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"code": "A51",
"name": "Ранний сифилис",
"icd_name": "Ранний сифилис",
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"lead": "Нарушение здоровья, относящееся к группе инфекции, передающиеся преимущественно половым путем",
"description": "Сифилис– венерическое заболевание, имеющее длительное волнообразное течение и поражающее все органы.",
"etiology": "<p>Бледная трепонема представляет собой микроорганизм спиралевидной формы; число оборотов спирали от 8 до 12, ее завитки равномерны, имеют идентичное строение. Совершает характерные виды движения: вращательные, поступательные, волнообразные и сгибательные. Размножается преимущественно путем поперечного деления на два или несколько сегментов, каждый из которых вырастает затем во взрослую особь. </p>\r\n<p>Микроорганизм также может существовать в виде цист и L-форм. Циста является формой выживания бледной трепонемы в неблагоприятных условиях среды и рассматривается как стадия покоя T. рallidum; обладает антигенной активностью. L-форма является способом выживания бледной трепонемы внутри организма без оболочки. </p>",
"pathogenesis": "<p>Бледная трепонема после контакта со слизистой или кожными покровами инфицированного человека бледная трепонема проникает в глубокие слои покровного эпителия. Проникая глубже, бактерия оказывает повреждающее действие на стенку сосудов – вызывая локальное ее разрушение и формирования микротромбов. Потому дальнейший процесс разрушения пораженной ткани происходит через некроз (омертвение) тканей с их последующим разрушением. Распространение бледной трепонемы в ближайшие ткани происходит с током лимфы. <br class=\"SCXW108655615\" /> <br class=\"SCXW108655615\" />В отдаленные органы бледная трепонема попадает с током крови. Доступ в кровеносное русло бледная трепонема получает в результате токсического действия на пораженные сосуды. Потому на поздних стадиях возможно поражение сифилисом сердца, скелета и иных органов, содержащих соединительную ткань. <br class=\"SCXW108655615\" /> <br class=\"SCXW108655615\" />Стоит обратить внимание на то, что бледная трепонема, даже будучи поглощенной иммунной клеткой, может сохранять свою жизнеспособность, находясь внутри фагоцита. Тем самым повышается устойчивость возбудителя сифилиса к антибиотикам и неспецифическому иммунитету. </p>",
"diagnostics": "<p>Абсолютным доказательством наличия заболевания является обнаружение бледной трепонемы в образцах, полученных из очагов поражений, с помощью микроскопии в темном поле зрения или прямой иммунофлюоресценции, а также выявление специфической ДНК и РНК возбудителя методом полимеразной цепной реакции (ПЦР). </p>\r\n<p>Используются методы определения специфических иммуноглобулинов к белой трепанеме - ИФА, иммуноблоттинг. </p>\r\n<p>Серологические методы исследования - РПГА, РИФ, РИБТ - позволяют выявить специфические антитела к бледной трепанеме. Диагностически значимым считается увеличение титра специфических антител в 4 раза и более. </p>\r\n<p>Диагностика сифилитического поражения внутренних органов и опорно-двигательного аппарата основывается также на клинических проявлениях, данных инструментальных исследований (рентгенологических, ультразвуковых, магнитно-резонансной томографии, компьютерной томографии). </p>",
"treatment": "<p>В основе лечения сифилиса – применение антибиотиков пенициллинового ряда, к которым бледная спирохета проявляет высокую чувствительность. При аллергических реакциях больного на производные пенициллина в качестве альтернативы рекомендуются эритромицин, тетрациклины, цефалоспорины. В случаях позднего сифилиса в дополнение назначают препараты йода, висмута, иммунотерапию, биогенные стимуляторы, физиолечение. </p>\r\n<p>Важно установить половые контакты больного сифилисом, обязательно провести превентивное лечение возможно зараженных половых партнеров. По окончании лечения все ранее больные сифилисом остаются на диспансерном наблюдении у врача до полного отрицательного результата комплекса серологических реакций. </p>",
"prevention": "<p>Профилактика сифилиса — выявление заражённых и круга их половых партнёров, превентивное лечение и личная гигиена после полового акта. Обследования на сифилис людей, принадлежащих к группам риска – медиков, учителей, персонала детсадов и учреждений общепита. </p>",
"clinical_picture": "<p>Начинается заболевание с появления первичного аффекта. Чаще всего первичные признаки проявляются в виде характерного твёрдого шанкра — глубокой, обычно безболезненной или почти безболезненной некровоточащей сифилитической язвочки с ровными боковыми поверхностями, ровным дном и ровными краями, имеющими правильную округлую форму. Язвочка плотная (за что и названа твёрдым шанкром), не спаяна с окружающими тканями, не проявляет тенденции к росту в диаметре, углублению или к формированию язв-спутников, возникает в результате иммунного ответа организма в месте внедрения бледной трепонемы в организм. Помимо классического варианта твёрдого шанкра могут наблюдаться его атипичные формы: множественный шанкр, индуративный отёк, шанкр панариций, шанкр амигдалит. </p>\r\n<p>Индуративный отёк возникает, как правило, в области половых органов и представляет собой увеличение и изменение цвета кожных покровов мошонки или клитора и половых губ. Как правило, больные не жалуются на боли, при надавливании на область отёка в месте нажатия не остаётся углубления, кожа приобретает застойно-синюшную окраску, бледнеющую от центра к периферии. </p>\r\n<p>Шанкр-панариций чаще развивается у медиков, во многом напоминает типичный панариций, поражает 1 — 3й пальцы правой кисти. В отличие от классического твёрдого шанкра он, как правило, болезненный, также может сопровождаться развитием классического твёрдого шанкра на половых органах. </p>\r\n<p>Шанкр-амигдалит развивается в ротоглотке и представляет собой одностороннее увеличение нёбной миндалины без дефектов на её поверхности. Увеличенная миндалина выпирает в глотку, вызывает боли и затруднение при глотании, к этому присоединяются общее недомогание, лихорадка, во многом такое течение сифилиса напоминает ангину, однако для сифилитического процесса характерно одностороннее поражение. Обязательно присутствует односторонний регионарный лимфаденит. </p>\r\n<p>Для вторичного сифилиса характерны генерализованные поражения кожи и слизистых оболочек, часто в виде очень характерной бледно-пятнистой сыпи («ожерелье Венеры») или в виде множественных мелких кровоизлияний в кожу и слизистые оболочки. Также наблюдается очаговое выпадение волос, вплоть до облысения. Характерен генерализованный лимфаденит, причём лимфатические узлы опять-таки увеличенные, плотные, при прощупывании инфильтрированные чем-то, но безболезненные или малоболезненные, не спаяны с окружающими тканями и на ощупь «холодные». </p>\r\n<p>Стадия сифилитической бактериемии, или вторичная стадия, обычно длится несколько дней, редко затягиваясь дольше 1—2 недель. При этом пятнистая сыпь постепенно бледнеет и исчезает, параллельно ослабевают и исчезают явления катара верхних дыхательных путей, отступают слабость и недомогание. </p>\r\n<p> </p>",
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},
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"name": "Поздний сифилис",
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"lead": "Нарушение здоровья, относящееся к группе инфекции, передающиеся преимущественно половым путем",
"description": "Сифилис– венерическое заболевание, имеющее длительное волнообразное течение и поражающее все органы.",
"etiology": "<p>Бледная трепонема представляет собой микроорганизм спиралевидной формы; число оборотов спирали от 8 до 12, ее завитки равномерны, имеют идентичное строение. Совершает характерные виды движения: вращательные, поступательные, волнообразные и сгибательные. Размножается преимущественно путем поперечного деления на два или несколько сегментов, каждый из которых вырастает затем во взрослую особь. </p>\r\n<p>Микроорганизм также может существовать в виде цист и L-форм. Циста является формой выживания бледной трепонемы в неблагоприятных условиях среды и рассматривается как стадия покоя T. рallidum; обладает антигенной активностью. L-форма является способом выживания бледной трепонемы внутри организма без оболочки.</p>",
"pathogenesis": "<p>Бледная трепонема после контакта со слизистой или кожными покровами инфицированного человека бледная трепонема проникает в глубокие слои покровного эпителия. Проникая глубже, бактерия оказывает повреждающее действие на стенку сосудов – вызывая локальное ее разрушение и формирования микротромбов. Потому дальнейший процесс разрушения пораженной ткани происходит через некроз (омертвение) тканей с их последующим разрушением. Распространение бледной трепонемы в ближайшие ткани происходит с током лимфы. <br class=\"SCXW233802150\" /> <br class=\"SCXW233802150\" />В отдаленные органы бледная трепонема попадает с током крови. Доступ в кровеносное русло бледная трепонема получает в результате токсического действия на пораженные сосуды. Потому на поздних стадиях возможно поражение сифилисом сердца, скелета и иных органов, содержащих соединительную ткань. <br class=\"SCXW233802150\" /> <br class=\"SCXW233802150\" />Стоит обратить внимание на то, что бледная трепонема, даже будучи поглощенной иммунной клеткой, может сохранять свою жизнеспособность, находясь внутри фагоцита. Тем самым повышается устойчивость возбудителя сифилиса к антибиотикам и неспецифическому иммунитету. </p>",
"diagnostics": "<p>Абсолютным доказательством наличия заболевания является обнаружение бледной трепонемы в образцах, полученных из очагов поражений, с помощью микроскопии в темном поле зрения или прямой иммунофлюоресценции, а также выявление специфической ДНК и РНК возбудителя методом полимеразной цепной реакции (ПЦР). </p>\r\n<p>Используются методы определения специфических иммуноглобулинов к белой трепанеме - ИФА, иммуноблоттинг. </p>\r\n<p>Серологические методы исследования - РПГА, РИФ, РИБТ - позволяют выявить специфические антитела к бледной трепанеме. Диагностически значимым считается увеличение титра специфических антител в 4 раза и более. </p>\r\n<p>Диагностика сифилитического поражения внутренних органов и опорно-двигательного аппарата основывается также на клинических проявлениях, данных инструментальных исследований (рентгенологических, ультразвуковых, магнитно-резонансной томографии, компьютерной томографии). </p>",
"treatment": "<p>В основе лечения сифилиса – применение антибиотиков пенициллинового ряда, к которым бледная спирохета проявляет высокую чувствительность. При аллергических реакциях больного на производные пенициллина в качестве альтернативы рекомендуются эритромицин, тетрациклины, цефалоспорины. В случаях позднего сифилиса в дополнение назначают препараты йода, висмута, иммунотерапию, биогенные стимуляторы, физиолечение. </p>\r\n<p>Важно установить половые контакты больного сифилисом, обязательно провести превентивное лечение возможно зараженных половых партнеров. По окончании лечения все ранее больные сифилисом остаются на диспансерном наблюдении у врача до полного отрицательного результата комплекса серологических реакций. </p>\r\n<p>При лечении нейросифилиса препаратами пенициллина обязательно сочетание перорального или внутримышечного введения антибактериальных препаратов с их эндолюмбальным введением и с пиротерапией, повышающей проницаемость гемато-энцефалического барьера. </p>\r\n<p>При распространённом третичном сифилисе на фоне выраженной устойчивости бледной трепонемы к антибактериальным препаратам и при хорошем общем состоянии больного, допускающем определённую токсичность проводимой терапии, может быть рекомендовано добавление к антибиотикам производных висмута или производных мышьяка. </p>",
"prevention": "<p>Профилактика сифилиса — выявление заражённых и круга их половых партнёров, превентивное лечение и личная гигиена после полового акта. Обследования на сифилис людей, принадлежащих к группам риска – медиков, учителей, персонала детсадов и учреждений общепита. </p>",
"clinical_picture": "<p>Если больной сифилисом не лечился или лечение было неполноценным, то через несколько лет после заражения у него появляются симптомы третичного сифилиса. Происходят серьезные нарушения органов и систем, внешность больного обезображивается, он становится инвалидом, в тяжелых случаях вероятен летальный исход. </p>\r\n<p>Клинические проявления раннего нейросифилиса появляются в первые 2—3 года после заражения и соответствуют вторичному периоду заболевания. Клиническая картина раннего нейросифилиса зависит от поражённых структур и во многом схожа с инфекционно-воспалительными заболеваниями мозга другой этиологии. </p>\r\n<p>Асимптомный нейросифилис - состояние, при котором клинических симптомов поражения нервной системы нет, а диагноз устанавливается на основании воспалительных изменений в ликворе. Воспалительные изменения в спиномозговой жидкости обнаруживаются в течение 12—18 месяцев с момента заражения. </p>\r\n<p>Спинная сухотка характеризуется поражением спинальных нервов, нервных ганглиев и задних столбов спинного мозга. В результате у больного формируется специфическое нарушение походки — сенситивная атаксия. Больной во время ходьбы не ощущает опоры. Он не может передвигаться с закрытыми глазами, теряется ощущение положения тела в пространстве. </p>\r\n<p>Прогрессивный паралич представляет собой прогрессирующий менингоэнцефалит, развивающийся постепенно с пиком заболеваемости в 15—20 лет после инфицирования. Имитирует проявления многих психических заболеваний. Начинается с раздражительности, снижения памяти, невозможности сосредоточиться и изменения личности. По мере прогрессирования присоединяются расторможенность, асоциальное поведение и бред. В терминальных стадиях развиваются деменция, параличи и нарушения функции тазовых органов. </p>\r\n<full></full>\r\n<p>Атрофия зрительного нерва может являться самостоятельной формой нейросифилиса. Характерно одностороннее ухудшение зрения, которое постепенно распространяется и на второй глаз. Лечение сифилиса приостанавливает снижение зрения. Исходом заболевания у нелечённых больных является слепота вследствие атрофии зрительного нерва. </p>\r\n<p>Гуммы головного мозга встречаются редко. Излюбленная локализация — основание мозга; реже располагается в мозговом веществе. Приводит к повышению внутричерепного давления. Клиническое течение напоминает таковое при опухоли мозга, с которой и следует проводить дифференциальный диагноз. </p>\r\n<p>Поздний висцеральный сифилис представляет собой поражение внутренних органов человека, чаще всего страдает сердечно-сосудистая система, на втором месте поражения печени, остальные органы поражаются значительно реже, хотя поздние поражения регистрировались во всех внутренних органах человека. </p>\r\n<p>Не осложненный сифилитический аортит является наиболее частым проявлением позднего висцерального сифилиса. При данной форме заболевания происходит расширение аорты, больные жалуются на слабость, головокружение, чувство сердцебиения, при малейшей нагрузке и в покое. При аускультацииу больного отмечается мягкий, не резко выраженный систолический шум и акцент 2 тона, на аорте. Также при сифилисе могут поражаться другие крупные сосуды и клапаны сердца, что приведёт к появлению клиники и жалоб, характерных для поражения этих отделов сердечно-сосудистой системы. </p>\r\n<p> </p>",
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