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"lead": "паразитарное заболевание, в основе возникновения которого лежит проникновение в организм специфических круглых червей, называющихся капилляриями",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Кишечный капилляриоз — зоонозный гельминтоз из группы нематодозов с фекально-оральным механизмом передачи возбудителя, характеризующийся диспептическим синдромом, снижением массы тела и кахексией.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возбудитель инфекции – круглый червь капиллярия, взрослые особи которого достигают 2-4 мм. Источниками инфекции могут служить больные люди и животные (млекопитающие, рыбы), в организме которых происходит размножение паразита. Попадая в окружающую среду с фекалиями, мочой, рвотой, мокротой, а также вследствие разложения тела организма-хозяина в случае естественной либо насильственной смерти, яйца гельминта в течение 30-45 дней превращаются в личиночную форму и сохраняют жизнеспособность более года. Промежуточными хозяевами выступают рыбы и дождевые черви.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Путь заражения преимущественно алиментарный (немытые ягоды, овощи и фрукты), реже инфицирование происходит путем непосредственного контакта с больным (при поцелуях, чихании, кашле, во время игр и ухода за бездомными и домашними котами и собаками). Группами риска являются рыбаки, работники рыбоперерабатывающих комбинатов, пищевой промышленности, дети, ветеринары, сотрудники служб по отлову бездомных животных.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">После попадания в организм человека личинки оседают преимущественно в тонкой (тощей) кишке. Прикрепляясь к слизистой оболочке, капиллярии нарушают естественное всасывание питательных веществ, оказывают механическое повреждающее воздействие, вызывают воспалительные изменения слизистой оболочки. При попадании в кровеносные сосуды кишечника гельминты могут распространяться по организму, обладая тропизмом к печеночной и легочной тканям.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вызываемые некротические изменения в тканях приводят к нарушению функции органов; при длительной инвазии поврежденные участки могут замещаться соединительной тканью. Фиброзные изменения способствуют снижению воздушности легких и нарушению газообмена; в печени процесс фиброзирования снижает способность органа к регенерации, элиминации продуктов жизнедеятельности и выработке компонентов свертывающей системы крови.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагностические манипуляции, позволяющие верифицировать диагноз, включают в себя:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Объективный осмотр. Физикальное обследование может выявить увеличение печени и селезенки, ослабление дыхания в легких, притупление перкуторного звука. Могут быть кожные высыпания различного характера, желтуха, отеки конечностей и лица, снижение сухожильных рефлексов. При пальпации живота обнаруживается также вздутие, урчание, диффузная или локальная болезненность. Необходимо оценить стул пациента (количество, консистенцию, наличие крови, гноя, слизи).</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные исследования. Общий анализ крови при данном гельминтозе демонстрирует лейкоцитоз (за счет эозинофилии), анемию, ускорение СОЭ. Биохимические маркеры болезни – увеличение активности АЛТ, АСТ, общего и прямого билирубина, снижение общего белка, изменения электролитного состава крови. Копрограмма показывает наличие креатореи, биливердина, стеатореи, внеклеточного (свободного) крахмала.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выявление инфекционных агентов. Микроскопия испражнений, мокроты, смывов со стенок бронхиального дерева больного проводится для выявления яиц капиллярий, личинок, взрослых гельминтов. При исследовании биоптата возможно обнаружение зрелых особей. Серологическая диагностика не разработана, ИФА проводится с антигенами других нематод и паразитов (трихинеллы, власоглава, аскариды, эхинококка, токсокары и других).</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лучевые методы. При рентгенографии лёгких можно обнаружить усиление легочного рисунка и очаговые затемнения. С целью дифференциальной диагностики может назначаться РХПГ, КТ и МРТ печени с контрастированием. УЗИ брюшной полости выявляет наличие локальных гиперэхогенных образований в печени диаметром до 1-2 мм, гепатомегалию, реже – увеличение размеров селезёнки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Биопсия. Проведение чрескожной тонкоигольной пункционной биопсии печени показано при подозрении на поражение этого органа и позволяет исследовать печеночную ткань на наличие паразита. Забор материала рекомендуется проводить под УЗ-контролем. Реже применяется бронхоскопия с биопсией легочной ткани.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Стационарному лечению подлежат пациенты с тяжелым течением болезни, декомпенсацией хронических патологий, дети, беременные, а также больные, проживающие в неблагополучных социально-бытовых условиях. Главным является возмещение потерь жидкости и электролитов – с целью восстановления баланса пациенту назначается соблюдение водного режима. Диета при капилляриозе играет важную роль, щадящее гипоаллергенное питание позволяет снизить повреждающее воздействие на кишечник и печень.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постельный режим необходим до нормализации температуры в течение 1-2 суток. В качестве этиотропной терапии используется мебендазол и его аналоги, преимущественно в виде таблетированных форм. Симптоматическое лечение включает в себя оральные регидранты и инфузионные электролитные растворы (дисоль, ацесоль, хлосоль), жаропонижающие (парацетамол), спазмолитики (дротаверин), сорбенты (полиметилсилоксана полигидрат, смектит), ферментные (панкреатин) препараты.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">С целью профилактики заражения следует тщательно мыть овощи и фрукты, следить за гигиеной рук, избегать употребления в пищу сырой рыбы.</span></p>\r\n<p><span id=\"docs-internal-guid-bc4cc7e1-7fff-b052-d750-760488729938\"> </span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При кишечном капилляриозе симптомы появляются постепенно спустя 4 и более недель после заражения. Хотя в некоторых случаях болезнь длительное время может не проявлять себя, что опасно переходом в более тяжелую стадию, когда лечение уже является затруднительным.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первыми неспецифическими признаками кишечного капилляриоза являются часто повторяющееся урчание в животе и периодически появляющиеся боли в области кишечника.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Такие симптомы наблюдаются в течение пары-тройки недель, после чего болезнь разворачивается в полную силу. Появляются основные симптомы заболевания:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">диарея с обильным выделением водянистых каловых масс,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">частая рвота,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ухудшение аппетита вплоть до полного его отсутствия,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">потеря веса,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">выраженная общая слабость, упадок сил,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">атрофия мышц с уменьшением их общей массы</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">появление отеков вследствие дегидратации,</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #454343; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушение неврологических рефлексов</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Могут наблюдаться и такие симптомы как отхаркивание крови, появление кровянистых выделений в слюне, снижение веса, большое количество эозинофилов в составе крови, зуд в области анального отверстия, общая слабость.</span></p>",
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