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"lead": "острое воспалительное зудящее заболевание кожи, возникающее вследствие проникновения в нее личинок шистосомных паразитов при купании в пресноводных водоемах",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Обычно это заболевание является результатом внедрения церкариев (личинок) трематод, паразитирующих в организме водоплавающих птиц, а человек в данном случае выступает в роли «случайного хозяина». Неприспособленность личинок паразита к условиям человеческого организма во многом обуславливает особенности течения шистосоматидного дерматита.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чаще всего церкарии обнаруживаются в теплых мелководных водоемах с пресной застойной водой. Обязательным условием является обитание в озере некоторых видов моллюсков, выступающих в качестве промежуточного хозяина для трематод – в их организме происходит превращение мирацидиев в церкарии. При купании человека в таком водоеме личинки паразита сначала прикрепляются к поверхности кожи, а затем при помощи грызущего аппарата проникают в ее толщу.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Причиной заражения человека является способность церкарий шистосоматид активно проникать через кожные покровы. Церкарии вызывают механические (часто множественные) поражения кожных покровов и оказывают токсическое и сенсибилизирующее воздействия на организм человека, способствуют заносу вторичной инфекции. Особенно тяжело церкариозы протекают у детей.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В местах внедрения церкариев в кожу человека развиваются отеки с лизисом клеток эпидермиса. По мере миграции церкариев в кориуме возникают инфильтраты из лейкоцитов и лимфоцитов. В результате развившейся иммунологической реакции шистосоматиды в коже человека погибают, и дальнейшее их развитие прекращается.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В диагностике шистосоматидного дерматита используют метод дерматологического осмотра, расспрос и изучение анамнеза больного, в спорных случаях может быть произведена биопсия кожи на пораженных участках и гистологическое исследование.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Анамнез и объективные данные. Больные шистосоматидным дерматитом жалуются на упорный кожный зуд, болезненность и жжение в области поражения. При расспросе выясняется, что первые симптомы заболевания проявились вскоре после купания в пресноводном водоеме. При осмотре выявляют эритематозную сыпь в виде красных пятен диаметром 1-4 миллиметра, при более тяжелом течении заболевания могут определяться папулы размером 2-4 миллиметра.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Морфологическое исследование. Гистологическая картина при шистосоматидном дерматите представлена признаками неспецифического воспаления (расширение артериол, отек, нейтрофильная инфильтрация) и лизисом клеток эпидермиса. Иногда под микроскопом можно обнаружить церкарии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Прочие анализы. Изредка на фоне развития церкариоза возникает шистосомоз мочевыделительных путей, кишечника или других органов, поэтому рекомендуется произвести анализ кала и мочи на яйца этих паразитов.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"treatment": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение шистосоматидного дерматита обычно неспецифическое, направлено на уменьшение активности аллергической и иммунологической реакции организма. Используют антигистаминные средства, в тяжелых случаях назначают препараты кальция и глюкокортикоиды. Наружно для уменьшения болезненности наносят анестетики (масляный раствор анестезина, лидокаин), для облегчения зуда и снижения воспалительных проявлений применяют цинковую мазь. В случае обнаружения шистосомоза назначают комплексную антигельминтную терапию.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В целях личной профилактики церкариозов при контактах с водой водоемов (при купании, стирке белья, играх в воде, рыбной ловле и т.д.) следует:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">избегать заросших водной растительностью мелководных участков водоемов (или их зон), где обитают утки (более безопасны прибрежные зоны, лишенные водной растительности);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при необходимости длительного пребывания в воде применять защитную одежду и обувь (сапоги, брюки, рубашку), предохраняющие от нападения церкарий шистосоматид;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">после контакта с водой в «подозрительной» зоне водоема тщательно вытереть кожу жестким полотенцем или сухой тканью и</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">быстро сменить промокшую одежду.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Общественная профилактика церкариозов включает:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">оснащение внутренних городских водоемов, где имеется риск заражения людей церкариями, указателями, запрещающими купание и игры в воде;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">регулирование (снижение) численности кряквы в городских водоемах, используемых в рекреационных целях;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">регулярную очистку водоемов (или наиболее посещаемых населением участков водоемов) от водной растительности.</span></li>\r\n</ul>\r\n<p> </p>",
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},
"code": "B66.1",
"name": "Клонорхоз",
"icd_name": "Клонорхоз",
"gender": 0,
"age_min": 1,
"age_max": 100,
"cause": [
"7"
],
"periodicity": 3,
"slug": "b66.1_klonorhoz",
"lead": "хронически протекающая глистная инвазия с преимущественным поражением протоков печени и поджелудочной железы",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возбудитель гельминтоза – двуустка китайская. Источниками инфекции служат люди и млекопитающие, путь передачи алиментарный. Взрослые черви обычно живут в желчных протоках окончательных хозяев, яйца выделяются с фекалиями. Пресноводные улитки могут служить первыми промежуточными хозяевами. Яйца в воде развиваются в мирацидии, а после проглатывания улитками – в спороцисты, редии и церкарии. Зрелые церкарии свободно плавают в воде, вторгаются во вторых промежуточных хозяев (пресноводных рыб) через кожу, а затем образуют метацеркарии в мускулатуре рыбы.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основными факторами риска клонорхоза являются работа в учреждениях общественного питания, рыболовном промысле и фермерских хозяйствах, низкая организованность социально-бытовых условий, малый размер доходов населения. Пораженность рыб метацеркариями в разных регионах варьируется от 7 до 102 пресноводных видов. Одним из свойств гельминта является длительное (до 40 лет) персистирование в организме без лечения, а также связь с формированием фиброза и злокачественных перерождений гепатоцитов, ткани билиарных протоков. Частота инвалидности после перенесенной нозологии коррелирует с выраженностью симптомов.</span></p>",
"pathogenesis": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Механизмы патологического воздействия клонорхов до конца не изучены. Гельминт вызывает перидуктальную фиброплазию, начиная с 7-го дня болезни, активирует перекисное окисление липидов, что сопровождается повреждением ДНК клеток гепатобилиарного аппарата. Гепатоциты подвергаются гидропической дегенерации, подавляется апоптоз аномальных клеток, что способствует опухолевому росту. Поддержание хронического воспаления приводит к фиброзным изменениям тканей, образованию карцином.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Подтверждение диагноза проводится инфекционистом, необходим тщательный сбор эпидемиологического анамнеза за прошедшие десятилетия. Основными диагностическими лабораторно-инструментальными признаками инфекции являются:</span></p>\r\n<ul>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Физикальные данные. Объективный осмотр при клонорхозе нередко не выявляет патологических изменений. В ряде ситуаций при пальпации живота обнаруживается значимая гепатомегалия, болезненность в области желчного пузыря, вздутие, метеоризм, реже спленомегалия, субиктеричность склер. Обязательным является изучение мочи и кала (изменение оттенка, запаха, консистенции физиологических выделений).</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные исследования. В анализе крови определяется лейкоцитоз, эозинофилия до 80%, ускорение СОЭ. Обнаруживается повышение активности печеночных трансаминаз, ГГТП, щелочной фосфатазы, общего и прямого билирубина, триглицеридов; гипоальбуминемия. В анализе мочи выявляется изменение цвета, увеличение плотности, появление билиарных пигментов, уробилиногена, единичных лейкоцитов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выявление инфекционных агентов. Обязательно проведение копроовоскопии по методу Като либо формалин-эфирного обогащения с учетом того, что яйца клонорха имеют схожесть с яйцами описторха и других трематод.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Инструментальные методы. Малоинформативны при симптомах клонорхоза, но помогают в проведении дифференциального диагноза с опухолевыми процессами, холангитами иного происхождения. Рекомендуется УЗИ органов брюшной полости. В некоторых случаях выполняется тонкоигольная биопсия печеночной ткани, диагностическая лапароскопия.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p><span id=\"docs-internal-guid-806f11ce-7fff-493c-573e-5ae05b0ba34c\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Госпитализация пациентов с симптомами хронического клонорхоза осуществляется по клиническим и эпидемиологическим показаниям, при остром течении производится в обязательном порядке. При выраженных аллергических, холестатических симптомах, тяжелом преморбидном фоне назначается постельный режим. Диетические рекомендации связаны с нарушениями функции желчевыводящей системы, печеночной ткани. Показано частое дробное щадящее питание, исключается жирное, жареное, маринады, кофе, алкоголь, газированные напитки. Питьевой режим желательно увеличить в пользу кипяченой воды, зеленых сортов чая, несладких компотов, отвара шиповника.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Установленный диагноз клонорхоза позволяет начать лечение после предварительного этапа, заключающегося в подготовке организма к дегельминтизации в течение 10-14 дней. Необходимо соблюдение щадящей диеты, уточнение варианта дискинезии желчевыводящих протоков (гипер-, гипокинетический) для адекватного определения путей элиминации паразитов, прием патогенетических средств. Затем пациенты получают этиотропную терапию, в дальнейшем необходимо восстановление функций гепатобилиарной системы.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Однократный курс антигельминтных препаратов продолжительностью 7-21 день эффективен в 90-94% случаев инфекции, при длительном (более 10 лет) существовании паразита в организме курсовое лечение рекомендуется повторить. Перспективные препараты, такие как трибендимидин, обладают минимальными побочными действиями по сравнению с празиквантелем. Применяются следующие виды лечения:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Этиотропная терапия. Используются антигельминтные средства с доказанной активностью в отношении клонорхов – празиквантел и трибендимидин, назначаемые курсом перорально. Пациентов информируют о преходящих симптомах диспепсии, головных болях и головокружении, связанных с действием лекарственных форм и не требующих медикаментозной коррекции. В качестве альтернативы перечисленным средствам иногда выбирают гексахлорпараксилол.</span></li>\r\n<li><span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">Патогенетическое лечение. Показаны желчегонные препараты из группы холекинетиков, спазмолитики (дротаверин), средства инфузионной дезинтоксикации – глюкозо-солевые растворы, хлосоль, сукцинат-содержащие медикаменты. Широко применяются такие десенсибилизирующие средства, как препараты кальция, при выраженном аллергозе показаны антигистаминные и глюкокортикостероиды.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптоматическая терапия. Включает ферменты, энтеросорбенты, тюбажи с сульфатом магния, боржоми, сорбитом 1-2 раза в неделю. При симптомах присоединения вторичной флоры проводится бактериологическое исследование желчи и дуоденального содержимого, в схему лечения добавляют антибиотики. Для восстановления эвакуаторной функции кишечника рекомендуются пробиотики.</span></li>\r\n</ul>\r\n<p> </p>",
"prevention": "<p><span id=\"docs-internal-guid-41e5225e-7fff-e176-4a61-1f35d293501c\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">В районах, где поражено более 20% населения, следует проводить ежегодное профилактическое лечение жителей. Вакцина не разработана, некоторые исследования свидетельствуют о положительном иммунологическом эффекте при введении облученных метацеркариев мышам. К неспецифическим защитным мерам относят отказ от употребления сырых и недостаточно термически обработанных пресноводных рыб и моллюсков, раннее начало лечения больных, контроль над системами водоснабжения, водоотведения.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Инкубационный период при клонорхозе составляет 14 - 30 суток. Данное заболевание проходит в два этапа - острая и хроническая фаза.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Острая фаза может иметь стертое, легкое, среднетяжелое и тяжелое течение. При стертом течении болезнь может проявляться субфебрильной температурой тела.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Легкое течение характеризуется внезапным началом, повышением температуры тела до 38°C (держится около 2 недель), снижением работоспособности, появлением утомляемости, боли в животе, головокружения, слабости, а также послаблением стула.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При среднетяжелом течении наблюдается повышение температуры тела до 39°C (держится около 3 недель), возникновение боли в суставах и мышцах, появление высыпаний на коже, увеличение селезенки и печени. Также отмечается тошнота, рвота и послабление стула.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для тяжелого течения клонорхоза характерно значительное повышение температуры тела, возникновение заторможенности, головных болей, сыпи, пожелтения кожных покровов. При этом отмечаются интенсивные приступообразные боли в правом подреберье и в области желудка, послабление стула, тошнота, вздутие, рвота. Также при обследовании обнаруживается увеличение печени и селезёнки.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для хронической фазы клонорхоза характерно ощущение распирания и тяжести в правом подреберье и области желудка, появление тошноты, рвоты, снижение аппетита. Также возможно появление изжоги и привкуса горечи. Хроническая фаза клонорхоза характеризуется увеличением печени.</span></p>",
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}
]
}
