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"etiology": "<p>Рак мочеточника составляет в среднем 4% от всех опухолей верхних мочевых путей. Переходно-клеточный рак мочеточника составляет приблизительно 7% всех почечных опухолей. Факторы риска те же, что и для рака мочевого пузыря. Самый распространенный – это курение. Также доказано увеличение риска заболевания при злоупотреблении обезболивающими лекарственными препаратами (например, фенацетин), хроническом раздражении слизистой оболочки (при мочекаменной болезни, шистосомозе), при длительном контакте химическими веществами, используемыми в промышленности. Кроме того, жители Балкан с эндемической семейной нефропатией имеют необъяснимую предрасположенность развития рака мочеточников.</p>",
"pathogenesis": "<p>По мнению большинства патоморфологов, все папиллярные опухоли лоханки и мочеточника, являются разными стадиями единого процесса. Опухоли мочеточника бывают эпителиального (папиллома, сосочковый и плоскоклеточный рак) и соединительнотканного (фиброма, лейомиома, саркома) происхождения. Чаще наблюдаются эпителиальные опухоли. Первичные новообразования склонны к раннему метастазированию. Метастазы распространяются гематогенным и лимфогенным путем.</p>",
"diagnostics": "<p>Во время исследования крови и мочи обнаруживают такие же изменения, и при опухолях почечной лоханки.</p>\r\n<p>При цистоскопии в момент гематурии удается уточнить источник кровотечения. Кроме того, в случае локализации папиллярного новообразования в нижнем отрезке мочеточника, при цистоскопи, иногда можно наблюдать, как в момент сокращения его отверстия, ворсинки опухоли появляются в просвете мочевого пузыря. Расположение папиллярных опухолей вокруг отверстия одного из мочеточников может свидетельствовать о первичной опухоли в мочеточнике или почечной лоханке.</p>\r\n<p>Катетеризация мочеточника позволяет выявить характерный признак его опухоли - выделение крови из мочеточникового катетера в момент чистой мочи после проведения его выше (симптом Шевассю).</p>\r\n<p>С помощью экскреторной урографии определяют нарушения секреторной и экскреторной функции почек, проявляют уретерогидронефроз на стороне поражения и дефект наполнения мочеточника. На уретеропиелограмме по обе стороны от дефекта наполнения мочеточника определяют затёки рентгенконтрастного вещества (симптом жала змеи).</p>\r\n<p>Если диагноз сомнителен, выполняют уретероскопию, которая позволяет осмотреть мочеточник, установить размеры поражения и характер распространения опухоли, инфильтрацию стенки, изменения мочевых путей выше опухоли. Выполнение биопсии опухолевой ткани с последующим гистологическим ее исследованием, помогает определить до операции правильный диагноз и даже установить стадию заболевания.</p>",
"treatment": "<p>Радикальным методом лечения может быть только оперативное вмешательство. При тотальном поражении мочеточника опухолью показана нефроуретерэктомия с резекцией мочевого пузыря, при условии хорошо функционирующей противоположной почки. При низком расположении допустимы резекция мочеточника вместе с прилегающей к устью стенкой мочевого пузыря и уретероцистоанастомоз (прямой или по Боари). Помимо хирургического лечения применяют химио- и радиотерапию, однако чувствительность опухолевых клеток к ним мала.</p>\r\n<p>После проведённого лечения пациентам рекомендуют выполнение контрольных цистоскопий через определённые промежутки времени, т.к. рак мочеточника имеет тенденцию распространяться в мочевой пузырь. В случае выявления такого процесса в ранней стадии может потребоваться выполнение трансуретральной резекции мочевого пузыря или внутрипузырных инстилляций противоопухолевых препаратов. Контрольное обследование, направленное на выявление метастазов такое же, как для рака мочевого пузыря.</p>",
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