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"etiology": "<p>Возбудитель заболевания Treponema Carateum Herrejin. По морфологическим и антигенным свойствам она сходна с бледной трепонемой. Возбудитель пинты обитает в почве, на растениях, фруктах. Инфицирование происходит при прямом и непрямом контактах с больным человеком. Возбудитель проникает через поврежденную кожу или слизистые оболочки. Доказана передача возбудителя насекомыми (комары, клопы, мошки). Заболеванию особенно подвержены дети. Среди эндогенных факторов следует выделить низкую иммунную реактивность, повышенную потливость кожи и щелочную реакцию ее водно-липидной мантии. Среди экзогенных факторов особенно выделяются скученность населения, микротравмы и мацерация при высокой температуре и влажности тропического климата. </p>",
"pathogenesis": "<p>Проникают трепанемы через поврежденные участки кожи и слизистые оболочки. Затем они локализуются преимущественно в роговом слое эпидермиса, где развивается гиперпигментация, утолщение кожи, межклеточный отек. Также происходит нарушение пигментной функции, так как наблюдается гибель меланоцитов. Поражаются регионарные лимфатические узлы. В поздней стадии развивается очаговая атрофия эпидермиса. </p>",
"diagnostics": "<p>Диагноз пинты основываются на появлении характерных пятен на коже и стадийности их изменений без нарушения общего состояния, за исключением кожного зуда. Диагноз подтверждается обнаружением в соскобах кожи трепонем; в поздних стадиях болезни становится положительной реакция Вассермана. </p>\r\n<p>Применяются серологические реакции, реакции иммунофлюоресценции - обнаруживаются специфические антитела к трепонеме. </p>",
"treatment": "<p>Лечение проводят дюрантным и препаратами пенициллина, типа бициллина, или новыми препаратами – экстенциллнн, ретарпен и др. Детям и взрослым, контактировавшим с больными, проводят профилактическое лечение бициллином.</p>",
"prevention": "<p> </p>\r\n<p>Профилактические мероприятия сводятся к выявлению и лечению больных и лиц, находящихся с ними в тесном контакте. Специфической профилактики не разработано. </p>",
"clinical_picture": "<p>Инкубационный период 7-20 дней. </p>\r\n<p>На месте внедрения трепонемы образуется эритематозная зудящая папула (узелок), размеры которой постепенно увеличиваются до нескольких сантиметров (примерно на 1 см в течение месяца). Вокруг папулы через 6-12 мес появляются мелкие пинтиды, зудящие, многочисленные, различного цвета (голубого, серого, бурого, желтого, фиолетового, красного и др.) разной величины и формы: круглые, овальные, неправильные; они шелушатся и напоминают чешуйчатый лишай или становятся лихеноидными (утолщенным). </p>\r\n<p>В поздней третьей стадии болезни - на коже обилие ахроматичных и пигментированных пятен; появляется утолщение подошв и ладоней, болезненные трещины, пигментные нарушения ногтей. </p>\r\n<p>Физическое состояние больных не нарушается, сохраняется трудоспособность, и заболевание продолжается неопределенно длительное время. </p>",
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"code": "A67",
"name": "Пинта [карате]",
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"lead": "Нарушение здоровья, относящееся к группе другие болезни, вызываемые спирохетами",
"description": "Пинта (карате) является редким кожным инфекционным заболеванием и поражает кожу и слизистые оболочки без вовлечения в процесс внутренних органов, суставов и костей. ",
"etiology": "<p>Возбудитель заболевания Treponema Carateum Herrejin. По морфологическим и антигенным свойствам она сходна с бледной трепонемой. Возбудитель пинты обитает в почве, на растениях, фруктах. Инфицирование происходит при прямом и непрямом контактах с больным человеком. Возбудитель проникает через поврежденную кожу или слизистые оболочки. Доказана передача возбудителя насекомыми (комары, клопы, мошки). Заболеванию особенно подвержены дети. Среди эндогенных факторов следует выделить низкую иммунную реактивность, повышенную потливость кожи и щелочную реакцию ее водно-липидной мантии. Среди экзогенных факторов особенно выделяются скученность населения, микротравмы и мацерация при высокой температуре и влажности тропического климата. </p>",
"pathogenesis": "<p>Проникают трепанемы через поврежденные участки кожи и слизистые оболочки. Затем они локализуются преимущественно в роговом слое эпидермиса, где развивается гиперпигментация, утолщение кожи, межклеточный отек. Также происходит нарушение пигментной функции, так как наблюдается гибель меланоцитов. Поражаются регионарные лимфатические узлы. В поздней стадии развивается очаговая атрофия эпидермиса. </p>",
"diagnostics": "<p>Диагноз пинты основываются на появлении характерных пятен на коже и стадийности их изменений без нарушения общего состояния, за исключением кожного зуда. Диагноз подтверждается обнаружением в соскобах кожи трепонем; в поздних стадиях болезни становится положительной реакция Вассермана. </p>\r\n<p>Применяются серологические реакции, реакции иммунофлюоресценции - обнаруживаются специфические антитела к трепонеме. </p>",
"treatment": "<p>Лечение проводят дюрантным и препаратами пенициллина, типа бициллина, или новыми препаратами – экстенциллнн, ретарпен и др. Детям и взрослым, контактировавшим с больными, проводят профилактическое лечение бициллином.</p>",
"prevention": "<p> </p>\r\n<p>Профилактические мероприятия сводятся к выявлению и лечению больных и лиц, находящихся с ними в тесном контакте. Специфической профилактики не разработано. </p>",
"clinical_picture": "<p>Инкубационный период 7-20 дней. </p>\r\n<p>На месте внедрения трепонемы образуется эритематозная зудящая папула (узелок), размеры которой постепенно увеличиваются до нескольких сантиметров (примерно на 1 см в течение месяца). Вокруг папулы через 6-12 мес появляются мелкие пинтиды, зудящие, многочисленные, различного цвета (голубого, серого, бурого, желтого, фиолетового, красного и др.) разной величины и формы: круглые, овальные, неправильные; они шелушатся и напоминают чешуйчатый лишай или становятся лихеноидными (утолщенным). </p>\r\n<p>В поздней третьей стадии болезни - на коже обилие ахроматичных и пигментированных пятен; появляется утолщение подошв и ладоней, болезненные трещины, пигментные нарушения ногтей. </p>\r\n<p>Физическое состояние больных не нарушается, сохраняется трудоспособность, и заболевание продолжается неопределенно длительное время. </p>",
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"lead": "Область медицины, включающая в себя лечение 211 заболеваний. В 341 клинике России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 114 заболеваний. В 600 клиниках России оказывается помощь по этому направлению медицины.",
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"lead": "Область медицины, включающая в себя лечение 37 заболеваний. В 153 клиниках России оказывается помощь по этому направлению медицины.",
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"code": "K51",
"name": "Язвенный колит",
"icd_name": "Язвенный колит",
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"lead": "Нарушение здоровья, относящееся к группе неинфекционный энтерит и колит",
"description": "<p>Язвенный колит или неспецифический язвенный колит (НЯК) – хроническое заболевание толстой кишки, характеризующееся иммунным воспалением ее слизистой оболочки. При язвенном колите поражается только толстая кишка, а воспаление никогда не распространяется на тонкую.</p>",
"etiology": "<p>В настоящее время рассматриваются следующие возможные причины язвенного колита: </p>\r\n<ul>\r\n<li>Генетическая предрасположенность (наличие у родственников болезни Крона или язвенного колита повышает риск развития язвенного колита у пациента). </li>\r\n<li>Бактерии, вирусы — роль этих факторов до конца не ясна. </li>\r\n<li>Факторы внешней среды вызывают значительный рост числа воспалительных заболеваний кишечника. Наиболее исследованы: употребление оральных контрацептивов, влияние курения и диет. </li>\r\n</ul>\r\n<p> </p>",
"pathogenesis": "<p>Основными патогенетическими факторами неспецифического язвенного колита являются: </p>\r\n<ul>\r\n<li>дисбактериоз кишечника - нарушение нормального состава микрофлоры в толстом кишечнике, что оказывает местное токсическое и аллергизирующее влияние, а также способствует развитию неиммунного воспаления толстой кишки; </li>\r\n<li>нарушение нейрогуморальной регуляции функции кишечника, обусловленное дисфункцией вегетативной и гастроинтестинальной эндокринной системы; </li>\r\n<li>значительное повышение проницаемости слизистой оболочки толстой кишки для молекул белка и бактериальных антигенов; </li>\r\n<li>повреждение кишечной стенки и образование аутоантигенов с последующим образованием аутоантител к стенке кишечника. Антигены некоторых штаммов Е. Coli индуцируют синтез антител к ткани толстой кишки; </li>\r\n<li>образование иммунных комплексов, локализующихся в стенке толстой кишки, с развитием в ней иммунного воспаления; </li>\r\n<li>развитие внекишечных проявлений болезни вследствие многогранной аутоиммунной патологии. </li>\r\n</ul>",
"diagnostics": "<p>Лабораторные исследования: </p>\r\n<ul>\r\n<li>анализ крови (выявляются признаки воспалительного процесса); </li>\r\n<li>C-реактивный белок крови (его подъем коррелирует с активностью болезни); </li>\r\n<li>копрограмма (в кале находят скрытую и явную кровь, наличие эритроцитов, лейкоцитов); </li>\r\n<li>оценка аутоантител (в 70 % случаев при язвенном колите находят перинуклеарные цитоплазматические антинейтрофильные антитела или pANCA); </li>\r\n<li>бактериологические посевы (исключение дизентерии, псевдотуберкулеза и других инфекций); </li>\r\n<li>молекулярно-генетические исследования (ПЦР) для исключения вирусного и паразитарного поражения; </li>\r\n<li>фекальный кальпротектин (этот параметр оценивают в кале, он отражает наличие воспаления в кишечнике, используется для исключения рецидива язвенного колита или невоспалительных кишечных болезней). </li>\r\n</ul>\r\n<p>Инструментальные исследования: </p>\r\n<ul>\r\n<li>фиброилеоколоноскопию – основной метод обследования (эндоскопический осмотр небольшого самого нижнего участка тонкой кишки и абсолютно всей толстой кишки, исследование уточняет протяженность и выраженность язвенного колита, наличие сужений, полипов и псевдополипов, предоставляет возможность забора материала для морфологической оценки); </li>\r\n<li>морфологический (гистологический) анализ (выявляет присущие язвенному колиту микроскопические признаки, исключает предраковые и раковые изменения); </li>\r\n<li>ирригоскопия (рентгенологический осмотр с контрастированием устанавливает воспалительные изменения толстой кишки, исключает сужения, новообразования, но не заменяет собой эндоскопическую процедуру); </li>\r\n<li>МРТ кишечника (процедура уточняет состояние толстой кишки и окружающих ее тканей, исключает вовлечение в процесс тонкой кишки, наличие свищей и инфильтратов); </li>\r\n<li>УЗИ (обнаруживает косвенные признаки болезни – расширение кишки, утолщение ее стенок) </li>\r\n</ul>\r\n<p> </p>",
"treatment": "<p>Диета: с момента обострения назначается диета № 4а, при стихании воспалительных процессов — диета 4б, в период ремиссии — диета 4в, затем обычная диета с исключением продуктов, плохо переносимых пациентом. В случае тяжелого обострения язвенного колита — назначение парентерального (через вену) и/или энтерального питания. </p>\r\n<p>Основные препараты для лечения язвенного колита — препараты 5-аминосалициловой кислоты. К ним относятся сульфасалазин и месалазин. Эти препараты обладают противовоспалительным действием и оказывают заживляющий эффект на воспаленную слизистую толстой кишки. </p>\r\n<p>Глюкокортикостероиды назначаются при недостаточной эффективности препаратов 5-АСК или при тяжелой атаке язвенного колита. Обычно их комбинируют с препаратами 5-аминосалициловой кислоты. Гормональные препараты не заживляют слизистую толстой кишки, они лишь снижают активность обострения. </p>\r\n<p>При гормонорезистентных формах заболевания используются биологические препараты на основе моноклональных антител. </p>\r\n<p>При развитии гормональной зависимости и резистентности применяются иммунодеперссанты (цитостатики), обладающие выраженным противовоспалительным эффектом. </p>\r\n<p>При неэффективности медикаментозного воздействия и развитии осложнений проводят радикальное хирургическое лечение. </p>",
"prevention": "<p>Специфической профилактики НЯК на данный момент нет, поскольку причины, вызывающие это заболевание, до конца не ясны. Профилактическими мерами возникновения рецидивов обострения является соблюдение предписаний врача по образу жизни (рекомендации по питанию (ограничение потребления молочных продуктов, уменьшение соджержания грубой клетчатки в рационе, отказ от алкоголя, острой еды, содержащих кофеин напитков), снижение количества стрессовых ситуаций и физического перенапряжения, психотерапия) и регулярное диспансерное наблюдение. Неплохой эффект в плане стабилизации состояния дает санаторно-курортное лечение.</p>",
"clinical_picture": "<p>Симптомы язвенного колита могут быть разнообразными и зависят от степени тяжести заболевания. Их можно разделить на кишечные и внекишечные. </p>\r\n<p>Основные кишечные симптомы заболевания: </p>\r\n<ul>\r\n<li>Диарея. Понос или кашицеобразный стул может быть с примесью крови, гноя и слизи, иногда в сочетании с тенезмами (болезненные, ложные позывы к дефекации). Частота стула может увеличиваться и уменьшатся без видимых причин и вне зависимости от проводимой терапии. </li>\r\n<li>Боли в животе, режущего и ноющего характера, чаще всего в левом боку. </li>\r\n<li>Вздутие живота. </li>\r\n<li>Заметное снижение аппетита и, как следствие, потеря массы тела. </li>\r\n<li>Лихорадка. </li>\r\n<li>Нарушение водно-электролитного баланса в организме, проявляющееся в нарушении работы почек, сердца. </li>\r\n</ul>\r\n<p>Внекишечные проявления язвенного колита включают артриты, спондилиты, поражения органа зрения (ириты, коньюктевиты и блефариты), заболевания полости рта (стоматиты), печени и желчевыводящих путей (холангит, цирроз и холелитиаз), а также заболевания кожи и подкожной клетчатки (гангренозная пиодермия, узловая эритема, узелковый полиартериит), тромбофлебиты и тромбоэмболии, нефролитиаз. </p>",
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{
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"lead": "одновременное воспаление тонкой и толстой кишки",
"description": "<p>Энтероколит - это <span style=\"background-color: transparent; font-family: Verdana; font-size: 7pt; white-space: pre-wrap;\">патологическое состояние желудочно-кишечного тракта, при котором происходит воспаление слизистой тонкого и толстого кишечника.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Энтероколит может иметь инфекционную и неинфекционную природу. К наиболее распространенным инфекциям, поражающим слизистую тонкого и толстого кишечника, относятся:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">кишечная палочка;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сальмонеллез;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">энтеровирус.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Помимо этого энтероколит может возникать при паразитарной инвазии, проникновении в кишечник простейших:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">описторхоз;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">трихомонады;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">амебные паразиты.</span></p>\r\n</li>\r\n</ul>\r\n<p><strong style=\"font-weight: normal;\"> </strong></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Неинфекционные причины появления кишечной патологии:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">длительное лечение антибиотиками;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">пищевая аллергия;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отравление;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушение обмена веществ;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">аутоиммунные заболевания;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">патологии органов ЖКТ (например, язвенный колит или секреторная недостаточность поджелудочной железы).</span></p>\r\n</li>\r\n</ul>\r\n<p><strong style=\"font-weight: normal;\"> </strong></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В последнее время особое распространение получили причины энтероколита, связанные с неправильным питанием современного человека. К заболеванию нередко приводят:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">частые перекусы «на бегу»;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">злоупотребление алкоголем;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">переедание;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">употребление жирной, жареной, копченой и пересоленной пищи;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">чрезмерное употребление продуктов с высоким содержанием углеводов;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">недостаток необходимых для организма микро- и макроэлементов, поступаемых с пищей.</span></p>\r\n</li>\r\n</ul>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При данной патологии наблюдается нарушение равновесия между физиологией иммунной системы и нормальной микрофлорой кишечника, в результате чего изменяется макро- и микроструктура слизистой оболочки, процессы регенерации и метаболизма в ней. Основное значение в патогенезе имеет изменение микробиоценоза кишечника, барьерной, секреторной и моторной функций. Нарушается активность мембранных ферментов, транспортных каналов, обеспечивающих поступление воды, ионов, продуктов расщепления белков, жиров и углеводов.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Дисбактериоз приводит к бродильным и гнилостным процессам, в результате которых образуется большое количество кислот, газа, а также эндогенных токсинов, которые также повреждают слизистую оболочку и нервные окончания. Развивается гиперсекреция слизи. Совокупность этих процессов приводит к поддержанию хронического воспаления кишечника и формированию атрофии его слизистой оболочки. При этом патогенез и тяжесть заболевания зависят в большей степени не от причины, а от степени повреждения энтероцитов.</span></p>",
"diagnostics": "<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">забор общего и биохимического анализа крови;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">анализ кала на химическое и бактериологическое исследование;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">забор мочи;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">колоноскопия, включая биопсию;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">УЗИ брюшной полости и органов таза;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ирригоскопия (рентгенологическое исследование кишечника)</span></p>\r\n</li>\r\n</ul>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия зависит от разновидности заболевания, стадии течения и степени поражения слизистой оболочки кишечника. Общим является медикаментозное лечение и диета.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лекарственное лечение энтероколита включает:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Антибиотики. Выбор препарата зависит от того, какой возбудитель стал причиной развития заболевания. Необходимость в проведении антибактериальной терапии возникает только при псевдомембранозном энтероколите.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Противопаразитарные средства. Назначаются в случае глистных инвазий с учетом выявленного паразита.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для улучшения самочувствия больного врач прописывает обезболивающие и спазмолитические препараты. С целью нормализации микрофлоры врач прописывает пре- и пробиотики, содержание энтеро- и бифидобактерии.</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Противодиарейные препараты, которые оказывают влияние на моторику кишечника, как правило, не назначаются. При энтероколите допустимы только лекарства адсорбирующего действия, стабилизирующие слизистую оболочку кишечника.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В обязательном порядке назначается диета №4 (3-5 дней), после чего №4 Б и В. после улучшения общего самочувствие рацион питания расширяется для восполнения дефицита микроэлементов и витаминов. Исключить только нужно продукты, к которым имеется индивидуальная непереносимость (глютен, лактоза).</span></p>",
"prevention": "<p><span id=\"docs-internal-guid-cd301701-7fff-8a9a-ac53-f623a53254f3\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Профилактические меры включают исключение антибиотиков без назначения врача. </span></span></p>\r\n<p><span id=\"docs-internal-guid-cd301701-7fff-8a9a-ac53-f623a53254f3\"></span><span id=\"docs-internal-guid-cd301701-7fff-8a9a-ac53-f623a53254f3\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Нужно исключить употребление непастеризованного молока, недостаточно обработанного мяса и яиц, плохо вымытых овощей и фруктов. </span></span></p>\r\n<p><span id=\"docs-internal-guid-cd301701-7fff-8a9a-ac53-f623a53254f3\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Профилактика включает соблюдение личной гигиены и прием противоглистных препаратов для предупреждения развития гельминтозов.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиническая картина энтероколита зависит от формы течения и степени тяжести заболевания. Так, острый энтероколит проявляется внезапно, чаще всего сопровождается резкими приступами боли в животе, сильным газообразованием, нарушением стула. Хроническое течение заболевания развивается постепенно, выраженность симптомов изменяется в зависимости от приема пищи, времени суток и т.д. Хроническая форма может протекать бессимптомно, а может проявляться опасным для здоровья обострением.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Острый энтероколит проявляется следующими симптомами:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">жидкий стул (более 10 раз в сутки);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">сильная боль в области живота;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">ощущение тошноты;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рвота.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Если заболевания спровоцировано попаданием в организм патогенных микроорганизмов, то наблюдаются выраженные признаки интоксикации. У заболевшего человека сильно повышается температура тела, появляется озноб и боль в голове.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У детей энтероколит может вызывать серьезное ухудшение самочувствия. Возможно появление судорог и даже потеря сознания. При наличии жидкого стула или рвоты возможно обезвоживание и состояние, угрожающее жизни малыша. В таком случае необходима обязательная госпитализации.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптомы хронической формы схожи с проявлением острого энтероколита. Обязательно наличие жидкого стула. Иногда понос чередуется с запорами.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Также характерно появление болевых ощущений в области живота. Правда боль при хронической форме менее выражена, чем при острой. Обычно она усиливается перед актом дефекации.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Кроме этого энтероколит хронический имеет следующие симптомы:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">периодически появляющееся чувство тошноты;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">отрыжка;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">вздутие живота;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушение функции пищеварения.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Больной хронической формой имеет бледную кожу, серый цвет лица, тусклые ломкие волосы. Он быстро устает, плохо концентрируется, жалуется на нарушение сна и памяти. Нарушение функции желудочно-кишечного тракта приводит к резкому снижению иммунитета и склонности к присоединению простудных и инфекционных заболеваний.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
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"code": "K51.2",
"name": "Язвенный (хронический) проктит",
"icd_name": "Язвенный (хронический) проктит",
"gender": 0,
"age_min": 20,
"age_max": 70,
"cause": [
"0"
],
"periodicity": 1,
"slug": "k51.2_yazvennyy_hronicheskiy_proktit",
"lead": "воспаление слизистой оболочки прямой кишки, которое осложняется образованием язв на её поверхности",
"description": "",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Язвенный проктит является тяжелой формой острого проктита и обычно возникает при высокой интенсивности повреждающего воздействия либо при сочетании нескольких этиологических причин и предрасполагающих условий. Заболевание многофакторное, может возникать вследствие следующих причин:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Погрешности питания. Язвенный проктит, возникший вследствие нарушений пищевого режима, называется алиментарным. Эта форма воспаления может развиться при злоупотреблении крепкими алкогольными напитками, жирной пищей, копченостями, острыми, пряными и солеными продуктами.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хронический запор. Провоцирует застойные язвенные проктиты. Непосредственной причиной развития воспаления в подобных случаях становятся постоянные повреждения нижних отделов толстого кишечника слишком плотными фекальными массами. Нарушения питания и застой кала часто сочетаются между собой или становятся отягчающими факторами, провоцирующими развитие язвенного проктита при других повреждающих воздействиях.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Механические травмы прямой кишки. Иногда язвенный проктит возникает после механической травмы (анального полового акта, введения в анус твердых или шершавых предметов, повреждения слизистой случайно проглоченными инородными телами), а также после операций по поводу трещины заднего прохода, геморроя и парапроктита.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повреждение слизистой раздражающими веществами. Язвенный проктит может развиваться после клизм с использованием веществ, раздражающих и повреждающих стенку кишки: хлоридом калия, борной кислотой, йодом, гипертоническим раствором карловарской или поваренной соли. Дополнительными травмирующими факторами в подобных случаях становятся злоупотребление клизмами, использование слишком горячих или слишком холодных растворов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Воздействие паразитов и инфекционных агентов. Иногда заболевание диагностируется на фоне дизентерии либо паразитарных инфекций. Особенно опасен в этом отношении власоглав (возбудитель трихоцефалеза), внедряющийся в стенку кишки. Кроме того, язвенный проктит может обнаруживаться при некоторых специфических инфекциях, например – при гонорейном поражении прямой кишки.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лучевая терапия. Язвенные поражения кишки могут быть следствием чрезмерно интенсивного облучения области малого таза у пациентов с онкологической патологией. Чаще всего тяжелые язвенные проктиты диагностируются у больных раком тела и шейки матки. При злокачественных опухолях других органов малого таза язвы на слизистой оболочке образуются реже.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В числе факторов, способствующих развитию язвенного проктита, специалисты указывают иммунные нарушения, переохлаждение и воспалительные заболевания органов малого таза.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"pathogenesis": "",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Диагноз язвенный проктит выставляется по результатам консультации проктолога, используются данные опроса, осмотра заднего прохода, ректального исследования, эндоскопию, биопсии и анализов кала. При опросе обращают внимание на факторы, способные спровоцировать развитие язвенного проктита (лучевое лечение, травмы прямой кишки, хронические запоры и пр.), давность появления симптомов и особенности течения заболевания.</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Визуальный осмотр. При осмотре области ануса на начальных стадиях обнаруживают спазм, а в последующем – чрезмерное расслабление сфинктера. При отсутствии заболеваний заднего прохода перианальная зона в первые дни болезни не изменена. В последующем из-за зияния сфинктера у больных язвенным проктитом может выявляться загрязнение кожи калом, кровью, гноем и слизью с развитием мацерации. Ректальное исследование подтверждает наличие отека прямой кишки.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Эндоскопия прямой кишки. Наиболее информативной методикой при язвенном проктите является ректороманоскопия, позволяющая визуально оценить выраженность и распространенность воспаления, количество, размеры и глубину язв. При проведении эндоскопического исследования осуществляют биопсию.</span></li>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Лабораторные тесты. Для определения причин развития язвенного проктита назначают копрограмму, анализы кала на бакпосев и на яйца глист. При подозрении на специфическую инфекцию (гонорею, сифилис) выполняют ПЦР и ИФА-диагностику, пациента направляют на консультацию к венерологу.</span></li>\r\n</ul>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение проводится в стационарных условиях. Пациента, страдающего язвенным проктитом, госпитализируют в отделение проктологии. Назначают постельный режим. Исключают из меню продукты, оказывающие раздражающее действие на стенку кишки. Рекомендуют отварное мясо и рыбу, бульон, рисовую и манную кашу на воде, кисели и отвары с обволакивающим действием (из подорожника либо семян льна). Осуществляется:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Этиотропная терапия. При лучевом язвенном проктите прекращают лучевое лечение. При кишечных инфекциях назначают антибактериальные препараты, при гельминтозах – антигельминтные средства.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Местная терапия. Используют теплые клизмы с настоем ромашки, рыбьим жиром, маслом облепихи, протарголом или колларголом. Применяют местные средства с обезболивающим, противовоспалительным и регенерирующим действием: свечи с прополисом, свечи с метилурацилом.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В процессе лечения язвенного проктита назначают повторные эндоскопические исследования для контроля за состоянием слизистой оболочки. В остром периоде хирургическое вмешательство показано только при перфорации кишки. При возникновении рубцовых стриктур в отдаленном периоде осуществляют соответствующую терапию (физиотерапевтические процедуры, введение гормонов, расширение бужами Гегара), при неэффективности консервативных мероприятий рубцовую ткань иссекают.</span></p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
"prevention": "<p><span id=\"docs-internal-guid-105b0809-7fff-8d5e-a3d2-90e74a26eba0\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Профилактика заключается в рациональном питании, своевременном опорожнении кишечника, предупреждении травм и повреждений слизистой, элиминации паразитов.</span></span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Клиническая симптоматика язвенного проктита соответствует другим формам заболевания. Характерно внезапное начало с гипертермией, слабостью, разбитостью, тенезмами, болями, зудом и жжением в области ануса. По мере развития язвенного проктита промежутки между актами дефекации сокращаются. Стул становится жидким.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">У некоторых пациентов наблюдаются непрерывные позывы с отхождением небольшого количества жидкого кровянистого кала или крови и слизи без примесей фекальных масс. Отличительными особенностями язвенного проктита являются более тяжелое течение и значительное количество крови в кале. Кровь обычно красная, располагается на поверхности оформленного кала или содержится в жидких фекальных массах в виде хорошо различимых включений.</span></p>",
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"etiology": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Псевдополипоз ободочной кишки характеризуется появлением бляшек различного размера и формы, выступающих над поверхностью стенки в просвет кишечника. Причиной образования таких бляшек становятся повреждения слизистой при воспалительных заболеваниях кишечника (неспецифическом язвенном колите, болезни Крона) и некоторых инфекционных поражениях ЖКТ (чаще всего при дизентерии). При болезни Крона псевдополипоз ободочной кишки выявляется гораздо реже, чем при неспецифическом язвенном колите, что обусловлено различиями в течении и преимущественной локализации воспалительного процесса при этих двух заболеваниях.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Узлы при псевдополипозе ободочной кишки могут представлять собой сохранившиеся участки нормальной слизистой оболочки, окруженные язвами и очагами поверхностного некроза. Такие выросты также могут образовываться в результате разрастания железистого эпителия при восстановлении слизистой. Под разрастаниями иногда обнаруживаются островки соединительной ткани. В некоторых случаях псевдополипоз ободочной кишки возникает в результате образования избыточных грануляций. В формировании узлов могут играть роль не только изъязвления слизистой, но и растяжения стенки кишечника при перистальтических движениях, травмы воспаленной слизистой твердыми каловыми массами и т. д.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Количество и размеры псевдополипов при псевдополипозе ободочной кишки существенно варьируют. У одних больных выявляются единичные узлы, у других – множественные образования, покрывающие значительную часть слизистой оболочки сигмовидной кишки. Средний диаметр узла при псевдополипозе ободочной кишки составляет 5-10 миллиметров, при этом отдельные псевдополипы могут достигать 5 и более сантиметров. С учетом внешнего вида узлов различают обычные псевдополипы, образования в форме шапочки и глубокий кистозно-полипозный колит.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Псевдополипоз ободочной кишки диагностируется на основании эндоскопических исследований. В процессе ректороманоскопии или колоноскопии врач изучает состояние слизистой, выявляет изъязвления и другие изменения, характерные для неспецифического язвенного колита и других заболеваний, способных спровоцировать псевдополипоз ободочной кишки. Эндоскопист оценивает количество, размер и форму псевдополипов, берет образцы ткани узлов и соседних участков слизистой оболочки для морфологического исследования.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В процессе изучения морфологической структуры образований, возникающих у больных псевдополипозом ободочной кишки, определяется неизмененный эпителий, разрастания эпителия или грануляционная ткань. При исследовании слизистой оболочки, пораженной язвенным колитом выявляются расширенные капилляры, кровоизлияния, язвы и крипт-абсцессы. Подслизистый слой обычно изменен незначительно. Слизистая оболочка кишечника у пациентов с болезнью Крона грубая, бугристая, по внешнему виду напоминает «булыжную мостовую».</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ирригоскопия при псевдополипозе ободочной кишки малоинформативна, поскольку позволяет обнаруживать только достаточно крупные псевдополипы и при этом не дает возможности оценивать форму узлов, состояние и общий вид слизистой оболочки. Компьютерная томография обеспечивает более точные результаты, но, как и контрастная рентгенография, не предоставляет врачу достаточно информации для дифференцировки псевдополипоза ободочной кишки и других заболеваний, сопровождающихся появлением дефектов наполнения на рентгенограммах. Обе методики применяют только при недоступности эндоскопических исследований или наличии противопоказаний к проведению ректороманоскопии и колоноскопии.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Тактику лечения псевдополипоза ободочной кишки определяют в зависимости от вида и степени тяжести основной патологии. При неспецифическом язвенном колите рекомендуют полноценное сбалансированное питание, в периоды обострения назначают иммуносупрессоры, глюкокортикоидные средства и препараты 5-аминосалициловой кислоты. При псевдополипозе ободочной кишки с выраженными нарушениями водно-электролитного обмена проводят инфузионную терапию. По показаниям применяют антибиотики. При неэффективности консервативной терапии, дисплазии слизистой оболочки, ярко выраженных внекишечных проявлениях и осложнениях неспецифического язвенного колита (мегаколоне, перфорации сигмовидной кишки, кишечном кровотечении, озлокачествлении участка измененной слизистой оболочки) осуществляют хирургические вмешательства.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапия псевдополипоза ободочной кишки при болезни Крона также предусматривает использование глюкокортикоидов, иммуносупрессоров, препаратов 5-аминосалициловой кислоты и антибиотиков. Дополнительно назначают блокаторы фактора некроза опухоли, блокаторы интегриновых рецепторов, витамин D и гипербарическую оксигенацию. При осложнениях проводят операции. Неспецифический язвенный колит и болезнь Крона являются хроническими заболеваниями с рецидивирующим течением. Пациентам необходимы регулярные осмотры и поддерживающая терапия в период ремиссии.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При псевдополипозе ободочной кишки, обусловленном дизентерией и другими кишечными инфекциями, назначают специальную диету, проводят этиотропную терапию с использованием противомикробных препаратов, осуществляют дезинтоксикационные мероприятия. Прогноз при данной патологии определяется типом и особенностями течения основного заболевания. Больные с псевдополипозом ободочной кишки находятся под наблюдением врача-проктолога и гастроэнтеролога.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">В основе профилактики – предупреждение травмирования и развития воспалительных процессов в ободочной кишке. Конкретными мероприятиями являются:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">аккуратное выполнение всех манипуляций на ободочной кишке, чтобы предотвратить травмирование ее слизистой оболочки; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">своевременное выявление и лечение неспецифического язвенного колита, болезни Крона и дизентерии – заболеваний, на фоне которых чаще всего и возникает псевдополипоз ободочной кишки, а также других предрасполагающих болезней; </span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">предупреждение возникновения запоров и формирования каловых камней – для этого следует в первую очередь отрегулировать питание.</span></li>\r\n</ul>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Специфическая симптоматика псевдополипоза ободочной кишки отсутствует. Пациенты предъявляют жалобы, характерные для основного заболевания. При неспецифическом язвенном колите наблюдаются поносы. Возможен кашицеобразный стул с примесями слизи, крови и гноя. Больных псевдополипозом ободочной кишки беспокоят частые ложные позывы и боли в левой половине живота. Отмечаются слабость, нарушения аппетита и потеря веса. Выраженность гипертермии зависит от тяжести патологии, температура тела может колебаться от 37 до 39 градусов. Иногда выявляются внекишечные симптомы: боли в суставах, анкилозирующий спондилит (болезнь Бехтерева), афтозный стоматит, увеит, узловатая эритема и пр.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Для псевдополипоза ободочной кишки при болезни Крона также характерны боли в животе, расстройства стула, потеря аппетита, снижение массы тела, слабость и гипертермия различной степени выраженности. Обнаруживаются те же внекишечные проявления, что и при неспецифическом язвенном колите. Отличительными особенностями псевдополипоза ободочной кишки при болезни Крона являются склонность к образованию рубцовых сужений просвета кишечника, более высокая частота развития осложнений (кишечной непроходимости, кишечного кровотечения, перфорации толстой кишки) и нарушения со стороны печени и почек. При дизентерийном псевдополипозе ободочной кишки наблюдаются острое начало, общие симптомы интоксикации и выраженные кишечные расстройства (многократный понос, урчание, схваткообразные боли, патологические примеси в кале).</span></p>",
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