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"lead": "Область медицины, включающая в себя лечение 486 заболеваний. В 491 клинике России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 136 заболеваний. В 177 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"lead": "Область медицины, включающая в себя лечение 204 заболеваний. В 249 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"lead": "Область медицины, включающая в себя лечение 730 заболеваний. В 623 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
"name": "эндоскопия",
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"lead": "Область медицины, включающая в себя лечение 53 заболеваний. В 414 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"slug": "drugoe",
"lead": "Область медицины, включающая в себя лечение 268 заболеваний. В 3931 клинике России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
"name": "пульмонология",
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"slug": "pulmonologiya",
"lead": "Область медицины, включающая в себя лечение 145 заболеваний. В 181 клинике России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"lead": "Область медицины, включающая в себя лечение 253 заболеваний. В 632 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"lead": "Область медицины, включающая в себя лечение 647 заболеваний. В 2328 клиниках России оказывается помощь по этому направлению медицины.",
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"slug": "oftalmologiya",
"lead": "Область медицины, включающая в себя лечение 851 заболевания. В 696 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 376 заболеваний. В 728 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 685 заболеваний. В 631 клинике России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
"name": "лечебная физкультура и спортивная медицина",
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"lead": "Область медицины, включающая в себя лечение 412 заболеваний. В 579 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 430 заболеваний. В 596 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 2214 заболеваний. В 886 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "ЛидОбласть медицины, включающая в себя лечение 1036 заболеваний. В 1140 клиниках России оказывается помощь по этому направлению медицины.",
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"slug": "ultrazvukovaya_diagnostika",
"lead": "Область медицины, включающая в себя лечение 515 заболеваний. В 980 клиниках России оказывается помощь по этому направлению медицины.",
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"disease_count": null,
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"slug": "psihoterapiya",
"lead": "Область медицины, включающая в себя лечение 335 заболеваний. В 180 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 114 заболеваний. В 600 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 351 заболевания. В 523 клиниках России оказывается помощь по этому направлению медицины.",
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"code": "M31.3",
"name": "Гранулематоз Вегенера",
"icd_name": "Гранулематоз Вегенера",
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"age_min": 10,
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"slug": "m31.3_granulematoz_vegenera",
"lead": "системный васкулит, при котором поражаются сосуды мелкого калибра: капилляры, венулы, артериолы, мелкие артерии и вены",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Гранулематоз Вегенера — это аутоиммунное гранулематозное воспаление стенок сосудов (васкулит), захватывающее мелкие и средние кровеносные сосуды: капилляры, венулы, артериолы и артерии, с вовлечением верхних дыхательных путей, глаз, почек, лёгких и других органов.</span></p>",
"etiology": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">На данный момент причины возникновения данного заболевания не выяснены. Принято считать, что гранулематоз Вегенера имеет генетическую предрасположенность, которая воспаляется под действием внешних факторов, удовлетворяющих условия появления болезни. Самый распространенный из таких факторов – инфекционные организмы, а именно Staphylococcus aureus (золотистый стафилококк).</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Патогенез васкулитов не до конца расшифрован. Не исключено, что пусковым механизмом их развития может быть перенесённая инфекция.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повреждение сосудов возникает после активации нескольких иммунных и неиммунных механизмов. При ГПА в поражении сосудов участвуют антитела против лизосомных ферментов нейтрофилов (АНЦА), также имеет место нарушение клеточного иммунного ответа и образование гранулём.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для заболевания характерен процесс некроза. В основном он наблюдается в сосудах микроциркуляторного русла, т. е. в самых мелких сосудах. Поражаются все три оболочки сосуда. Формируются некротизирующие гигантоклеточные гранулёмы, склонные к распаду. Воспалительный процесс заканчивается склерозом артерий — они становятся менее эластичными, их просвет уменьшается.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Некротизирующие гранулёмы располагаются в основном в органах, контактирующих с внешней средой, — дыхательные пути, желудочно-кишечный тракт. Такие гранулёмы склонны к быстрому распространению, охвату большой площади поражения и распаду. Гранулёмы в почках и печени (органах, не имеющих прямого контакта с внешней средой) содержат много фибробластов и склонны к рубцеванию.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Комплекс диагностических процедур при гранулематоза Вегенера включает консультацию ревматолога, лабораторные анализы, диагностические операции, рентгенологические исследования. Клиническое исследование крови обнаруживает нормохромную анемию, ускорение СОЭ, тромбоцитоз, общий анализ мочи – протеинурию, микрогематурию. При биохимическом анализе крови определяется повышение γ-глобулина, креатинина (при почечном синдроме), мочевины, фибрина, серомукоида, гаптоглобина. </span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При рентгенографии легких в их ткани определяются инфильтраты, полости распада, плевральный экссудат. Проводят бронхоскопию с биопсией слизистых верхних дыхательных путей. При исследовании биоптатов выявляются морфологические признаки гранулематозно-некротизирующего васкулита.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При ограниченной и генерализованной форме гранулематоза Вегенера назначается иммуносупрессивная терапия циклофосфамидом в комбинации с преднизолоном. Быстро прогрессирующее течение альвеолита или гломерулонефрита служит показанием к проведению комбинированной пульс-терапии высокими дозами метилпреднизолона и циклофосфамида. При переходе течения гранулематоза Вегенера в стадию ремиссии дозы циклофосфамида и преднизолона постепенно снижают; на длительный (до 2-х лет) срок назначают метотрексат.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Генерализация процесса при гранулематозе Вегенера (кровохарканье, гломерулонефрит, наличие антител к нейтрофильным лейкоцитам) требует проведения экстракорпоральной гемокоррекции - криоафереза, плазмафереза, каскадной фильтрации плазмы, экстракорпоральной фармакотерапии. При лечении рецидивирующего гранулематоза Вегенера эффективно проведение внутривенной иммуноглобулиновой терапии. С целью продления ремиссии может проводиться терапия ритуксимабом. Стенозирующие изменения гортани при гранулематозе Вегенера требуют наложения трахеостомы и реанастомоза.</span></p>",
"prevention": "<p><span id=\"docs-internal-guid-06f680ac-7fff-f99a-961f-21367d7f44f6\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Первичной профилактики, направленной на предотвращение появления заболевания, не существует. Вторичная профилактика заключается в соблюдении рекомендаций по лечению и регулярном посещении врача. Эффективность и безопасность терапии следует контролировать каждые 1-3 месяца. Пациентам в стадии стойкой ремиссии проводится лабораторное исследование раз в шесть месяцев.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Общая симптоматика гранулематоза Вегенера включает лихорадку, ознобы, повышенное потоотделение, слабость, потерю массы тела, миалгии, артралгии, артриты. Ведущим проявлением заболевания, встречающимся у 90% пациентов, служит поражение верхних отделов дыхательных путей. Для клиники гранулематоза Вегенера типично упорное течение ринита, гнойно-геморрагическое отделяемое из носа, изъязвление слизистых оболочек вплоть до перфорации носовой перегородки, седловидная деформация носа. Гранулематозно-некротические изменения развиваются также в полости рта, гортани, трахее, слуховых ходах, придаточных пазухах носа.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У 75% пациентов с гранулематозом Вегенера определяются инфильтративные изменения в легочной ткани, деструктивные полости в легких, кашель с кровохарканьем, свидетельствующий о развитии плеврита плевральный выпот. Вовлечение почек проявляется развитием гломерулонефрита с явлениями гематурии, протеинурии, нарушений выделительной функции. Стремительно прогрессирующее течение гломерулонефрита при гранулематозе Вегенера приводит к острой почечной недостаточности. Изменения со стороны кожи проявляются геморрагической сыпью с последующей некротизацией элементов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Поражение органов зрения включает развитие эписклерита (воспаления поверхностных тканей склеры), образование орбитальных гранулем, экзофтальм, ишемию зрительного нерва с ухудшением функции зрения вплоть до ее полной утраты. При гранулематозе Вегенера поражаются нервная система, коронарные артерии, миокард.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Локализованная форма гранулематоза Вегенера протекает с преимущественным поражением верхних дыхательных путей – упорным насморком, затруднением носового дыхания, носовыми кровотечениями, образованием кровянистых корочек в носовых ходах, осиплостью голоса. Генерализованная форма характеризуется различными системными проявлениями – лихорадкой, суставно-мышечными болями, геморрагиями, полиморфной сыпью, приступообразным надсадным кашлем с кровянисто-гнойной мокротой, абсцедирующей пневмонией, нарастанием сердечно-легочной и почечной недостаточности.</span></p>",
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