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"lead": "переизбыток витамина D в организме",
"description": "<p><span id=\"docs-internal-guid-a74da852-7fff-25ed-f642-9947485c9c2c\"><span style=\"font-size: 7pt; font-family: Verdana; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;\">Гипервитаминоз D – это патологическое состояние, вызванное D-витаминной интоксикацией, сопровождающееся гиперкальциемией и отложением солей кальция во многих внутренних органах.</span></span></p>",
"etiology": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Существует две причины гипервитаминоза D:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">переизбыток этого витамина в организме человека из-за чрезмерного его употребления в составе различных витаминных препаратов;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">чувствительность организма к стандартным дозам витамина D. Она может возникнуть при неполноценном питании, а также в стрессовых ситуациях.</span></p>\r\n</li>\r\n</ul>",
"pathogenesis": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Основным патогенетическим звеном гипервитаминоза D выступает нарушение минерального (прежде всего, фосфорно-кальциевого) обмена, влекущее за собой сдвиги в белковом, углеводном, жировом обменах, метаболический ацидоз, повреждение клеточных структур.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Нарушение обмена кальция сопровождается его повышенным всасыванием в кишечнике с развитием гиперкальциемии и гиперкальциурии, метастатической кальцификации стенок сосудов и внутренних органов. Кальциноз органов при гипервитаминозе D носит генерализованный характер: наиболее интенсивно кальций накапливается в почках, сердце, сосудах, лимфоузлах, слизистой ЖКТ, мышцах, связках, хрящах.</span></p>",
"diagnostics": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лабораторная диагностика гипервитаминоза D включает определение уровней кальция и фосфата в крови и моче, щелочной фосфатазы, уровня метаболизма костной ткани. Биохимическими маркерами гипервитаминоза D служат гиперкальциемия, гипофосфатемия, гипокалиемия, гипомагниемия, повышение концентрации кальцитонина и снижение паратиреоидного гормона; гиперкальциурия, гиперфосфатурия, положительная проба Сулковича.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Рентгенография трубчатых костей при гипервитаминозе D характеризуется интенсивным отложением кальция в эпифизах трубчатых костей, повышенной порозностью диафизов.</span></p>",
"treatment": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Лечение детей с гипервитаминозом D должно осуществляться в стационаре. Исключение могут составлять легкие формы гипервитаминоза D, которые могут наблюдаться амбулаторно врачом-педиатром.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Терапию гипервитаминоза D начинают с отмены витамина D, исключения инсоляции, назначения диеты с ограничением кальция и повышенным количеством калия. Для снятия D-витаминной интоксикации применяются витамины А, В, С, Е; проводятся внутривенные инфузии глюкозы, бикарбоната натрия, альбумина, солевых растворов, введение аскорбиновой кислоты, кокарбоксилазы. В комплексной медикаментозной терапии гипервитаминоза D применяется форсированный диурез, глюкозо-инсулиновая терапия, кортикостероиды. Токоферол, ретинол, преднизолон являются физиологическими антагонистами витамина D, поэтому их применение в лечении гипервитаминоза D обязательно.</span></p>",
"prevention": "<p> </p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Профилактические меры включают обоснованное назначение и точное соблюдение дозировок лекарственных форм витамина D, врачебный контроль за приемом препарата, лабораторный мониторинг уровня кальция и фосфора в крови, кальция в моче 1 раз в 7—10 дней.</span></p>",
"clinical_picture": "<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Различают две формы заболевания: острую и хроническую. Острая форма возникает при применении высоких доз витамина D в течение 2-10 недель, а хроническая — при длительном применении (от 6 до 8 месяцев).</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">При острой форме гипервитаминоза D проявляются такие симптомы: снижение аппетита или полное его отсутствие; жажду; рвоту; сонливость; вялость; нарушение стула.</span></p>\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">Симптомами хронической формы гипервитаминоза D являются те же симптомы, как и у острой формы, а также:</span></p>\r\n<p> </p>\r\n<ul style=\"margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;\">\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">раздражительность;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">нарушение сна;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">повышение артериального давления;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">боли в костях и пояснице;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">увеличение печени, селезенки;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">снижение иммунитета;</span></p>\r\n</li>\r\n<li style=\"list-style-type: disc; font-size: 6pt; font-family: Verdana; color: #333536; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;\" dir=\"ltr\">\r\n<p style=\"line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;\" dir=\"ltr\"><span style=\"font-size: 6.999999999999999pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;\">учащенное мочеиспускание.</span></p>\r\n</li>\r\n</ul>",
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"code": "E68",
"name": "Последствия избыточности питания",
"icd_name": "Последствия избыточности питания",
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"lead": "Ожирение",
"description": " \r\n\r\nТермин ожирение алиментарно-конституционального генеза или первичное ожирение подразумевает расстройство в функционировании организма, спровоцированное нехваткой двигательной активности и неправильно составленным рационом питания – так называемым перееданием. \r\n",
"etiology": "<p>Эндогенные (внутренние) причины развития болезни: </p>\r\n<ul>\r\n<li>Генетическая предрасположенность – если в семье есть люди, страдающие от этого заболевания, то риск его развития у следующих поколений повышен; </li>\r\n<li>Строение жировой ткани, скорость обмена жиров; </li>\r\n<li>Активность функционирования центров голода и сытости в гипоталамусе; </li>\r\n<li>Изменения гормонального фона, которые могут быть вызваны периодом беременности, родов и лактации, климактерическим синдромом. </li>\r\n</ul>\r\n<p>К экзогенным (внешним) факторам развития заболевания относятся: </p>\r\n<ul>\r\n<li>Ожирение алиментарно-конституционального генеза может быть вызвано избыточным потреблением пищи в любом возрасте, включая детский; </li>\r\n<li>Рефлексы, привязанные ко времени и количеству еды, – некоторые люди в стрессовых ситуациях успокаиваются только во время принятия пищи, другие отдыхают после рабочего дня на диване перед телевизором с тарелкой, полной любимых, но не всегда полезных продуктов; </li>\r\n<li>Национальные традиции, исходя из которых люди усваивают определенный тип, а также рацион питания; </li>\r\n<li>Распространенный во всем мире малоактивный образ жизни, приводящий к гиподинамии.</li>\r\n</ul>",
"pathogenesis": "<p> Алиментарное ожирение базируется на стимуляции секреции инсулина в результате обильной еды, повышении активности центра голода и торможения центра сытости, находящихся в гипоталамусе. </p>\r\n<p>В патогенезе ожирения нельзя не придавать значения эндокринным органам и прежде всего гипофизу, надпочечникам, островковому аппарату поджелудочной железы, щитовидной и половым железам. </p>\r\n<p>Повышение функциональной активности системы гипофиз - кора надпочечников и инсулярного аппарата поджелудочной железы способствует накоплению жира в жировых депо. Снижение соматотропной активности аденогипофиза, сопровождающееся ослаблением процессов мобилизации жира из депо и последующего его окисления в печени, также выступает в качестве патогенетического фактора. </p>\r\n<p>Пониженное образование адреналина - активного липолитического фактора - имеет существенное значение в понижении мобилизации жира и является одним из патогенетических факторов ожирения. </p>",
"diagnostics": "<p>Для диагностики ожирения в практической медицине наиболее часто используют индекс массы тела (ИМТ). Применяется также индекс Борнгардта, в отличие от ИМТ учитывающий телосложение человека. </p>\r\n<p>Показателем для определения избыточного веса является Индекс массы тела (ИМТ). </p>\r\n<p>ИМТ = масса тела/рост2 (кг/м2).. </p>\r\n<p>Нормальной массе тела соответствует ИМТ 18,5-24,5. ИМТ 25,0-29,9 говорит об избытке массы тела, а ИМТ более 30 указывает на наличие у пациента ожирения. </p>\r\n<p>Диагноз I степени ставится при ИМТ 30,0 – 34,9, </p>\r\n<p>II степени – при ИМТ 35,0 – 39,9, </p>\r\n<p>III степени при ИМТ более 40. </p>\r\n<p>Нужно помнить, что показатель ИМТ не является достоверным для детей, беременных, а также спортсменов и лиц с очень развитой мускулатурой. Для этих категорий пациентов наличие ожирения и его степень определяется по-другому. </p>\r\n<p>Наиболее точным методом определения количества жировой ткани в организме считается МРТ. </p>\r\n<p>В быту количество жировой ткани в организме человека обычно определяется бытовыми весами с анализатором состава тела методом биоимпедансометрии (метод диагностики состава тела человека посредством измерения импеданса – электрического сопротивления участков тела – в разных частях организма). </p>",
"treatment": "<p>Основные способы лечения при избыточном весе и ожирении</p>\r\n<p>К ним относят соблюдение диеты с повышенным содержанием клетчатки, витаминов и других биологически активных компонентов (злаки и цельнозерновые продукты, овощи, фрукты, орехи, зелень и др.) и ограничением употребления легкоусваиваемых организмом углеводов (сахар, сладости, выпечка, хлебобулочные и макаронные изделия из муки высших сортов), а также физические упражнения. </p>\r\n<p>Общий подход при лекарственном лечении ожирения состоит в испытании всех известных препаратов для лечения ожирения.</p>\r\n<p>По механизму действия препараты для лечения ожирения делятся на три группы: </p>\r\n<ol>\r\n<li>снижающие потребление пищи (подавляющие аппетит); </li>\r\n<li>увеличивающие расход энергии; </li>\r\n<li>уменьшающие всасывание питательных веществ. </li>\r\n</ol>\r\n<p>Если результат медикаментозного лечения оказывается незначительным или его нет, то необходимо прекратить такое лечение. Возможно рассмотрение вопроса целесообразности проведения хирургического лечения. Используют бариатрические операции (направленные на уменьшение объема желудка) и косметические операции (удаление излишков жировой ткани). </p>\r\n<p>Применяется также психотерапевтическое лечение (поведенческая терапия). </p>",
"prevention": "<p>Людям со склонностью к избыточному весу следует уравновесить количество потребляемой пищи и уровень физических нагрузок. Диета должна быть сбалансированной. Увеличение физических нагрузок, занятия спортом должны идти вслед за изменением диеты.</p>",
"clinical_picture": "<p>К симптомам первичного ожирения относятся: </p>\r\n<ul>\r\n<li>гипертензия; </li>\r\n<li>завышенные показатели индекса массы тела (ИМТ) по сравнению с нормой; </li>\r\n<li>инсулинорезистентность (снижение чувствительности тканей к действию инсулина); </li>\r\n<li>нарушения в работе внутренних органов, в первую очередь сердечно-сосудистой системы; </li>\r\n<li>одышка; </li>\r\n<li>повышенное потоотделение; </li>\r\n<li>постепенное увеличение объёмов пищи, переедание; </li>\r\n<li>развитие внутренних комплексов из-за внешнего вида; </li>\r\n<li>сахарный диабет II типа; </li>\r\n<li>значительная прибавка в весе; </li>\r\n<li>увеличение объёмов талии (у женщин — превышает 80 см, у мужчин — 94)</li>\r\n</ul>",
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