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},
"code": "D03",
"name": "Меланома in situ",
"icd_name": "Меланома in situ",
"gender": 0,
"age_min": 15,
"age_max": 100,
"cause": [
3,
0
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"slug": "d03_melanoma_in_situ",
"lead": "Нарушение здоровья, относящееся к группе новообразования in situ",
"description": "Меланома in situ – это злокачественное новообразование кожи, развивающееся из клеток меланоцитов, развивающееся в пределах верхнего слоя кожи - эпидермиса. Чаще всего развивается на открытых участках тела, которые больше всего подвержены ультрафиолетовому облучению.",
"etiology": "<p>К предрасполагающим факторам, способствующим развитию меланомы, относят:</p>\r\n<ul>\r\n<li>инсоляция солнечными лучами кожи;</li>\r\n<li>особенности кожи – белая, с трудом поддается загару, солнечный ожог развивается за 30 минут воздействия ультрафиолетовых лучей;</li>\r\n<li>невусы (родинки) – доброкачественные новообразования на коже, вырабатывающие меланин – кожный пигмент;</li>\r\n<li>травмирование родинок;</li>\r\n<li>генетическая предрасположенность – наличие у родственников старшего поколения меланомы;</li>\r\n<li>перенесенный рак кожи;</li>\r\n<li>предраковое заболевание кожи – пигментная ксеродерма;</li>\r\n<li>пожилой возраст;</li>\r\n<li>расовая принадлежность человека. Согласно статистике ВОЗ, чернокожие в 4 раза реже страдают от меланомы, чем европеоиды;</li>\r\n<li>наличие сопутствующих хронических заболеваний, которые приводят к снижению общего иммунитета человека.</li>\r\n</ul>",
"pathogenesis": "<p>При изучении процессов возникновения и развития меланом кожи следует учитывать, что эта опухоль является уникальной для изучения вопросов ее канцерогенеза, так как более 50% первичных меланом кожи развивается на фоне предсуществующих пигментных невусов, что позволяет расценивать последний как факультативный предрак, и так как наиболее важными экзогенными этиологическими факторами этой опухоли являются УФ-радиация и травма невусов.</p>\r\n<p>Механизм канцерогенного действия УФ-радиации может заключаться в образовании в нормальных клетках высокоактивных свободных химических радикалов. В основе возникновения опухоли лежат процессы повреждения этими радикалами ДНК клетки, нарушение ее нормальной репарации. Последовательность процессов возникновения меланомы кожи под воздействием УФ-радиации можно схематически представить в следующем виде: УФ-радиация- меланобласты, меланоциты или невусные клетки - повреждение ДНК клетки - нарушение дифференцировки клетки - изменение белковой структуры клетки с возникновением новых мембранных антигенов - гипореактивность - бесконечно долгое размножение (опухолевый рост). Вероятно, такой механизм канцерогенеза меланом кожи является наиболее коротким во времени, так как в данном случае отсутствует длительная пролиферация нормальных клеток и тканей. Клиническим подтверждением возможности «включения» этого механизма канцерогенеза является факт более частого возникновения меланом после однократного и интенсивного воздействия УФ-радиации (солнечного ожога).</p>\r\n<p>Напротив, механизм канцерогенного действия травмы предсуществующих пигментных невусов включает в себя пролиферацию тканей в ответ на их повреждение, но сама травма не приводит к развитию опухоли. Доказано, что клетки в состоянии пролиферации обладают повышенной чувствительностью к канцерогенному воздействию и особенно уязвимы, находясь в фазе митотического цикла. Поэтому интенсивное размножение (пролиферация) клеток может привести к их неопластической трансформации. Последовательность процессов возникновения меланом кожи в результате травмы предсуществующих пигментных невусов можно схематически представить в следующем виде: повреждение - невусные клетки - воспаление и пролиферация поврежденной ткани - длительная пролиферация + воздействие эндогенных канцерогенных факторов (иммунологических, эндокринных, нейрогенных и др.) - нарушение структуры ДНК клетки - нарушение дифференцировки клетки - изменение белковой структуры клетки с возникновением новых мембранных антигенов - гипореактивность - бесконечно долгое размножение (опухолевый рост).</p>\r\n<p>Что касается действия эндогенных канцерогенных факторов меланомы кожи, то, очевидно, что точкой их приложения являются длительно пролиферирующие нормальные клетки и ткани, которые под воздействием этих факторов могут трансформироваться в опухолевые.</p>",
"diagnostics": "<p>Дерматоскопия -макроскопический осмотр образования при помощи дерматоскопа.</p>\r\n<p>Биопсия с последующим гистологическим анализом. Гистологическая диагностика представляет собой осмотр микропрепарата (тончайший срез исследуемого образца), подвергшегося специфической или неспецифической окраске. Помимо окраски с целью определения клеточного или тканевого атипизма, применяются также иммуногистохимический и иммуноферментный анализы</p>",
"treatment": "<p>Основным методом терапии является локальное иссечение первичной опухоли до фасции. Количество иссекаемых тканей зависит от распространенности опухолей и рассматриваются индивидуально, обычно с небольшим захватом здоровых тканей. Лекарственная терапия меланомы in situ проводится редко, только при гистологической верификации метастазирования опухоли. Поскольку к химиотерапии рак кожи в последние годы всё более устойчив, а химиопрепараты крайне токсичны, активно развивается иммунотерапия. Для лечения прогрессирующей меланомы используют препараты на основе альфа-интерферонов, интерлейкина и моноклональных антител.</p>\r\n<p>Третий вид терапии злокачественных опухолей – лучевая. Облучение назначается до операции с целью уменьшения объема хирургического вмешательства либо после операции.</p>\r\n<p>Комбинацию и методы врач подбирает индивидуально исходя из существующих особенностей меланомы in situ в каждом конкретном случае.</p>",
"prevention": "<p>Чтобы предотвратить переход доброкачественного процесса в злокачественное, люди входящие в группу риска должны регулярно наблюдаться у врача. Любыми видоизменения родинок, усиление пигментации, увеличение родимых пятен в размерах, уплотнение невусов должны стать поводом немедленного обращения к врачу. Люди, на теле которых множество родинок и невусов должны внимательно относиться к своему здоровью. Необходимо избегать попадания прямых солнечных лучей на места скопления родимых пятен, не допускать повреждения образований и регулярно посещать косметолога в целях профилактики. </p>\r\n<p> </p>",
"clinical_picture": "<p>Меланома in situ характеризуется появлением следующих клинических симптомов:</p>\r\n<ul>\r\n<li>Усилением пигментации пятна, его ростом и выраженным затвердением. В отличие от доброкачественных родинок, форма in situ не имеет осевой симметрии, ее очертания неровные. Пигментированное пятно состоит из мелких скоплений. Если у доброкачественных родинок цвет всегда равномерный, то у радиальной меланомы он может сочетаться светло-коричневым и песочным оттенками.</li>\r\n<li>Появление красного ободка вокруг меланомы и застойных явлений</li>\r\n<li>Появление пигментных разрастаний в виде лучей, отходящих от меланомы в разные стороны.</li>\r\n</ul>\r\n<p>В некоторых случаях первым клиническим симптомом прогрессирующей меланомы in situ является увеличение крупных лимфатических узлов, тогда как давно существующая родинка или невус на поверхности кожи не изменяется по своей окраске и в размерах. Прогрессирующее увеличение родинки или невуса на поверхности кожи, а также его затвердение и изменение окраски является первым симптомом того, что заболевание перешло в злокачественную форму течения.</p>\r\n<p>Очень часто рядом с растущим пигментным пятном начинают появляться различные плотные узелки усиленной пигментации. </p>\r\n<p> </p>",
"image": null,
"image_alt": null,
"standard_type": 3,
"danger": 1,
"published": 2,
"parent": null,
"block_rubric": 36,
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},
{
"id": 7998,
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},
"code": "D04",
"name": "Карцинома in situ кожи",
"icd_name": "Карцинома in situ кожи",
"gender": 0,
"age_min": 40,
"age_max": 100,
"cause": [
"0"
],
"periodicity": 1,
"slug": "d04_karcinoma_in_situ_kozhi",
"lead": "внутриэпидермальный рак кожи и слизистых, разновидность карциномы, которая поражает чешуйчатые клетки эпидермиса, но не распространяется на базалиоциты",
"description": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Карцинома in situ кожи - это разновидность неинвазивного рака кожи. Опухоль начинается с клеток, обычно находящихся на поверхности кожи. Другое название плоскоклеточного рака кожи in situ - болезнь Боуэна.</span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Ученые выделили ряд факторов, предрасполагающих к развитию патологии:</span></p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">гены (наследование определенных дефектов);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">влияние химических факторов (например, ароматические амины или углеводороды);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">физические влияния (ионизирующие излучения, ультрафиолет);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">биологические факторы (заражение определенными онкогенными вирусами – гепатит, папилломавирус);</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">расстройства гормонального статуса – нарушение метаболизма определенных гормонов.</span></p>\r\n</li>\r\n</ul>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Карцинома – это тип рака, который начинается в клетках, составляющих кожу или ткани, выстилающие органы, такие как печень или почки. Как и другие виды рака, карциномы - это аномальные клетки, которые бесконтрольно делятся. Они могут распространяться на другие части тела, но не всегда. Карцинома in situ остается в тех клетках, где она возникла. Не все виды рака являются карциномами.</span></p>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Развитие заболевания связано с изменением митотической активности клеток росткового слоя эпидермиса по причине мутации основного гена-супрессора опухолевого роста TP53. В месте развития патологического процесса кожа утолщается за счет быстрого увеличения численности шиповатых клеток. В течение длительного времени опухолевый рост локализован в эпидермисе, но последующие мутации способствуют перемещению раковых клеток в глубжележащие ткани, распространению их гематогенным и лимфогенным путем.</span></p>\r\n<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Повышение степени злокачественности новообразования может происходить постепенно или скачкообразно под воздействием провоцирующих внешних и внутренних факторов. До тех пор, пока измененные клетки располагаются выше базальной мембраны (границы между эпидермисом и дермой), болезнь Боуэна расценивается как неинвазивный рак. Как только патологический рост охватывает дерму, можно говорить об инвазивном раке.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Постановкой диагноза занимаются онкологи, они помимо оценки жалоб и осмотра, назначают целый ряд обследований. К ним относят:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">полное лабораторное обследование крови и мочи, включая анализ на онкомаркеры;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">эндоскопические исследования респираторного тракта и пищеварительной трубки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">рентгенографию предполагаемого места опухоли для выявления повреждений окружающих тканей;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">КТ и МРТ для уточнения размера опухоли, определения метастазов;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 7.5pt; font-family: Verdana; color: #212529; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">биопсию подозрительного очага для подтверждения типа рака</span></p>\r\n</li>\r\n</ul>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Консервативная терапия</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Местное воздействие на очаги поражения позволяет снизить общую нагрузку на организм, что особенно важно для ослабленных больных, пациентов с иммунодефицитом, лекарственной непереносимостью и другими ограничивающими факторами. К числу методов терапевтического лечения относят:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-style: normal; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Местное применение лекарственных средств. Назначаются кремы с имиквимодом или 5-фторурацилом. Длительность лечения для каждого из пациентов определяется в индивидуальном порядке, составляет от 1 недели до 2-3 месяцев. Обеспечивают более глубокое проникновение 5-фторурацила, достижение значительной его концентрации в тканях окклюзионные повязки, ионофорез или предварительное лазерное облучение патологического очага.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Фотодинамическая терапия. Метод предполагает применение средств, повышающих чувствительность тканей к световому воздействию. Активные ингредиенты лекарств накапливаются преимущественно в очагах поражения. Под воздействием света опухолевые клетки гибнут. Показано фотодинамическое лечение в первую очередь пациентам с множественными очагами значительной площади.</span></li>\r\n</ul>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Хирургическое лечение</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Способ удаления измененных тканей определяется техническим оснащением клиники, уровнем подготовки хирурга. Высокотехнологичные методы позволяют провести лечение с меньшим риском рецидива и рубцевания, однако они доступны далеко не везде. Более простые методики не требуют значительных затрат времени и финансов для того, чтобы получить удовлетворительный результат. Хирургическое лечение может включать:</span></p>\r\n<ul>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Простое оперативное удаление. Хирург иссекает новообразование в пределах здоровых тканей. Образец кожных покровов с дискератозом отправляется в лабораторию на экспресс-диагностику. Края раны стягиваются или проводится кожная пластика. Метод подходит для устранения патологических очагов небольшой площади, расположенных на туловище и конечностях. На лице могут остаться заметные рубцы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Микрографическую операцию Мооса. Данная хирургическая техника позволяет удалить новообразование слой за слоем, не повреждая здоровые ткани. Применяется она при рецидивах болезни Боуэна, иммунодефицитных состояниях, для удаления элементов в зонах повышенного риска: вокруг глаз и носа, в области гениталий. Более тонкая и аккуратная работа хирурга снижает вероятность развития рубцов.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Кюретаж. Выскабливание очага поражения при помощи кюретки позволяет удалить эпидермис с очагами внутриэпидермального рака. Процедура имеет небольшое количество противопоказаний, проводится под местным обезболиванием, не нарушает самочувствия пациента, поэтому ее применение оправдано у широкого круга лиц старшей возрастной группы.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Криотерапию. Метод эффективен в отношении одиночных образований небольшого диаметра. Под воздействием жидкого азота измененные ткани необратимо повреждаются и спустя некоторое время ссыхаются в плотную корочку. Заживление очагов происходит без рубцевания. Проведение криотерапии не требует предварительного обезболивания за исключением чувствительной к воздействиям области лица.</span></li>\r\n<li><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лазерную абляцию. Процедура проводится на неодимовой или углекислотной медицинской лазерной установке. Изменяя настройки аппарата, хирург может контролировать глубину и степень повреждения тканей. При помощи лазера удаляются одиночные очаги небольшого размера. Проводится лазерное лечение под местной анестезией. После удаления новообразований, расположенных в верхних слоях кожи, риск рубцевания минимальный.</span></li>\r\n</ul>\r\n<p> </p>\r\n<p><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\"> </span></p>",
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},
"code": "D06",
"name": "Карцинома in situ шейки матки",
"icd_name": "Карцинома in situ шейки матки",
"gender": 2,
"age_min": 15,
"age_max": 89,
"cause": [],
"periodicity": 1,
"slug": "d06_karcinoma_in_situ_sheyki_matki",
"lead": "Нарушение здоровья, относящееся к группе новообразования in situ",
"description": "Карцинома in situ считается самой ранней формой рака. Врачи нередко рассматривают данную опухоль как предраковое состояние. Это связано с тем, что раковые клетки при данной патологии обнаруживаются только в поверхностном слое шейки матки, и не распространяются на глубокие ткани. Рак шейки матки является одной из наиболее распространенных злокачественных опухолей у женщин, занимает второе место по частоте встречаемости после рака молочной железы.",
"etiology": "<p>Чаще всего раку шейки матки подвержены женщины в возрасте 40 – 55 лет. На развитие рака шейки матки могут влиять:</p>\r\n<p>— ранее начало половой жизни,<br /> — половые инфекции,<br /> — курение,<br /> — несоблюдение интимной гигиены,<br /> — слабый иммунитет,<br /> — хронические воспалительные процессы шейки матки и наличие заболеваний таких как: дисплазия шейки матки, эрозия шейки матки, лейкоплакия,<br /> — заражение вирусом папилломы человека (80-100% пациенток с раком шейки матки заражены ВПЧ). Существует более 100 типов вируса папилломы человека, среди которых 16 и 18 типы вызывают рак шейки матки, а также могут быть причинами плоскоклеточного рака глотки и рака ануса у женщин и у мужчин.</p>",
"pathogenesis": "<p>Факторами, способствующими запуску механизмов вирусного канцерогенеза, являются вирусного канцерогенеза, являются снижение иммунитета. Развитие рака шейки матки имеет ортодоксальный закономерный характер: в поверхностном (базальном) слое матки развивается гиперпластический процесс – дисплазия, для которого свойственна атипия эпителия с нарушением слоистости, но без вовлечения поверхностного слоя и стромы. Затем в этих участках формируется преинвазивный рак с поражением всего эпителиального пласта, затем происходит прорыв базальной мембраны и развитие инвазивного процесса. Чрезвычайно важен факт существования латентного периода (длительность которого весьма вариабельна), необходимого для перехода дисплазии в преинвазивный рак и далее в инвазивный. Этот период обеспечивает возможность активной профилактики заболеваемости инвазивным раком шейки матки путем выявления дисплазии и внутриэпителиального рака и своевременного адекватного их лечения.</p>",
"diagnostics": "<p>В современной онкогинекологии существует двухэтапная система обследования пациентки. На первом этапе производится первичное выявление — скрининг, на втором — используются методы углубленной диагностики при подозрении на предрак или рак репродуктивной системы.</p>\r\n<p>Цель скрининга:</p>\r\n<p>1) определение групп риска развития рака шейки матки;</p>\r\n<p>2) выявление контингента женщин с предраковой патологией шейки матки;</p>\r\n<p>3) направление женщин для второго этапа углубленного обследования.</p>\r\n<p>На этапе скрининга собирают анамнез, проводят общий осмотр и обследование молочных желез, осмотр наружных половых органов, влагалища и шейки матки в зеркалах, цитологическое исследование мазков, взятых с поверхности шейки матки из зоны трансформации и цервикального канала, бимануальное ректовагинальное исследование. Цитологическое залючение составляется с учетом классификации, аналогичной классификации Папаниколау, предусматривающей описание пяти типов мазков:</p>\r\n<p>I — цитограмма без особенностей;</p>\r\n<p>II — воспалительный тип мазка;</p>\r\n<p>III — морфологические изменения клеток, соответствующие дисплазии;</p>\r\n<p>IV — подозрение на рак;</p>\r\n<p>V — цитограмма рака.</p>\r\n<p>На основании клинико-цитологической информации отбираются женщины, которым показано более углубленное обследование.</p>\r\n<p>Задачи углубленной диагностики:</p>\r\n<p>1) верификация и установление стадии заболевания;</p>\r\n<p>2) определение местной распространенности опухолевого процесса;</p>\r\n<p>3) выявление отдаленных метастазов;</p>\r\n<p>4) оценка функционального состояния органов и систем.</p>\r\n<p>Для верификации диагноза производится осмотр шейки в зеркалах, выполняется кольпоскопия, из патологических очагов берется прицельно биопсия конхотомом, скальпелем, электропетлей и выполняется выскабливание цервикального канала ложечкой Фолькманна, кюреткой.</p>\r\n<p>Местное распространение опухоли определяется при осмотре в зеркалах, ректовагинальном бимануальном исследовании органов малого таза, параметральной клетчатки, мочевого пузыря и прямой кишки на глубину пальца. Степень местного распространения уточняется при цистоскопии, ректороманоскопии. Ультразвуковое исследование позволяет выявить метастазы в подвздошных, парааортальных лимфоузлах, печени и других паренхиматозных органах брюшной полости. Под контролем УЗИ выполняется тонкоигольная пункция через влагалищные своды с целью верификации метастатического поражения регионарных лимфоузлов. С целью исключения отдаленных метастазов выполняется рентгенография органов грудной полости, при подозрении метастатического поражения костей проводится сканирование скелета. На основании полученных результатов клинического обследования выставляется стадия заболевания.</p>",
"treatment": "<p>При выборе метода лечения ранней онкологической патологии шейки матки необходимо стремиться к соблюдению двух основных принципов:</p>\r\n<p>1) обеспечение надежного излечения, в результате чего предупреждаются рецидивы заболевания и переход в более выраженный патологический процесс;</p>\r\n<p>2) применение органосохраняющих и щадящих методов лечения у женщин молодого возраста.</p>\r\n<p>Конизация шейки матки (процедура, при которой удаляют конусообразный кусок шейки матки) может быть выполнена скальпелем, электроножом, хирургическим лазером. Основные достоинства метода конизации заключаются в радикальном удалении патологически измененных тканей шейки матки в пределах здоровых тканей, небольшом количестве осложнений, сохранении физиологических функций, включая детородную. Предпочтительнее применять методики конизации, позволяющие исследовать удаленный препарат шейки матки. Метод лазерной конизации исключает эту возможность. Метод электроконизации возможен даже в амбулаторных условиях.</p>\r\n<p>Ампутация шейки матки является альтернативным методом лечения преинвазивного рака шейки матки. Этот метод показан при грубых деформациях шейки матки, вызванных ее разрывами в родах, при поражении цервикального канала, когда выполнение электроконизации шейки матки сопряжено с большим риском развития рецидива.</p>\r\n<p>Экстирпация (удаление) матки показана:</p>\r\n<p>пациентам в возрасте старше 50 лет; при преимущественной локализации опухоли в шеечном канале; распространенном анапластическом варианте с врастанием в железы; отсутствии в препарате участков, свободных от преинвазивного рака (особенно по линии отсечения) после произведенной ранее конизации; сочетании преинвазивного рака с миомой матки или опухолями придатков; рецидивах после крио- или лазерной деструкции.</p>\r\n<p>Методы криодеструкции, лазерной коагуляции, лазерной конизации шейки матки, фотодинамической лазерной коагуляции, электрокоагуляции применяются в онкогинекологии. </p>\r\n<p>Они менее целесообразны для лечения преинвазивного рака шейки матки, так как не позволяют исследовать инвазию патологического процесса</p>",
"prevention": "<p>Предупредительные мероприятия в отношении рака включает:</p>\r\n<ul>\r\n<li>проведение широкомасштабной просветительской работы, с целью повышения онконастороженности;</li>\r\n<li>внедрение плановых скрининговых обследований, начиная с 21-25 лет с целью выявления дисплазии стенок половых органов;</li>\r\n<li>проведение планомерной вакцинации от вируса папилломы человека, в отношении рака шейки, создание системы контроля безопасности вакцинопрофилактики;</li>\r\n<li>совершенствование образа жизни, наиболее реальная рекомендация касается внимательного отношения к нормализации белкового, углеводного обмена.</li>\r\n</ul>\r\n<p> </p>",
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