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},
"code": "L10",
"name": "Пузырчатка [пемфигус]",
"icd_name": "Пузырчатка [пемфигус]",
"gender": 0,
"age_min": 18,
"age_max": 100,
"cause": [
3,
0
],
"periodicity": 4,
"slug": "l10_puzyrchatka_pemfigus",
"lead": "хроническое заболевание аутоиммунной природы, которое характеризуется появлением пузырей на клинически здоровой коже и слизистых оболочках.",
"description": "Не заразное, крайне тяжелое заболевание кожи.",
"etiology": "<p>Наиболее вероятными причиной пузырчатки являются нарушения аутоиммунных процессов, в результате чего клетки организма становятся для иммунной системы антителами. Нарушение антигенной структуры клеток эпидермиса происходит под воздействием внешних факторов, в частности воздействие ретровирусов и агрессивных условий окружающей среды.</p>",
"pathogenesis": "<p>Повреждающее действие на клетки эпидермиса и выработка специфических антигенов приводит к нарушению связи между клетками в результате чего и образуются пузыри.</p>",
"diagnostics": "<p>Диагностика пузырчатки осуществляется врачом-дерматологом и основана на совокупности результатов осмотра, цитологического, гистологического и иммунологического обследований. При всех формах заболевания отмечают отложение иммуноглобулинов G в поверхностных слоях кожи.</p>",
"treatment": "<p align=\"justify\">Все пациенты больные пузырчаткой должны находиться на диспансерном наблюдении у дерматолога, рекомендован щадящий режим работы, отсутствие физических нагрузок и избегание инсоляции. Частая смена нательного и постельного белья предотвращает присоединение вторичной инфекции.</p>\r\n<p> </p>\r\n<p align=\"justify\">Показано назначение глюкокортикостероидов сразу в высоких дозах, так как иначе терапевтического эффекта достигнуто не будет, после купирования острых проявлений пузырчатки дозировки гормональных препаратов постепенно снижают до минимально эффективных. В лечении пузырчатки применяют методы экстракорпоральной гемокоррекции: гемосорбцию, криоаферез и мембранный плазмаферез. </p>\r\n<p> В качестве местного лечения пузырчатки используют анилиновые красители и неагрессивные антисептические растворы.</p>\r\n<p>Прогноз пузырчатки всегда неблагоприятный, так как в случае отсутствия адекватного лечения смерть пациентов наступает довольно быстро от присоединившихся осложнений. Длительная гормональная терапия в высоких дозах повышает риск возникновения побочных эффектов, но при отказе от глюкокортикостероидов пузырчатка начинает рецидивировать</p>",
"prevention": "",
"clinical_picture": "<p align=\"justify\">Пузырчатка имеет длительное волнообразное течение, и отсутствие адекватного лечения приводит к нарушению общего состояния пациента.</p>\r\n<p> </p>\r\n<p align=\"justify\">При вульгарной форме пузырчатки пузыри локализуются по всему телу, имеют разный размер и наполнены серозным содержимым, при этом покрышка на пузырях вялая и тонкая.</p>\r\n<p> </p>\r\n<p align=\"justify\">Дебютирует вульгарная пузырчатка как правило на слизистой рта и носа, а потому пациенты длительно и безуспешно получают терапию у стоматологов и отоларингологов. На этой стадии пузырчатки пациенты предъявляют жалобы на боль во время приема пищи и при разговоре, гиперсаливацию и специфический неприятный <a href=\"/symptom/zapah_izo_rta/\" title=\"Перейти на страницу симптома Запах изо рта\">запах изо рта</a>. Продолжительность этого периода от трех месяцев до года, после чего пузырчатка принимает распространенный характер и в воспалительный процесс вовлекаются кожные покровы.</p>\r\n<p>Иногда пациенты не замечают наличие пузырей из-за их небольшого размера и тонкой покрышки, пузыри вскрываются быстро, а потому основные жалобы больных пузырчаткой на данном периоде – это болезненные <a href=\"/symptom/izmeneniya_struktury_kozhi/\" title=\"Перейти на страницу симптома Изменения структуры кожи\">эрозии</a>. Проводится длительная и безуспешная терапия стоматитов, прежде чем диагностируют пузырчатку. Пузыри, которые локализуются на коже, имеют тенденцию к самопроизвольному вскрытию с обнажением эрозированной поверхности и с остатками покрышки, которая ссыхается в корки.</p>\r\n<p> <a href=\"/symptom/izmeneniya_struktury_kozhi/\" title=\"Перейти на страницу симптома Изменения структуры кожи\">Эрозии</a> при пузырчатке ярко-розовые, с гладкой глянцевой поверхностью, отличаются от эрозий при других заболеваниях склонностью к периферическому росту и к генерализации с формированием обширных очагов поражения. Если пузырчатка принимает такое течение, то общее состояние пациента ухудшается, развивается интоксикация, присоединяется вторичная инфекция и без должного лечения такие пациенты умирают.</p>\r\n<p> При вульгарной пузырчатке синдром Никольского положительный в очаге поражения и порой на здоровой коже - при незначительном механическом воздействии происходит отслойка верхнего слоя эпителия.</p>",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наиболее вероятными причиной пузырчатки являются нарушения аутоиммунных процессов, в результате чего клетки организма становятся для иммунной системы антителами. Нарушение антигенной структуры клеток эпидермиса происходит под воздействием внешних факторов, в частности воздействие ретровирусов и агрессивных условий окружающей среды.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повреждающее действие на клетки эпидермиса и выработка специфических антигенов приводит к нарушению связи между клетками в результате чего и образуются пузыри. Факторы риска при пузырчатке не установлены, но у лиц с наследственной предрасположенностью процент заболеваемости выше.</span></p>",
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"diagnostics": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клинические проявления особенно на первоначальных этапах болезни малоинформативны, и поэтому опрос пациента позволяет избежать ошибочного диагноза. Лабораторные исследования позволяют заподозрить пузырчатку, так в мазках-отпечатках при цитологическом исследовании обнаруживаются акантолитические клетки. При гистологическом исследовании обнаруживается внутриэпидермальное расположение пузырей.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Больные ставятся на диспансерный учёт, они должны избегать чрезмерных физических нагрузок и стрессов, как можно чаще менять одежду и постельное бельё, соблюдать диету и правила гигиены.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основу лечения составляет медикаментозная терапия:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Высокие дозы глюкокортикоидов (Полькортолон, Метипред, Дексаметазон, Преднизолон). Если наблюдается регресс заболевания, дозировка постепенно уменьшается.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При заболеваниях ЖКТ назначаются пролонгированные глюкокортикоиды – Дипроспан, Метипред-депо, Депо-медрол.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение дополняется гормональными средствами, недостаток которых – высокая вероятность осложнений: депрессии, бессонницы, артериальной гипертензии, повышенной возбудимости, ангиопатии, увеличения веса, тромбоза, язвы (эрозии) желудка (кишечника), стероидного диабета.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При ухудшении состояния назначаются препараты для восстановления слизистой желудка (Альмагель и др.), диета, предполагающая минимум жиров и углеводов, максимум белка и витаминов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Параллельно принимаются иммуносупрессоры и цитостатики – Азатиоприн, Метотрексат, Сандиммун.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы избежать нарушения электролитного баланса, рекомендуется приём калия и кальция.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Дополнительные методы лечения:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Очищение крови – гемодиализ, плазмаферез, гемосорбция. Подобные процедуры удаляют из крови иммуноглобулины, токсические вещества и циркулирующие иммунные комплексы. Они особенно полезны пациентам с гипертиреозом, атеросклерозом, сахарным диабетом.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Фотохимиотерапия – воздействие ультрафиолетовых лучей параллельно с G-метоксипсораленом снижает активность клеток крови и направляет её в русла сосудов, очищает организм от токсинов и иммуноглобулинов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Местное лечение – мази с глюкокортикоидами, спреи с ксилокаином, лидокаином и другими местными анестетиками, растворы с анилиновыми красителями (бриллиантовый зелёный, Фукорцин), ванны с перманганатом калия, обработка язв Куриозоном.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диета – из рациона исключают продукты, способные вызвать аллергию, грубую пищу, простые углеводы, соль, консервы. В меню вводят продукты с высоким содержанием белка и витаминов. При образовании пузырей в ротовой полости рекомендуются супы-пюре и мягкие каши, исключающие механическое повреждение слизистой оболочки.</span></li>\r\n</ul>\r\n<p> </p>",
"prevention": "<p><span id=\"docs-internal-guid-f64e4608-7fff-1f25-0349-f35a80423c3c\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Специфических мер нет. Профилактика болезни проста и универсальна. Она заключается в строгом соблюдении элементарных принципов гигиены, отсутствии вредных привычек, здоровом питании с высоким содержанием белка и активном, в независимости от возраста, подвижном образе жизни.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Некоторые симптомы пузырчатки характерны для всех видов и форм. Это стремительный прогресс при отсутствии лечения и волнообразность – болезнь то затихает, то усиливается снова. Другие признаки зависят от вида и формы заболевания:</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вульгарная (обыкновенная) пузырчатка. Пузыри разного размера распространяются по всему телу. Они имеют вялую и тонкую покрышку (поверхность), внутри заполнены прозрачной или полупрозрачной жидкостью – серозным экссудатом. Чаще всего первые пузырьки появляются на слизистой рта и носа, из-за чего появляется:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Боль при жевательных движениях, глотании и разговоре.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Усиленное слюноотделение.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Боль при высмаркивании.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Неприятный запах изо рта.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Патологический процесс на слизистых затягивается на длительное время – от 3 месяцев до 1 года. Потом волдыри появляются на разных участках тела. Часто это происходит настолько стремительно, что пациент не замечает их образования. Иногда пузырьки лопаются, на их месте образуются эрозии ярко-розового цвета с гладкой, глянцевой поверхностью, вызывающие боль, потом формируются сухие корки. Как правило, они распространяются от центра скопления пузырьков к краям и образуют обширные зоны. При диагностике пузырчатки обыкновенной проба Никольского даёт положительный результат – при незначительном воздействии на кожу в очаге поражения отслаивается верхний слой. Во время болезни ощущается слабость, повышается температура.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Эритематозная пузырчатка. Сначала пузырьки появляются на гpyди, шее, лице и волосистой части головы, симптомы похожи на себорею – чёткие границы зон поражения, быстрое самовскрытие пузырей с вялой и дряблой поверхностью, эрозии, бурые или желтоватые корочки разной толщины на их месте. Синдром Никольского при этом имеет локальный характер, но постепенно затрагивает другие участки тела.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вегетирующая пузырчатка. Доброкачественное заболевание, которое протекает много лет, не ухудшая самочувствие пациентов. Сначала пузырьки появляются в естественных складках кожи, вокруг рта, носа и ушей, в области пoлoвых органов и aнaльного отверстия. Они самопроизвольно вскрываются, на их месте образуются эрозии с неприятно пахнущим серозно-гнойным или серозным налётом, окружённые пустулами. При постановке диагноза болезнь нужно дифференцировать от хронической вегетирующей пиодермии, проба Никольского даёт положительный результат только в зонах поражения.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Листовидная пузырчатка. Сначала плоские, слегка возвышающиеся над кожей пузыри появляются на теле, потом образуются на слизистых оболочках. Характерный признак – одновременное наличие пузырьков и корочек, наслаивающихся друг на друга.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Бразильская пузырчатка. Встречается только в странах Латинской Америки (Венесуэле, Парагвае, Перу, Боливии, Аргентине и Бразилии и т. д.), на других континентах никогда не выявлялась. Причина возникновения до сих пор не установлена, но скорее всего заболевание имеет инфекционную природу. Чаще бразильская пузырчатка диагностируется у женщин моложе 30 лет, поражает только кожный покров. Сначала появляются плоские пузырьки, потом они вскрываются и покрываются чешуйчатыми расслаивающимися корочками, под которыми образуются эрозии, незаживающие по нескольку лет. Синдром Никольского на поражённых участках даёт положительный результат, болезнь вызывает сильный дискомфорт – сопровождается болью и жжением.</span></p>",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пульпит развивается при кариозном разрушении целостности зуба, когда пища и микроорганизмы проникают полость зуба (пульпу). Еще один путь развития болезни — это инфицирование от соседних пораженных зубов через кровеносные сосуды, что происходит гораздо реже и носит название ретроградный пульпит. Различают и другие, редко встречающиеся, пульпиты:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Травматический, развивается в результате трещины, слома, скола зуба. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Конкрементозный возникает при избыточном отложении минеральных образований, которые начинают замещать внутренние ткани зуба. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Воспаление, развивается из-за неверно проведенного лечения, применения некачественных материалов, нечаянного вскрытия пульпы. </span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Среди факторов, увеличивающих вероятность развития пульпита выделяют: недостаточную гигиену, остеопороз и сахарный диабет.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При воспалении пульпы зуба развивается комплекс функциональных и структурных изменений, характерных для воспаления вообще.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Характерны резкие экссудативные проявления, так как с ранних этапов развития процесса воспаление пульпы протекает по гиперергическому типу, способствуя резкому отеку ткани пульпы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При этом объем пульпы увеличивается, нервные элементы испытывают значительные раздражающие воздействия, что проявляется в клинике болевым синдромом.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Через 3-4 часа от начала обострения воспаление пульпы приобретает характер гнойного процесса с образованием плотных инфильтратов и абсцессов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исходом острого воспаления пульпы может быть ее некроз или процесс переходит в хроническую стадию, давая начало одной из форм хронического пульпита.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Развиваются активные экссудативные явления с абсцедированием. Такая форма получила название обострение хронического пульпита.</span></li>\r\n</ul>\r\n<p> </p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">На первом этапе проводится беседа с пациентом с тщательным сбором жалоб. Врач уточняет характер боли, ее взаимосвязь с раздражителями, давность появления и ряд других характеристик.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Следующий этап – осмотр полости рта с помощью зеркал и проведение ряда простых исследований. К ним относятся:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">перкуссия пораженного зуба (легкое постукивание) – позволяет выявить болезненность и ее интенсивность; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">температурные пробы – воздействие на зуб высоких и низких температур дает дополнительные данные о восприимчивости зуба к термическому раздражению; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">зондирование – обследование пораженных зубов с помощью тонкого стоматологического зонда и оценка состояния тканей зуба (дентина, пульпы). </span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Из инструментальных методов диагностики применяются рентгенография и электродиагностика. Результаты исследований позволяют достоверно подтвердить диагноз пульпита и исключить другие зубные болезни.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первая помощь, оказанная пациенту с острой формой пульпита, предполагает применение специального обезболивающего препарата, что дает возможность быстро облегчить самочувствие пациента.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В настоящее время в стоматологии применяется несколько эффективных методов лечения пульпита:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">витальные методы: хирургическое лечение (ампутация, которая заключается в частичной резекции пульпы с сохранением ее функции) и консервативное лечение (применение медикаментов или физиологических методик терапии, посредством которых устраняются воспалительные процессы и болевой синдром);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">девитальные методы применяются при отсутствии признаков жизнеспособности пульпы, они предполагают полное ее удаление из полости зуба.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выбор метода лечения должен сделать стоматолог, основываясь на характере симптомов и индивидуальных особенностях развития пульпита.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Консервативное лечение пульпита состоит из нескольких ключевых этапов:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">обезболивание пораженной области;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">стоматологическая обработка кариозной полости посредством специальных профессиональных инструментов;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">второй этап обработки при помощи медикаментозных препаратов для устранения инфекции и болезнетворных бактерий (обычно стоматологи используют йодинол, димексид, хлоргексидин, трипсин и другие известные препараты);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">очищение и высушивание кариозной полости;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">установка прокладки для купирования воспалений в пульпе, снижения боли и стимуляции формирования нового дентина, пломбирование.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хирургический метод, подразумевающий устранение пульпы из полости зуба и его каналов, считается одним из самых эффективных и распространенных способов лечения пульпита. Врач применяет его при отсутствии признаков жизнеспособности пульпы</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактика любых стоматологических заболеваний, в том числе и пульпита, заключается в соблюдении ряда простых правил:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рациональное сбалансированное питание, богатое всеми необходимыми витаминами и минералами; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отказ от углеводистой пищи, особенно кондитерских изделий и сладостей; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">тщательная чистка зубов по специальным методикам; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">применение дополнительных средств для поддержания хорошей гигиены полости рта (флоссы, ополаскиватели для ротовой полости); </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">регулярная профессиональная чистка зубов;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">профилактические осмотры стоматолога даже при отсутствии каких-либо жалоб; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">устранение и лечение очагов хронической инфекции в организме.</span></li>\r\n</ul>\r\n<p> </p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пульпит может развиваться в двух формах, каждая из которых имеет ряд характерных клинических особенностей:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">острая форма проявляется в виде выраженного болевого синдрома, локализующегося в зоне расположения пораженного зуба (как правило, боль отдает в голову);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">хроническая форма отличается тем, что проявляется в виде периодической боли, склонной к усилению ближе к вечеру или ночи.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При остром пульпите пораженный зуб часто реагирует на разные уровни температуры принимаемой пищи и питьевой воды, а также на химические и механические раздражители (например, на остатки пищи, которые случайно проникли в кариозную полость зуба, горячий напиток, на прикосновение инструмента врача и т.п.). Чаще всего при устранении раздражительного фактора интенсивность болевого синдрома постепенно снижается.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При отсутствии своевременного лечения пульпит переходит из острой формы в хроническую, при которой также может проявляться реакция на широкий спектр раздражителей. Кроме того, при хронической форме может наблюдаться разрастание пораженной пульпы. Нередко хронический пульпит становится причиной неприятного запаха из ротовой полости. Без лечения хронического пульпита могут быть существенные осложнения в виде воспалений в костной структуре челюсти.</span></p>",
"image": null,
"image_alt": null,
"standard_type": 0,
"danger": 20,
"published": 1,
"parent": 6648,
"block_rubric": 110,
"standards": []
},
{
"id": 6676,
"symptoms": [
{
"id": 2620,
"synonyms": [
{
"name": " Внутритазовое выбухание"
},
{
"name": "Внутрибрюшная припухлость"
},
{
"name": "Внутрибрюшное уплотнение"
}
],
"body_points": [
{
"x": 452,
"y": 3977,
"r": 300
}
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"lead": "Нарушение здоровья, относящееся к группе грыжи",
"description": "Пупочная грыжа – состояние, при котором внутренние органы (кишечник, большой сальник) выходят за пределы передней брюшной стенки через отверстие, локализующееся в области пупка (пупочное кольцо).",
"etiology": "<p>Грыжи возникают вследствие дефекта анатомического строения пупочного кольца и действия факторов, которые вызывают повышение внутрибрюшного давления и растяжение передней брюшной стенки. Существует мнение о возможной роли наследственной предрасположенности в образовании пупочной грыжи у взрослых, что выражается в недоразвитии или отсутствии пупочной фасции, и это действительно выявляется во время операций. Однако пупочная фасция может разрушаться и вторично - из-за давления растущей грыжи. Причины, вызывающие повышение внутрибрюшного давления и растяжение брюшной стенки: беременность, ожирение, асцит различного происхождения, быстро растущие опухоли брюшной полости, упорные запоры. </p>\r\n<p>Образованию пупочной грыжи в детском возрасте способствует плач ребенка, постоянные запоры, газообразование в кишечнике, недоношенность. Иногда появление грыжи совпадает с началом хождения ребенка, особенно в тех случаях, когда он слишком рано принимает вертикальное положение. Склонность к образованию пупочной грыжи имеют дети с врожденным гипотиреозом, болезнью Дауна, болезнью Харлера, лактазной недостаточностью, дисбактериозом кишечника.</p>",
"pathogenesis": "<p>Пупочные грыжи формируются как результат дефекта развития передней брюшной стенки. Обычно самым слабым местом является верхний отдел пупочного кольца, через который проходит только пупочная вена, не имеющая мышечной оболочки. При недоразвитии брюшной фасции она прикрывает изнутри пупочное кольцо лишь частично, образуя дефекты, или же бывает слишком истончена и недостаточно прочна. При этом к возникновению грыжи могут привести все факторы, вызывающие резкое повышение внутрибрюшного давления.</p>\r\n<p> </p>",
"diagnostics": "<p>Диагноз ставится на основании клиники. К дополнительным методам исследования относят:</p>\r\n<ol>\r\n<li>УЗИ – позволяет выявить при больших грыжах содержимое грыжевого мешка и провести дифференциальную диагностику.</li>\r\n<li>Рентгеноконтрастное исследование и обзорная рентгенография практически не используются при неущемленных грыжах у детей, но могут быть применены при диагностических затруднениях у взрослых. Диагностически значимыми считаются обнаружение петель кишечника в проекции грыжевого мешка, нарушение пассажа контраста. </li>\r\n</ol>",
"treatment": "<p>У детей пупочная грыжа может спонтанно регрессировать, что связано с физиологическим укреплением мышц живота. Поэтому до 5-летнего возраста показано наблюдение за пупочной грыжей. В этот период рекомендуется выкладывание детей на животик, назначается тонизирующий массаж передней брюшной стенки, общий массаж, ЛФК, наложение лечебной лейкопластырной повязки на пупок.</p>\r\n<p>Взрослым и детям старше 5 лет с нерегрессировавшей пупочной грыжей показано хирургическое лечение (герниопластика). При пупочной грыже применяются два типа операций – герниопластика местными тканями и с использованием сетчатых имплантов.</p>",
"prevention": "<p> </p>\r\n<p>Мерами профилактики пупочной грыжи служат: предупреждение ситуаций, связанных с натуживанием грудного ребенка (надсадного крика и плача, вздутия живота, запоров и пр.), рациональное кормление, профилактический массаж и гимнастика, направленные на укрепление брюшной стенки, лечение дисбактериоза кишечника, ношение беременными дородового бандажа.</p>\r\n<p> </p>",
"clinical_picture": "<p>Пупочные грыжи у детей В вертикальном положении ребенка и при натуживании в области пупка появляется грыжевое выпячивание округлой или овальной формы, которое, как правило, вправляется самостоятельно при смене положения ребенка в горизонтальное на спине. В этом случае легко пальпируется расширенное пупочное кольцо, являющееся грыжевыми воротами. Ворота могут быть широкими - грыжа легко выходит и вправляется в брюшную полость, не причиняя ребенку никаких беспокойств и не травмируя внутренние органы. Если же грыжевые ворота узкие, ребенок периодически ведет себя беспокойно, плачет. </p>\r\n<p>Пупочные грыжи у взрослых Клинические проявления зависят от следующих факторов:</p>\r\n<p>- величина грыжи;</p>\r\n<p>- размеры грыжевых ворот;</p>\r\n<p>- выраженность спаечного процесса;</p>\r\n<p>- наличие или отсутствие осложнений;</p>\r\n<p>- сопутствующее ожирение. </p>\r\n<p>Размеры грыжи могут варьироваться от 1-2 см в диаметре до 20-30 см и более. Однако даже при очень больших грыжах грыжевые ворота достаточно малы и редко достигают в диаметре более 10 см.</p>\r\n<p>Небольшие пупочные грыжи (при условии, что они вправимы и не ущемлены) не причиняют больным значительных беспокойств. В том случае, когда содержимым грыжи является фиксированный в грыжевых воротах участок большого сальника, который как бы полностью тампонирует грыжу, она протекает бессимптомно и не увеличивается в размерах. Более часто, вследствие узости ворот, выхождение грыжи сопровождается болями, которые могут также зависеть от натяжения большого сальника, припаянного к стенкам грыжевого мешка. </p>\r\n<p>Большие грыжи при относительно узких воротах затрудняют проход содержимого по кишечнику. Типичные проявления: запоры, метеоризм, периодически появляющиеся боли в области грыжи, тошнота, рвота. Особенно сильно выражены эти явления при невправимых грыжах. Состояние пациентов может отягощаться тучностью и отвислым животом, что в сочетании с грыжей причиняет им значительные неудобства при ходьбе, физической нагрузке и сопровождается болями в спине.</p>\r\n<p>Когда больной находится в вертикальном положении и при натуживании в пупочной области появляется характерное выпячивание. Часто через истонченную кожу отчетливо видны контуры кишечных петель и их перистальтика. </p>\r\n<p> </p>",
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