная физкультура занимает одно из ведущих мест в лечении больных с паралитическими формами полиомиелита. К ней необходимо приступить в раннем восстановительном периоде, то есть сразу после появления первых признаков движений в пораженных мышцах. Основная задача лечебных упражнений в раннем восстановительном периоде - тренировка основных параметров двигательной системы, которая заключается в постепенном и дозированном увеличении силы мышечного сокращения, амплитуды. На этом этапе лечения больному необходима помощь в овладении простыми движениями, а затем элементами утраченного сложного двигательного навыка. У больных с глубокими парезами при мышечной силе в пределах 1-0 балла, помимо лечения положением, применяют пассивные и пассивно-активные упражнения с переходом к активным упражнениям. </li>\r\n<li>Стимулирующий массаж пораженных конечностей, мышц спины. </li>\r\n<li>Физиолечение - магнитотерапия, биоптрон, УВЧ на пораженные сегменты спинного мозга, электростимуляция паретичных мышц импульсным током, озокеритовые или парафиновые аппликации на область паретичных мышц, суставы; электрофорез галантамина, прозерина по Вермелю. </li>\r\n<li>Иглорефлексотерапия. </li>\r\n<li>Ортопедическая профилактика паретичных конечностей с использованием шин, лонгет, валиков, мешков с песком, разработка контрактур. </li>\r\n</ol>\r\n<p> Медикаментозное лечение </p>\r\n<ol>\r\n<li>Стимулирующая терапия: антихолинэстеразные препараты - прозерин, галантамин. </li>\r\n<li>Витаминотерапия: аскорбиновая кислота, витамины группы В - В1, В6, В12. </li>\r\n<li>Последние годы в лечении полиомиелита используются анаболические стероиды (нерабол, ретаболил, метандростеналон). </li>\r\n<li>Лечение препаратами, действующими на сосудистую систему, улучшающими реологические свойства крови и микроциркуляцию, проводится в виде последовательных курсов, каждый из них длительностью 2-3 недели. </li>\r\n<li>Спазмолитическим, сосудорасширяющим, стимулирующим влиянием на спинной мозг обладает дибазол. Лечение продолжается в течение 3-4 недель, показаны повторные курсы лечения. </li>\r\n<li>Препараты, улучшающие метаболизм (ноотропы). </li>\r\n<li>Метаболические средства - фолиевая кислота, аевит, оротат калия. </li>\r\n</ol>",
"prevention": "<p>Неспецифическая направлена на общее укрепление организма, увеличение его устойчивости к различным инфекционным агентам (закаливание, правильное питание, своевременная санация хронических очагов инфекции, регулярные физические нагрузки, оптимизация цикла сон-бодровствание и др.), борьба с насекомыми, которые являются разносчиками патогенных микроорганизмов (различные виды дезинсекции), соблюдение правил личной гигиены (в первую очередь это мытье рук после улицы и после посещения туалета), тщательная обработка овощей, фруктов и других продуктов перед употреблением их в пищу. </p>\r\n<p>Специфическая профилактика заключается в проведении вакцинации против полиомиелита. </p>\r\n<p> </p>",
"clinical_picture": "<p>В зависимости от того, какую форму заболевания перенес человек, могут отличаться и последствия полиомиелита. Так абортивная форма проходит в среднем через 7 дней, не оставляя совершенно никаких последствий. Полное выздоровление наступает и после перенесенной менингиальной формы заболевания, но спустя значительно больший промежуток времени. </p>\r\n<p>Даже самая сложная, паралитическая форма может пройти абсолютно бесследно и все функции пораженной полиовирусом ЦНС будут восстановлены. Однако если параличи и парезы носили глубокий, стойкий характер, то добиться абсолютно полного восстановления пораженных отделов нервной системы будет невозможно. После тяжёлой паралитической формы остаются мышечные атрофии, остеопороз, деформации конечностей. В ряде случаев остаются суставные контрактуры с ограничением объёма активных и пассивных движений в них, привычные вывихи, паралитическое искривление позвоночного столба, деформации стоп, косолапость. Дети после перенесенного полиомиелита обычно сильно отстают в физическом развитии, часто у них наблюдается укорочение пораженной конечности. </p>\r\n<p>При возникновении у больного центральных и периферических изменений дыхания, нарушений сердечно-сосудистой системы, при парализации гладкой мускулатуры желудочно-кишечного тракта в большинстве случаев заболевание заканчивается смертельным исходом. </p>",
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}
]
}
