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"pathogenesis": "<p>Роды – это естественный процесс, ряд ритмичных, усиливающихся сокращений матки (схваток), в результате которых плод постепенно перемещается через шейку матки (нижнюю часть матки) и влагалище (родовой канал) наружу.</p>",
"diagnostics": "<p>Когда женщина, начавшая рожать (с сильными схватками с интервалами 5 минут или меньше и расширением шейки матки более 4 см), поступает в роддом, измеряют ее вес, артериальное давление, пульс, частоту дыхания и температуру тела, а также берут мочу и кровь для анализа. Врач обследует живот женщины, чтобы определить, насколько велик плод, как он расположен в матке (положение плода) и какая часть тела находится у шейки матки – головка, ягодицы или плечо (предлежание). Врач выслушивает сердцебиение плода стетоскопом. Отмечается сила, продолжительность и частота сердечных сокращений плода. Обычно обследуется влагалище, чтобы определить, разорвались ли плодные оболочки и насколько расширена и сглажена шейка матки; но это обследование может не проводиться, если у женщины происходит кровотечение или оболочки разорвались ранее</p>",
"treatment": "<p>Как правило, женщины рожают в медицинских учреждениях, но некоторые желают рожать дома. Врачи обычно не рекомендуют роды в домашних условиях, поскольку не исключены неожиданные осложнения, которые включают внезапную отслойку плаценты, нарушение состояния плода (обычно вызываемое недостаточной доставкой кислорода к плоду во время родов), недиагностированную многоплодную беременность и послеродовые осложнения, например послеродовое кровотечение. Роды в домашних условиях возможны только у женщин, которые уже перенесли по крайней мере одну неосложненную беременность и роды. При таких родах должен присутствовать врач или акушерка, предпочтительно тот же самый медицинский работник, который ранее уже обеспечивал пренатальную (во время беременности) медицинскую помощь. Если возможно, дом должен быть расположен около больницы; если женщина живет слишком далеко, это может быть дом родственника или подруги. На всякий случай заранее должен быть составлен план быстрой транспортировки из дома в больницу.</p>\r\n<full></full>\r\n<p>На первой стадии (периоде) родов женщине обычно рекомендуют воздержаться от напряжения (потуг) брюшного пресса, поскольку оно до полного раскрытия шейки матки является пустой тратой энергии и может привести к разрыву шейки матки. Частота сердечных сокращений матери и плода проверяется каждые 15 минут. Наиболее простым способом определить угрожающее состояние плода является мониторинг частоты его сердцебиения, который проводится с помощью специального прибора (фиброфетоскопа) или электронного устройства. Если частота сердцебиений плода становится слишком высокой или, наоборот, низкой, врач может провести кесарево сечение, воспользоваться щипцами или принять другие меры: предложить женщине повернуться на левый бок, увеличить количество вводимой внутривенно жидкости или дать кислород через носовые трубки (катетеры).</p>\r\n<p>На второй стадии (периоде) родов женщина, за которой постоянно наблюдают, тужится при каждой схватке, что способствует продвижению плода по родовым путям. Частота сердцебиений плода проверяется после каждого сокращения матки (схватки) или каждые 3 минуты, если схватки возникают реже.</p>\r\n<p>Когда женщина рожает в роддоме, она может быть переведена из предродовой палаты в родовую (небольшую комнату, используемую только для приема родов) или оставаться в индивидуальном родильном блоке. Внутривенное вливание продолжают. Мужа или других лиц, оказывающих поддержку женщине при родах, просят ее сопровождать.</p>\r\n<p>В родовой палате женщина занимает полусидячее положение – промежуточное между положением лежа и сидя. Спиной она опирается на подушку или спинку кровати (кресла). Полусидячее положение позволяет использовать силу тяжести – давление, которое оказывает плод под действием силы тяжести, – помогая постепенному растяжению родового канала и промежности (области между входом во влагалище и задним проходом) с меньшей опасностью разрывов тканей. Такая поза также позволяет женщине меньше напрягать спину и таз. Некоторые женщины предпочитают рожать лежа, однако родоразрешение в этой позе может быть более длительным и более вероятно, что может потребоваться акушерское пособие. Патологическое учащение или замедление частоты сердцебиений реже отмечаются у детей, рожденных женщинами, находившимися во время родов в полусидячем положении, чем у новорожденных, матери которых рожали лежа.</p>\r\n<p>В процессе родов врач и акушерка проводят влагалищное обследование продвижения головки плода. Мать просят наклоняться вперед и тужиться при схватках, чтобы облегчить перемещение головки плода вниз через таз, растяжение влагалища и появление головки. Когда из влагалища появляется головка плода приблизительно на 3-5 см, врач или акушерка кладут руку на нее во время схваток, чтобы контролировать и, если необходимо, слегка замедлять продвижение плода. Головку и подбородок плода высвобождают из влагалища для предотвращения разрыва тканей у матери. Это вмешательство помогает облегчить родоразрешение.</p>\r\n<p>После того как появилась головка плода, его туловище поворачивают боком, что облегчает прохождение плечиков. Остальная часть тела ребенка обычно выходит быстро. Из носа, полости рта и глотки новорожденного отсасывают слизь и жидкость. Пуповину пережимают в двух местах и рассекают между зажимами, чтобы предотвратить кровотечение из ее концов. Затем новорожденного обертывают в пеленки или легкое одеяло и помещают на живот матери или в нагретую кроватку.</p>\r\n<p>После рождения ребенка врач или акушерка осторожно кладут руку на живот матери, чтобы удостовериться, что матка сокращается. Во время первой или второй схватки после родов плацента обычно отделяется от стенки матки, и вскоре изливается кровь. Обычно после этого плацента выходит сама в результате потуг матери. Если этого не происходит и появляется обильное кровотечение, врач или акушерка интенсивно надавливают женщине на живот, что вызывает отделение плаценты от матки и ее выход. Если плацента не отделяется или выходит не полностью, врач или акушерка удаляет ее оставшиеся части из матки с помощью операции, называемой ручным отделением плаценты.</p>\r\n<p>Как только плацента вышла из влагалища, женщине вводится окситоцин, а живот периодически массируется, чтобы стимулировать сокращения матки. Эти сокращения необходимы, чтобы предотвратить дальнейшее кровотечение из участка, где к матке была присоединена плацента.</p>\r\n<p>Врач зашивает разрез, сделанный при эпизиотомии, и все другие возможные разрывы шейки матки или стенки влагалища. Затем женщину переводят в послеродовую палату или оставляют в индивидуальном родильном блоке; новорожденный, который не нуждается в медицинской помощи, остается с матерью. Как правило, мать, ребенок и отец на 3-4 часа остаются вместе в теплом отдельном помещении, что способствует их сближению. Многие матери начинают кормление грудью вскоре после родов. Потом ребенка передают в отделение новорожденных. Во многих больницах мать может попросить оставить ребенка с ней. В стационарах с индивидуальными родильными блоками это даже требуется. При таком порядке мать кормит новорожденного, когда он выражает желание есть, и мать учится уходу за ребенком, пока находится в больнице. Если мать нуждается в отдыхе, она может оставить ребенка в отделении новорожденных.</p>\r\n<p>Поскольку осложнения, особенно кровотечение, как правило, возникают в течение первых 4 часов после родов (четвертая стадия родов), в это время за женщиной тщательно наблюдают.</p>",
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"code": "B48.1",
"name": "Риноспоридиоз",
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"lead": "хронический глубокий гранулематозный микоз, сопровождающийся поражением слизистой оболочки носа и носоглотки",
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"etiology": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возбудитель заболевания – дрожжеподобный гриб Rhinosporidium seeberi. Морфологически это крупные толстостенные сферические спорангии размером 50-350 мкм, заполненные овальными эндоспорами размером от 7 до 10 мкм. Среда обитания – почва, закрытые загрязненные водоемы в топической и субтропической климатической зоне. Существует теория, согласно которой водные ресурсы инфицируются птицами, страдающими болезнью Зеебера. Механизм заражения человека – контактный. Входными воротами служат слизистые оболочки, взаимодействующие с грунтом или водой. В связи с этим в группу риска входят сотрудники гидротехнических сооружений, сельские жители, занимающиеся рисоводством, использующие воду из застойных водоемов, контактирующие с домашними животными и скотом. Передача возбудителя от больного человека к здоровому не характерна.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Патогенез риноспоридиоза окончательно не изучен. Считается, что патогенные грибы проникают в организм через травмированные слизистые оболочки. В этом месте формируется первичный очаг заболевания, возможна гематогенная и лимфогенная диссеминация. Далее в пораженных тканях возникает хронический воспалительный процесс, сопровождающийся отеком, кровоизлияниями, образованием телеангиэктазий и грануляционной ткани, насыщенной капиллярами и клеточными элементами. Инфильтрат характеризуется скоплением плазмоцитов, эозинофилов, лимфоцитов, фибробластов и гигантских клеток Пирогова-Лангханса. Одновременно в очаге развиваются спорангии, наполненные эндоспорами, и непосредственно сами споры. В некоторых случаях на слизистой оболочке появляются микроабсцессы с центральным некрозом.</span></p>\r\n<p><span id=\"docs-internal-guid-82b3dae4-7fff-fd7f-eabd-95aca6ab2272\"> </span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постановка предварительного диагноза не вызывает затруднений у опытного отоларинголога или инфекциониста. Основными критериями при первичном осмотре служат данные анамнеза и физикального исследования. При опросе специалист обращает внимание на место жительства, профессию и условия работы пациента, динамику развития симптомов. Полная программа обследования включает:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Осмотр носовой полости и ротоглотки. Передняя риноскопия и мезофарингоскопия позволяют выявить характерные поражения слизистой оболочки – различное количество папилломатозных вегетаций и/или язвенных дефектов, сливающихся между собой. При механическом воздействии образования обильно кровоточат.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Общеклинические методы исследования. В общем анализе крови отображается умеренный лейкоцитоз со сдвигом лейкоцитарной формулы в сторону юных и палочкоядерных нейтрофилов, повышение СОЭ. Изменения в клиническом анализе мочи наблюдаются при развитии метастатического поражения мочеполовой системы, могут включать в себя мутность мочи, протеинурию, увеличение удельного веса, лейкоцитурию, смещение рН в кислую сторону.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Световую или люминесцентную микроскопию. В качестве материала для исследования используется мазок из ротоглотки или носоглотки. В нем обнаруживаются крупные толстые нити диаметром от 50 до 350 мкм, наполненные овальными спорами размером до 9 мкм.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гистологическое исследование. Наиболее достоверный метод диагностики. При его проведении определяется большое количество эозинофилов, плазматических клеток, фибробластов, лимфоцитов в сочетании со спорангиями и спорами гриба.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Окончательный диагноз устанавливается после получения результатов гистологического исследования. </span></p>",
"treatment": "<p><span id=\"docs-internal-guid-2b4c99ef-7fff-69fc-a3f3-ce2cc5d9c1b3\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Основная тактика – хирургическая. Лечение проводится в условиях отоларингологического или хирургического стационара. Его суть заключается в иссечении патологических образований при помощи проволочной петли, путем электро– или лазерной коагуляции с последующей обработкой пораженных участков слизистой оболочки антисептиками. Этиотропных фармакологических средств на данный момент не разработано. У части пациентов наблюдается положительная динамика при внутримышечном введении солянокислого эметина в течение 10 суток или внутривенных инъекций солюсурьмина на протяжении 20-27 дней.</span></span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Специфической профилактики заболевания не существует. Неспецифические превентивные мероприятия в отношении риноспоридиозной гранулемы состоят из оптимизации условий труда, предотвращения или ограничения продолжительности контакта с потенциально опасными водоемами и грунтом, использования защитных костюмов при работе на гидротехнических сооружениях в эндемичных регионах.</span></p>\r\n<p><span id=\"docs-internal-guid-fd30a045-7fff-8185-d7fd-e0f0f46aaa67\"> </span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клинические проявления риноспоридиозной гранулемы довольно специфичны. Инкубационный период точно неизвестен. Характерная локализация – носовая полость, носоглотка, ротоглотка, реже слизистые рта, мягкого неба, гортани. Первыми симптомами обычно становятся очаги гиперемии, на поверхности которых постепенно формируются мелкие папилломатозные узелки светло- или бледно-розового цвета с желтым центром. При контакте они легко травмируются и кровоточат. При повторном инфицировании или интенсивном развитии возбудителя происходит деструкция этих образований. На их месте возникают папилломатозно-язвенные дефекты со слизистым содержимым и фестончатым краем.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">По мере развития заболевания количество очагов возрастает, образуются новые вегетации различного размера, достаточно быстро увеличивающиеся за счет хорошей васкуляризации. Специфический симптом этой стадии риноспоридиоза – «ягоды малины» или «кочаны цветной капусты». Часто вторичные образования имеют ножку, обуславливают ухудшение носового дыхания, закрытую гнусавость, а при травматизации – обильные назофарингеальные и носовые кровотечения. В целом течение заболевания доброкачественное, продолжительность может составлять от 15 до 30 лет. В литературе описаны полипы, способные деформировать лицевую область – масса некоторых из них достигала 5-7 кг.</span></p>",
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