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"code": "D22",
"name": "Меланоформный невус",
"icd_name": "Меланоформный невус",
"gender": 0,
"age_min": 1,
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"cause": [
"0"
],
"periodicity": 1,
"slug": "d22_melanoformnyy_nevus",
"lead": "кожное образование из видоизмененных клеток кожного пигмента меланина",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Меланоформный невус туловища или других частей тела появляется под воздействием нескольких факторов. При перемещении меланобластов из нейроэктодермальной трубки в меланоциты происходят нарушения, вследствие чего происходит скопление меланина в одной зоне. Так возникают невусы врожденным путем. При этом такие образования у ребенка остаются незаметными. Их наличие на теле определяется с возрастом. Риск появления признаков перерождения доброкачественных новообразований в злокачественные опухоли выше, если невусы занимают большую площадь тела.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Приобретенные меланоформные невусы появляются по разным причинам. К самым распространенным факторам, вызывающим развитие новообразований на теле, относятся:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">длительное нахождение под солнечными лучами;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">частые кожные заболевания;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">изменения на гормональном уровне, к примеру, при беременности.</span></li>\r\n</ul>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ранняя диагностика способна не только выявить вид меланоформного образования, но и первые признаки развития меланомы. Для исследования используются следующие виды диагностики:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">люминесцентная микроскопия (исследует клетки новообразования);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">компьютерная диагностика (посредством данного метода можно установить точное строение невуса, а, значит, поставить точный диагноз и назначить курс лечения);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">анализ крови (для выявления онкомаркеров).</span></li>\r\n</ul>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Большинство приобретённых невусов на протяжении всей жизни остаются доброкачественными и требуют только наблюдения. Однако пациентам с множественными невусами следует раз в год или чаще проходить осмотр всего тела и консультироваться по поводу защиты от солнца.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Приобретённые меланоцитарные невусы удаляют в следующих случаях:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">если они расположены на подошве или ладонях, имеют пятнистую пигментацию или диаметр более 5 мм;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">образовались в матриксе ногтя, имеют вид отдельных полос тёмного цвета или шириной более 4 мм;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">имеют выраженный асимметричный контур, участки розового или красного цвета или окрашены в несколько оттенков;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">быстро растут, меняют цвет или структуру;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">выделяются среди других невусов на теле, например имеют другой цвет.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Также следует удалять гало-невусы, центральная часть которых имеет нетипичные черты, и невус Шпитц с атипичными признаками: диаметром более 1 см, асимметрией и изъязвлением.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Волоски в структуре невуса не доказывают его доброкачественность. Невусы удаляют, если есть атипичные признаки, независимо от наличия или отсутствия волос. Показанием к удалению может также служить косметический дискомфорт и постоянная травматизация участка, где расположен невус.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Специфических мер, которые могут предотвратить появление невусов, не существует.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Единственный управляемый фактор — это воздействие УФ-излучения. Чтобы контролировать его, нужно:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">не находиться под прямыми солнечными лучами днём, с 10 до 16 часов;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">использовать солнцезащитный крем с высокой степенью защиты (SPF 30+);</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">надевать солнцезащитную одежду, в том числе головные уборы с широкими полями, закрывающими лицо, шею и уши;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">использовать очки с защитой от ультрафиолета;</span></li>\r\n<li><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">не применять солнечные лампы и не посещать солярий.</span></li>\r\n</ul>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Меланоцитарный невус — это хорошо отграниченное, круглая или овальная опухоль кожи, обычно, имеющая размеры от 2 до 6 мм в диаметре. Хотя, множество невусов имеют небольшую асимметрию, границы, обычно, правильные и хорошо определимы. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Пограничный меланоцитарный невус — это образование в виде пятна с небольшим усилением кожного рисунка, заметным при боковом освещении. Пограничный меланоцитарный невус также характеризуется однородной коричневой или темно-коричневой окраской. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Сложный меланоцитарный невус выступает на различную высоту, имеет слегка более светлую окраску, чем пограничный. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Внутридермальный меланоцитарный невус, обычно, больше возвышается и более светлой окраски, чем сложный невус, иногда, даже телесного цвета. Тем не менее, необходимо подчеркнуть, что существует клиническая и дерматоскопическая схожесть между всеми тремя типами обычных меланоцитарных невусов. Внутридермальный меланоцитарный невус в большей степени, чем сложный, имеет форму куполообразной шишки или папилломы. Интрадермальный невус или сложный могут напоминать себорейный кератоз своей бородавчатой поверхностью. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Многие невусы имеют более жесткие и темные волосы по сравнению с волосами на окружающей коже. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Меланоцитарный невус на ладони и подошве часто выглядит как темное пятно и лишь слегка возвышается, имеет правильные, хорошо определимые края и однородную коричневую окраску. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Невус ногтевого ложа представлен однородно окрашенной светло или темно-коричневой продольной полосой с правильными различимыми границами. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Важным аспектом меланоцитарного невуса является отношение с меланомой. Значительный процент пациентов с меланомой сообщают о длительном присутствии меланоцитарного невуса на участке кожи, где впоследствии развилась меланома. Гистологические исследования находят остатки меланоцитарного невуса в трети удаленных меланом. Повышенное количество меланоцитарных невусов означает повышенный риск меланомы. В большей степени это утверждение относится к диспластическим разновидностям.</span></p>",
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},
"code": "C51",
"name": "Рак вульвы",
"icd_name": "Рак вульвы",
"gender": 2,
"age_min": 30,
"age_max": 85,
"cause": [
0
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"lead": "злокачественное опухолевое поражение области наружных гениталий (половых губ, клитора, преддверия влагалища, задней спайки, уретры и т. д.).",
"description": "\r\nЗлокачественные опухоли вульвы составляют 2–5% среди злокачественных онкогинекологических заболеваний, занимая четвёртое место после РШМ, рака эндометрия и рака яичников. ",
"etiology": "<p>Основные причины развития рака вульвы — нейроэндокринные нарушения, возникающие в постменопаузе. Определённое значение имеет снижение уровня рецепторов к эстрогену в тканях вульвы. У подавляющего числа пациенток злокачественная опухоль возникает на фоне возрастных инволютивных изменений вульвы. Этот процесс проходит несколько этапов: возрастная инволюция кожи и слизистой оболочки, дистрофические изменения, на фоне которых формируются участки пролиферации, развитие дисплазии и трансформация в преинвазивный и инвазивный рак.</p>",
"pathogenesis": "<p>Среди потенциальных экзогенных факторов патогенеза особое место следует отвести вирусу папилломы человека, имеющему чётко обозначенную тропность к плоскому эпителию.</p>",
"diagnostics": "<p>При сборе анамнеза следует обращать внимание на следующие факторы: позднее менархе, раннее наступление менопаузы, укорочение репродуктивного периода на фоне высокой фертильности, воспалительные процессы.</p>\r\n<p>Первичная локализация рака вульвы чётко определяется только при начальных стадиях процесса.</p>\r\n<p>Наиболее агрессивным течением отличаются опухоли с локализацией в области клитора. Обильное кровоснабжение и особенности лимфооттока обусловливают быстрое прогрессирование, раннее метастазирование в паховобедренные и подвздошные лимфатические узлы. Изолированные гематогенные метастазы (без поражения лимфатических узлов) выявляют в основном при раке клитора.</p>\r\n<p>Опухоли, ограниченные малыми половыми губами, имеют наиболее благоприятное течение.</p>\r\n<p>Рак вульвы с локализацией в области больших половых губ диагностируют наиболее часто (до 60%), и по клиническому течению опухоль занимает промежуточное место между раком клитора и раком малых половых губ.</p>\r\n<p>Рак бартолиновой железы диагностируют приблизительно в 1% случаев.</p>\r\n<p>По характеру роста опухоли выделяют экзофитную, эндофитную и инфильтративноотёчную форму. Наиболее часто встречается экзофитная форма рака вульвы. Наиболее неблагоприятное течение имеет инфильтративноотёчная форма.</p>\r\n<p>Характерная черта рака вульвы — мультифокальность очагов малигнизации.</p>\r\n<p>Рак вульвы метастазирует преимущественно лимфогенным путём.</p>\r\n<p>Первый этап — паховобедренные лимфатические узлы.<br />Второй этап — подвздошные лимфатические узлы. Чаще поражаются наружные подвздошные и запирательные.<br />Третий этап — общие подвздошные лимфатические узлы.</p>\r\n<p>Частота метастазирования в паховобедренные лимфатические узлы зависит от размеров опухоли. При опухоли до 1 см в диаметре их поражение выявляют у 5% больных, а при размерах опухоли 4 см и более — у 30–50%. Поражение тазовых лимфатических узлов возникает в среднем у 5% больных.<br />Гематогенные метастазы развиваются крайне редко.</p>\r\n<p>ЛАБОРАТОРНЫЕ ИССЛЕДОВАНИЯ</p>\r\n<ul>\r\n<li>Цитологическое исследование мазков с опухоли.</li>\r\n<li>Вульвоскопия.</li>\r\n<li>Фотодинамическая диагностика.</li>\r\n<li>Гистологическое исследование биопсийного материала подозрительного участка или опухоли.</li>\r\n</ul>\r\n<p>ИНСТРУМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</p>\r\n<p>При инвазивном раке вульвы для уточнения распространённости процесса необходимо выполнение:</p>\r\n<ul>\r\n<li>УЗИ малого таза, печени, паховобедренных и забрюшинных лимфатических узлов (при их увеличении выполняют<br />пункцию с цитологическим исследованием);</li>\r\n<li>рентгенографии органов грудной клетки;</li>\r\n<li>цистоскопии и ректоскопии при значительном распространении опухоли;</li>\r\n<li>общего клинического обследования;</li>\r\n<li>КТ, МРТ (по показаниям).</li>\r\n</ul>\r\n<p>Степень распространения опухолевого процесса определяют на основании совокупности данных клинического, лабораторно-инструментального обследования, а также результатов цитологического и гистологического исследования.</p>\r\n<p>Правильное определение стадии рака вульвы и адекватная оценка общего соматического статуса пациентки позволяют выработать оптимальную тактику лечения и достичь наилучшего результата.<br />Все больные с подозрением на рак вульвы должны быть направлены на консультацию к онкологу (онкогинекологу) для проведения углублённого обследования.</p>",
"treatment": "<p>НЕМЕДИКАМЕНТОЗНОЕ ЛЕЧЕНИЕ РАКА ВУЛЬВЫ</p>\r\n<p>Наиболее широко используют хирургический и лучевой методы. При интраэпителиальной неоплазии вульвы (дисплазии и карциноме in situ) возможна фотодинамическая терапия и лазерная аблация.</p>\r\n<p>МЕДИКАМЕНТОЗНОЕ ЛЕЧЕНИЕ (ХИМИОТЕРАПИЯ) РАКА ВУЛЬВЫ</p>\r\n<p>Применение химиотерапии при раке вульвы ограничено в связи с невысокой эффективностью. При местнораспространённом процессе проводят химиолучевое лечение в предоперационном периоде.<br />При отдалённых метастазах используют препараты, имеющие активность при плоскоклеточном раке.</p>",
"prevention": "<p>Наиболее реальная возможность профилактики инвазивного рака вульвы — своевременная диагностика и лечение фоновых, предраковых заболеваний и преинвазивного рака.</p>\r\n<p>Особо выделяют фоновые дистрофические процессы, к которым относят, в первую очередь, крауроз и лейкоплакию вульвы.</p>",
"clinical_picture": "<p>Симптоматика рака вульвы разнообразна. Иногда специфические симптомы могут отсутствовать. Чаще пациенты предъявляют жалобы на раздражение и в области гениталий, дискомфорт. По мере роста опухоли и присоединения воспалительного компонента появляются жалобы на боли, наличие изъязвления или экзофитного образования, гнойные и кровянистые выделения.</p>\r\n<p>Вторичные симптомы развиваются в результате регионарного метастазирования и поражения соседних органов: вульвы, лобка, конечностей, нарушение функции мочеиспускания, температура, общая , \"></a>, .</p>",
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