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"periodicity": 1,
"slug": "t78.2_anafilakticheskiy_shok_neutochnennyy",
"lead": "резкая обостряющаяся, особо опасная аллергическая реакция",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Анафилактический шок – это тяжелая системная аллергическая реакция немедленного типа, развивающаяся при контакте с чужеродными веществами-антигенами (медикаментозными средствами, сыворотками, рентгеноконтрастными препаратами, пищевыми продуктами, при укусах змей и насекомых), которая сопровождается выраженными нарушениями кровообращения и функций органов и систем.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Непосредственной причиной развития шока становится попадание в организм человека сенсибилизированного аллергена, на который крайне остро и бурно реагирует иммунная система.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аллерген может иметь любую природу, и реакции зависят от генетической предрасположенности организма к анафилаксии. Помимо шока, могут развиваться также крапивница или отек Квинке (реакции этого же типа действия). Наиболее часто анафилактический шок провоцируют:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лекарственные препараты, средства для общего наркоза и местной анестезии, вакцинные препараты, сыворотки, гормональные средства, антибиотики, ферментные препараты. Кроме того, шоковые реакции возможны на введение препаратов для рентгено-контрастного исследования, проведения химиотерапии.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Яды жалящих насекомых или змей. Наиболее опасны укусы пчел и шершней, хотя возможны реакции на яд ос, шмелей, муравьев.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аллергены пищевых продуктов. Нередко анафилактические реакции вызывают белковые соединения из продуктов питания из «группы риска»: соя, морепродукты, белок яйца, молоко, арахис. Однако помимо самих продуктов, аллергенными могут быть искусственные добавки, которые попадают в пищу в ходе ее промышленной обработки. Наиболее опасны красители, некоторые консерванты (особенно сульфиты), а также средства, которыми обрабатывают плоды для транспортировки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Латексные изделия. Сок каучукового дерева, из которого производят некоторые латексные изделия, может сенсибилизировать иммунную систему. Опасны медицинские перчатки, шины, различные типы катетеров, презервативы. В некоторых случаях отмечаются перекрестные реакции на экзотические фрукты (киви, авокадо, банан).</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Влияние физических факторов. Редкие варианты анафилактического шока – это влияние экстремальных физических факторов (перегрев, замерзание, высокоинтенсивные нагрузки), провоцирующие образование в организме особых белков, которые провоцируют реакции иммунной системы. Такие реакции чаще бывают не изолированными, а сочетаются с одновременным приемом некоторых видов пищи (морепродукты, курица, орехи, фрукты). По отдельности реакции возникают редко, а сочетание белков может грозить шоком.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В основе патогенеза анафилактического шока лежит так называемая гиперчувствительность иммунной системы, развивающаяся по немедленному типу (в период от 30 секунд до 60-90 минут).Причем это генерализованная (то есть общая) реакция со стороны всего организма, связанная с выделением большого количества реагинов – иммуноглобулинов типа Е на фоне образования комплекса аллерген-антитело. Реагины стимулируют быстрый выброс в кровь воспалительных медиаторов (веществ, провоцирующих острое воспаление) – особенно гистамина, лейкотриенов, брадикинина и факторов хемотаксиса. Эти вещества влияют на стенки сосудов, состав крови, реакции нервной системы, сердца, пищеварения и кожи.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для анафилактического шока характерно резкое снижение тонуса сосудов, что приводит к резкому снижению давления, нарушению кровоснабжения мозга и развитию обморока. Кроме того, возникает острая сердечно-сосудистая недостаточность, спазм гладких мышц в бронхах, что провоцирует еще и недостаточность дыхания. Из-за острой гипоксии страдает работа пищеварения, кожи, органов малого таза, синтез гормонов и функции головного мозга. Без оказания немедленной помощи прогрессирующее течение анафилактического шока может закончиться летальным исходом.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагноз анафилактического шока устанавливается преимущественно по клинической симптоматике, так как времени на подробный сбор анамнестических данных, проведение лабораторных анализов и аллергологических проб не остается. Помочь может лишь учет обстоятельств, во время которых наступила анафилаксия – парентеральное введение лекарственного средства, укус змеи, употребление в пищу определенного продукта и т. д.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Во время осмотра оценивается общее состояние больного, функция основных органов и систем (сердечно-сосудистой, дыхательной, нервной и эндокринной). Уже визуальный осмотр пациента с анафилактическим шоком позволяет определить ясность сознания, наличие зрачкового рефлекса, глубину и частоту дыхания, состояние кожных покровов, сохранение контроля над функцией мочеиспускания и дефекации, наличие или отсутствие рвоты, судорожного синдрома. Далее определяются наличие и качественные характеристики пульса на периферических и магистральных артериях, уровень артериального давления, аускультативные данные при выслушивании тонов сердца и дыхания над легкими.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">После оказания неотложной помощи пациенту с анафилактическим шоком и ликвидации непосредственной угрозы для жизни проводятся лабораторные и инструментальные исследования, позволяющие уточнить диагноз и исключить другие заболевания со сходной симптоматикой:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные тесты. При проведении лабораторного общеклинического обследования выполняют клинический анализ крови (чаще выявляется лейкоцитоз, увеличение количества эритроцитов, нейтрофилов, эозинофилов), оценивается выраженность респираторного и метаболического ацидоза (измеряется pH, парциальное давление углекислого газа и кислорода в крови), определяется водно-электролитный баланс, показатели системы свертывания крови и др.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Аллергологическое обследование. При анафилактическом шоке предусматривает определение триптазы и ИЛ-5, уровня общего и специфического иммуноглобулина E, гистамина, а после купирования острых проявлений анафилаксии – выявление аллергенов с помощью кожных проб и лабораторного исследования.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Инструментальная диагностика. На электрокардиограмме определяются признаки перегрузки правых отделов сердца, ишемия миокарда, тахикардия, аритмия. На рентгенограмме органов грудной клетки могут выявляться признаки эмфиземы легких. В острый период анафилактического шока и в течение 7-10 дней проводится мониторинг артериального давления, частоты сердечных сокращений и дыхания, ЭКГ. При необходимости назначается проведение пульсоксиметрии, капнометрии и капнографии, определение артериального и центрального венозного давления инвазивным методом.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечебные мероприятия при анафилактическом шоке направлены на скорейшее устранение нарушений функции жизненно важных органов и систем организма. В первую очередь необходимо устранить контакт с аллергеном (прекратить введение вакцины, лекарственного средства или рентгеноконтрастного вещества, удалить жало осы и т. п.), при необходимости – ограничить венозный отток путем наложения жгута на конечность выше места введения лекарства или ужаления насекомым, а также обколоть это место раствором адреналина и приложить холод. Необходимо восстановить проходимость дыхательных путей (введение воздуховода, срочная интубация трахеи или трахеотомия), обеспечить подачу в легкие чистого кислорода.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Проводится введение симпатомиметиков (адреналина) подкожно повторно с последующим внутривенным капельным введением до улучшения состояния. При тяжелой форме анафилактического шока внутривенно вводится допамин в индивидуально подобранной дозе. В схему неотложной помощи включаются глюкокортикоиды (преднизолон, дексаметазон, бетаметазона), проводится инфузионная терапия, позволяющая восполнить объем циркулирующей крови, устранить гемоконцентрацию и восстановить приемлемый уровень артериального давления. Симптоматическое лечение включает использование антигистаминных средств, бронхолитиков, диуретиков (по строгим показаниям и после стабилизации АД).</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Стационарное лечение пациентов с анафилактическим шоком проводится в течение 7-10 дней. В дальнейшем необходимо наблюдение для выявления возможных осложнений (поздние аллергические реакции, миокардит, гломерулонефрит и т. д.) и их своевременного лечения.</span></p>",
"prevention": "",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Развитие шока зависит от возраста, особенностей пациента и сенсибилизации к конкретному веществу. Кроме того, течение анафилактического шока зависит от того, какой из органов станет «шоковым», и какая симптоматика будет преобладать в клинике. Наиболее часто поражаются кожные покровы, респираторный тракт, сосуды и сердце, головной мозг.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Типичны следующие симптомы:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">резкое снижение давления, сопровождающееся слабостью, обмороком, головокружением, ощущением дурноты;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушения работы сердца с развитием тахикардии, аритмий, боли за грудиной, страха смерти, участков ишемии миокарда (микроинфаркты);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">респираторные расстройства – одышка, хрипы, свисты при дыхании, спазм бронхов, асфиксия (удушье);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">проблемы нервной системы – головная боль, возбуждение, тревога и страх, судороги;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">непроизвольное отхождение мочи и стула;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сыпь на коже, отечность, краснота.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Стадии развития шока:</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Во многом тяжесть состояния и риски для жизни, осложнения будут зависеть от стадии процесса. Выделяется 4 степени тяжести анафилактического шока.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При первой стадии давление снижается в пределах 40 мм рт. ст., не нарушается сознание, возникает кашель, боль в груди, ощущение жара, беспокойство, кожные высыпания.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При второй степени давление снижается в пределах 80-60 мм рт. ст. 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"code": "F10.6",
"name": "Амнестический синдром",
"icd_name": "Амнестический синдром",
"gender": 0,
"age_min": 30,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "f10.6_amnesticheskiy_sindrom",
"lead": "психическое расстройство, возникающее вследствие органического поражения головного мозга и характеризующееся грубыми расстройствами памяти при отсутствии интеллектуальных нарушений",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Преимущественно амнестический синдром возникает при поражении медиальных и диэнцефальных височных образований (например, сосочковых тел, свода головного мозга).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Часто фактором, порождающим развитие описываемой патологии, является таламическая недостаточность, вызванная хроническим алкоголизмом. Другими факторами, вызывающими данное нарушение, могут быть мозговые травмы, дегенеративные изменения, опухолевые процессы и церебральная гипоксия.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ниже представлены факторы, провоцирующие развитие амнестического синдрома:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">опухолевые процессы в мозге;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">дефицит тиамина, вызванный продолжительным голоданием, карциномой желудка, алкогольной интоксикацией;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">повреждение головы с поражением коры мозга;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">субарахноидальные кровоизлияния, обусловленные разрывом аневризмы, гипертонической болезнью, артериовенозной мальформацией;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сосудистые патологии (двусторонний гиппокампальный некроз, наступивший вследствие закупорки из-за эмболии артерии или в результате тромбоза);</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">интоксикация окисью изониазидом, углерода, мышьяком, свинцом;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">дегенеративные церебральные заболевания, например, сенильная деменция либо патология под названием болезнь Альцгeймера;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гематомы или гипоксия мозга, возникшая вследствие разнообразных причин;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">двустороннее поражение области лимбической системы (гиппокампа), порожденное оперативным вмешательством;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">вследствие инсулинокоматозной терапии;</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">перенесение внутричерепных инфекций, энцефалита, менингита.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Развитие кратковременных амнестических эпизодов наблюдается при обмороках, преходящих патологиях мозгового кровообращения и инсультах.</span></p>",
"pathogenesis": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Точный механизм развития амнезии неизвестен. Считается, что функцию хранения и воспроизведения информации несут церебральные нейроны. В основе мнестических нарушений органического генеза лежит разрушение межнейрональных сообщений, дисфункция нейронов. Возможна полная утрата имеющейся в мозге информации, обусловленная гибелью хранящих её структурных элементов. Психогенная амнезия имеет иной механизм формирования. В литературе по неврологии и психиатрии авторы объясняют его как утрату способности восстановить в памяти определённую информацию. Типичным является избирательное выпадение из памяти отдельной группы взаимосвязанных событий, имеющих субъективный внутренний смысл для больного.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностика амнестического синдрома требует участия нескольких специалистов, в зависимости от основной картины заболевания. К работе привлекается невролог, нарколог, нейрохирург, инфекционист, при необходимости проводится консультация психиатра. Для определения патологии используется:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Изучение истории болезни на основании данных опроса больного и его близких родственников, а также предоставленной медицинской документации.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Оценка состояния нервной системы. Она помогает определить наличие или исключить органические поражения мозга, последствия черепно-мозговой травмы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Оценка психического состояния. Проводится у людей с подозрением на психогенную амнезию и с симптомами психического расстройства.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исследования особенностей кровообращения ЦНС при вероятном сосудистом нарушении. Для этого проводится РЭГ, УЗДГ сосудов головы, МРТ.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При черепно-мозговой травме назначается КТ или МРТ головного мозга. Данные способы помогают с высокой точностью определить наличие, размеры и локализацию опухоли, гематомы, дегенерации тканей, очагов поражения после инсульта.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ЭЭГ используется с целью определения патологической электрической активности мозга при эпилептических припадках.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные анализы крови и мочи. Позволяет провести тест на наркотики, определить уровень витамина B1, наличие токсических веществ в организме.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исследование ликвора. Забор цереброспинальной жидкости и ее анализ используется при инфекционном происхождении амнестического синдрома или внутричерепного кровоизлияния.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Целью оказания помощи пациенту с потерей памяти является ее восстановление или стабилизация состояния с достижением длительной ремиссии. Амнестический синдром не имеет определенной схемы лечения. Каждый больной получает индивидуальный план оказания помощи. Он зависит от причины развития нарушения, особенностями проявления. При органической форме используется преимущественно прием медикаментов или хирургическое вмешательство, а при психогенной – психотерапия. Из препаратов чаще всего применяются:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 8pt; font-family: Verdana; color: #434343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сосудистые средства для снижения вязкости крови и расширения микроциркуляторного русла и улучшения церебрального кровотока;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 8pt; font-family: Verdana; color: #434343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нейропротекторы, ноотропы и антиоксиданты для улучшения метаболизма в клетках мозга, снижения их чувствительности к ишемии, нормализации когнитивных функций;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 8pt; font-family: Verdana; color: #434343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">антихолинэстеразные средства и препараты гинкго билобы при деменции с целью снижения прогрессирования слабоумия у стариков и повышения дневной активности;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 8pt; font-family: Verdana; color: #434343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">при болезни Альцгеймера применяют мемантины для улучшения мнестических функций.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У больного с психическими нарушениями используются антидепрессанты, нейролептики, транквилизаторы, нормотимики. Они помогают нормализовать поведение, восстановить контроль за биологическим ритмом, улучшить настроение при депрессии, устранить беспокойство, фобию, тревогу.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При обнаружении опухоли, гематомы или кисты в мозге прибегают к ее оперативному удалению. Методы психотерапии позволяет в совокупности с приемом лекарств добиться ускорения восстановления памяти больного. При отсутствии органических нарушений помогает вернуть воспоминания гипнотерапия. У данных пациентов практикуется когнитивно-поведенческая методика, которая позволяет выявить негативные мыслительные догмы и заменить их позитивными. С ее помощью человек проще относится к своей проблеме и это помогает ему ускорить выздоровление.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При психогенной форме амнезии целью лечения становится не столько возвращение памяти, сколько помощь в принятии больным ее потери. Метод психоанализа устраняет психотравмы, идущие из глубокого детства, а семейная терапия улучшает отношения между близкими и способствует оптимизации прогноза при амнестическом синдроме. У людей с отсутствием склонности к демонстрации своих чувств и переживаний помогает креативные виды лечения в виде арт-терапии, сказкотерапии. Помощь алкоголикам с амнезией оказывается в виде применения витаминов и средств для детоксикации организма.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактика амнестического синдрома включает предупреждение травм головы, инфекций, интоксикаций, психотравмирующих воздействий, корректное и своевременное лечение мигрени, эпилепсии, сосудистых расстройств.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Базовый симптом – невозможность вспомнить произошедшие обстоятельства. Утрата воспоминаний касается определённого временного промежутка в жизни пациента. Последовательность описана законом Рибо: вначале забывается то, что произошло недавно, затем факты ближайшего прошлого, потом – более давние события. Восстановление памяти происходит в обратном порядке. Иногда отмечаются конфабуляции – вымышленные воспоминания, которыми больной пытается заполнить образовавшиеся пробелы в памяти. Амнестический симптомокомплекс наблюдается в сочетании с другими проявлениями, свойственными основному заболеванию.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постинсультная амнезия сочетается с гипомнезией (общим снижением памяти на события настоящего), парамнезией (путаницей обстоятельств прошлого и настоящего), расстройствами речи, двигательным дефицитом. Амнезия, являющаяся составной частью психоорганического синдрома, проявляется на фоне когнитивных расстройств: снижения способности усваивать информацию, уменьшения внимательности, замедленности мышления. Диссоциативной потере памяти сопутствует рассеянность, возможны аффективные состояния, бродяжничество. Транзиторная глобальная амнезия характеризуется преходящими эпизодами вплоть до дезориентации больного. Комбинирование различных типов амнезии характерно для синдрома Корсакова.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Стационарное расстройство тяжело переживается пациентами, провоцирует формирование ложного чувства вины, развитие депрессии. Прогрессирующая амнезия приводят к утрате трудоспособности. Больные забывают дорогу домой, неспособны ориентироваться в знакомой ранее местности. Из памяти исчезают приобретённые знания, навыки. В последующем наблюдается дезориентации во времени, в собственной личности. Пациент требует постоянного ухода.</span></p>\r\n<p> </p>",
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},
"code": "E85",
"name": "Амилоидоз",
"icd_name": "Амилоидоз",
"gender": 0,
"age_min": 0,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "e85_amiloidoz",
"lead": "системное заболевание, характеризующееся нарушением белкового обмена и функционирования иммунной системы",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Амилоидоз – это заболевание, которое сопровождается нарушением белкового обмена и работы иммунной системы. Последствием таких нарушений является амилоид - межклеточное отложение гомогенных белковых масс во всех без исключения органах организма и его тканях. Прогрессируя, он вытесняет и замещает здоровые клетки пораженного органа, тем самым обуславливая утрату гиподинамии, что зачастую провоцирует развитие дистрофии.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Данная форма заболевания характеризуется отложением амилоида во многих органах и тканях, причем причину его образования установить, как правило, не удается. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">В абсолютном большинстве случаев при первичном амилоидозе отмечается мутационное перерождение клеток иммунной системы и образование AL-амилоида, который накапливается в тканях мезодермального происхождения (в сердечно-сосудистой системе, мышцах, нервах и коже).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Другой причиной образования AL-амилоида может быть миеломная болезнь (плазмоцитома) – опухолевое заболевание, характеризующееся злокачественным перерождением и размножением плазмоцитов (дифференцированных В-лимфоцитов). Они выделяют аномальные глобулины в больших количествах, которые связываются с нуклеопротеидами плазмы и превращаются в амилоид.</span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вторичный амилоидоз</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вторичный амилоидоз характеризуется образованием АА-амилоида и развивается в результате длительно прогрессирующих воспалительных процессов, то есть всегда является осложнением других заболеваний.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Причиной вторичного амилоидоза могут быть:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хронические инфекции – малярия, лепра (проказа), сифилис, туберкулез и хронические неспецифические воспалительные заболевания легких, бронхоэктатическая болезнь, хронический пиелонефрит (инфекционное воспаление почечной ткани).</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хронические гнойные заболевания – остеомиелит (гнойное разрушение кости), длительное нагноение ран.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Неспецифический язвенный колит – воспалительное заболевание толстого кишечника.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Опухоли – лимфогранулематоз, лейкозы и другие опухоли системы крови.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Ревматологические заболевания – ревматоидный артрит, анкилозирующий спондилоартрит и другие.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вторичный амилоидоз может поражать практически любые органы и ткани в организме человека. Клиническая картина начинает проявляться через несколько лет (иногда через десятилетия) после начала основного заболевания и характеризуется нарушением функции того органа, в котором отложение амилоида наиболее выражено (обычно это почки и надпочечники, печень, селезенка, лимфатические узлы). По мере прогрессирования заболевания поражаются остальные органы, развивается полиорганная недостаточность и наступает смерть.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">К наследственному амилоидозу относится:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Периодическая болезнь (семейная средиземноморская лихорадка). Данное заболевание встречается преимущественно у арабов, армян и евреев. Клинически данная форма амилоидоза характеризуется приступами лихорадки (повышением температуры выше 39ºС, проливным потом, головными и мышечными болями), сопровождающимися воспалением серозных оболочек организма – брюшины (оболочки органов брюшной полости), плевры (оболочки легких) и синовиальных оболочек (выстилающих внутренние поверхности суставов). Часто отмечаются психические отклонения.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Семейный нефропатический амилоидоз (английский амилоидоз, болезнь Макла и Уэллса). Характеризуется приступами лихорадки, крапивницей и нарушением слуха (вплоть до глухоты).</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственный нейропатический амилоидоз. Для данной формы заболевания характерно поражение нервной ткани различной локализации. Могут поражаться нервы ног (португальский амилоидоз) или рук (американский амилоидоз), а также встречается сочетанное поражение нервной системы, почек и роговицы глаза (финский амилоидоз). </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственный кардиопатический амилоидоз. Встречается преимущественно у жителей Дании и по клиническим проявлениям схож с первичным генерализованным амилоидозом.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">К старческому амилоидозу относится:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Старческий церебральный (мозговой) амилоидоз. Встречается при болезни Альцгеймера и характеризуется отложением амилоида типа Ab в ткани головного мозга.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Старческий сердечный амилоидоз. Характеризуется поражением сердечной мышцы, причем при разных формах данного заболевания образуются разные типы амилоида. Так, в состав амилоида может входить мутантная форма транстиретина (белка крови, в норме транспортирующего гормон щитовидной железы тироксин и витамин А в организме), что характеризуется преимущественным поражением желудочков сердца. В другом случае амилоид может образовываться из предсердного натрийуретического пептида (гормона, выделяющегося клетками сердца), что характеризуется отложением амилоида преимущественно в области предсердий. В обоих случаях депозиты амилоида обнаруживаются и в тканях других органов (селезенки, легких, поджелудочной железы).</span></li>\r\n</ul>\r\n<p><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 8pt; margin-bottom: 8pt;\" dir=\"ltr\"><span style=\"font-size: 7.5pt; font-family: Verdana; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Развитие амилоидоза связано с нарушением белково-синтетической функции ретикуло-эндотелиальной системы, накоплением в плазме крови аномальных белков, служащих аутоантигенами и вызывающих образование аутоантител.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 8pt; margin-bottom: 8pt;\" dir=\"ltr\"><span style=\"font-size: 7.5pt; font-family: Verdana; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">В результате взаимодействия антигена с антителом происходит осаждение грубодисперсных белков, участвующих в образовании амилоида. Откладываясь в тканях, амилоид вытесняет функциональные элементы органа, что ведет к гибели этого органа.</span></p>\r\n<p><span style=\"font-size: 7.5pt; font-family: Verdana; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для постановки диагноза необходимо провести всестороннее обследование организма:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">лабораторные анализы (кровь, моча, кал);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ЭКГ;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рентген грудной клетки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ брюшной полости.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Самый информативный метод диагностики заболевания —биопсия органов.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Отсутствие полноты знаний об этиологии и патогенезе заболевания обусловливают трудности, связанные с лечением амилоидоза. При вторичном амилоидозе важное значение имеет активная терапия фонового заболевания. Рекомендации по питанию предполагают ограничение приема поваренной соли и белка, включение в рацион сырой печени. Симптоматическая терапия амилоидоза зависит от наличия и выраженности тех или иных клинических проявлений. В качестве патогенетической терапии могут назначаться препараты 4-аминохинолинового ряда (хлорохин), диметилсульфоксид, унитиол, колхицин. Для терапии первичного амилоидоза используются схемы лечения цитостатиками и гормонами (мельфолан+преднизолон, винкристин+доксорубицин+дексаметазон). При развитии ХПН показан гемодиализ или перитонеальный диализ. В отдельных случаях ставится вопрос о трансплантации почек или печени.</span></p>\r\n<p><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"prevention": "<p><span id=\"docs-internal-guid-6eaffb40-7fff-24f8-b308-a1c9a348db23\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Для профилактики амилоидоза почек необходимо своевременное лечение любой хронической патологии, которая может привести к развитию заболевания. В качестве его профилактики необходимо отказаться от употребления алкоголя и курения, правильно питаться и вести здоровый образ жизни. Кроме того, необходимо избегать контакта с токсическими веществами, а также необоснованного приема лекарственных препаратов.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Симптомы первичного амилоидоза:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Миастения с последующей атрофией мышц;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Диспепсия и диарея;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Патология мочеполовой и репродуктивной системы;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Поражение органов зрения.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вторичный</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Является осложнением какого-либо воспалительного заболевания. Причиной его появления могут стать:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хронические инфекционные заболевания: пиелонефрит, туберкулез, бронхоэктатическая болезнь, малярия, сифилис или проказа (лепра);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Хронические гнойные заболевания: остеомиелит, гнойные язвы и раны;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Язвенный колит – воспаление толстой кишки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Опухолевые поражения органов кроветворения: лейкоз, лимфогранулематоз и т.д.;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Ревматологическая патология: различные артриты и прочее.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Вторичный амилоидоз образуется во внутренних органах. Наблюдается нарушение деятельности органов с наибольшим отложением амилоида – в области почек, селезенки, печени или лимфоузлов. В дальнейшем поражение распространяется на остальные органы с последующим смертельным исходом.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственный</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Подобная форма образуется из-за генетических аномалий в клетках иммунной системы, приводящих к появлению амилоидобластов. Подобная патология диагностируется в некоторых национальных группах или в определенной географической области. К наследственной форме можно отнести:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Периодическая болезнь – семейная лихорадка Средиземноморья;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Семейный нефропатический или английский амилоидоз;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственный нейропатический амилоидоз – португальский, американский или финский;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Наследственный кардиопатический или датский амилоидоз.</span></p>\r\n</li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Старческий</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Системный подход позволяет выявить данную патологию у людей после 80 лет. В нее входит:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Церебральный или мозговой амилоидоз. Диагностируется при болезни Альцгеймера;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #333333; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 7pt; color: #000000; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Амилоидоз сердца. Поражает сердечную мышцу. Отложения образуются также в легких, печени и поджелудочной железе.</span></p>\r\n</li>\r\n</ul>",
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"image_alt": "Амилоидоз кожи",
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"danger": 51,
"published": 1,
"parent": null,
"block_rubric": 52,
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