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"code": "C62",
"name": "Рак яичка",
"icd_name": "Рак яичка",
"gender": 1,
"age_min": 15,
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"cause": [
"0",
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"slug": "c62_rak_yaichka",
"lead": "злокачественное поражение тестикул – половых желез у мужчин.",
"description": "<p>Рак яичка — это злокачественная опухоль, развивающаяся из тканей яичек (мужских половых желез, расположенных в мошонке). Чаще встречается в возрасте от 15 до 40 лет, хотя возникновение опухоли возможно в любом возрасте, включая младенцев и пожилых людей. Выявлено три возрастных пика, связанных с возникновением рака яичка: у мальчиков до 10 лет, молодых мужчин от 20 до 40 лет и пожилых людей старше 60 лет.</p>",
"etiology": "<p align=\"justify\">Выявлено три возрастных пика, связанных с возникновением рака яичка: у мальчиков до 10 лет, молодых мужчин от 20 до 40 лет и пожилых людей старше 60 лет.</p>\r\n<p align=\"justify\">У детей рак яичка в 90% случаев развивается на фоне малигнизации эмбриональной доброкачественной тератомы. В более старшем возрасте факторами, провоцирующими развитие рака яичка, могут стать травмы мошонки, эндокринные заболевания (гипогонадизм, гинекомастия, бесплодие), радиационное излучение и др. Риск возникновения рака яичка возрастает при синдроме Клайнфельтера.</p>\r\n<p align=\"justify\">Наиболее часто рак яичка выявляется у пациентов с крипторхизмом – неопущением желез в мошонку. Различные формы крипторхизма увеличивают риск возникновения рака в неопустившемся яичке в 10 раз. При одностороннем поражении яичка вероятность возникновения опухоли контралатеральной железы также велика.</p>\r\n<p align=\"justify\">Шансы на развитие рака яичка выше у мужчин, чьи родственники первой степени (брат, отец) имели аналогичное заболевание. Рак яичка в 5 раз чаще встречается у европейцев, особенно жителей Германии и Скандинавии; реже – в азиатских и африканских странах.</p>",
"pathogenesis": "",
"diagnostics": "<ul class=\"list list-description\">\r\n<li>Анализ анамнеза заболевания и жалоб (когда появились боли, чувство тяжести в мошонке, обнаружились образования в яичке при прощупывании, увеличилось ли оно в размерах и т.д.).</li>\r\n<li>Анализ анамнеза жизни (перенесенные заболевания, оперативные вмешательства, травмы).</li>\r\n<li>Выявление наследственного фактора (были ли случаи рака яичка у близких родственников и т.д.).</li>\r\n<li>Осмотр, пальпация (прощупывание) мошонки, живота, лимфоузлов.</li>\r\n<li>УЗИ (ультразвуковое исследование) мошонки – позволяет получать изображение внутренних органов и оценивать наличие каких-либо изменений).</li>\r\n<li>Диафаноскопия — просвечивание мошонки светоисточником</li>\r\n<li>Определение в крови уровня b-ХГЧ (бета-ХГЧ, хорионический гонадотропин человека, у мужчин синтезируется опухолями), АФП (альфа-фетопротеин, значительное его повышение у мужчин указывает на наличие опухоли) и ЛДГ (лактатдегидрогеназа, фермент, участвующий в процессе окисления глюкозы и образовании молочной кислоты, накапливается в тканях организма при развитии опухоли).</li>\r\n<li>Рентгенологические исследования грудной клетки.</li>\r\n<li>МРТ (магнитно-резонансная томография, метод получения диагностических изображений, основанный на использовании физического явления ядерно-магнитного резонанса, он безопасен для организма).</li>\r\n<li> КТ (компьютерная томография, вид рентгеновского обследования, позволяющий получить на компьютере послойное изображение органов) проводятся для выявления метастазов (вторичные очаги роста опухоли, возникающие в близлежащих и удаленных органах, лимфоузлах).</li>\r\n<li>Биопсия (исследование кусочка тканей под микроскопом) тканей яичка (после операции по его удалению) – подтверждение диагноза.</li>\r\n</ul>",
"treatment": "<p align=\"justify\">Возможность органосохраняющей операции при раке яичка рассматривается при двусторонней опухоли или поражении единственной железы. После резекции яичка всем пациентам показано проведение адъювантной лучевой терапии.</p>\r\n<p align=\"justify\">Стандартом хирургического лечения рака яичка служит орхиэктомия, при необходимости с забрюшинной лимфаденэктомией. Удаление семиномных опухолей Т1-Т2 стадий дополняется лучевой терапией; при стадиях семиномы Т3-Т4, а также при несеминомном раке яичка требуется назначение системной химиотерапии. В случае двухсторонней орхфуникулэктомии или низкого уровня тестостерона пациентам назначается гормонозаместительная терапия.</p>\r\n<p align=\"justify\">Комплексное лечение рака яичка (орхиэктомия, радиотерапия, химиотерапия) могут привести к временному или длительному бесплодию и импотенции. Поэтому пациентам фертильного возраста перед лечением рака яичка рекомендуется обследование у андролога с оценкой уровня гормонов (тестостерона, ЛГ, ФСГ) и спермограммы. При намерении в дальнейшем иметь детей до начала лечения мужчина может прибегнуть к криоконсервации спермы.</p>",
"prevention": "<p>Профилактика рака яичка заключается в своевременном устранении крипторхизма, предупреждении травм мошонки, исключении облучения гениталий. Своевременному выявлению рака яичка способствует регулярное самообследование и раннее обращение к урологу-андрологу при обнаружении каких-либо изменений.</p>",
"clinical_picture": "<p>Чистая семинома протекает менее злокачественно по сравнению с другими формами опухолей яичка. Метастазы дает несколько позже, по лимфатической системе. Опухоль гормонально не активная.<br />Эмбриональный рак и тератоидная опухоль яичка отличаются более злокачественным течением, метастазы появляются рано, распространяясь как по лимфатической, так и по кровеносной системам. Опухоль гормонально активна.<br />Хорионэпителиома — наиболее злокачественная форма опухолей яичка. Метастазирует рано по кровеносной системе в легкие, печень, мозг и другие органы; метастазы могут образоваться при пальпаторно неопределяемой первичной опухоли. Опухолевая ткань вырабатывает гонадотропный гормон.<br />Интерстициальноклеточные опухоли яичка у взрослых вызывают гинекомастию и другие признаки феминизации, у детей — раннее половое развитие.<br />Для опухолей яичка характерна скудная симптоматика или начальное бессимптомное течение, вследствие чего почти в половине случаев больные обращаются к врачу с выраженными метастазами. Вначале отмечается незначительное увеличение яичка или <a title=\"Перейти на страницу симптома Отек тканей\" href=\"/symptom/otek_tkaney/\">уплотнение</a> в нем, появляется чувство тяжести или легкая болезненность в яичке. По мере увеличения яичка болезненные ощущения могут увеличиваться. Сильные боли в яичке могут зависеть от кровоизлияния, некроза или инфаркта опухоли. При поражении неопустившегося яичка прощупывается опухоль в подвздошной области или в паху. С развитием метастазов в забрюшинных лимфатических узлах появляются боли в пояснице, запоры, динамическая непроходимость, отеки нижних конечностей и др. В дальнейшем метастазы появляются в лимфатических узлах подвздошных, левой надключичной области, средостения, в печени, легких.</p>",
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"lead": "злокачественное поражение половых желез у мужчин",
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"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выявлено три возрастных пика, связанных с возникновением рака яичка: у мальчиков до 10 лет, молодых мужчин от 20 до 40 лет и пожилых людей старше 60 лет. У детей патология в 90% случаев развивается на фоне малигнизации эмбриональной доброкачественной тератомы. В более старшем возрасте факторами, провоцирующими развитие новообразования, могут стать травмы мошонки, эндокринные заболевания (гипогонадизм, гинекомастия, бесплодие), радиационное излучение и др. Риск возникновения неоплазии возрастает при синдроме Клайнфельтера.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Наиболее часто болезнь выявляется у пациентов с крипторхизмом – неопущением желез в мошонку. Различные формы крипторхизма увеличивают риск возникновения рака в неопустившемся яичке в 10 раз. При одностороннем поражении яичка вероятность возникновения опухоли контралатеральной железы также велика. Вероятность развития рака выше у мужчин, чьи родственники первой степени (брат, отец) имели аналогичное заболевание.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Окончательная причина возникновения рака яичка до сих пор не установлена, но прослеживается ряд факторов, наличие которых существенно повышает риск развития заболевания.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Выделяют три группы факторов риска: перинатальные (связанные с внутриутробным развитием плода), постпубертатные (относящиеся к периоду развития человека после завершения полового созревания) и генетические.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Перинатальные факторы: установлено, что эстрогены и эстрогеноподобные вещества могут оказывать влияние на внутриутробное формирование гонад у плода. Женские половые гормоны способны индуцировать возникновение тетраплоидии герминогенных клеток (редкий вариант хромосомных аномалий, при котором увеличивается полный набор хромосом зародышевых клеток). Это является одним из признаков развития у плода carcinoma in situ (предшественницы всех раков).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Генетические факторы риска: описана связь между генетическими изменениями (в гене-супрессоре опухоли PTEN) и риском возникновения опухолей половых клеток яичка.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Крипторхизм (неопущение яичка) увеличивает риск развития рака яичка в 5-10 раз. В утробе матери у плода мужского пола развитие яичек происходит в брюшной полости.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Обычно яички опускаются в полость мошонки при рождении или на первом году жизни. Если этот процесс задерживается или яички не опустились в мошонку, создаются неблагоприятные условия, способствующие развитию дегенеративных изменений. Чем глубже и дольше яичко расположено в брюшной полости, тем сильнее нарушается сперматогенная (репродуктивная) функция мужчины.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для постановки диагноза необходимо записаться на прием к андрологу или урологу. Обследование состоит из таких составляющих:</span></p>\r\n<p> </p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Осмотр, пальпация проблемных зон, опрос пациента и сбор анамнеза. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ. </span><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Эффективность ультразвукового исследования в этом случае очень высока. </span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">МРТ либо КТ. </span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Остеосцинтиграфия — необходима для выявления метастазов. </span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Анализы крови на онкомаркеры. </span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Биопсия через паховый доступ.</span></li>\r\n</ul>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Возможность органосохраняющей операции рассматривается при двусторонней опухоли или поражении единственной железы. После резекции яичка всем пациентам показано проведение адъювантной лучевой терапии. Стандартом хирургического лечения патологии служит орхиэктомия, при необходимости с забрюшинной лимфаденэктомией. Удаление семиномных опухолей Т1-Т2 стадий дополняется лучевой терапией; при стадиях семиномы Т3-Т4, а также при несеминомном раке требуется назначение системной химиотерапии. В случае двухсторонней орхифуникулэктомии или низкого уровня тестостерона пациентам назначается гормонозаместительная терапия.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Комплексное лечение (орхиэктомия, радиотерапия, химиотерапия) могут привести к временному или длительному бесплодию и импотенции. Поэтому пациентам фертильного возраста перед началом терапии рекомендуется обследование у онкоуролога с оценкой уровня гормонов (тестостерона, ЛГ, ФСГ) и спермограммы. При намерении в дальнейшем иметь детей до начала лечения мужчина может прибегнуть к криоконсервации спермы.</span></p>",
"prevention": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Чтобы снизить риски развития рака яичка, необходимо придерживаться следующих профилактических мер:</span></p>\r\n<p> </p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Регулярно (минимум раз в месяц) проводить самообследование мошонки и яичек на предмет разных уплотнений, образований, изменений размера и т. д. При появлении любых непонятных изменений обращаться за консультацией к урологу, андрологу. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Вести здоровый образ жизни: отказаться от курения, алкоголя, достаточно времени проводить в движении, питаться здоровой пищей. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Исключить перегрев мошонки, а также ношение слишком тесной натирающей одежды. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Избегать различных травм половых органов. </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если травма все же произошла, обязательно показаться андрологу.</span></li>\r\n</ul>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Первые признаки рака яичка проявляются не сразу. На ранних стадиях течение болезни обычно бессимптомное, лишь иногда появляется ощущение тяжести, наблюдаются изменения размеров яичка либо мошонки. Это уже повод немедленно обратиться к урологу и пройти обследование.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">По мере развития заболевания могут появляться такие симптомы и признаки рака яичек (по нарастающей):</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">болевые ощущения в мошонке; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">возникновение уплотнения, которое можно прощупать самостоятельно; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">изменение консистенции яичка (если сравнивать с другим) — пациент тоже может ощутить это сам; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">болевые ощущения в спине — с этого признака и дальше говорится о симптомах, свойственных течению болезни при метастазировании; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отечность нижних конечностей; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">проблемы с мочеиспусканием, в работе почек; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">одышка и кашель при поражении легких; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">увеличение надключичных лимфатических узлов.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если вовремя не начать лечение рака яичка, метастазы будут распространяться очень быстро, подрывая здоровье мужчины.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Иногда случается, что симптомы рака яичка сопровождаются дополнительными изменениями на фоне сильных гормональных нарушений. В таком случае выделяют еще ряд признаков:</span></p>\r\n<p> </p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гинекомастия — то есть увеличение молочных желез у мужчины; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">эректильная дисфункция и снижение либидо у взрослых; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">частые и долгие эрекции у мальчиков — симптомом является именно длительность и частота, а не сам факт эрекции, что для мальчиков нормально; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">преждевременное увеличение полового члена, а также раннее появление волос на лобке; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">развитие костей и мышц, которое опережает возраст.</span></li>\r\n</ul>",
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