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"description": "Базалиома отличается довольно редким метастазированием и с первого взгляда кажется не таким опасным заболеванием, но это далеко не так. Без грамотной терапии она может привести к тяжелому поражению кожного покрова. При самом худшем прогнозе последствием базалиомы является разрушение подлежащих хрящевой и костной тканей.\r\nМеланомой кожи называют злокачественную опухоль, развивающуюся из пигментных клеток родинок. Чаще всего этот вид рака кожи характеризуется агрессивностью и плохими прогнозами.\r\n",
"etiology": "<p>Факторами риска развития рака кожи могут являться:</p>\r\n<ul>\r\n<li>ультрафиолетовое и ионизирующее излучение;</li>\r\n<li>воздействие химических канцерогенов, попадающих на кожу;</li>\r\n<li>курение;</li>\r\n<li>прием препаратов, ослабляющих иммунитет (иммуносупрессоров);</li>\r\n<li>семейная предрасположенность (генетические особенности организма).</li>\r\n</ul>",
"pathogenesis": "",
"diagnostics": "<p>Диагноз рака кожи устанавливается на основании клинических и лабораторных данных с обязательным проведением морфологического исследования (цитологического и гистологического). <br /><br /><br /></p>",
"treatment": "<p class=\"bodytext\">От стадии рака кожи напрямую зависит способ лечения.</p>\r\n<p class=\"bodytext\">Лечение локальных стадий подразумевает широкое иссечение опухолей в пределах здоровых тканей. При произведении резекции нужно отступить от видимой границы меланомы кожи на 1 см при толщине опухоли 1–2 мм по Бреслоу и 2 см при толщине — 2 мм. Лимфаденэктомия в профилактических целях не применяется. Можно провести биопсию так называемого сторожевого лимфоузла.</p>\r\n<p class=\"bodytext\">Так как гормонотерапия и профилактическая химиотерапия не улучшают результаты лечения, то применять их при меланоме кожи, симптомах ее проявления не следует. Возможно осуществление профилактической иммунотерапии при помощи препарата интерферон-а при наличии неблагоприятного прогноза (в связи с молодым возрастом, изъязвленной опухолью и т. д.).</p>\r\n<p class=\"bodytext\">Не рекомендуется использовать вне клинических исследований профилактическую иммунотерапию посредствам других цитокинов с включением препарата интерлейкин 2, а также иммунохимиотерапию, вакцинотерапию.</p>\r\n<p class=\"bodytext\">Лечение рака кожи локорегиональной стадии подразумевает одномоментное иссечение первичной опухоли и лимфаденэктомию (удаление всех лимфоузлов зоны и окружающей клетчатки). Для профилактики меланомы кожи в отдельных случаях можно применять иммунотерапию, лучевую или химиотерапию в зависимости от симптомов. Назначение подобного лечения надлежит осуществлять на консилиуме, на котором должны присутствовать лучевой терапевт и химотерапевт.</p>\r\n<p class=\"bodytext\">Лечение диссеминированной стадии при наличии метастазов в головном мозге предполагает нейрохирургическое удаление и / или стереотаксическое облучение. Если единичные метастазы присутствуют в легких, то можно использовать различные лечебные комбинации оперативной, химио- и иммунотерапии. Если есть болезненные метастазы в костях, то можно назначить обезболивающую лучевую терапию.</p>\r\n<p class=\"bodytext\">При лечении меланомы кожи со множественными метастазами одного или нескольких органов проводится системная химио- и иммунотерапия.</p>",
"prevention": "",
"clinical_picture": "<ul>\r\n<li>изменение размера: увеличение <a href=\"/symptom/pyatno_na_kozhe/\" title=\"Перейти на страницу симптома Пятно на коже\">родинки</a> в два и более раз за 6 мес.;</li>\r\n<li>изменение цвета: потемнение (до черного), осветление, появление просветления в центре и одновременное потемнение по краям, неоднородная пигментация;</li>\r\n<li>асимметрия формы;</li>\r\n<li>нечеткие границы: в данном случае <a href=\"/symptom/hloazma/\" title=\"Перейти на страницу симптома Хлоазма\">пигмент</a> плавно сливается с окружающей кожей, так что границы становятся смазанными;</li>\r\n<li>боли;</li>\r\n<li>изъязвление <a href=\"/symptom/pyatno_na_kozhe/\" title=\"Перейти на страницу симптома Пятно на коже\">родинки</a>;</li>\r\n<li><a href=\"/symptom/vypadenie_volos/\" title=\"Перейти на страницу симптома Выпадение волос\">выпадение волос</a>, если таковые имелись ранее на родинке.</li>\r\n</ul>",
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