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"etiology": "<p> В основе развития лежат ферментные нарушения в волосяных фолликулах, спастическое состояние сосудов, т. е. нарушение микроциркуляции крови в области дермы.Триггерными факторами заболевания могут являться стрессы, вакцинация, вирусные заболевания, инфекционные заболевания, прием антибактериальных препаратов, наркозы.</p>",
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"diagnostics": "<ul>\r\n<li>Диагноз ставится на основании клинической картины заболевания:</li>\r\n<li>■ наличия на коже очагов алопеции с четкими границами;</li>\r\n<li>■ наличия в очаге пеньков волос в виде восклицательного знака и зоны «расшатанных волос» на границе очага (активная стадия); ■</li>\r\n<li>обнаружения при микроскопическом исследовании эпилированных из очага волос дистрофичных проксимальных концов в виде «оборванного каната»;</li>\r\n<li>■ наличия в очаге роста светлых пушковых волос (в стадии регресса); иног- да по одному краю очага имеются обломки волос в виде восклицательно- го знака, а на противоположном — рост веллюса;</li>\r\n<li>■ обнаружения при осмотре ногтей признаков ониходистрофии: напер- стковидных вдавливаний, продольной исчерченности, изменений сво- бодного края в виде волнистых узур;</li>\r\n<li>■ выявления при трихоскопии (дерматоскопии волосистой части головы) «желтых точек», кадаверизированных волос, волос в виде восклицатель- ных знаков. При сомнительном диагнозе, а также перед назначением лечения реко- мендуется проведение лабораторных исследований:</li>\r\n<li>■ микроскопического исследования кожи и волос на наличие патогенных грибов;</li>\r\n<li>■ микроскопического исследования волос, эпилированных из краевой зоны очага (выявление дистрофичных концов волос — признака, пато- гномоничного для ГА);</li>\r\n<li>■ гистологического исследования фрагмента кожи волосистой части голо- вы. Гистологически ГА характеризуется состоящим в основном из Т-кле- ток воспалительным инфильтратом внутри и вокруг луковиц анагеновых волосяных фолликулов. Однако гистопатологические признаки ГА зави- сят от стадии заболевания, в случае хронического течения заболевания классические признаки могут отсутствовать;</li>\r\n<li>■ клинического анализа крови;</li>\r\n<li>■ серологических исследований для исключения красной волчанки и си- филиса;</li>\r\n<li>■ определения в крови уровня кортизола (при планировании лечения глю- кокортикоидными средствами системного действия — до лечения и спу- стя 4 недели после его окончания);</li>\r\n<li>■ биохимического анализа крови: АЛТ, АСТ, общий белок, билирубин, хо- лестерин, сахар крови, щелочная фосфатаза (при подозрении на токсиче- скую алопецию, а также перед назначением фотохимиотерапии с приме- нением фотосенсибилизаторов внутрь);</li>\r\n<li>■ обзорной рентгенографии черепа (для исключения объемных образова- ний области турецкого седла);</li>\r\n<li>■ анализа крови на гормоны щитовидной железы (Т3 свободного, Т4 сво- бодного, ТТГ, АТ к ТПО, АТ к ТГ) для исключения патологии щитовидной железы и пролактин для исключения геперпролактинемии. Реовазоэнцефалограмма (РЭГ) рекомендуется при распространенных формах ГА детям в возрасте до 12 лет с целью диагностики возможных нарушений кровообращения в системе церебральных сосудов. По показаниям назначаются консультации других специалистов: невро- лога, эндокринолога, психотерапевта.</li>\r\n</ul>",
"treatment": "<p>Лечение гнездовой алопеции проводится с помощью введения глюкокортекостероидов в патологические очаги, смысл этой терапии заключается в иммуносупрессивном действии препаратов. Если площадь поражения составляет более 50 % кожных покровов головы, на которых происходит рост волос, то лечение кортикостероидами не оказывает нужного эффекта.</p>\r\n<p>На сегодняшний день местное лечение препаратами, содержащими кортикостероиды, признано малоэффективным даже в сочетании с носителями, способствующими более глубокому проникновению гормональных препаратов.</p>\r\n<p>Топическая иммуносупрессивная терапия гнездной алопеции может проводиться с применением динитрохлорбензола, дибутилового эфира скваровой кислоты и дифенилциклопропенона.</p>\r\n<p>Правильно подобранное системное использование стероидов способно повернуть быстро прогрессирующую гнездную алопецию вспять.</p>\r\n<p>Подавить активные клоны лимфоцитов можно иммунотропными лекарственными средствами.</p>\r\n<p>В ряде случаев эффективна фотохимиотерапия, а также некоторые адъювантные методы воздействия на очаги поражения.</p>\r\n<p>При выборе методов лечения гнездовой алопеции принимают во внимание особенности конституции пациентов, фоновые заболевания.</p>\r\n<p>Использование биогенных стимуляторов позволяет ускорить процессы восстановления тканей. Для коррекции некоторых показателей крови могут быть рекомендованы препараты, содержащие экстракт слюны пиявок. При некоторых формах гнездовой алопеции могут быть показаны препараты цинка.</p>\r\n<p>К наружным средствам сопутствующей терапии относят широкий спектр раздражающих средств (скипидарную мазь, эфкамон), стимуляторы процессов пролиферации креатиноцитов, препараты, улучшающие питание тканей, а также способствующие улучшению микроциркуляции тканей. Наружно могут также использоваться лекарственные средства, содержащие кремний, которые позволяют улучшить структуру волоса, или же препараты, терапевтический эффект которых обусловлен воздействием на пораженные участки кожи вытяжки из плаценты.</p>",
"prevention": "<p>Методов профилактики не существует.</p>",
"clinical_picture": "<p>Заболевание начинается внезапно с появлением очага выпадения волос на волосистой части головы. Как правило, очаги круглые или овальные с неизменной по цвету и консистенции кожей величиной от 1,5 см до размера ладони ребенка. Очаги могут сливаться, образуя обширные участки облысения. Субъективные признаки отсутствуют. Существуют следующие клинические разновидности:</p>\r\n<p>1) мелкоочаговая алопеция (чаще встречаются у детей);</p>\r\n<p>2) лентовидные очаги облысения затылочной части головы, распространяющиеся к вискам, нередко изъязвляющиеся. При регрессии остаются рубцы. Эта форма резистентна к терапии;</p>\r\n<p>3) стригущая форма – в очаге облысения определяются обломанные волосы;</p>\r\n<p>4) субтотальная – почти полное или полное <a href=\"/symptom/vypadenie_volos/\" title=\"Перейти на страницу симптома Выпадение волос\">выпадение волос</a> на голове;</p>\r\n<p>5) тотальная (злокачественная) алопеция – полное <a href=\"/symptom/vypadenie_volos/\" title=\"Перейти на страницу симптома Выпадение волос\">выпадение волос</a> на голове, туловище, конечностях, включая ресницы и брови.</p>",
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},
"code": "L60.1",
"name": "Онихолиз",
"icd_name": "Онихолиз",
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"lead": "дистрофическое поражение ногтевой пластины, проявляющееся в ее отделении от ложа при частичном или полном сохранении привычной формы",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В подологии принято выделять несколько видов онихолизиса, которые напрямую связаны с причинами возникновения заболевания:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Бактериальный – причина развития патологического процесса связана с присоединением вторичной инфекции.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Грибковый – развивается в результате поселения колоний грибков. Микотическая инфекция не всегда разрушает структуру ногтя, при этом поражается ложе, образуется очаг вторичного онихолиза.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Травматический – причина патологии кроется в химическом, термическом или физическом воздействии, длительном ношении тесной и неудобной обуви, ортопедической патологии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Системный – развивается на фоне текущих хронических патологий желудочно-кишечного тракта, эндокринных расстройств, дерматологических поражений.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аллергический – спровоцирован отслоением ногтя некоторыми лекарственными препаратами, на фоне которых развиваются фотосенсибилизирующие реакции. Также иногда наблюдается развитие онихолиза при длительном контакте с бытовой химией, агрессивными веществами, а также воздействии ультрафиолета. Ногти особенно чувствительны к химическому воздействию, поэтому иногда разрушающее состояние наблюдается при использовании низкокачественных лаков и покрытий типа Shellak.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Дерматологический – ногтевое ложе может деформироваться в результате длительных дерматозов, которые становятся причиной развития воспалительного очага.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чаще всего онихолизис на пальцах стоп появляется из-за травм ступней, микоза и аллергии. Если был удар, то в этом случае страдает и ноготь, и ложе одновременно. Возникает подногтевая гематома. Ноготь деформируется, сосуды сдавливаются, из-за чего нарушается питание пластины, ослабевает связь между ней и ложем, начинается отслаивание.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При аллергической реакции замедляется процесс регенерации, наблюдается гиперсенсибилизация кожи, что в итоге усугубляет развивающийся процесс деформации. Симптоматика аллергической природы сходна с проявлениями воспаления. </span></p>",
"pathogenesis": "",
"diagnostics": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Обычно диагноз не вызывает затруднений у дерматолога. Предшествующее онихолизису поражение ногтей линиями Бо – ценный диагностический признак, свидетельствующий либо о постоянном травмировании ногтя, либо о периодическом прекращении его роста на фоне соматических заболеваний. Наличие поражения на одном или нескольких ногтях пальцев рук или ног и определение возможной причины отслойки позволяют установить клинический диагноз при значительном разнообразии патоморфологической картины онихолизиса (изменение цвета, структуры, прозрачности, разные по глубине и площади гиперкератотические наслоения). В обязательном порядке берут соскоб на грибы для исключения микотического поражения.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия патологического процесса комплексная. По возможности необходимо купировать основное заболевание, послужившее причиной онихолизиса. При развитии лекарственного онихолизиса рекомендуется с помощью гастроэнтеролога откорректировать работу пищеварительной системы, поскольку отслойка ногтя происходит в результате недостатка минералов и витаминов, без которых невозможен нормальный рост ногтя. При травматическом онихолизисе с частичным отслоением небольшой площади ногтя осуществляют ежедневное состригание отслоившегося участка с дезинфекцией и защитой ногтевого ложа антибактериальным пластырем.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Большое по площади отслоение лечат хирургическим путём, накладывают повязки с антибактериальными и антисептическими растворами. В процессе операции удаляют гиперкератотические наслоения, гематомы и грязь. Ноготь восстанавливают с помощью длительного применения желатиновых растворов различной концентрации. При онихолизисе бактериальной или микотической природы дополнительно используют спиртовые растворы анилиновых красок, антибактериальные и антимикотические препараты. Пациентам с онихолизисом показаны витамины, препараты железа и кальция, общеукрепляющие средства. Противопоказан контакт с водой, косметическими лаками и бытовой химией. </span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактические меры по предотвращению развития онихолизиса включают в себя своевременное лечение хронических и острых системных заболеваний, полноценное питание, прием витаминов и иные меры по укреплению иммунитета. Рекомендуется соблюдение следующих защитных и гигиенических процедур:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">бережный уход за ногтями;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">использование специальных средств, призванных защищать ногти и кожу во время работы с агрессивными химическими реагентами, бытовой химией;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">использование качественных и безопасных косметических средств.</span></li>\r\n</ul>\r\n<p> </p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиническая картина заболевания одинакова при всех типах патологии: ногтевая пластина отделяется от ложа со свободного края в дистальном или боковых отделах до луночки ногтя. Окраска пластинки меняется с телесной на серо-белую из-за попадания воздуха в подногтевой промежуток. При развитии в образовавшемся свободном пространстве патогенной микрофлоры возможно дальнейшее изменение цвета: желтый становится результатом бактериальных инфекций, коричневый – формирования колонии микрогрибов, зеленый – поражения синегнойной палочкой.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Бактериальные инфекции влияют на структуру и прочность ногтевой пластинки. Поверхность ногтей теряет блеск, становится шероховатой и постепенно деформируется. Подногтевое пространство наполняется грязью и кератином. Это приводит к развитию гиперкератоза, характеризующегося неприятным запахом. При запущенных стадиях патологии может развиться очаг вторичного воспаления. Отслоение части ногтя называется частичным онихолизисом, всей пластинки – тотальным.</span></p>",
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