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},
"code": "R82.0",
"name": "Хилурия",
"icd_name": "Хилурия",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "r82.0_hiluriya",
"lead": "наличие примеси лимфы в моче",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хилурия может быть следствием сообщения (свищ) между лимфатическими и мочевыводящими путями. Чаще всего лимфомочевая фистула возникает между крупными лимфатическими сосудами и почечной лоханкой (чашечками), реже отмечают вовлечение в патологический процесс мочевого пузыря. Чаще всего хилурия обнаруживается при филяриатозе - паразитарном заболевании, вызываемом нематодами класса Filariata. Филяриатозу свойственно эндемическое распространение. Заболевание передается через кровососущих насекомых (главным образом через комаров) и манифестирует одновременным поражением мочевых и лимфатических путей. Хилурия может быть следствием посттравматических, воспалительных, посттуберкулёзных и неопластических процессов, ведущих к сдавлению брюшного и грудного лимфатического коллектора, выступать в качестве моносимптома.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Её сопровождают, а зачастую ей предшествуют признаки лимфостаза нижней половины туловища: отёк кожи живота, полового члена, мошонки, нижних конечностей. Описаны наблюдения, свидетельствующие о возникновении почечной колики вследствие обтурации ВМП сгустками лимфатического содержимого. Отмечена корреляция степени интенсивности хилурии от положения тела пациента и приёма пищи. При ортостазе (стоя) и после приёма пищи хилурия выше, чем после пребывания пациента в положении клиностаза (лежа) и натощак.</span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Определение причин хилурии находится в ведении врачей-лимфологов. В небольших населенных пунктах, где такие специалисты отсутствуют, обследование проводят флебологи. Пациентам может потребоваться консультация инфекциониста, онколога или фтизиатра. Лабораторный симптом подтверждается по данным клинического анализа мочи. Наличие хилурии нередко распознается невооруженным глазом, для точного определения производится отстаивание жидкости и микроскопия осадка.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При подозрении на филяриатоз мазок или толстую каплю крови исследуют на микрофилярии. По показаниям осуществляют биопсию лимфатических узлов и кожных покровов с последующим морфологическим анализом. Выполняют иммунологические тесты (ИФА, РСК, РПГА). Перечень визуализационных методик может включать УЗИ почек и мочевого пузыря, УЗИ органов брюшной полости и малого таза, рентгенографию ОГК. Для оценки состояния лимфатической системы проводят лимфосцинтиграфию, рентгеновскую лимфографию, КТ, МРТ.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Консервативная терапия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При лимфостазе рекомендуют возвышенное положение конечности, компрессионное бандажирование, лимфодренажный массаж. Пациентов с филяриатозом госпитализируют, для дегельминтизации назначают дитразин, эффект оценивают с помощью повторных лабораторных исследований мазков на гельминты. При наличии аллергического компонента в схему лечения включают кортикостероиды и антигистаминные препараты.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пациентам со злокачественными опухолями назначают лучевую терапию, химиотерапию. В зависимости от локализации и распространенности онкологического процесса консервативные методики применяются отдельно либо в комплексе с хирургическими операциями. Если причиной сдавления лимфатических путей является воспалительный инфильтрат, используют противовоспалительные средства.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хирургическое лечение</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">При лимфедеме выполняют туннелирование, наложение лимфовенозных анастомозов. При водянке мошонки на фоне филяриатоза или сдавления лимфатических протоков производят пункцию, операцию Бергмана либо Винкельмана. Доброкачественные опухоли удаляют в пределах здоровых тканей. Больным со злокачественными новообразованиями проводят расширенные вмешательства.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"prevention": "",
"clinical_picture": "<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отеки кожных покровов брюшной полости, мошонки, члена, ног.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Моча принимает белый мутный цвет, через время в емкости она распределяется на три слоя.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">При атаке организма паразитами симптомы на начальном этапе никак не выражены. После поражения лифмосистемы, иммунитета и почек, возникает лихорадка, озноб, быстрая утомляемость, увеличение до гигантских размеров мошонки, нижних конечностей, поражаются глаза.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нарушение мочеиспускания, острые боли в поясничном отделе, почках, колики.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наследственный фактор у ребенка сопровождается постоянными отеками кожи, слоновости ног. В результате нарушения лимфотока возникают язвы.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Болезнь имеет стадии ремиссии и рецидивов на протяжении нескольких месяцев.</span></p>",
"image": null,
"image_alt": null,
"standard_type": 0,
"danger": 42,
"published": 1,
"parent": 7243,
"block_rubric": 196,
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},
{
"id": 14757,
"symptoms": [
{
"id": 2848,
"synonyms": [
{
"name": "мышечная боль"
},
{
"name": "боль в мышцах"
},
{
"name": "мышцы болят"
},
{
"name": "Миалгия"
},
{
"name": "ломота"
},
{
"name": "боль в мышцах рук"
},
{
"name": "боль в мышцах ног"
},
{
"name": "боль в мышцах после тренировки"
},
{
"name": "боль в мышцах спины"
},
{
"name": "боль икроножная"
}
],
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"r": 0
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"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Миоглобинурия — синдром, выражающийся в наличии в моче пигмента миоглобина, являющегося хромопротеидом; наблюдается при патологическом распаде мышечного белка. При этом моча приобретает красно-бурую окраску. </span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причины миоглобинурии</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наследственно-семейные патологии:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">с выясненным механизмом аномалии (синдром Мак-Ардла, синдром Таруи, недостаточность карнитинпальмитилтрансферазы);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">с неизвестной первичной аномалией (злокачественная форма гипертермии, расстройство синтеза молочной кислоты, неправильное окисление жирных кислот);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">врожденный вариант миопатии на фоне дополнительного фактора – наркоза (дистрофия мышечная врожденная Ши и Меджи, миопатия Дюшенна, хондродистрофическая миотония).</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Приобретенные патологии:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">изменения, связанные с механическим нарушением (травма, инфаркт, ишемия);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гипернагрузка на мускулатуру (перегруз нетренированной мускулатуры, подъем тяжелых предметов, эпистатус, психоз, электрошок);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">лихорадочные состояния (интоксикации, инфекции и пр.);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">инфекции без лихорадки (грипп, столбняк, заболевания, которые сопровождаются ацидозом и нарушением электролитного баланса);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">воспалительные процессы, отравления, интоксикации.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Провоцирующими факторами при миоглобинурии могут выступать:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">физические гиперусилия;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">чрезмерное напряжение мышц;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ограниченное поступление углеводов в организм;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">воспалительные заболевания мышечной ткани;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">механические повреждения мышечной ткани (травмы, краш-синдром, синдром позиционного сдавления);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">перетренировки;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">токовое воздействие;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">интоксикации (лекарственные, алкогольные и пр.).</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Миоглобинурия может развиваться у людей, страдающих алкогольной зависимостью, а также у тех, кто выкуривает более пачки сигарет ежедневно. В подобной ситуации патология возникает в результате токсического влияния этилового спирта, угарного газа и никотиновых смол.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Заболевание нередко поражает любителей кокаина, героина, амфетамина, а также наблюдается после укусов змей, скорпионов, ядовитых пауков, после отравления грибами.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для оценки состояния больного, уточнения вида патологии, сопровождающейся миоглобинурией, назначаются следующие диагностические процедуры:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Биохимическое исследование крови. Типична увеличенная концентрация миоглобина и КФК. Уровень соединений постепенно повышается на протяжении первых 12 часов. Максимальная активность миоглобина наблюдается в течение первых суток, креатинфосфокиназы – на 3-5 день. В анализах повышено количество мочевой кислоты и креатинина, наблюдаются гипокальциемия, гиперкалиемия, гиперфосфатемия, гиперурикемия.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Оценка диуреза. Имеет большую клиническую значимость из-за риска ОПН. О наличии осложнения свидетельствует уменьшение количества отделяемой мочи на 8-10%. В дальнейшем диурез сокращается на четверть, в тяжелых случаях развивается анурия. При восстановлении почечных функций объем суточного диуреза увеличивается, затем постепенно нормализуется.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Измерение субфасциального давления. Дает возможность подтвердить миофасциальный компартмент-синдром, исключить иные патологии. Выполняется специальным прибором. Полученные результаты сравнивают с диастолическим давлением. Разница менее 40 мм рт. ст. говорит в пользу сдавления мышц.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Электрофизиологические методы. Электромиография и электронейрография применяются для диагностики миопатии, дифференцировки патологии от миелита, нарушений спинномозгового кровообращения, новообразований спинного мозга. По результатам ЭМГ определяется сокращение длительности, уменьшение амплитуды мышечных потенциалов. Множество коротких пиков указывает на прогрессирующий характер процесса.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Другие методики. При сдавлении тканей в отдельных случаях выполняются УЗИ или МРТ, визуализирующие отек, разрушение скелетных мышц. Для исключения переломов и вывихов требуется рентгенологическое исследование. Тяжесть поражения миокарда при инфаркте, миопатиях, гаффской болезни оценивают с помощью ЭКГ, УЗИ сердца.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Консервативная терапия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Устранение миоглобинурии осуществляется путем лечения основной патологии. При высоком уровне миоглобина в анализе мочи необходима срочная госпитализация в реанимационное отделение, контроль диуреза, диета с низким содержанием белка и калия. Схема медикаментозной терапии включает следующие направления:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактика ОПН. Подразумевает назначение диуретиков, внутривенное капельное введение раствора гидрокарбоната натрия.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Восстановление объема жидкости. Инфузионную терапию с использованием солевых растворов начинают при поступлении, оптимально – в первые 6 часов с момента повреждения мышц. Лечение производится под контролем КОС крови и диуреза.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Устранение интоксикации и обменных нарушений. Предусматривает введение инсулина с глюкозой, агонистов бета-адренорецепторов, гидрокарбоната натрия, глюконата кальция. Для удаления токсинов из ЖКТ применяют энтеросорбенты.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Экстракорпоральная гемокоррекция. Чаще выполняется гемосорбция, иногда – плазмаферез. Больным с почечной недостаточностью показано проведение гемодиализа.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При открытых травмах, газовой гангрене, формировании некротических очагов необходима антибиотикотерапия. Пациентам с гаффской болезнью назначают анальгетики, противосудорожные и антигистаминные средства, медикаменты для улучшения микроциркуляции, поливитаминные комплексы. Иногда требуются гипербарическая оксигенация, переливание свежезамороженной плазмы, тромбоцитарной и эритроцитарной массы.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Патогенетическое лечение миопатий не разработано. Симптоматическая терапия направлена на активизацию метаболических процессов в мышечной ткани. Рекомендованы аминокислоты, неостигмин, АТФ, анаболические стероиды, антихолинэстеразные препараты, кальций, калий, тиаминпирофосфат. Медикаментозные методы дополняют ЛФК, массажем, физиотерапией.</span></p>\r\n<p><strong id=\"docs-internal-guid-82a2a015-7fff-8e08-88c8-84fe27577349\" style=\"font-weight: normal;\"> </strong></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хирургическое лечение</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В раннем периоде оперативные вмешательства требуются пациентам с миоглобинурией на фоне обширного рабдомиолиза, тяжелого сдавления мышц, образования участков некроза. В отдаленные сроки некоторые больные нуждаются в устранении вторичных дефектов костно-мышечной системы. С учетом стадии заболевания и имеющейся симптоматики проводятся:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Декомпрессионная фасциотомия. Показана при высоком давлении в фасциальном футляре вследствие компартмент-синдрома. Позволяет восстановить питание и сохранить жизнеспособность мышечной ткани, снизить риск возникновения ОПН.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Некрэктомия. Необходима при электротравме, термических ожогах, СДР, газовой гангрене. При обширных поражениях, подтверждении нежизнеспособности конечности, угрозе ОПН из-за поступления токсинов в организм осуществляется ампутация или экзартикуляция.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Реконструктивно-пластические вмешательства. Проводятся для улучшения функциональности конечностей. Включают пластику рубцов, миопластику, замещение дефектов мягких тканей с использованием филатовского стебля.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"prevention": "",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматика при миоглобинурии далеко не во всех случаях одинакова: это зависит от концентрации миоглобина и наличия сопутствующих патологических расстройств. Большинство больных жалуются на внезапную сильную слабость, болезненность в мышцах, тяжесть в поясничной области, приступы тошноты. Объем выделяемой мочевой жидкости резко и сильно снижается – не исключается также развитие анурии. Обращает на себя внимание изменение цвета мочи. Так, первые признаки миоглобинурии заключаются в том, что мочевая жидкость становится от насыщенно красной до насыщенно бурой, вплоть до почернения.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Бензидиновая проба оказывается положительной. Удельный вес мочи постепенно снижается, обнаруживается протеинурия. Мочевой осадок содержит цилиндры, гематин, эритроциты.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если в дальнейшем развивается острая недостаточность почечной деятельности, то нарастают признаки общей интоксикации, наблюдаются азотемия, гиперкалиемия, явления ацидоза.</span></p>",
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},
"code": "R82.3",
"name": "Гемоглобинурия",
"icd_name": "Гемоглобинурия",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "r82.3_gemoglobinuriya",
"lead": "ряд синдромов, в основе которых лежит внутрисосудистое повреждение эритроцитов с выходом гемоглобина за пределы сосудистого русла и в мочу",
"description": "<p><span id=\"docs-internal-guid-a140c118-7fff-38a8-0b40-af4bfe621c6e\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Гемоглобинурия – это одна из форм гемолитической анемии (гемоглобинемии), точнее симптом патологического внутрисосудистого повреждения красных кровяных телец (эритроцитов), когда гемоглобин массово выходит в околососудистую среду и мочу. Присутствие гемоглобина в моче – это прямое свидетельство интенсивного распада эритроцитов, причиной которого может стать как внутреннее заболевание (грипп, пневмония, острая инфекция), так и внешний фактор – переохлаждение, чрезмерная физическая нагрузка, травмы, интоксикация.</span></span></p>",
"etiology": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гемоглобинурия наблюдается при некоторых заболеваниях крови, переливании иногруппной крови, отравлениях некоторыми красителями (анилин) и ядами (карболовая кислота, бертолетова соль), обширных ожогах, когда большая часть гемоглобина находится в связанном состоянии, а его небольшая свободная фракция образуется за счёт разрушения стенки эритроцитов. Истинная гемоглобинурия не существует без гемоглобинемии и связанной с ней желтухи. Гемоглобинурия также наблюдается при длительной физической нагрузке, беге, ходьбе и др.</span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основным макроскопическим признаком гемоглобинурии служит изменение цвета и структуры собранной мочи. Цвет мочи может быть темно-красным, коричневым или почти черным. При отстаивании моча отчетливо разделяется на 2 слоя: верхний – прозрачный и нижний – содержащий примесь в виде детрита. Лабораторными тестами, подтверждающими гемоглобинурию, служат проба с сульфатом аммония, обнаружение гемосидерина в осадке, исследование мочи методом электрофореза или иммуноэлектрофореза.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для уточнения общей картины крови исследуется гемограмма. С целью выявления компонентов комплемента или антител, фиксированных на поверхности эритроцитов, проводится проба Кумбса. Показано исследование коагулограммы, биохимических показателей крови (билирубина, мочевины, щелочной фосфатазы и др.). Для оценки состояния кроветворения, особенно в случае панцитопении при пароксизмальной ночной гемоглобинурии, требуется проведение пункции костного мозга и исследование миелограммы.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечебная тактика при различных формах гемоглобинурии определяется гематологом. Маршевая и пароксизмальная холодовая гемоглобинурия обычно разрешаются без специального вмешательства. В случае развития хронической аутоиммунной холодовой гемоглобинурии назначаются глюкокортикоиды и иммунодепрессанты (циклофосфамид, азатиоприн).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия пароксизмальной ночной гемоглобинурии в основном симптоматическая: трансфузии эритроцитов, введение непрямых антикоагулянтов, прием препаратов железа. При гипоплазии красного костного мозга назначаются глюкокортикостероиды (преднизолон), анаболические препараты (метандиенон) или андрогены, антитимоцитарный иммуноглобулин. При выраженном гиперспленизме может быть оправдана спленэктомия. При отсутствии эффекта от других методов лечения пароксизмальной ночной гемоглобинурии решается вопрос о пересадке костного мозга, от совместимого по HLA-системе донора.</span></p>\r\n<p><span id=\"docs-internal-guid-b751125d-7fff-92c6-882d-c8fa6478e08c\"> </span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">С целью предотвращения развития гемоглобинурии рекомендуется избегать провоцирующих факторов: отравлений, интоксикаций, инфекционной заболеваемости, чрезмерных физических нагрузок, травм и пр.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмальная ночная гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отличительной особенностью пароксизмальной ночной гемоглобинурии (болезни Маркиафавы-Микели) служат приступы внутрисосудистого гемолиза (гемолитические кризы), развивающиеся преимущественно в ночное время. Гемолитические кризы могут провоцироваться переохлаждением, инфекцией, вакцинацией, гемотрансфузиями, физическими нагрузками, хирургическими вмешательствами.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмы гемолиза эритроцитов сопровождаются лихорадочным состоянием, артралгиями, сонливостью, болями за грудиной, в животе и пояснице. Признаком нарастающей железодефицитной анемии служат общая слабость, желтушность кожных покровов и слизистых оболочек. Характерно увеличение печени и селезенки. Выделение мочи темного цвета отмечается только у четверти пациентов с пароксизмальной ночной гемоглобинурией.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наиболее опасными проявлениями пароксизмальной ночной гемоглобинурии служат тромбозы брыжеечных сосудов, сосудов почек, периферических сосудов. Тромбоз печеночных вен сопровождается резким увеличением размеров печени, прогрессирующим асцитом, варикозным расширением вен пищевода. Постоянная гемосидеринурия часто приводит к возникновению канальцевого нефрита; на высоте гемолитического криза может развиться острая почечная недостаточность.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Маршевая гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматика маршевой гемоглобинурии обычно более стертая и развивается постепенно. Озноб и повышение температуры нехарактерны. Отмечается слабость, которая также может быть следствием общего физического утомления от марш-броска. Вместе с тем, патогномоничным признаком данной формы гемоглобинурии является темная окраска мочи. После прекращения маршевой нагрузки самочувствие нормализуется, моча светлеет. Практически у всех лиц, столкнувшихся с маршевой гемоглобинурией, имеется выраженный поясничный лордоз.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Холодовая пароксизмальная гемоглобинурия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Редкая форма гемолитической анемии - пароксизмальная холодовая гемоглобинурия протекает приступообразно. Пароксизмы холодовой гемоглобинурии обычно провоцируются переохлаждением и сопровождаются гипертермией (иногда до 40°С), потрясающими ознобами, тошнотой и рвотой, абдоминальными болями. Выявляется гепато- и спленомегалия, желтоватый цвет кожи и склер, характерная окраска мочи.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пароксизмальная холодовая гемоглобинурия, вызванная острыми вирусными инфекциями, обычно разрешается вместе с основным заболеванием. При сифилисе и малярии заболевание может длиться годами.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
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},
"code": "R82.4",
"name": "Ацетонурия",
"icd_name": "Ацетонурия",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "r82.4_acetonuriya",
"lead": "состояние, когда кетоновые тела появляются в моче",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ацетонурия (кетонурия) – повышенное содержание в моче кетоновых тел, которые являются продуктами неполного окисления белков и жиров в организме. К кетоновым телам относится ацетон, оксимасляная кислота, ацетоуксусная кислота.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причины появления ацетона в моче</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У взрослых это явление может быть вызвано целым рядом причин:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Преобладание в рационе жирной и белковой пищи, когда у организма нет возможности полностью расщепить жиры и белки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Недостаток пищи, содержащей углеводы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Физические нагрузки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Жесткая диета или длительное голодание.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сахарный диабет I типа или истощенное состояние поджелудочной железы при длительно протекающем сахарном диабете II типа.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У детей ацетон в моче появляется в результате сбоев в работе поджелудочной железы, которые могут возникнуть по многим причинам. До 12 лет идет развитие поджелудочной железы. В это время она просто может не справляться со всеми ударами, которые на нее обрушиваются. При подавлении работы поджелудочной железы вырабатывается значительно меньшее количество ферментов, чем необходимо.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основные причины детской ацетонурии:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Погрешности в питании.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Переедание, жирная пища, продукты, имеющие в своем составе химические ароматизаторы, консерванты и красители – неполный перечень нарушений детского питания, которые могут привести к появлению ацетона в моче ребенка.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повышенная возбудимость или стрессы (которые родители ошибочно принимают за простые капризы).</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Физическая нагрузка.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Переутомление.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Глисты, диатез, дизентерия.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Бесконтрольный прием антибиотиков.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Высокая температура.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Переохлаждение.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При беременности появления ацетона в моче является в какой-то степени загадочным явлением. Точную причину ацетонурии беременных никто пока сказать не может, но все же специалисты выделяют несколько факторов, способствующих возникновению этого синдрома:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Отрицательное влияние окружающей среды.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Большие психологические нагрузки у будущей мамы не только в настоящем, но и в прошлом.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Снижение иммунитета.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наличие в употребляемых продуктах химических веществ – красителей, консервантов и ароматизаторов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Токсикоз, при котором основным симптомом является постоянная рвота. </span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностика ацетонурии предполагает проведение различных исследований урины. Наиболее простым и быстрым в проведении является клинический анализ, однако чаще всего исследуется суточный объем мочи. Данное исследование позволяет получить полную информацию о динамических изменениях показателей пациента в течение дня. Также специалист может назначить следующие анализы:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">анализ мочи по Нечипоренко;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">трехстаканная проба;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">экспресс-тест.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Последнее исследование проводится в домашних условиях либо в медицинской клинике при экстренной госпитализации пациента в состоянии диабетической комы.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы восстановить уровень кетонов в моче до нормы, необходимо устранить или вылечить основное заболевание. Необходимо компенсировать нарушения кислотно-основного и водно-электролитного обмена. Это особенно важно в случае диабета, осложнением которого может быть кетоновая кома.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы избавиться от кетонов в моче при диабете, необходимо нормализовать уровень глюкозы и инсулина в крови. В случае кетонурии, вызванной недоеданием, необходимо изменить рацион питания на высококалорийный и обеспечить адекватный калорийный баланс. Во время рвоты назначаются противорвотные препараты.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">С целью предупреждения негативных изменений в плане функционирования жизненно важных органов, нарушения обменных процессов рекомендуется прохождение регулярных плановых осмотров и ежегодной полномасштабной диагностики в целях профилактики обострений. Чтобы предотвратить развитие кетоацидотической комы, следует регулярно сдавать мочу для анализа на наличие ацетона и проводить экспресс-тесты в домашних условиях.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Неотъемлемой частью профилактики считается диета. Ежедневный рацион следует составлять таким образом, чтобы предупредить формирование дефицита глюкозы и избытка жиров.</span></p>",
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